Update on NKCC2 regulation in the thick ascending limb (TAL) by membrane trafficking, phosphorylation, and protein-protein interactions by Dipak Maskey, Dipak Maskey, Jessica Granados Pineda, Jessica Granados Pineda, Pablo A. Ortiz, Pablo A. Ortiz

“…Here, we update the latest molecular mechanisms and players that control NKCC2 function, which gives an increasingly complex picture of NKKC2 regulation in the apical membrane of the TAL.Recent FindingsProtein-protein interactions are required as a regulatory mechanism in many cellular processes. …”
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Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells. by Adam G Grieve, Rachel D Daniels, Elena Sanchez-Heras, Matthew J Hayes, Stephen E Moss, Karl Matter, Martin Lowe, Timothy P Levine

“…We show that a proportion of OCRL1 targets intercellular junctions at the early stages of their formation, co-localizing both with adherens junctional components and with tight junctional components. Correlating with this distribution, OCRL1 forms complexes with junctional components α-catenin and zonula occludens (ZO)-1/2/3. …”
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Data-driven prediction and design of bZIP coiled-coil interactions. by Vladimir Potapov, Jenifer B Kaplan, Amy E Keating

“…Testing more than 132 candidate protein complexes using a fluorescence resonance energy transfer assay confirmed the formation of tight and selective heterodimers between the designed peptides and their targets. …”
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Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies by Shu-Yun Li, Francesco John DeMayo

“…Implantation is a complex and tightly regulated process essential for the establishment of pregnancy. …”
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Identifying the effectiveness of face mask in a large population with a network-based fluid model. by Akshay Anand, Kourosh Shoele

“…The study also elucidates the complex role of nose clips in improving sealing efficacy for tightly fitted masks and redirecting leaked flow in typical imperfect facemasks. …”
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Cell-specific genetic expression profile of antennal glia in Drosophila reveals candidate genes in neuron-glia interactions by Ana Castañeda-Sampedro, Esther Alcorta, Carolina Gomez-Diaz

“…Additionally, similarities between the molecular signatures of peripheral glia in Drosophila and vertebrates highlight the utility of model organisms in elucidating glial cell functions in complex systems.…”
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The interplay between epidermal barrier distribution, microbiota composition, and immune infiltrate defines and stratifies psoriasis patients and is associated with disease severit... by Elizabeth M. Ortega Rocha, Paul Hernández-Herrera, Sofia V. de los Santos- Carmona, Saraí G De León-Rodríguez, Ángel Juárez-Flores, Vadim Pérez-Koldenkova, Octavio Castro-Escamilla, Samira Muñoz-Cruz, Alicia Lemini-López, Laura C. Bonifaz

“…Our findings emphasize the complex interplay between epidermal barrier distribution, SEB localization, and functional CD4 TCRvβ17 cells in psoriatic skin, highlighting their potential in patient stratification in association with the severity of the disease.…”
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The Centriole Stability Assay: A Method to Investigate Mechanisms Involved in the Maintenance of the Centrosome Structure in Drosophila Cultured Cells by Mariana Lince-Faria, Ana Ferreira-Silva, Ana Pimenta-Marques

“…Centrosome numbers are tightly regulated, typically duplicating once per cell cycle, during the S phase. …”
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Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. by Luke Boldock, Amanda Inzoli, Silvia Bonardelli, Sarah Hsiao, Alberto Marzo, Andrew Narracott, Julian Gunn, Gabriele Dubini, Claudio Chiastra, Ian Halliday, Paul D Morris, Paul C Evans, Perrault C M

“…Stents had striking effects on fluid flow streamlines, flow separation or funnelling, and the accumulation of particles at areas of complex geometry that were tightly coupled to stent shape. …”
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Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22phox N-Terminus: An Elusive Target by Gábor Csányi, Patrick J. Pagano

