Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency by Shao Yang, Yawei Sun, Wei Luo, Xiaofeng Zhou, Xiao Gu, Wenzhe Zhang, Huashan Zhu, Wenjia Wu, Xueying Wu, Mengru Yu, Shan Wang

“…Dominant follicles play a vital role in ovarian endocrine and reproductive function. Zona pellucida glycoprotein 3 (ZP3) is a specific component of the zona pellucida around the oocyte and is tightly associated with the dominant follicle. …”
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Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care by Alina-Georgiana Cristea (Hohotă), Elena-Lăcrămioara Lisă, Simona Iacob (Ciobotaru), Ionut Dragostin, Claudia Simona Ștefan, Iuliu Fulga, Andra Monica Anghel (Ștefan), Maria Dragan, Ionela Daniela Morariu, Oana-Maria Dragostin

“…Wound healing is a complex, tightly regulated process essential for maintaining skin barrier function. …”
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Cleavage site heterogeneity at the pre-mRNA 3′-untranslated region regulates gene expression in oxidative stress response by Feba Shaji, Jamshaid Ali, Rakesh S. Laishram

“…The endonucleolytic cleavage step of the eukaryotic mRNA 3′-end processing is considered imprecise, which leads to heterogeneity of cleavage site (CS) with hitherto unknown function. Contrary to popular belief, we show that this imprecision in the cleavage is tightly regulated, resulting in the CS heterogeneity (CSH) that controls gene expression in antioxidant response. …”
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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

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Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells by Akiko Sugimoto-Ishige, Aya Jodo, Takashi Tanaka

“…Activation of transcription factor NF-κB is tightly regulated by negative regulatory systems that prevent excessive inflammation leading to autoimmune diseases. …”
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Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes by Martin V. Hamann, Shweta Godbole, Maisha Adiba, Sabrina M. Leddy, Jelena Navolić, Ghazaleh Tabatabai, Daniel J. Merk, Ulrike C. Lange, Julia E. Neumann

“…The sole recurrent biallelic loss-of-function mutation in SMARCB1 in ATRTs, a core component of the SWI/SNF chromatin remodeling complex, raises the question of how TE transcription contributes to ATRT development. …”
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RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation by Alejandro Rosell, Agata Adelajda Krygowska, Marta Alcón Pérez, Cristina Cuesta, Mathieu-Benoit Voisin, Juan de Paz, Héctor Sanz-Fraile, Vinothini Rajeeve, Ana Carreras-González, Alberto Berral-González, Ottilie Swinyard, Enrique Gabandé-Rodríguez, Julian Downward, Jordi Alcaraz, Juan Anguita, Carmen García-Macías, Javier De Las Rivas, Pedro R Cutillas, Esther Castellano Sanchez

“…Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. …”
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Alloimmune Causes of Recurrent Pregnancy Loss: Cellular Mechanisms and Overview of Therapeutic Approaches by Cristina Uța, Alexandru Tîrziu, Elena-Larisa Zimbru, Răzvan-Ionuț Zimbru, Marius Georgescu, Laura Haidar, Carmen Panaitescu

“…Recurrent pregnancy loss (RPL) is a complex early pregnancy complication affecting 1–2% of couples and is often linked to immune dysfunction. …”
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Effects of Pueraria montana and Melastoma dodecandrum Intercropping on Soil and Tea Plant Growth in Terraced Tea Gardens: A Sustainable Agricultural Practice by Lingshan Shi, Dongliang Li, Shuaibo Shao, Fajie Feng, Qisong Li, Fanfan Zeng, Lingyuan Shi, Jianming Zhang, Yongcong Hong, Pumo Cai

“…However, HWT has a greater impact on functional microorganisms related to C and N cycles, especially N cycling. …”
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Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate by Peng Zuo, Weize Wang, Zonglin Dai, Jiye Zheng, Shang Yu, Guangxi Wang, Yue Yin, Ling Liang, Yuxin Yin

“…Abstract Inorganic phosphate (Pi) is essential for life, and its intracellular levels must be tightly regulated to avoid toxicity. XPR1, the sole known phosphate exporter, is critical for maintaining this balance. …”
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An integrated structural and biophysical approach to study carbon metabolism in Mycobacterium tuberculosis by Evelyn Y.-W. Huang, Francis Kuang, Haozhe Wu, Chai Xin Yu, Xiaoxu Chen, Glenda Vasku, Le Thao Anh Nguyen, Katherine J. Jeppe, Anna K. Coussens, Brooke X.C. Kwai, Ivanhoe K.H. Leung

