Mechanistic insights into the recognition of Fe2+ and solvent-driven selectivity of chalcone-based receptors by Ajay Shankar

“…Spectrosc. 287 (2023) 122107; 303 (2023) 123129], this study offers novel insight into the supramolecular recognition of Fe2+ by receptor R1, wherein the conventional chalcone binding strategy is extended. Density Functional Theory (DFT) is used to differentiate the complexation behavior of chalcone-based receptors (R1, R2, R3), revealing key nucleophilic centres, particularly the carbonyl and phenolic oxygen atoms, as primary coordination sites. …”
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PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL by A. L. Unanyan, I. S. Sidorova, E. A. Kogan, D. V. Baburin

“…We have identified risk factors and determined their significance and relative risk in endometrial oncotransformation based on mathematical analysis of clinical and anamnestic data and molecular-biological indicators. The structural, functional and molecular mechanisms of hyperplastic processes of endometrium in premenopausal women were investigated based on a complex immunohistochemical studies. …”
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Stability and Finite-Time Synchronization Analysis for Recurrent Neural Networks with Improved Integral-Type Time-Varying Delays by Meng Li, Gulijiamali Maimaitiaili

“…Firstly, a sufficient criterion for universal asymptotic stability of RNNs with integral time-varying delays is obtained by estimating a tight upper bound of augmented Lyapunov-Krasovskii functional (LKF) derivative with inequality scaling technique and mutually convex combined inequality. …”
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Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis by Zhiqi Xiong, Xiaolin Yang, Shule Wang, Caitlan J. Smart, Hazel M. Sisson, Zhenli Lin, Tianyu Hu, Yuting Ran, Chuyao Xu, Xiuna Yang, Yao Zhao, William J. Jowsey, Gregory M. Cook, Matthew B. McNeil, Luke W. Guddat, Zihe Rao, Bing Zhang

“…The stalk secures the tight association of the three MmpL5 subunits and exhibits intrinsic structural flexibility. …”
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Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis by Cong Hu, Heli Li, Jinru Cui, Yunjie Li, Feiyan Zhang, Hao Li, Xiaoping Luo, Yan Hao

“…Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by social communication deficits and restricted, repetitive behaviors. …”
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PcG-mediated higher-order chromatin structures modulate replication programs at the Drosophila BX-C. by Federica Lo Sardo, Chiara Lanzuolo, Federico Comoglio, Marco De Bardi, Renato Paro, Valerio Orlando

“…However, the interconnection between replication timing control and PcG functions remains unknown. Using Drosophila embryonic cell lines, we find that, while presence of specific PcG complexes and underlying transcription state are not the sole determinants of cellular replication timing, PcG-mediated higher-order structures appear to dictate the timing of replication and maintenance of the silenced state. …”
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Evaluasi Kualitas Layanan terhadap Operator Telekomunikasi: Tinjauan Perspektif Pelanggan by Suryat Handoko, Nilda Tri Putri, Jonrinaldi Jonrinaldi

“…PT Semen Padang is now actively promoting synergies and pursuing the company's performance growth to be able to cope with competition in an increasingly tight and complex cement industry. In order to face this, it is necessary to have adequate human resource management from the company. …”
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How (Ultra‐)Rare Gene Variants Improve Our Understanding of More Common Autoimmune and Inflammatory Diseases by Alexandre Belot, Maud Tusseau, Jade Cognard, Sophie Georgin‐Lavialle, Guilaine Boursier, Christian M. Hedrich

“…Additional monogenic diseases such as ELF4, WDR1 mutations and trisomy 8 further illustrate the genetic complexity of this condition. Observations from genetic studies in SLE and Behçet syndrome highlight the complexity of systemic inflammatory diseases in which distinct molecular defects caused by single‐gene mutations can promote lupus or Behçet syndromes, often unrecognizable from their genetically complex “classical” forms. …”
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A Novel Multi-Agent-Based Approach for Train Rescheduling in Large-Scale Railway Networks by Jin Liu, Lei Chen, Zhongbei Tian, Ning Zhao, Clive Roberts

