Discovery and Timing of Four γ-Ray Millisecond Pulsars by M. Kerr, S. Johnston, C. J. Clark, F. Camilo, E. C. Ferrara, M. T. Wolff, S. M. Ransom, S. Dai, P. S. Ray, J. E. Reynolds, J. M. Sarkissian, E. D. Barr, M. K. Kramer, B. W. Stappers

“…Indeed, all four new γ -ray MSPs have lower-than-average efficiency, a potential indication of bias in earlier searches. …”
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Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT by Rob Horne, Caroline Sabin, Trudie Chalder, Vanessa Cooper, Lucy Campbell, Elizabeth Glendinning, Iris Mosweu, Paul McCrone

“…In Workstream 3, we did not meet the recruitment targets and our trial was underpowered for the primary outcome: 143 participants met the inclusion criteria and were randomised (care as usual, n = 72; care as usual plus cognitive–behavioural therapy, n = 71). …”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…These scores suggest the mother–infant scores in THRIVE were slightly below average in terms of maternal sensitivity and baby’s co-operativeness. …”
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Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT by Melanie J Davies, Shona Agarwal, Danielle H Bodicoat, Alan Brennan, Simon Dixon, Helen Eborall, Agnieszka Glab, Laura J Gray, Michelle Hadjiconstantinou, Lisa Huddlestone, Nicky Hudson, Anju Keetharuth, Kamlesh Khunti, Caroline Kristunas, Graham Martin, Alison Northern, Mike Patterson, Daniel Pollard, Rebecca Pritchard, Sally Schreder, Jane Speight, Bernie Stribling, Jackie Sturt, Jess Turner, Christina Weis

“…There were 19 page views on average per week for the toolkit (including by study staff as data could not be separated). …”
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Metabolomic profiling in heart failure as a new tool for diagnosis and phenotyping by Maria V. Kozhevnikova, Yuri N. Belenkov, Ksenia M. Shestakova, Anton A. Ageev, Pavel A. Markin, Anastasiia V. Kakotkina, Ekaterina O. Korobkova, Natalia E. Moskaleva, Ivan V. Kuznetsov, Natalia V. Khabarova, Alexey V. Kukharenko, Svetlana A. Appolonova

“…Metabolomic profiling (MP) offers a means to identify unique pathophysiological changes across different phenotypes, presenting a promising approach for the diagnosis and prognosis of HF, as well as for the development of targeted therapies. In our study, MP was performed on 408 HF patients (54.9% male). …”
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Techniques to mitigate lead migration for percutaneous trials of cervical spinal cord stimulation by Jonathan N. Finney, Isaiah R. Levy, Isaiah R. Levy, Santosh Chandrasekaran, Santosh Chandrasekaran, Santosh Chandrasekaran, Jennifer L. Collinger, Jennifer L. Collinger, Jennifer L. Collinger, Jennifer L. Collinger, Jennifer L. Collinger, Michael L. Boninger, Michael L. Boninger, Michael L. Boninger, Robert A. Gaunt, Robert A. Gaunt, Robert A. Gaunt, Robert A. Gaunt, Robert A. Gaunt, Eric R. Helm, Lee E. Fisher, Lee E. Fisher, Lee E. Fisher, Lee E. Fisher, Lee E. Fisher

“…The objective of this study was to optimize the implantation procedure of cervical SCS leads to minimize lead migration and increase lead stability during SCS trials.MethodsIn this study, four subjects underwent percutaneous placement of three SCS leads targeting the cervical spinal segments as part of a clinical trial aiming to restore sensation for people with upper-limb amputation. …”
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Global, Regional, and National Burden of Breast Cancer in Adolescents and Young Adults Aged 15–39 Years From 1990 to 2021 Based on the Global Burden of Disease Study 2021 by Zheng Qu, Zheng Li, Shengbin Pei, Ye Lu, Qiang Liu, Peikai Ding, Yazhe Yang, Luxiao Zhang, Jing Wang, Yi Fang

