Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro Ki and pharma... by Toshiaki Tsuchitani, Motohiro Kato, Atsuko Tomaru, Yasunori Aoki, Yuichi Sugiyama

“…While increasing the in vitro pharmacological potency (lowering Ki) of a compound to its target is expected to decrease the therapeutic dose, its benefit is not necessarily clarified. …”
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ZPTM: Zigzag Path Tracking Method for Agricultural Vehicles Using Point Cloud Representation by Shuang Yang, Engen Zhang, Yufei Liu, Juan Du, Xiang Yin

“…A local straight path was created by linking two adjacent anchor points, forming the local target path to be tracked, which simplified the navigation algorithm for zigzag path tracking. …”
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Efficient high-resolution microscopic ghost imaging via sequenced speckle illumination and deep learning from a single noisy image by Sukyoon Oh, Sukyoon Oh, Tong Tian, Tong Tian, Zhe Sun, Christian Spielmann, Christian Spielmann

“…This method resulted in an average Structural Similarity Index (SSIM) improvement of over 324% and a resolution enhancement exceeding 33% across various target images. …”
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Sonar-based object detection for autonomous underwater vehicles in marine environments by Zhen Wang, Zhen Wang, Jianxin Guo, Shanwen Zhang, Yucheng Zhang

“…Extensive experimental results demonstrate that our method outperforms state-of-the-art detectors on the Underwater Acoustic Target Detection (UATD) dataset. Specifically, our approach achieves a mean average precision (mAP) of 81.86%, an improvement of 7.85% compared to the best-performing existing model. …”
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Hydrate occurrence identification of shallow loose sediments in deep water and its saturation calculation by Jun Zhao, Chao Zheng, Jianxiang Pei, Di Tang, Jiang Jia

“…The results indicate that the predicted values using the joint inversion method in the YL target area of the QDN Basin are closest to the measured values obtained from the chloride ion concentration method, with prediction errors ranging from 0.09 % to 14.89 % and an average error of 6.85 %. …”
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YOLO-ALW: An Enhanced High-Precision Model for Chili Maturity Detection by Yi Wang, Cheng Ouyang, Hao Peng, Jingtao Deng, Lin Yang, Hailin Chen, Yahui Luo, Ping Jiang

“…Chili pepper, a widely cultivated and consumed crop, faces challenges in accurately determining maturity due to issues such as occlusion, small target size, and similarity between fruit color and background. …”
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Intelligent deep learning architecture for precision vegetable disease detection advancing agricultural new quality productive forces by Jun Liu, Xuewei Wang, Qian Chen, Peng Yan, Dugang Guo

“…In the context of advancing agricultural new quality productive forces, addressing the challenges of uneven illumination, target occlusion, and mixed infections in greenhouse vegetable disease detection becomes crucial for modern precision agriculture. …”
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A Cross-Project Defect Prediction Model Based on Deep Learning With Self-Attention by Wanzhi Wen, Ruinian Zhang, Chuyue Wang, Chenqiang Shen, Meng Yu, Suchuan Zhang, Xinxin Gao

“…Cross-project defect prediction technique is a hot topic in the field of software defect research because of the huge difference in data distribution between source project and target project. Software defect prediction technique usually first extracts software project features and then trains prediction models based on various classifiers. …”
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THE EVALUATION OF ANTIHYPERTENSIVE EFFICACY OF ORALLY-DISPERSING FORM OF PERINDOPRIL IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION by R. A. Khokhlov, E. E. Tsareva, V. I. Taranina

“…Therapy with Prestarium A in patients with non-complicated mild and moderate arterial hypertension during 12 weeks with average dosage 8,4±2,3 mg made it to achieve target blood pressure levels in 86% patients. …”
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Mobile robot path planning using deep deterministic policy gradient with differential gaming (DDPG-DG) exploration by Shripad V. Deshpande, Harikrishnan R, Babul Salam KSM Kader Ibrahim, Mahesh Datta Sai Ponnuru

“…Reward shaping considers finer details, ensuring even small advantages in each iteration contribute to learning.Through diverse test scenarios, it is demonstrated that DG exploration, compared to random exploration, results in an average increase of 389% in successful target reaches and a 39% decrease in collisions. …”
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Pear Fruit Detection Model in Natural Environment Based on Lightweight Transformer Architecture by Zheng Huang, Xiuhua Zhang, Hongsen Wang, Huajie Wei, Yi Zhang, Guihong Zhou

