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Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches
Published 2025-02-01“…It also highlights recent advances in antiviral strategies targeting host factors such as lipid metabolism, ion channels, and proteasomes, as well as viral targets like NS2B-NS3 proteases and nonstructural proteins. …”
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Pig herd management and infection transmission dynamics: a challenge for modellers
Published 2024-05-01“…We therefore developed a novel approach that combines Multi-Level Agent-Based Systems (MLABS) with spatial and temporal organization, allowing for a tuned representation of the transmission processes amongst the host population. …”
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Characteristics of Plasmodium vivax apicomplexan amino acid transporter 8 (PvApiAT8) in the cationic amino acid transport
Published 2025-02-01“…These parasites invade and multiply extensively within hepatocytes and erythrocytes in the host, relying on nutrient acquisition for their growth and replication. …”
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The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections
Published 2021“…Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARSCov- 2 pandemic progresses. …”
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Utilisation of an in vivo malaria model to provide functional proof for RhopH1/CLAG essentiality and conserved orthology with P. falciparum
Published 2025-02-01“…Abstract Background Malaria parasites establish new permeation pathways (NPPs) at the red blood cell membrane to facilitate the transport of essential nutrients from the blood plasma into the infected host cell. The NPPs are critical to parasite survival and, therefore, in the pursuit of novel therapeutics are an attractive drug target. …”
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Folded pseudochiral Fermi surface in 4Hb-TaSe2 from band hybridization with a charge density wave
Published 2025-02-01“…Abstract Stacking of strongly-correlated 2D materials is opening the possibility to demonstrate novel electronic or magnetic ordering phenomena. …”
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Dysbiosis and extraintestinal cancers
Published 2025-02-01“…Abstract The gut microbiota plays a crucial role in safeguarding host health and driving the progression of intestinal diseases. …”
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SHASI-ML: a machine learning-based approach for immunogenicity prediction in Salmonella vaccine development
Published 2025-02-01“…IntroductionAccurate prediction of immunogenic proteins is crucial for vaccine development and understanding host-pathogen interactions in bacterial diseases, particularly for Salmonella infections which remain a significant global health challenge.MethodsWe developed SHASI-ML, a machine learning-based framework for predicting immunogenic proteins in Salmonella species. …”
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Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications
Published 2025-02-01“…Sepsis is a life-threatening syndrome characterized by organ dysfunction caused by a dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) is a frequent and serious complication of sepsis that considerably impacts both short-term and long-term survival outcomes. …”
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Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis
Published 2020-12-01“…The phyloepidemiologic analyses suggested that the coronaviruses are circulating in human hosts evolving gradually by times in response to the different environment stimuli facing the virus inside the host in different geographical areas. …”
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Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections
Published 2025-02-01“…Analysis of vB_Kpn_HF0522 characteristics, including optimal multiplicity of infection (MOI), one-step growth curve, host range, stability in different environments, and adsorption capacity. …”
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The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections
Published 2023“…Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARS-Cov- 2 pandemic progresses. …”
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Taung and beyond: The mining history, geology and taphonomy of Australopithecus in South Africa
Published 2025-02-01“… South Africa is host to the single richest early hominin fossil record worldwide, including many examples of the endemic species Australopithecus africanus fossils. …”
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Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis
Published 2025-01-01“…Conclusion Immunization with the ICD dying tumor cells evokes potent tumor-specific T cell immunity, which provides a novel approach for cancer immunotherapy.…”
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Progress in the structural modification and pharmacological activity of isosteviol
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Airborne Transmission of the SARS-CoV-2 Delta Variant and the SARS-CoV-2 Omicron Variant
Published 2021-12-01“…The average viral loads in hosts infected with the SARS-CoV-2 Delta variant were unprecedentedly high, therefore the SARS-CoV-2 Delta variant aerosols must be considered in this pandemic. …”
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Advances in Gene Therapy for Neurologic Disorders: An Overview
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Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy
Published 2025-04-01“…This preparation was surface modified with BTN2A2 antibodies and internally contained T cells isolated from the blood of tumor hosts, along with simulated collagen peptide CMP. …”
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The Japanese encephalitis virus NS1' protein facilitates virus infection in mosquitoes.
Published 2025-01-01“…This finding offers new insights into the transmission mechanisms of JEV, elucidating novel aspects of viral propagation.…”
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