“…Although NADPH oxidase 4 (Nox4) is the most abundant Nox isoform in systemic vascular endothelial and smooth muscle cells, its function in the vascular tissue is not entirely known. …”
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The Interplay of Iron and Lipid Homeostasis in Non-Alcoholic Fatty Liver Disease by Clinton J. Kidman, Cyril D.S. Mamotte, Keea R. Inder-Smith, Mark J. Tobin, Mark J. Hackett, Ross M. Graham

“… The liver is essential for numerous metabolic functions and is the primary site of iron storage and regulation in addition to maintaining critical functions in lipid metabolism. …”
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Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation by Wenhan Ju, Shuai Zhao, Danping Li, Jinfu Zhang, Jinfu Zhang, Shan Xiang, Fang Lian

“…The cyclic recruitment of primordial follicles and the preservation of oocyte quality involve complex and tightly regulated biological processes. …”
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A targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy by Muhan Wang, Zhijie Zhang, YouYou Yang, Xiaoyi Peng, Hongping Yin

“…TRIAS-expressing tumor cells exhibited enhanced antitumor activity, likely due to increased cytokine release and upregulated major histocompatibility complex (MHC) expression, enabling tumor cells to function as antigen-presenting cells. …”
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The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. by David S Guttery, Jon K Pittman, Karine Frénal, Benoit Poulin, Leon R McFarlane, Ksenija Slavic, Sally P Wheatley, Dominique Soldati-Favre, Sanjeev Krishna, Rita Tewari, Henry M Staines

“…Due to its varied and essential roles, free Ca(2+) is tightly regulated by complex mechanisms. These mechanisms are therefore of interest as putative drug targets. …”
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Successful management of severe anaerobic infection inducing mediastinal and subcutaneous emphysema, septic shock, and ARDS: a case report highlighting VV-ECMO and NGS-guided thera... by Haohao Wu, Pin Lan, Kechun Zhou, Xingzhen Wu, Lutao Xie

“…After 7 days of ECMO support and anti-infective treatment, the patient’s oxygenation improved significantly, inflammatory markers decreased, and ECMO was successfully weaned.ConclusionVV-ECMO is of critical value in managing septic shock and ARDS caused by severe anaerobic infections, effectively improving oxygenation and supporting organ function. This case highlights the pivotal role of airway management, VV-ECMO support, and comprehensive therapeutic strategies in the management of complex infectious ARDS, providing valuable insights for similar clinical scenarios.…”
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Case Report: Giant pheochromocytoma complicated by takotsubo syndrome: a case of emergency robot-assisted left adrenalectomy and multidisciplinary management by Jia Miao, Jia Miao, Xuanhan Hu, Xuanhan Hu, Ting Wang, Feng Liu, Dahong Zhang, Haibin Wei

“…Postoperatively, cardiac function normalized within three months, and catecholamine levels returned to baseline. …”
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Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development by Divyesh Joshi, Preeti Jindal, Ronak K Shetty, Maneesha S Inamdar

“…The transforming growth factor β (TGFβ) signaling pathway is critical for survival, proliferation, and cell migration, and is tightly regulated during cardiovascular development. …”
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Crosstalk between metabolism and epigenetics during macrophage polarization by Kangling Zhang, Chinnaswamy Jagannath

“…Abstract Macrophage polarization is a dynamic process driven by a complex interplay of cytokine signaling, metabolism, and epigenetic modifications mediated by pathogens. …”
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An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure by Cristina Manuela Drăgoi, Anca Zanfirescu, Ion-Bogdan Dumitrescu, Anca Ungurianu, Denisa Marilena Margină, Alina-Crenguţa Nicolae

“…Additionally, the influence of calcium and magnesium ions on the resulting complexes of these indole derivatives with ct-DNA has been evaluated. …”
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Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets by Chetan Pundkar, Rex Jeya Rajkumar Samdavid Thanapaul, Manoj Govindarajulu, Gaurav Phuyal, Joseph B. Long, Peethambaran Arun

“…Conclusions: These findings highlight the complex regulatory mechanisms underlying retinal responses to bTOI, involving neuroinflammation, oxidative stress, and disruptions in melatonin synthesis and photoreceptor cell functions. …”
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