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Abdominal Wall Defects: Hydrogel based solutions in Abdominal Wall Reconstruction
Published 2025-01-01“…This paper presents hydrogel-based materials as a novel approach to addressing these abdominal wall defect repair challenges. …”
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PGC-1α activation to enhance macrophage immune function in mycobacterial infections.
Published 2025-01-01“…Our results suggest that pharmacologic approaches to enhance mitochondrial function provide a novel approach to target macrophage immune function and means to combat NTM infections.…”
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Protein multiplicity: exemplifying an overwhelmingly likely pattern of molecular evolution?
Published 2024-10-01“…We observe over 13 million multiplicious proteins, ranging from the highly conserved (including histones, components of photosystems, and the electron transport chain) to the rapidly evolving viral proteins that are involved in infection and adaptation to novel host species. CoHSI predicts that when considered globally across all three domains of life and the viruses, multiplicity will show a distinctive variant of the Zipfian distribution. …”
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Mimosa diplotricha (Fabaceae) Recruits Native Pollinators, But Does it Matter?
Published 2020-01-01“…In sum, that the population of M. diplotricha is still expanding in Nigeria against the backdrop of their utilisation by native pollinators is suggestive of a continual recruitment of the pollinators, which may prefer the novel host within a mosaic of widely scattered native flowering plants. …”
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Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics
Published 2025-02-01“…Abstract Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, and tumors. …”
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Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches
Published 2025-02-01“…It also highlights recent advances in antiviral strategies targeting host factors such as lipid metabolism, ion channels, and proteasomes, as well as viral targets like NS2B-NS3 proteases and nonstructural proteins. …”
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Characteristics of Plasmodium vivax apicomplexan amino acid transporter 8 (PvApiAT8) in the cationic amino acid transport
Published 2025-02-01“…These parasites invade and multiply extensively within hepatocytes and erythrocytes in the host, relying on nutrient acquisition for their growth and replication. …”
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The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections
Published 2021“…Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARSCov- 2 pandemic progresses. …”
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Utilisation of an in vivo malaria model to provide functional proof for RhopH1/CLAG essentiality and conserved orthology with P. falciparum
Published 2025-02-01“…Abstract Background Malaria parasites establish new permeation pathways (NPPs) at the red blood cell membrane to facilitate the transport of essential nutrients from the blood plasma into the infected host cell. The NPPs are critical to parasite survival and, therefore, in the pursuit of novel therapeutics are an attractive drug target. …”
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Folded pseudochiral Fermi surface in 4Hb-TaSe2 from band hybridization with a charge density wave
Published 2025-02-01“…Abstract Stacking of strongly-correlated 2D materials is opening the possibility to demonstrate novel electronic or magnetic ordering phenomena. …”
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Dysbiosis and extraintestinal cancers
Published 2025-02-01“…Abstract The gut microbiota plays a crucial role in safeguarding host health and driving the progression of intestinal diseases. …”
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SHASI-ML: a machine learning-based approach for immunogenicity prediction in Salmonella vaccine development
Published 2025-02-01“…IntroductionAccurate prediction of immunogenic proteins is crucial for vaccine development and understanding host-pathogen interactions in bacterial diseases, particularly for Salmonella infections which remain a significant global health challenge.MethodsWe developed SHASI-ML, a machine learning-based framework for predicting immunogenic proteins in Salmonella species. …”
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Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis
Published 2020-12-01“…The phyloepidemiologic analyses suggested that the coronaviruses are circulating in human hosts evolving gradually by times in response to the different environment stimuli facing the virus inside the host in different geographical areas. …”
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Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections
Published 2025-02-01“…Analysis of vB_Kpn_HF0522 characteristics, including optimal multiplicity of infection (MOI), one-step growth curve, host range, stability in different environments, and adsorption capacity. …”
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The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections
Published 2023“…Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARS-Cov- 2 pandemic progresses. …”
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Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis
Published 2025-01-01“…Conclusion Immunization with the ICD dying tumor cells evokes potent tumor-specific T cell immunity, which provides a novel approach for cancer immunotherapy.…”
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Progress in the structural modification and pharmacological activity of isosteviol
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Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy
Published 2025-04-01“…This preparation was surface modified with BTN2A2 antibodies and internally contained T cells isolated from the blood of tumor hosts, along with simulated collagen peptide CMP. …”
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Biodiversity reporting: Comparing listed entities in the United Kingdom and South Africa
Published 2025-01-01“…The primary reason for this is because of a higher biodiversity ranking and hosting more biodiversity hotspots, which impact South African organisations. …”
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