COMPARISON OF EFFICACY AND TOLERABILITY OF ORIGINAL AND GENERIC DRUGS OF SIMVASTATIN IN PATIENTS WITH HYPERLIPIDAEMIA AND HIGH RISK OF ISCHEMIC HEART DISEASE COMPLICATIONS by S. N. Tolpygina, S. Y. Martsevich

“…Simvahexal dose was increased to 30 mg/day, if the target level of LDL cholesterol had not been reached after first 6 weeks of therapy.Results. …”
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Traffic environment perception algorithm based on multi-task feature fusion and orthogonal attention by Zhengfeng LI, Mingen ZHONG, Yihong ZHANG, Kang FAN, Zhiying DENG, Jiawei TAN

“…Through experimental evaluations conducted on the BDD100k public dataset, MTEPN achieved impressive results, with an average mean average precision (mAP) of 79.4% for vehicle target detection and an average intersection-over-union (mIoU) of 92.4% for pixels extracted from the drivable area. …”
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VBM-YOLO: an enhanced YOLO model with reduced information loss for vehicle body markers detection by Bin Wang, Chao Li, Chao Zhou, Jun Sun

“…During training, AGB incorporates feature information from different target layers to help the current layer retain complete gradient information. …”
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Transfer Kernel Extreme Learning Machine Based on Bidirectional Cross Domain Approximation by Yuanxiao Zeng, Huimin Li, Yanbing Song

“…Furthermore, we introduce two output weight approximation terms into these transfer KELMs - referred to as source transfer KELM and target transfer KELM - in order to enhance knowledge transfer across domains. …”
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Comparative genomics of Lentilactobacillus buchneri reveals strain-level hyperdiversity and broad-spectrum CRISPR immunity against human and livestock gut phages. by Ismail Gumustop, Ibrahim Genel, Ibrahim Cagri Kurt, Fatih Ortakci

“…The defined PAM preferences of the identified CRISPR systems, together with the broad predicted target range of their spacers, highlight their potential for biotechnological applications-most notably targeted CRISPRization of L. buchneri strains and in-silico-guided phage control during fermentation. …”
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Ship Contour Extraction from Polarimetric SAR Images Based on Polarization Modulation by Guoqing Wu, Shengbin Luo Wang, Yibin Liu, Ping Wang, Yongzhen Li

“…Subsequently, an optimization criterion for target amplitude modulation to achieve uniformity is designed. …”
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AC-YOLO: A lightweight ship detection model for SAR images based on YOLO11. by Rui He, Dezhi Han, Xiang Shen, Bing Han, Zhongdai Wu, Xiaohu Huang

“…Specifically, we design a lightweight cross-scale feature fusion module that adaptively fuses multi-scale feature information, enhancing small target detection while reducing model complexity. …”
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The system of anesthesiological support for coloproctological operations by G. A. Myshkov, M. V. Abritsova, N. R. Torchua

“…Spinal anesthesia was achieved with 0.5% isobaric bupivacaine solution, the average dose was 8.5 ± 0.12 mg. For drug sedation, a continuous infusion of propofol was used at a target concentration of 5–4–3 mg/kg per hour. …”
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Closed-Loop Aerial Tracking with Dynamic Detection-Tracking Coordination by Yang Wang, Heqing Huang, Jiahao He, Dongting Han, Zhiwei Zhao

“…Existing work has failed to provide robust solutions when handling target disappearance, viewpoint changes, and tracking drifts in practical scenarios with limited UAV resources. …”
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HE ASSESSMENT OF SUSTAINABLE DEVELOPMENT FACTORS IN THE RURAL AREAS - A CASE STUDY FROM AZERBAIJAN by Fariz ALAKBAROV, Sait ENGINDENIZ, Ramina MUSTAFAYEVA, Muhammad ALAKBAROV

“…To eliminate the negative effects of urbanization in target villages, there is a great need to improve rural income sources and promote employment for people in rural areas.…”
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A Novel Transformer-Based Object Detection Method With Geometric and Object Co-Occurrence Prior Knowledge for Remote Sensing Images by Nan Mo, Ruixi Zhu

“…Artificial target detection is a key technology for Earth observation applications in remote sensing images, including environmental monitoring, urban planning, intelligence reconnaissance, and land mapping. …”
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Evaluation of the Coupling Coordination Between Energy Low Carbonization and the Socioeconomic System in China Based on a Comprehensive Model by Xin Li, Yuchen Lu, Jingjing Chen, Lihong Peng, Xiaochou Chen

“…Reaching the 2030 carbon intensity reduction target would be challenging under the baseline scenario. …”
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Data-driven design of topologically optimized auxetic metamaterials for tailored stress–strain and Poisson’s ratio-strain behaviors by Yueyou Tang, Anfu Zhang, Qi Zhou, Mu He, Liang Xia

“…Compression experiments on polyurethane specimens fabricated via precision milling validate the feasibility of the proposed method, showing an average curve-matching accuracy of 98.2% between the experimental and target curves. …”
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An integrated approach based on FDA adverse event reporting system, network pharmacology, molecular docking, and molecular dynamics simulation analysis to study the cardiac adverse... by Wenjuan Wang, Hong Liu, Yongqing Wen, Yanhua Zhang, Xu Ma