“…Many of these enzymes are tightly regulated by feedback mechanisms. To fully understand their roles and modulation, it is crucial to investigate the relationship between their structure, catalytic mechanism, and function. …”
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Robust Symbol Detection in Large-Scale Overloaded NOMA Systems by Hiroki Iimori, Giuseppe Thadeu Freitas De Abreu, Takanori Hara, Koji Ishibashi, Razvan-Andrei Stoica, David Gonzalez G., Osvaldo Gonsa

“…</italic>, 2020), the method is not relaxed into the <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula>-norm, but rather approximated with a continuous and asymptotically exact expression without resorting to parallel interference cancellation (PIC). The objective function of the resulting formulation is thus a sum of concave-over-convex ratios, which is then tightly convexified via the quadratic transform (QT), such that its solution can be obtained via the iteration of a simple closed-form expression that closely resembles that of the classic zero-forcing (ZF) receiver, making the method particularly suitable to large-scale set-ups. …”
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A controllable photoresponsive potassium transporter by Zhongyan Li, Lin Yuan, Wenju Chang, Junqiu Liu, Jie Shen, Huaqiang Zeng

“…We report here a controllable, photoresponsive, ion-transporting carrier, achieving controllability through a photoregulated β-cyclodextrin (β-CD)-azobenzene host-guest complex. In this complex, a lipid-anchored β-CD serves as the launch base, tightly immobilizing through host-guest interactions the otherwise freely moving trans-transporter derived from a crown ether-modified trans-azobenzene motif, but rapidly releasing most of it upon 365 nm UV irradiation that converts transporter to its cis-configuration. …”
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CCR3 deficiency shifts adaptive to innate-driven immunity in asthma by Susanne Krammer, RPh, Zuqin Yang, PhD, Hannah Mitländer, MD, Janina C. Grund, MD, Carol I. Geppert, MD, Ralf J. Rieker, MD, Sabine Zirlik, MD, Susetta Finotto, PhD

“…Background: Because of repeated contact with airborne allergens, patients suffering from allergic asthma experience acute asthma attacks, characterized by shortness of breath, chest tightness, and coughing. The underlying immune response is highly complex and involves various immune cells. …”
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The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae. by Scott G Shanks, Lindsay N Carpp, Marion S Struthers, Rebecca K McCann, Nia J Bryant

“…Intracellular membrane trafficking pathways must be tightly regulated to ensure proper functioning of all eukaryotic cells. …”
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Niemann - Pick C2 regulates steroid hormone secretion and lipid deposition in chicken follicular granulosa cells by Ruihao Yu, Shuo Wei, Felix Kwame Amevor, Liuting Wu, Dan Xu, Zheliang Liu, Kunlong Qi, Yingjie Wang, Gang Shu, Xiaoling Zhao

“…Follicular development is tightly regulated by the coordinated action of multiple hormones and complex gene regulatory networks in granulosa cells, which play a crucial role in egg production and fertility in hens. …”
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Measuring communities’ efficiencies within the global tourism network by He Zhu

“…Abstract Tourist flows between countries shape the global tourism network, with tightly interconnected nations forming distinct communities. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…While epilepsy and psychiatric behaviors increase in severity with age, communication abilities and motor function tend to improve. iPSCs, which were differentiated into GABAergic neurons, represent the first in vitro neuronal model of SSADHD and express the neuronal marker microtubule-associated protein 2 (MAP2), as well as GABA. …”
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PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease by Purin Charoensuksai, Wei Xu

“…The circadian rhythm, controlled by a complex network of cellular transcription factors, orchestrates behavior and physiology in the vast majority of animals. …”
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Enhanced propionate and butyrate metabolism in cecal microbiota contributes to cold-stress adaptation in sheep by Xindong Cheng, Yanping Liang, Kaixi Ji, Mengyu Feng, Xia Du, Dan Jiao, Xiukun Wu, Chongyue Zhong, Haitao Cong, Guo Yang

“…Correlation analysis indicated that butyrate holds a central position in both networks, with Hulunbuir sheep exhibiting a more complex and tightly regulated network involving SCFAs, microbiota, microbial functions, and transcriptomes. …”
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