The Diversity of Cold Worlds: A Blended-light Binary Straddling the T/Y Transition in Brown Dwarfs by Daniella C. Bardalez Gagliuffi, Jacqueline K. Faherty, Genaro Suárez, Sherelyn Alejandro Merchan, Brianna Lacy, Ben Burningham, Klara Matuszewska, Rocio Kiman, Johanna M. Vos, Austin Rothermich, Jonathan Gagné, Caroline Morley, Melanie J. Rowland, Dan Caselden, Aaron Meisner, Adam C. Schneider, Marc J. Kuchner, Charles A. Beichman, Peter R. Eisenhardt, Christopher R. Gelino, Ehsan Gharib-Nezhad, Eileen C. Gonzales, Federico Marocco, Niall Whiteford, J. Davy Kirkpatrick

“…Carbon disequilibrium chemistry strongly shapes the mid-infrared spectra of these sources, as a complex function of the metallicity and surface gravity. …”
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Proteoglycans in normal physiology and carcinogenesis by A. V. Suhovskih, E. V. Grigorieva

“…An important role in this process belongs to the complex protein-carbohydrate molecules – proteoglycans (PG), which are one of the main component of ECM and cell surface of any tissue and are tightly involved in cell-cell and cell-matrix interactions and signaling. …”
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Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections by Kayle Brenna Dickson, Juan Zhou, Christian Lehmann

“…Iron is a key nutritional requirement for a variety of physiological functions, and its metabolism is tightly controlled under homeostatic conditions. …”
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Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies by Yang Xinyi, Reshetov Igor Vladimirovich, Narasimha M. Beeraka, Allaka Satyavathi, Dinisha Kamble, Vladimir N. Nikolenko, Allaka Naga Lakshmi, Basappa Basappa, Padmanabha Reddy Y, Ruitai Fan, Junqi Liu

“…Abstract Background Hematopoiesis within the bone marrow (BM) is a complex and tightly regulated process predominantly influenced by immune factors. …”
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Quantitative determination of iron (III) in polymaltose haematinic formulations on the Ghanaian market. by Rita Okwampah, Kofi Dzorgbenyuie Bedzra, Oti Kwasi Gyamfi, James Ataki, Foster Kyei, Martin Adarkwah-Yiadom, Edem Sosu, Emmanuel Boateng

“…Iron is an essential element needed by living organisms to enable their bodies to perform a variety of cellular functions and it is tightly regulated in the body systems of living organisms. …”
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Transmission interference microscopy of anterior human eye by Samer Alhaddad, Wajdene Ghouali, Christophe Baudouin, Albert Claude Boccara, Viacheslav Mazlin

“…Specifically, we show that the tightly localized illumination spot at the sclera functions analogously to a closed condenser aperture in conventional microscopy, significantly enhancing interference contrast. …”
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Regulators and Effectors of Arf GTPases in Neutrophils by Jouda Gamara, François Chouinard, Lynn Davis, Fawzi Aoudjit, Sylvain G. Bourgoin

“…G protein-dependent signalling pathways tightly control PMN functions. In this review, we will focus on the small monomeric GTPases of the Arf family and their guanine exchange factors (GEFs) and GTPase activating proteins (GAPs) as components of signalling cascades regulating PMN responses. …”
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Versatility of vimentin assemblies: From filaments to biomolecular condensates and back by Dolores Pérez-Sala, Silvia Zorrilla

“…Recent findings have unveiled the importance of low complexity sequence domains in vimentin filament assembly. …”
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Defining the Protein Phosphatase 2A (PP2A) Subcomplexes That Regulate FoxO Transcription Factor Localization by Adeline M. Luperchio, Daniel J. Salamango

“…FoxO transactivation activity is tightly regulated by a complex network of signaling pathways and post-translational modifications. …”
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The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells. by Jennifer Olt, Philomena Mburu, Stuart L Johnson, Andy Parker, Stephanie Kuhn, Mike Bowl, Walter Marcotti, Steve D M Brown

“…Hair bundles show a stair-case structure composed of rows of stereocilia, and each stereocilium contains a core of tightly-packed and uniformly-polarized actin filaments. …”
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GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans. by Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W Skinner, Kerstin A Baran, Laura I Lascarez-Lagunas, Saravanapriah Nadarajan, Nara Shin, Carlos G Silva-García, Takamune T Saito, Sara Beese-Sims, Brianna N Diaz-Pacheco, Elizaveta Berson, Ana B Castañer, Sarai Pacheco, Enrique Martinez-Perez, Philip W Jordan, Monica P Colaiácovo