“…Molecular docking confirmed strong binding affinity with binding energies below −7.5 kJ/mol for key targets (AKT1: -9.9 kJ/mol; ALB: −8.4 kJ/mol). Molecular dynamics simulations (100 ns) demonstrated stable binding of osimertinib-AKT1/ALB complexes, with average RMSD values of 0.52 nm and 0.50 nm, respectively, and binding free energies of −44.63 kJ/mol (AKT1) and −42.92 kJ/mol (ALB).ConclusionThis study clarifies osimertinib-induced CAR mechanisms involving multi-target interactions and pathway dysregulation, aiding clinical safety and future research.…”
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RS-DETR: An Improved Remote Sensing Object Detection Model Based on RT-DETR by Hao Zhang, Zheng Ma, Xiang Li

“…Finally, we propose a novel bounding box regression loss function, Focaler-GIoU, which makes the model focus more on difficult samples, improving detection performance for small and overlapping targets. Experimental results on the satellite imagery multi-vehicles dataset (SIMD) and the high-resolution remote sensing object detection (TGRS-HRRSD) dataset show that the improved algorithm achieved mean average precision (mAP) of 78.2% and 91.6% at an intersection over union threshold of 0.5, respectively, which is an improvement of 2.0% and 1.5% over the baseline model. …”
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DYNAMICS OF STRUCTURAL AND FUNCTIONAL STATUS OF MYOCARDIUM DUE TO COMBINATION THERAPY WITH AMLODIPINE AND BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION by I. L. Zapesochnaya, A. G. Avtandilov

“…Echocardiography was performed at baseline, after 12 weeks, and after 6 months of therapy.Results. The target blood pressure (BP) level in group 1 was achieved in 92.9%. …”
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The lipid-lowering therapy effectiveness and IHD course after coronary stenting by Skoromna A.S., Khomych A.V., Romanenko S.V., Koval O.A.

“…The period of observation of patients was on average 4,6 ± 1,3 years. Results and Discussion: The study found that the best five-year survival rate of patients without adverse cardiovascular events after stenting was significantly associated with previous PCI, presence of stable angina not higher than 2nd FC (61%, p<0,0001), achieving target level of CH-LDL (35%, p = 0.014), TG level less than 1,7 mmol/l was associated with a sta¬tistically significant reduction in risk of the primary endpoint 0,68 (long-rank p <0,0001) while taking statins after stenting. …”
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Gearbox fault diagnosis method based on adaptive multi-sensor data level fusion and fine-grained domain adaptation by Yabin Shi, Gaige Chen, Lin Li, Xiaozheng Jin, Jian Zheng, Zhongquan Li

“…Ultimately, a teacher model generates reliable pseudo-labels for the target domain, thereby reducing class-conditional shifts between the source and target domains. …”
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Pharmacoeconomic analysis of the anidulafungin (EraxisR) in adult patients with invasive candidiasis by S. V. Nedogoda, A. S. Salasyuk, I. N. Barykina, V. O. Smirnova

“…The average savings in the 3‑year study horizon, taking into account the gradual switching of 25, 50 and 75 % of the target patient population, amounted to 1277.9 million rubles per year or 14.4 %. …”
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Ecological Water Level Determination and Safeguard Measures for Rivers in Northern Jiangsu Plain by WANG Zhenqi, FANG Hongyuan, XU Guangdong, ZHU Ye, WANG Chengjie

“…Effective methods of calculating the threshold of river ecological flow (water level) need to be employed to obtain measures of controlling the ecological state of rivers in a plain river network and to build a robust long-term mechanism of ecological flow control.The Zongliutang River in the river network area of Northern Jiangsu Plain is divided into upper,middle,and lower reaches according to its objective environment and its actual operation and management situation.Then,the controlling condition of the ecological water level of each reach is analyzed respectively.Considering the hydrological characteristics,hydrodynamic characteristics,and observed hydrological data conditions of rivers in this river network area,several methods are utilized to calculate the ecological water level threshold of the middle reach of the river respectively.Those methods include the annual minimum water level method with a 90% guarantee rate,the wetted perimeter method,the minimum monthly average water level method,and the lowest survival water depth method.Through the comparative analysis of actual river operation and management schemes,the ecological water level targets of the upper,middle,and lower reaches of the river are comprehensively determined as 17.40 m,8.96 m,and 7.50 m respectively.After the control value of the ecological water level of the river is obtained by comprehensive analysis,the actual operation and management situation of the river is taken into account to propose specific safeguard measures for maintaining the ecological water level (flow) target of the river from multiple perspectives.Some of the measures are constructing a robust and feasible ecological flow control system,accelerating the construction of an information monitoring system of ecological flow and water intake and an early warning system safeguarding the ecological water level target,and strengthening the supervision and assessment of the implementation of river and lake ecological flows (water levels).…”
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