An Electrochemical Biosensor Analysis of the Interaction of a Two-Vector Phospholipid Composition of Doxorubicin with dsDNA and Breast Cancer Cell Models In Vitro by Lyubov V. Kostryukova, Anastasia S. Serdyukova, Veronica V. Pronina, Victoria V. Shumyantseva, Yulia A. Tereshkina

“…<b>Methods:</b> The effect of the substance doxorubicin, doxorubicin embedded in phospholipid nanoparticles, and doxorubicin with phospholipid nanoparticles modified by targeting vectors (cRGD and folic acid) on dsDNA and breast cancer cell lines (MCF-7, MDA-MB-231) was studied. …”
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An improved YOLOv5s-based method for detecting rice leaves in the field by Cheng Zhou, Caohang Zhou, Lili Yao, Yagang Du, Xin Fang, Zhangbin Chen, Chengliang Yin

“…First, we added a high-resolution layer and removed the original low-resolution detection layer, using the K-Means++ clustering algorithm to reset the anchor box sizes, enhancing the model’s ability to identify small leaf tip targets while reducing the number of parameters. Second, we introduced a coordinate attention mechanism (CA) to strengthen focus on leaf tip features under weed interference and leaf occlusion conditions. …”
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Folate-Modified Smart Responsive Nanosystems for Enhancing Anti-Tumor Therapy Through Calcium Overload and Chemotherapy by Tang Y, Huang J, Cui C, Yang F, Li K, Gao B, Fu S, Yang X

“…The nanoparticles (NPs) were characterized and the release kinetics and anti-tumor effectiveness of FA-DCFP were studied in vitro and in vivo.Results: The prepared nanoparticles had an average particle size of 188.79± 0.93nm and exhibited pH-sensitive drug release. …”
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Causes of drug resistance and glioblastoma relapses by A. A. Mitrofanov, D. R. Naskhletashvili, V. A. Aleshin, D. M. Belov, A. Kh. Bekyashev, V. B. Karakhan, N. V. Sevyan, E. V. Prozorenko, K. E. Roshchina

“…Glioblastoma multiform^ is one of the most aggressive malignancies, wich standard of treatment not changed over the past decade, and the average life expectancy from diagnosis to death does not exceed two years in the most optimistic trials. …”
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Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases by Lin X, Zhou Y, Lv K, Wu W, Chen C

“…Future advancements in nanomedicine hold potential for personalized, non-invasive ocular therapies, revolutionizing ophthalmology.Keywords: nanomedicine, ophthalmic drug delivery, ocular diseases, physiological barriers, targeted delivery…”
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The impact of early special educational needs provision on later hospital admissions, school absence and education attainment: A target trial emulation study of children with isola... by Vincent Nguyen, Kate Lewis, Ruth Gilbert, Bianca De Stavola, Lorraine Dearden

“…Causal effects were measured in terms of average treatment effects (ATE) and average treatment effects on the treated (ATT), expressed as rate ratios (RaR) for hospitalisations and absences, risk ratios (RiR) for persistent absences, and mean differences (Δ) for academic scores. …”
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Causal effect of chemotherapy received dose intensity on survival outcome: a retrospective study in osteosarcoma by Marta Spreafico, Francesca Ieva, Marta Fiocco

“…Methods Chemotherapy administration data from BO03 and BO06 Randomized Clinical Trials (RCTs) in ostosarcoma are employed to emulate a target trial with three RDI-based exposure strategies: 1) standard, 2) reduced, and 3) highly-reduced RDI. …”
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Associations of long-term hyperoxemia, survival, and neurological outcomes in extracorporeal cardiopulmonary resuscitation patients undergoing targeted temperature management: A re... by Tomoaki Takeda, Hayato Taniguchi, Hiroshi Honzawa, Takeru Abe, Ichiro Takeuchi, Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda

“…However, research on associations of hyperoxemia with survival and neurological outcomes after ECPR remains limited, especially considering targeted temperature management (TTM) administration to patients. …”
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A monocular distance measurement method for underground track obstacles based on deep learning by Yuanyuan XU, Qinghua CHEN, Yingsong CHENG

“…First, the y coordinate at the bottom of the Yolov5 detection frame is used to locate the target obstacle and the track on the same horizontal line. …”
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Four-Channel Emitting Laser Fuze Structure Based on 3D Particle Hybrid Collision Scattering Under Smoke Characteristic Variation by Zhe Guo, Bing Yang, Zhonghua Huang