“…Aiming at the problems of low precision, slow speed and difficult detection of small target pear fruit in a real environment, this paper designs a pear fruit detection model in a natural environment based on a lightweight Transformer architecture based on the RT-DETR model. …”
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Two-dimensional dynamic multileaf collimator (2DDMLC) technique for improved treatment quality in intensity modulated radiation therapy by Hyojun Park, Chul Hee Min, So-Yeon Park, Jung-In Kim

“…The conformity index (CI) and average difference from the optimal fluence map were calculated. …”
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MICROINVASIVE TRANSSCLERAL FIXATION TECHNOLOGY OF THE FOLDABLE IOL by A. A. Kasyanov

“…In almost all cases, was obtained a reliable fixation of the IOL without significant tilting optics and decentration. The target refraction was achieved in 90% of cases. The percentage of lost endothelial cells ranged from 1.6 to 3.8 %,with an average value of 2.2%. …”
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Efficient Small Object Detection You Only Look Once: A Small Object Detection Algorithm for Aerial Images by Jie Luo, Zhicheng Liu, Yibo Wang, Ao Tang, Huahong Zuo, Ping Han

“…Aerial images have distinct characteristics, such as varying target scales, complex backgrounds, severe occlusion, small targets, and dense distribution. …”
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Real-world effectiveness and safety of fixed-ratio combination insulin glargine 100 u/ml plus lixisenatide in adults with type 2 diabetes (T2DM): subanalysis of the international,... by O. K. Vikulova, R. A. Atanesyan, S. D. Movsesyan, Yu. P. Kasatkina, A. A. Perevyazka, E. L. Zaytseva, M. I. Kharakhulakh, N. V. Andreeva, I. A. Krivosheyeva, S. V. Vorobyev, T. V. Saprina, D. A. Avaliani, M. A. Prudnikova, M. V. Shestakova, N. G. Mokrysheva

“…The mean change of HbA1c at month 6 was -1.81%, and -2.03% at month 12. 51.3% patients achieved individual HbA1c targets at month 12, 46.7% of patients achieved the HbA1c target without hypoglycemia and weight gain. …”
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Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system by Yinxiangzi Sheng, Lennart Volz, Weiwei Wang, Marco Durante, Christian Graeff

“…Compared to SyngoRT, TRiP4D underestimated the target RBE-weighted dose; however more efficient in RBE-weighted dose calculation. …”
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VEGF-R1/Flt-1 Receptor as a Characteristic of the Angiogenic Phenotype of Uveal Melanoma by V. G. Likhvantseva, O. A. Anurova, S. E. Astakhova, M. V. Vereshchagina, V. E. Ovanesyan, E. V. Stepanova

“…The peak of reception for the maximum average percentage of positive cells and the average cellular IGH gradation of expression was recorded at the T2 stage, after which there was a slow decline to the T4 stage. …”
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Impact of health intervention coverage on reducing maternal mortality in 126 low- and middle-income countries: a Lives Saved Tool modelling study by Xi-Ru Guo, Jue Liu, Hai-Jun Wang

“…With a modest, substantial, or universal scale-up, the 2030 average MMR would be 172.1 (117.6–262.9), 139.8 (95.6–213.5) or 98.6 (67.8–149.7), not reaching the SDG Target 3.1. …”
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A scalable multi-modal learning fruit detection algorithm for dynamic environments by Liang Mao, Liang Mao, Zihao Guo, Mingzhe Liu, Yue Li, Linlin Wang, Jie Li

“…A sliding slice method is then employed to predict image targets, thereby reducing the miss rate of small targets.ResultsExperimental results demonstrate that the proposed model improves accuracy, recall, and mean average precision (mAP) by 9.5, 0.9, and 12.3 percentage points, respectively, compared to the original YOLOv5s model. …”
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The duration of remission and minimal disease activity after initiation and discontinuation of biological agents in patients with early psoriatic arthritis (data from the all-russi... by E. Yu. Loginova, T. V. Korotaeva, S. I. Glukhova, E. L. Nasonov

“…The first DAS/DAPSA  remission occurred after an average of 4.8±2.2/5.8±3.2 months; MDA – after 4.0±1.9 months. …”
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