miRNA-targeting oligonucleotide constructs with various mechanisms of action as effective inhibitors of carcinogenesis by S. K. Miroshnichenko, O. A. Patutina, M. A. Zenkova

“…This study analysed known oligonucleotide-based miRNA inhibitors with different mechanisms of action. Based on their mechanism of action, miRNA-targeted inhibitors can be classified into two groups. …”
Get full text

SYNTHESIS OF NEW N-HYDROXYPHENYL AND TOLYL DERIVATIVES OF PYRIMIDINE-4(1H) –ONE WITH ANTI-INFLAMMATORY ACTIVITY by I. P. Kodonidi, O. O. Novikov, S. A. Kuleshova, Ju. I. Rjabukhin, S. S. Shatokhin, A. V. Ivchenko, M. I. Kodonidi, O. M. Zhilina

Subjects: “…pyrimidin-4(1h)-one, molecular construction, targeted synthesis, cyclocondensation, cyclooxygenase, anti-infl ammatory action, antiexudative activity…”
Get full text

Application of Reinforcement Learning in Controlling Quadrotor UAV Flight Actions by Shang-En Shen, Yi-Cheng Huang

“…Unifying the state inputs of simulated and OD environments and replacing the original simulated image inputs with a maximum dual-target approach, the experimental simulation achieved a target traversal rate of 52% ultimately. …”
Get full text

Better together: participatory action research for co-constructing an intervention to enhance leisure activities in non-ambulatory adolescents with cerebral palsy by Caline Jesus, Isabelly Cristina Rodrigues Regalado, Ilma Menezes, Rafael Coelho Magalhães, Marcílio de Oliveira Lima Júnior, Karolinne Souza Monteiro, Egmar Longo

Get full text

Climate action contributor and carbon space appropriator: national image construction of China in dual-carbon commitment from Indian media’s perspective by Yuxin Wu, Xiufeng Zhao

“…As regards China’s national image, Indian media construct China as a significant contributor to global climate action while evaluating its international role as a carbon space ‘appropriator’, with ‘too ambitious’ carbon goals and ‘disappointing’ carbon practices. …”
Get full text

Effectiveness of a Theory-Based Educational Intervention on the Constructs of the Health Action Process Approach (HAPA) Model and Sun Protective Behaviors in Male Students by Qazal Olad Azimi, Isa Mohammadi Zeidi, Hadi Morshedi, Mohammadreza Maleki, Saeed Shahsavari, Amir Pakpoor

“…The intervention consisted of five 45-minute group training sessions, each accompanied by a 3–5-minute summarized educational audio file and two targeted SMS messages. Data were collected using a multi-section questionnaire comprising demographic items, 31 items measuring subscales of the Health Action Process Approach (HAPA) model, and an 8-item behavioral evaluation checklist. …”
Get full text

Les politiques de formation professionnelle en région : un processus lent et complexe de construction de l’action publique régionale by Jean-Paul Géhin

Get full text

Construction and application of a precise evaluation method for the quality of traditional Chinese medicine based on “target-combined quality evaluation” using safflower as an exam... by Yongfeng Zhou, Yongfeng Zhou, Qinghua Wu, Chaoxiang Ren, Huajuan Jiang, Xulong Huang, Jiang Chen, Ping Zhang, Dingkun Zhang, Jin Pei

Get full text

Construction project change management in Indian construction industry: status, importance and impact by Ammar Taher, Rizwan Ahmad Khan, Mohd Ashraf Khan

“…The findings are significant for project stakeholders, including decision-makers, policy-makers, and practitioners in the construction industry. They provide actionable insights to enhance change management practices, improving project quality, cost efficiency, and adherence to schedules while mitigating risks. …”
Get full text

In silico prediction of the action of bromelain on PI3K/Akt signalling pathway to arrest nasopharyngeal cancer oncogenesis by targeting phosphatidylinositol-4,5-bisphosphate 3-kina... by Alyaa Syafiqah Shamsuri, Edmund Ui -Hang Sim

Get full text

Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its p... by Jinpu Peng, Shili Wang, Xingyu Pan, Moudong Wu, Xiong Zhan, Dan Wang, Guohua Zhu, Wei Wang, Hongyu Tang, Nini An, Jun Pei

“…Finally, we combined ssGSEA enrichment analysis with animal experiments to further validate the potential mechanism of action of key genes.ResultsIn total, we identified 98 of the most relevant modular genes for AKI and 417 DEGs, which intersected to yield a total of 24 AKI candidate genes. …”
Get full text

Arts, creative & cultural initiatives for citizen engagement on climate action: Insights from Ireland's Creative Climate Action Fund by J. Mac Mahon, A. Revez, M. Burke, P. Hogan, M.M. Nyhan

“…Respondents reported an increased sense of self-efficacy and capacity to take achievable climate actions. Community-centred, peer-sharing formats emerged as trusted and valued opportunities for accessing relevant climate information, aiding constructive dialogue on complex topics. …”
Get full text

Minimal biophysical model of combined antibiotic action. by Bor Kavčič, Gašper Tkačik, Tobias Bollenbach

“…Here, we build on bacterial "growth laws," which capture physiological feedback between translation and cell growth, to construct a minimal biophysical model for the combined action of ribosome-targeting antibiotics. …”
Get full text

CONSTRUCTION PROJECT COST MANAGEMENT by P. V. Sachek

“…The paper proposes a mechanism for controlling the cost of the construction project which allows to an investor to foresee the project requirements in additional investments, to organize economical expenditure of monetary resources, to control their target use and make timely decisions which reduce the cost of the project.…”
Get full text

Preservation of Health - constructive or destructive „Interference“ by Ivana Marasović Šušnjara, Maja Vejić, Julija Vejić

“…But, is the action of these participants coherent? Is their interaction constructive? …”
Get full text

IMPROVING THE QUALITY OF INVESTMENT DESIGN IN INDUSTRIAL CONSTRUCTION by I. M. Meylanov

“…A mechanism of inclusion of industrial construction objects into the Federal targeted investment programme is revealed. …”
Get full text

Revealing the multi-target compounds of Sarcandra glabra identification and inhibition of novel target genes for the treatment of pancreatic cancer by Xing Liu, Jianghong Ou

“…Differentially expressed genes were identified using data from the Gene Expression Omnibus (GEO) database, and their protein–protein interaction (PPI) network was constructed using the STRING platform. The target genes of S. glabra were further assessed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses in the R software. …”
Get full text

The Effect Components and Mechanisms of Action of Cimicifugae Rhizoma in the Treatment of Acute Pneumonia by Zhu J, Huang Y, Ye C, Deng X, Zou Y, Yuan E, Chen Q

Get full text

Integrated network pharmacology reveals the mechanism of action of Xianlinggubao prescription for inflammation in osteoarthritis by Jingyi Hou, Yubo Li, Yu Zhang, Ning Yang, Bin Chen, Guiyun Ma, Naiqiang Zhu

“…Network pharmacology and bioinformatics approaches were employed to construct compound-target and protein–protein interaction (PPI) networks, enabling the identification of pivotal therapeutic targets. …”
Get full text

Enhancing Akt Imaging through Targeted Reporter Expression by Limin Zhang, Mahaveer S. Bhojani, Brian D. Ross, Alnawaz Rehemtulla

“…The use of molecular imaging technologies has contributed significantly to drug discovery research with an emphasis on drug efficacy, the mechanism of action, and target validation studies. We constructed a genetically engineered hybrid bioluminescent Akt reporter (BAR) molecule that reports on Akt serine/threonine kinase activity. …”
Get full text