“…Delayed homologous chromosome pairing, synaptonemal complex (SC) assembly, and DNA double-strand break repair progression are partially rescued by the expression of human CYTIP in gras-1 mutants, supporting functional conservation. …”
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Socio-economic and ecological aspects of land management in cities by Olga Petrakovska, Mariia Mykhalova

“…Land relations have always been one of the determining factors of socio-economic development and tightly exist in a single system of socio-economic matters. …”
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Endoscopic Debridement, Ostectomy, Release, and Radiofrequency: A Fully Endoscopic Technique for Treating Recalcitrant Plantar Fasciitis by Walter-Soon-Yaw Wong, M.B.Ch.B., M.R.C.S., Dhivakaran Gengatharan, M.B.B.S., Inderjeet Singh Rikhraj, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Keen Wai Chong, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Wen Xian Png, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Eric Wei Liang Cher, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth)

“…This comprehensive approach aims to improve patient satisfaction and functional outcomes.…”
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Challenges in Management of a Post-Traumatic Stiff Elbow – When to Perform Open Arthrolysis: A Case Report by S Adithyaa, K R Tarun Prashanth, M R Thirunthaiyan, R Dorai Kumar, B Sundararaja

“…The elbow joint is particularly susceptible to stiffness due to its highly congruent bony anatomy, relatively confined joint space tightly stabilizing collateral ligament complex, and the close relationship of the surrounding muscles acting as secondary stabilizers. …”
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PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control. by Romy Walser, John E Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L Williams, Muriel Laffargue, Matthias P Wymann

“…All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through interactions that have been thought to be constitutive. …”
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Loss of ARID1A leads to a cold tumor phenotype via suppression of IFNγ signaling by Pamela M. Watson, Chelsea A. DeVaux, Kevin W. Freeman

“…Our work clarifies that the loss of ARID1A, which tightly associates with MYCN amplification, causes reduced inflammatory signaling. …”
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Preparation and Characterization of Rosa roxburghii Tratt Polyphenol-Sodium Alginate-Soy Protein Isolate Nanocomposites and Their Antioxidant Activity by Han LIU, Xiaoyan LIU, Yinping GUO, Xingyan MU, Zihui SHI

“…To investigate the stability and functional properties of binary (SPI-SA, SPI-RRTP) and ternary (SPI-SA-RRTP) complexes of soy protein isolates (SPI) with sodium alginate (SA) and Rosa roxburghii Tratt polyphenols (RRTP). …”
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A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

“…Proteomics and biochemical reconstitution reveal that Ypl225w functions as a co-translational chaperone by forming dual interactions with the eEF1A G domain nascent chain and the UBA domain of ribosome-bound nascent polypeptide-associated complex (NAC). …”
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Non-canonical internalization mechanisms of mGlu receptors by Marta Cimadevila, Junke Liu, Damien Maurel, Isabelle Brabet, Marine Hoscar, Julia Drube, Carsten Hoffmann, Asuka Inoue, Philippe Rondard, Pierre-André Lafon, Laurent Prézeau, Jean-Philippe Pin

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The TOR kinase pathway is relevant for nitrogen signaling and antagonism of the mycoparasite Trichoderma atroviride. by Rossana Segreto, Hoda Bazafkan, Julia Millinger, Martina Schenk, Lea Atanasova, Maria Doppler, Christoph Büschl, Mélanie Boeckstaens, Silvia Soto Diaz, Ulrike Schreiner, Fabiano Sillo, Raffaella Balestrini, Rainer Schuhmacher, Susanne Zeilinger

“…Here we describe how alteration of the activity of TOR1, the single and essential TOR kinase of T. atroviride, by treatment with chemical TOR inhibitors or by genetic manipulation of selected TOR pathway components affected various cellular functions. Loss of TSC1 and TSC2, that are negative regulators of TOR complex 1 (TORC1) in mammalian cells, resulted in altered nitrogen source-dependent growth of T. atroviride, reduced mycoparasitic overgrowth and, in the case of Δtsc1, a diminished production of numerous secondary metabolites. …”
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