“…Joinpoint regression analysis was used to calculate the average annual percentage changes (AAPCs) in incidence, mortality, and DALYs. …”
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Relative age effect on the physical activity and sedentary behavior in children and adolescents aged 10 to 18 years old: a cross-sectional study in Japan by Takaaki Mori, Takumi Aoki, Kan Oishi, Tetsuo Harada, Chiaki Tanaka, Shigeho Tanaka, Hideki Tanaka, Kazuhiko Fukuda, Yasuko Kamikawa, Nobuhiro Tsuji, Keisuke Komura, Shohei Kokudo, Noriteru Morita, Kazuhiro Suzuki, Masashi Watanabe, Ryoji Kasanami, Taketaka Hara, Ryo Miyazaki, Takafumi Abe, Koji Yamatsu, Daisuke Kume, Hedenori Asai, Naofumi Yamamoto, Taishi Tsuji, Tomoki Nakaya, Kojiro Ishii

“…Although these studies mainly targeted elementary and middle school students, no study has reported on the relative age effect on physical activity in ordinary high school students. …”
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Fully Automated Assessment of Cardiac Chamber Volumes and Myocardial Mass on Non-Contrast Chest CT with a Deep Learning Model: Validation Against Cardiac MR by Ramona Schmitt, Christopher L. Schlett, Jonathan I. Sperl, Saikiran Rapaka, Athira J. Jacob, Manuel Hein, Muhammad Taha Hagar, Philipp Ruile, Dirk Westermann, Martin Soschynski, Fabian Bamberg, Christopher Schuppert

“…Based on CMR measurements, the average LVEDV was 166 ± 64 mL, RVEDV was 144 ± 51 mL, and LVM was 115 ± 39 g. …”
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Use of tofacitinib in real clinical practice to treat patients with rheumatoid arthritis resistant to synthetic and biological disease-modifying antirheumatic drugs: Results of a m... by D. E. Karateev, D. E. Abdulganieva, A. R. Babaeva, A. A. Baranov, L. P. Evstigneeva, O. N. Ivanova, G. V. Lukina, E. L. Luchikhina, V. I. Mazurov, A. S. Misiyuk, O. V. Semagina, A. E. Sizikov, V. N. Sorotskaya

“…Tofacitinib (TOFA), a member of a new class of targeted synthetic disease-modifying antirheumatic drugs (DMARDs), is a promising medication for the treatment of rheumatoid arthritis (RA) and other immunoinflammatory diseases. …”
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Towards interactive AI-authoring with prototypical few-shot classifiers in histopathology by Petr Kuritcyn, Rosalie Kletzander, Sophia Eisenberg, Thomas Wittenberg, Volker Bruns, Katja Evert, Felix Keil, Paul K. Ziegler, Katrin Bankov, Peter Wild, Markus Eckstein, Arndt Hartmann, Carol I. Geppert, Michaela Benz

“…To this end, we realized a workflow and user interface that targets non-technical users.…”
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Effects of ambient temperature, energy density, and energy source on energy partition and plasma metabolomics profile of finishing pigs by Dan Jiang, Kai Zhou, Dongsheng Che, Hailong Jiang, Rui Han, Guixin Qin

“…Increasing the energy density of the diet by adding oil changed the energy source in a low-temperature environment, improved crude fat digestibility (P < 0.001), and reduced the feed/gain ratio of pigs (P = 0.004), with a tendency for higher average daily gain (P = 0.098), which would increase energy utilization. …”
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Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch... by Karl Michaëlsson, Rui Zheng, John A. Baron, Tove Fall, Alicja Wolk, Lars Lind, Jonas Höijer, Carl Brunius, Eva Warensjö Lemming, Olga E. Titova, Bodil Svennblad, Susanna C. Larsson, Shuai Yuan, Håkan Melhus, Liisa Byberg, Hannah L. Brooke

