Coupled motions direct electrons along human microsomal P450 Chains. by Christopher R Pudney, Basile Khara, Linus O Johannissen, Nigel S Scrutton

“…Motions critical to the broader biological functions of CPR are tightly coupled to enzyme chemistry in the human NADPH-CPR-CYP redox chain. …”
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Modern View on the Role of Epidermal Barrier in Atopic Phenotype Development in Children by Nikolay N. Murashkin, Alena A. Savelova, Roman A. Ivanov, Dmitri V. Fedorov, Leonid A. Opryatin, Wasel Ahmad

“…Filaggrin and tight junctions (TJs) proteins are important structural components of the epidermal barrier. …”
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Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes by Ana Filipa Sobral, Inês Costa, Vanessa Teixeira, Renata Silva, Daniel José Barbosa

“…In particular, astrocytes are essential for BBB function, as they maintain BBB integrity through their end-feet, which form a physical and biochemical interface that enhances endothelial cell function and barrier selectivity. …”
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A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity. by Satoko Nishimoto, Carolina Minguillon, Sophie Wood, Malcolm P O Logan

“…Forelimb-restricted expression of Tbx5 and ultimately forelimb formation is therefore achieved through co-option of two characteristics of Hox genes; their colinear expression along the body axis and the functional specificity of different paralogs. Active complexes can be formed by Hox PG proteins present throughout the rostral-caudal LPM while restriction of Tbx5 expression is achieved by superimposing a dominant repressive (Hoxc9) complex that determines the caudal boundary of Tbx5 expression. …”
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“Loss of polarity of basal cells” – The term revisited in the light of genomics by Debasish Pramanick, Richa Singh, Bidyut Roy, Anjana Mazumdar, Sandip Ghose

“…The epithelial cells exhibit apicobasal polarity which is maintained by Crumbs complex located at apical region of tight junction, ‘PAR’ complex at sub-apical region of tight junction and Scribble complex at adherens junction. …”
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Elucidating Key Motifs Required for Arp2/3-Dependent and Independent Actin Nucleation by Las17/WASP. by Ellen G Allwood, Joe J Tyler, Agnieszka N Urbanek, Iwona I Smaczynska-de Rooij, Kathryn R Ayscough

“…Actin nucleation is the key rate limiting step in the process of actin polymerization, and tight regulation of this process is critical to ensure actin filaments form only at specific times and at defined regions of the cell. …”
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RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. by Kelly E Coller, Kristi L Berger, Nicholas S Heaton, Jacob D Cooper, Rosa Yoon, Glenn Randall

“…Hepatitis C virus (HCV) enters hepatocytes following a complex set of receptor interactions, culminating in internalization via clathrin-mediated endocytosis. …”
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Clostridium butyricum: a promising approach to enhancing intestinal health in poultry by Xiaopeng Tang, Yan Zeng, Meijun Li

“…Clostridium butyricum (C. butyricum) is a probiotic bacterium that has been shown to be a promising candidate for improving intestinal function and subsequently optimizing poultry growth. …”
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Examining Stromal Cell Interactions in an In Vitro Blood–Brain Barrier Model with Human Umbilical Vein Endothelial Cells by Andrea Margari, Simon Konig, Vignesh Jayarajan, Silvia Rizzato, Giuseppe Maruccio, Emad Moeendarbary

“…Understanding the function of the blood–brain barrier (BBB) in health and disease, as well as improving drug delivery across the BBB, remains a critical priority in neuroscience research. …”
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Entry Guidance for Hypersonic Glide Vehicles via Two-Phase hp-Adaptive Sequential Convex Programming by Xu Liu, Xiang Li, Houjun Zhang, Hao Huang, Yonghui Wu

“…This paper addresses the real-time trajectory generation problem for hypersonic glide vehicles (HGVs) during atmospheric entry, subject to complex constraints including aerothermal limits, actuator bounds, and no-fly zones (NFZs). …”
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A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia by Geli Li, Yuchen Ma, Sujie Zhang, Wen Lin, Xinyi Yao, Yating Zhou, Yanyong Zhao, Qi Rao, Yuchen Qu, Yuan Gao, Lianmin Chen, Yu Zhang, Feng Han, Meiling Sun, Chen Zhao

