Study on the potential diagnostic value of metabolomics changes in different biological fluids for aspiration pneumonia by Lianghui Chen, Yazhen Chen, Fansen Lin, Jianbao Wang, Hongzhi Gao, Yuqi Liu

“…While the diagnosis of AP relies on clinical history, swallowing assessments, and imaging, these methods have significant limitations, often leading to underdiagnosis or misdiagnosis. …”
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Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced... by Yoon-Young Sung, Won-Kyung Yang, Jong Hoon Kim, Dongseok Shin, Seok June Son, Seung-Hyung Kim

“…BALB/c mice were injected with PM10D via intranasal trachea three times over a period of 12 days and RelA were orally dispensed for 12 days. RelA inhibited infiltrating neutrophils, total number of immunocytes in lung and bronchoalveolar lavage fluid (BALF). …”
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Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle by Gustavo R. D. Rodrigues, Joslaine N. S. G. Cyrillo, Lúcio F. M. Mota, Patrícia I. Schmidt, Júlia P. S. Valente, Eduarda S. Oliveira, Lúcia G. Albuquerque, Luiz F. Brito, Maria E. Z. Mercadante

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Cancer-associated fibroblasts promote pro-tumor functions of neutrophils in pancreatic cancer via IL-8: potential suppression by pirfenidone by Tomohiko Yagi, Shunsuke Kagawa, Shohei Nogi, Atsuki Taniguchi, Masashi Yoshimoto, Kanto Suemori, Yasuo Nagai, Shuto Fujita, Shinji Kuroda, Satoru Kikuchi, Yoshihiko Kakiuchi, Fuminori Teraishi, Kosei Takagi, Toshiaki Ohara, Hiroshi Tazawa, Toshiyoshi Fujiwara

“…PFD suppresses IL-8 secretion from CAF-stimulated neutrophils and mitigates the malignant traits of pancreatic cancer cells. …”
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Role of serotonin in physiology and diseases of gastro-intestinal tract by E. F. Barinov, O. N. Sulayeva

“…At analysis of pathogenesis of atopic/allergic diseases it is important to take into account mast cells releasing serotonin as well. The secreted serotonin is accumulated in platelets and released at aggregation. …”
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Modeling critical dosing strategies for stromal-induced resistance to cancer therapy by Anna K. Kraut, Colleen M. Garvey, Carly Strelez, Shannon M. Mumenthaler, Jasmine Foo

“…We propose a mathematical model for a common tumor-stromal interaction motif where stromal cells secrete factors that promote drug resistance. …”
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Exploring RNA cargo in extracellular vesicles for pleural mesothelioma detection by Agnieszka Kraft, Michaela B. Kirschner, Vanessa Orlowski, Manuel Ronner, Caroline Bodmer, Valentina Boeva, Isabelle Opitz, Mayura Meerang

“…In this study, we characterized the transcriptomic profile of EVs secreted by PM primary cells and explored their potential as a biomarker source for PM detection. …”
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Contrastive-learning of language embedding and biological features for cross modality encoding and effector prediction by Yue Peng, Junze Wu, Yi Sun, Yuanxing Zhang, Qiyao Wang, Shuai Shao

“…With cross-modality biological features, CLEF outperforms state-of-the-art (SOTA) models in predicting type III, type IV, and type VI secreted effectors (T3SEs/T4SEs/T6SEs) in enteric pathogens. …”
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Infants’ digestion at breast feeding (enzymological viewpoints) by G. F. Korot'ko

“…At child breast milk nutrients are hydrolysed in natural conditions by milk enzymes, secretions of digestive glands and secretory intestinal epithelial cells as autolytic-induced digestion with subsequent addition and advance of autologous digestion. …”
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CD22 modulation alleviates amyloid β-induced neuroinflammation by Yu Dong Mai, Qingqing Zhang, Cheuk Lim Fung, Shui On Leung, Chi Ho Chong