“…The proteins should be further evaluated as shared targets for developing pharmacological interventions to prevent fractures and cardiovascular disease. …”
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Adolescent mental health before, during, and after the COVID-19 pandemic in Iceland: a repeated, cross-sectional, population-based studyResearch in context by Erin Haskell, Berglind Sigmarsdottir, Ingibjorg Eva Thorisdottir, Audun Valborgarson, Elena Bonilla Aparicio, Olli Kiviruusu, Jaana Suvisaari, Zheng Chang, Eivind Ystrom, Agnieszka Butwicka, Bryndis Bjork Asgeirsdottir, Heiddis Bjork Valdimarsdottir, Inga Dora Sigfusdottir, John Philip Allegrante, Thorhildur Halldorsdottir

“…Interpretation: The COVID-19 pandemic has had a serious and continuing negative effect on adolescents’ mental health. Targeted interventions are needed to address the increase in mental health problems during the COVID-19 pandemic, with a focus on enhancing parental support and managing screen use. …”
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Global burden of cancer attributable to high BMI (1990–2031): a multidimensional analysis based on GBD and Mendelian randomization by Xianglin Zhu, Xianglin Zhu, Yushuai Mi, Lang Wang, Lang Wang, Hao Liang, Hao Liang, Jie Zhang, Jie Zhang, Shijun Zhao, Shijun Zhao, Cheng Zhao, Cheng Zhao, Yinlu Ding

“…These findings underscore the need to develop targeted prevention strategies and health promotion interventions that are tailored to specific demographic and regional profiles.…”
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Comparative Analysis of the Bioactivity and Anti-Inflammatory Effects Against Endotoxin in Mitochondria for Transplantation: Impact of Muscle Origin in Rats by Da-Wei Huang, Heng-Juei Hsu, Pei-Wen Chen, Ming-Tse Wu, Chia-En Wong, Chi-Chen Huang, Po-Hsuan Lee, Hui-Fang Chen, Jung-Shun Lee

“…Mitochondrial dysfunction has been implicated in various neurological disorders, prompting the development of novel therapeutic approaches targeting these organelles. Among these, mitochondrial transplantation (MT), which replaces dysfunctional mitochondria with healthy counterparts from donor tissues, has emerged as a promising strategy. …”
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Rubber plant root properties induce contrasting soil aggregate stability through cohesive force and reduced land degradation risk in southern China by W. Ali, A. Milinga, T. Luo, M. N. Khan, A. Shah, K. Shehzad, Q. Yang, H. Yang, W. Long, W. Liu

“…Rubber plant root traits enhance soil aggregate stability and mitigate land degradation risk in tropical regions, offering practical soil restoration strategies through targeted root trait selection to strengthen soil cohesion, ensure long-term agricultural productivity, and preserve environmental quality, highlighting the need for further research across diverse ecological zones and forest types.…”
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Program Report—Transplant Manitoba Adult Kidney Program Cutting Costs, Not Corners: Value of Quality Improvement Initiatives by Christie Rampersad, Aaron Trachtenberg, James Shaw, Nancy Dodd, Krista Maxwell, Martin Karpinski, Chris Wiebe, Peter Nickerson, Julie Ho

“…Programs for hepatitis C-viremic donor kidneys and age-targeted allocation increased transplant opportunities and optimized deceased donor organ use. …”
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The potential of bacteriophage for controlling Vibrio parahaemolyticus as in-vitro by Bagus Ansani Takwin, Dinamella Wahjuningrum, Widanarni Widanarni, Hasan Nasrullah

“…Phage plaques were amplified with an average density of 3.5×109 PFU/mL. Host range tests revealed that only V. parahaemolyticus Situbondo was susceptible to the isolated phages, while five other bacterial strains were not. …”
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Cohort profile: Mother and Infant Metabolome and Microbiome (MIMM) study, a prospective cohort study of mothers and infants in Boston, Massachusetts by Carmen Monthe-Dreze, Sarbattama Sen, Camilia R Martin, Chloe Andrews, Saumya Vodapally, Laurie Pane Foster, Isabella Lawandy, Margot Murphy, Marianna Castellanos, Denisse Moncada, Maria Laura Mourao, Brij Bhushan, Paige K Berger, Raina Fichorova, Steven D Freedman, Asimenia Angelidou

“…The overall objective of the MIMM study is to identify potential targets to improve breastfeeding outcomes, human milk composition and ultimately, maternal and child health. …”
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