“…While recent research has introduced intelligent solutions to railway traffic management, the tight interdependence of train timetables and the intrinsic complexity of railway networks have hindered the scalability of these approaches to large-scale systems. …”
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Trans-synaptic molecular context of NMDA receptor nanodomains by Michael C. Anderson, Poorna A. Dharmasri, Martina Damenti, Sarah R. Metzbower, Rozita Laghaei, Thomas A. Blanpied, Aaron D. Levy

“…Abstract Tight coordination of spatial relationships between protein complexes is required for cellular function. …”
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BIOLOGICAL RESPONSE OF TREATMENT WITH SAFFRON PETAL EXTRACT ON CYTOKYNE-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN THE CACO-2/THP1 COCOLTURE MODEL

“…Furthermore, the results of our model suggest that SPE treatment restores the functionality of the intestinal barrier by reducing the destruction of tight junctions induced by the inflammatory stimulus. …”
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THE OPTIMIZATION METHOD OF FUZZY AUTOMATIC CLASSIFICATION IN THE PROBLEM OF COMBINING THE ASSESSMENTS OF TRAJECTOR MEASUREMENTS IN THE RADAR SYSTEM by A. V. Khizhniak

“…By a radiolocation system the author mean an automated hierarchical technical complex that combines, using communication tools, a set of asynchronously functioning radiolocation tools, as well as central and intermediate points that collect, process and issue trajectory radiolocation information. …”
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A new methodology to associate SNPs with human diseases according to their pathway related context. by Burcu Bakir-Gungor, Osman Ugur Sezerman

“…Our methodology is based on functionalization of important SNPs to identify effected genes and disease related pathways. …”
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Depletion reveals role of bicarbonate in the photosynthetic electron transport chain of Limnospira maxima by Leslie Castillo, Stavroula Nicolaou, Colin Gates, Colin Gates

“…Using chlorophyll fast repetition rate fluorometry, it was observed under bicarbonate depletion that oscillations were still present in a fraction of PSIIs, confirming the functionality of the water oxidizing complex remains in this fraction of centers. …”
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Microbial metabolites and immune modulation by Hassan Ghasemi

“…Even lipopolysaccharides (LPS), traditionally regarded as pro-inflammatory, can have nuanced roles; at low doses, they may condition immune cells to adopt a tolerogenic state, highlighting the complexity of microbial metabolite interactions.9 Microbial metabolites significantly influence innate immunity by enhancing the pathogen-clearing abilities of macrophages, as SCFAs optimize their phagocytic functions. …”
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VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma by Zuqian Wu, Issei Omura, Atsushi Saito, Kazunori Imaizumi, Yasunao Kamikawa

“…The Nuclear envelope (NE) is frequently challenged by mechanical stimuli involving cells passing through a tight space and such stress is known as “NE stress.” …”
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Large system study of chalcopyrite and pyrite flotation surfaces based on SCC-DFTB parameterization method by Jianhua Chen, Yibing Zhang

“…In this study, we employed the self-consistent charge density functional tight-binding (SCC-DFTB) parameterization method to develop a parameter set, CuFeOrg, which includes the interactions between Cu-Fe-C-H-O-N-S-P-Zn elements, to investigate the surface interactions in large-scale flotation systems of chalcopyrite and pyrite. …”
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Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control. by David Cobley, Lenka Hálová, Marie Schauries, Adrian Kaczmarek, Mirita Franz-Wachtel, Wei Du, Karsten Krug, Boris Maček, Janni Petersen

“…Tight coupling of cell growth and cell cycle progression enable cells to adjust their rate of division, and therefore size, to the demands of proliferation in varying nutritional environments. …”
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Barriers and Strategies for Oral Peptide and Protein Therapeutics Delivery: Update on Clinical Advances by Kshitis Chandra Baral, Ki Young Choi

“…In particular, functional biomaterials, active targeting, and lymphatic transport strategies have provided new platforms for oral PP delivery. …”
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Optimisation of the performance and structure of soluble ball seat metal sealing rings based on response surface by CHEN Zhen, RAN Qingjie, CHEN Nengpeng, WANG Qiaomu

“…Horizontal well fracturing technology, as a core tool for efficient development of tight oil and gas reservoirs, is of strategic significance for enhancing the recovery rate of unconventional oil and gas resources. …”
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