“…Further, membrane CD22 inhibited Amyloid β (Aβ) induced-NFκB signaling pathway and mechanistic study delineated that suciraslimab suppressed Aβ-induced IL-1β secretion in human microglia and PBMC. Suciraslimab also suppressed IL-12 and IL-23 secretion in human PBMC. …”
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Structure, Immune and Anti-aging Activities of Capsular Polysaccharide Produced by Lactobacillus plantarum W1 by Yongjiao GAO, Kun WANG, Jing ZHAO, Feng ZUO

“…Furthermore, CPS had been found to enhance the proliferation and phagocytosis of RAW264.7 cells, as well as promote the secretion of NO and cytokines, thereby exerting an immunomodulatory effect. …”
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Constipation at endocrine diseases by Yu. O. Shulpekova, A. G. Komova

“…Gastro-intestinal motility disorder at this syndrome is related to development of diabetic autonomous neuropathy, asynchrony of peristalsis and pressure of sphincters, acute decrease of cells of Cajal density, change of gastrointestinal hormones secretion. …”
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Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by Tongling Huang, Zhaocheng Lu, Zihui Wang, Lixin Cheng, Lu Gao, Jun Gao, Ning Zhang, Chang-An Geng, Xiaoli Zhao, Huaiyu Wang, Chi-Wai Wong, Kelvin W. K. Yeung, Haobo Pan, William Weijia Lu, Min Guan

“…ESRRA abrogation results in enhanced SPP1 and decreased leptin secretion from both visceral adipocytes and BMAds, concertedly dictating bone marrow stromal stem cell fate commitment and restoring type H vessel formation, constituting a feed-forward loop for bone formation. …”
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Characterization of Escherichia coli outer membrane vesicles and the impact of pathogenic ones on NLR signaling pathways by Roghayeh Mohammadzadeh, Ava Behrouzi, Farzam Vaziri, Seyed Davar Siadat

“… Background and Objectives: The secretion of outer membrane vesicles (OMVs) is a universal event among bacteria. …”
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The refractory form of gastroesophageal reflux disease: clinical and endoscopical, functional and morphofunctional criteria by M. A. Osadchuk, A. M. Osadchuk, D. V. Balashov, I. M. Kvetnoy

“…In contrast to NFGERD and EFGERD, at RFGERD higher grade of hyperplasia of esophageal neuroendocrine cells secreting neurotensin, and esophageal epithelial cells expressing р53 was observed.Conclusions. …”
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Autophagy-lysosome pathway in insulin & glucagon homeostasis by Yi Wu, Yi Wu, Yi Wu, Hui Wang, Huoyan Xu

“…Glucose homeostasis relies on tightly regulated insulin secretion by pancreatic β cells, and their dysfunction is a hallmark of type 2 diabetes. …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…In synergy with the effect of anti-PD-1 Ab, Met boosts CD8TIL proliferation and IFN-γ secretion, resulting in decreased glycolysis and oxidative phosphorylation in tumor cells. …”
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SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate by Ernesto Luna, Sophie Ruiz, Marie Garinot, Cyril Chavagnac, Pankaj Agrawal, John Escobar, Laurent Revet, Marie-Jeanne Asensio, Fabienne Piras, Francis G. Fang, Donald R. Drake, Bachra Rokbi, Daniel Larocque, Jean Haensler

“…When compared in an in vitro human innate immunity construct to AS01B, the QS21/MPL® liposomal adjuvant system of GSK, and with QS21-Liposomes used as benchmarks, SPA14 displayed the strongest immunostimulatory potential based on antigen-presenting cell (APC) activation and cytokine secretion, which was essentially driven by the highly active E6020 agonist in this assay. …”
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Analysis and Characterization of the Immunogenicity of Rhoptry Protein 18 by Masoud Foroutan, Amir Karimipour-Saryazdi, Ali Dalir Ghaffari, Hamidreza Majidiani, Arezo Arzani Birgani, Elaheh Karimzadeh-Soureshjani, Shahrzad Soltani, Hany M Elsheikha

“…Rhoptry protein 18 (ROP18) is a key virulence factor secreted into host cells during the invasion of Toxoplasma gondii ( T. gondii ) and plays an important role in the pathogenesis of infection. …”
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