MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1 by Yue Zu, Qianyan Gao, Yisheng He, Qiao Deng, Guodong Li, Xiping Li, Tianze Shang, Xinwei Cheng, Chenglong Zhu, Jianqiao Wang, Dong Liu, Chengliang Zhang

“…We demonstrated that miR-128-3p targeted the 3’-untranslated region of PDZK1 in EIC and consequently promoted MRP2 internalization. …”
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SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer by Mutangala Muloye Guy, Tingting Bian, Longyun Sun, Yiping Hao, Xinlin Jiao, Wenjing Zhang, Teng Zhang, Baoxia Cui

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4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models by Ignacio Melero, Alvaro Teijeira, Christian Klein, Maria E Rodriguez-Ruiz, Christina Claus, Pablo Umana, Tamara Tanos, Carlos E De Andrea, Carlos Luri-Rey, Paloma Sanchez-Mateos, Leticia Fernández-Rubio, María Collantes, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Antonio Rullan, Jon Ander Simon, Eneko Garate-Soraluze, Claudia del Pilar Herrero

“…Biodistribution studies of muFAP-4-1BBL indicated enriched tumor targeting to irradiated tumors. Human colorectal cancer samples pre and post irradiation showed enhanced FAP expression after radiotherapy.Conclusion Increased FAP expression in the TME as a result of radiotherapy can be exploited to target agonist 4-1BB immunotherapy to malignant tumor lesions using an FAP-4-1BBL antibody fusion protein.…”
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Production of novel theranostic nano-vector based on superparamagnetic iron oxide nanoparticles/miR-497 targeting colorectal cancer by Asmaa M. Elfiky, May M. Eid, May El-Manawaty, Zeinab A. Elshahid, Elham Mohamed Youssef, Khaled Mahmoud

“…Immune checkpoint inhibition medication is likely to remain a crucial part of CRC clinical management. This study aims to create new super paramagnetic iron oxide nano-carrier (SPION) that can effectively transport miRNA to specific CRC cell lines. …”
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EN The combined effect of heating zone length and inclination angle on start-up, transient and operational characteristics of pulsating heat pipe by К. Мане, Є.С. Алексеїк

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Automated quantification of axonal and myelin changes in contusion, dislocation, and distraction spinal cord injuries: Insights into targeted remyelination and axonal regeneration by Xuan Li, Yuan He, Fangyao Chen, Xin Tong, Yunlong Fan, Yuzhe Langzhou, Jie Liu, Kinon Chen

“…Quantifying axons and myelin is essential for understanding spinal cord injury (SCI) mechanisms and developing targeted therapies. This study proposes and validates an automated method to measure axons and myelin, applied to compare contusion, dislocation, and distraction SCIs in a rat model. …”
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START:AV taikymas laisvės atėmimo bausmę atliekančių jaunų suaugusiųjų imtyje: psichometrinių charakteristikų ir konvergentinio validumo tikrinimas by Virginija Klimukienė, Alfredas Laurinavičius

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Review (Swedish): Pontus Folkesson, Att skola en stormakt: Framväxten av 1600-talets skolsystem genom lokalsamhällets aktörer by Esbjörn Larsson

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Another new karst-dwelling rock gecko in the Cnemaspis siamensis group (Reptilia, Gekkonidae) from Kanchanaburi Province, western Thailand by Attapol Rujirawan, Akrachai Aksornneam, Siriporn Yodthong, Parinya Pawangkhanant, Bryan L. Stuart, Anchalee Aowphol

“…Phylogenetically, the new species is recovered as the sister taxon to C. huaseesom, but the two species are separated by 8.3–9.4% uncorrected pairwise genetic divergences in the mitochondrial NADH dehydrogenase subunit 2 gene and flanking tRNAs.…”
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AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription by Lingshan Zhou, Yuan Yang, Qian Qiao, Yingying Mi, Yuling Gan, Ya Zheng, Yuping Wang, Min Liu, Yongning Zhou

“…Conclusion AKT1 induces the Notch1 phosphorylation and promotes the activation and nuclear translocation of Notch1-IC by targeting the regulation of IRS-1, thereby advancing the progression of GC.…”
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Temporal associations between microclimate, adult Aedes mosquito indices, and dengue cases at the residence level in Malaysia: Implications for targeted interventions. by Nur Athen Mohd Hardy Abdullah, Nazri Che Dom, Biswajeet Pradhan, Siti Aekball Salleh, Rahmat Dapari

“…The findings offer valuable insights for decision-makers, providing them with evidence-based information to implement targeted interventions and strategies aimed at controlling Aedes mosquito populations and mitigating the spread of dengue virus infections.…”
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Vivir en los márgenes. Fronteras porosas y circulación de población en la Nueva Vizcaya tardo colonial by Sara Ortelli

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Development of a novelly selective HPLC-chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food products by Mengdie Cai, Xinyu Wang, Kun Lu, Bixiao Zhou, Lijun Wei, Xianglei Cheng

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ETNIA E RELAÇÕES DE PODER: o caráter politico das "minorias étnicas" desde uma perspectiva Sul-Sul by Fernando Ribot Cortes

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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson’s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

“…The glutathione peroxidase 3 (GPX3) gene emerged as a pivotal hub gene, with its expression significantly altered in both TBI and PD datasets.Conclusion: This study underscores the critical role of GPX3 in the molecular intersection of TBI and PD, suggesting it as a novel and potential therapeutic target, offering new insights into potential therapeutic strategies.Keywords: traumatic brain injury, Parkinson’s disease, bioinformatics, oxidative stress, mitochondrial dysfunction, neurodegenerative diseases…”
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TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis by Eeva Moilanen, Katriina Vuolteenaho, Teemu Moilanen, Elina Nummenmaa, Mari Hämäläinen, Lauri J Moilanen

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Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 by Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng, Jigang Wang

“…However, the direct protein targets and exact molecular mechanisms of caffeic acid in epilepsy, remain largely elusive. …”
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Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

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Unpacking the ‘explorer’ narrative and its impacts on African palaeoanthropology by Rebecca R. Ackermann, Keneiloe Molopyane, Sheela Athreya

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SEARCHING FOR GOD: THEOLOGY, IMAGINATION, BEAUTY AND THE ARTS by G.E. Thiessen

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