“…To better understand the complex multifaceted roles of BMECs in the regulation of ischemic stroke pathophysiology and facilitate BMEC-based drug target discovery, we utilized a transcriptomics-informed systems biology modeling approach and constructed a mechanism-based computational multipathway model to systematically investigate BMEC function and its modulatory potential. …”
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Thermo-Hydro-Mechanical Coupling Numerical Simulation on Mechanical Heterogeneity of Coal Rock by Shuiqing Hu, Daobing Wang, Yipeng Li, Xiongfei Liu, Fujian Zhou, Meng Wang, Chunming He, Bo Yu

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The Intestinal Thread of Fate: How the Microbiota Shapes the Story of Liver Disease by Carlo Acierno, Riccardo Nevola, Luca Rinaldi, Ferdinando Carlo Sasso, Luigi Elio Adinolfi, Alfredo Caturano

“…The gut–liver axis plays a critical role, with factors like altered bile acid metabolism and toxic metabolites such as hydrogen sulfide worsening intestinal barrier function and fueling chronic inflammation. This review aims to explore the complex role of the gut–liver axis in MASLD progression, highlighting the mechanisms of intestinal barrier dysfunction, dysbiosis, and microbial contributions to liver injury. …”
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Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis by Ina Lackner, Birte Weber, Shinjini Chakraborty, Sonja Braumüller, Markus Huber-Lang, Florian Gebhard, Miriam Kalbitz

“…The development of septic cardiomyopathy is due to complex interactions of damage-associated molecular patters, cytokines, and complement activation products. …”
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Porcine intestinal organoids cultured in an organ-on-a-chip microphysiological system by James Bacon, Halie Kitchel, John Stutz, Jack Jia Hua Chen, Aaron Smith, Robert D. Van Horn, Christopher Moreland, Trent Abraham, Thomas Baker, Eitaro Aihara, Kathleen Hillgren

“…These cultures formed villi-like structures and established a tight barrier replete with F-actin and tight junctions. …”
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Production, purification and characterization of recombinant, full-length human claudin-1. by Nicklas Bonander, Mohammed Jamshad, Dominik Oberthür, Michelle Clare, James Barwell, Ke Hu, Michelle J Farquhar, Zania Stamataki, Helen J Harris, Karsten Dierks, Timothy R Dafforn, Christian Betzel, Jane A McKeating, Roslyn M Bill

“…The transmembrane domain proteins of the claudin superfamily are the major structural components of cellular tight junctions. One family member, claudin-1, also associates with tetraspanin CD81 as part of a receptor complex that is essential for hepatitis C virus (HCV) infection of the liver. …”
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The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. by Krasimir Slanchev, Thomas J Carney, Marc P Stemmler, Birgit Koschorz, Adam Amsterdam, Heinz Schwarz, Matthias Hammerschmidt

“…On the molecular level, EVL cells of epcam mutant embryos display reduced levels of membranous Ecad, accompanied by an enrichment of tight junction proteins and a basal extension of apical junction complexes (AJCs). …”
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Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium. by Talita B Gagliardi, Monty E Goldstein, Daniel Song, Kelsey M Gray, Jae W Jung, Maxinne A Ignacio, Kimberly M Stroka, Gregg A Duncan, Margaret A Scull

“…Finally, RV-C15 infection resulted in a temporary loss in epithelial barrier integrity and the translocation of tight junction proteins while a reduction in mucociliary clearance indicated cytopathic effects on epithelial function. …”
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Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation by Dingwu Qu, Zhennan Gu, Saisai Feng, Leilei Yu, Fengwei Tian, Hao Zhang, Wei Chen, Qixiao Zhai

“…The probiotic strains differed in regulating the intestinal microbiota, cytokines (IL-10, IL-1β and interferon (IFN)-γ), and tight junction function (Zonulin-1 and Occludin). …”
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JMY powers dendritogenesis and is regulated by CaM revealing a general, critical principle in neuromorphogenesis by Maja Kühne, Anna-Lena Zepernick, Britta Qualmann, Michael Manfred Kessels, Maryam Izadi-Seitz

“…Here, we identify the WH2 domain-based actin nucleator JMY as target of the calcium sensor calmodulin, reveal that JMY is critical for dendritic arbor formation and unravel that JMY’s molecular mechanisms employed in dendritic arborization are depended on Arp2/3 complex interaction, Arp2/3 complex activity and functionality of JMY’s WH2 domains, i.e. on JMY’s abilities to promote actin filament formation. …”
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