“…With this structure of the laser fuze prototype, the smoke echo signal and the target echo signal could be separated, and the average amplitude growth rate of the target echo signal was improved. …”
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YOLOv8-OCHD: A Lightweight Wood Surface Defect Detection Method Based on Improved YOLOv8 by Zuxing Chen, Junjie Feng, Xueyan Zhu, Bin Wang

“…This method demonstrates significant performance improvement in handling common multi-scale and small target defects on wood surfaces. Firstly, to enhance the ability to capture multi-dimensional features of wood surface defects and reduce information loss, a fully dynamic convolution (ODConv) is introduced. …”
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Multi-label semantic segmentation of magnetic resonance images of the prostate gland by Mark Locherer, Christopher Bonenberger, Wolfgang Ertel, Boris Hadaschik, Kristina Stumm, Markus Schneider, Jan Philipp Radtke

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Implementation of C-reactive protein point of care testing to improve antibiotic targeting in respiratory illness in Vietnamese primary care (ICAT): a study protocol for a cluster... by H Rogier van Doorn, Behzad Nadjm, Yoel Lubell, Rachel Claire Greer, Sabine Dittrich, Sonia Lewycka, Nga Thi Thuy Do, Maida Vandendorpe, Van Anh Nguyen, Pham Ngoc Thach, Ta Thi Dieu Ngan, Nguyen Van Kinh, Cao Hung Thai, Le Thi Kim Dung, Tu Nguyen Thi Cam, Thanh Ha Nguyen

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Exposure–Response Relationships for Toceranib in Dogs with Solid Tumors: A Pilot Study by Young-Rok Kim, Ji-Hwan Park, Kieun Bae, Kyong-Ah Yoon, Jung-Hyun Kim

“…The existence of considerable interpatient variability in pharmacokinetic exposure necessitates dose adjustment to avoid potential adverse events and suboptimal efficacy in targeted therapy. Exposure–response relationships for toceranib phosphate (TOC), the most commonly used tyrosine kinase inhibitor in veterinary oncology, remain unclear. …”
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Pharmacokinetic Model‐Informed Precision Dosing of Natalizumab in Multiple Sclerosis by Stefan P. H. van denBerg, Alyssa A. Toorop, Femke Hooijberg, Gertjan Wolbink, Nivea M. F. Voelkner, Liza M. Y. Gelissen, Joep Killestein, Zoé L. E. vanKempen, Thomas P. C. Dorlo, Theo Rispens

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Progress of Nimotuzumab Application in Nasopharyngeal Carcinoma by Tianci LIANG, Yue ZHAO, Chenchen SONG, Chaoyi ZHANG, Chen CHEN, Qiaoran LI, Biaoxue RONG

“…Nimotuzumab, a targeted therapy that acts on the epidermal growth factor receptor, has prompted continuous progress in NPC treatment. …”
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Understanding Effectiveness of International Sanctions by Thomas Biersteker

“…Thomas Biersteker took part in 2019 Gerda Henkel Forum: Values and Interests in Communication Between Russia and The West held in MGIMO-University in late April this year and on the margins of the Forum he was kind enough to give an interview to our editor Vadim Belenkov on effectiveness of targeted international sanctions. Professor Biersteker is a renowned expert on this issue, he co-edited a book «Targeted Sanctions» recently published by Cambridge University Press. …”
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Estimating the Economically Justifiable Price of Limited-Duration Treatment with Donanemab for Early Symptomatic Alzheimer’s Disease in the United States by Malaz Boustani, Erin G. Doty, Louis P. Garrison Jr, Lee J. Smolen, Timothy M. Klein, Daniel R. Murphy, Andrew W. Spargo, Mark Belger, Joseph A. Johnston

“…Conclusions Results from this modeling simulation informed by the TRAILBLAZER-ALZ 2 study support an EJP for limited-duration treatment with donanemab that exceeds per-dose list prices for currently available amyloid-targeting therapies, implying potentially lower lifetime costs and better value for money.…”
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Current trends and landscape of drug resistance in renal cell carcinoma: a bibliometric analysis by Kenan Zhang, Shixu Chen, Zhenzhen Zhou, Shuanbao Yu, Yonghao Zhan, Xuepei Zhang

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aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed... by Yi Tang, Qingling Shen, Peng Lin, Zhixin Chen, Denghui Fan, Minling Zhuo, Yajiao Gan, Yixi Su, Qingfu Qian, Liwu Lin, Ensheng Xue, Zhikui Chen

“…In this study, aPD-L1-modified docetaxel and perfluoropentane-loaded liquid‒vapor phase-transformation lipid nanoparticles (aPDL1-DTX/PFP@Lipid) were synthesized and had an average diameter of 61.63 nm with 84.3% antibody modification. …”
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