Mediation Analyses Link Cardiometabolic Factors and Liver Fat With White Matter Hyperintensities and Cognitive Performance: A UK Biobank Study by Daniel E. Askeland-Gjerde, Lars T. Westlye, Patrik Andersson, Max Korbmacher, Ann-Marie de Lange, Dennis van der Meer, Olav B. Smeland, Sigrun Halvorsen, Ole A. Andreassen, Tiril P. Gurholt

“…Experimental studies are warranted to determine relevant targets for preventing vascular-driven cognitive impairment.…”
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Nanoparticles encapsulating phosphatidylinositol derivatives promote neuroprotection and functional improvement in preclinical models of ALS via a long-lasting activation of TRPML1... by Valentina Tedeschi, Valeria Nele, Valeria Valsecchi, Serenella Anzilotti, Antonio Vinciguerra, Laura Zucaro, Maria Josè Sisalli, Chiara Cassiano, Nunzia De Iesu, Giuseppe Pignataro, Lorella Maria Teresa Canzoniero, Anna Pannaccione, Giuseppe De Rosa, Agnese Secondo

“…Of interest, autophagy dysfunction is emerging as one of the main putative targets of ALS therapy. A tune regulation of this cleansing process is affordable by a proper stimulation of TRPML1, one of the main lysosomal channels. …”
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Behaviour change interventions to promote physical activity in people with intermittent claudication: the OPTIMA systematic review by Ukachukwu O Abaraogu, Philippa Dall, Chris Seenan, Sarah Rhodes, Trish Gorely, Joanna McParland, Julie Brittenden, Ebuka M Anieto, Lorna Booth, Cathy Gormal, Jeremy Dearling, Candida Fenton, Sarah Audsley, Kimberley Fairer, Lindsay Bearne, Dawn A Skelton

“…Only 2 (out of 22 studies) did not achieve acceptable recruitment rates (40%). Average retention rate was 88%, and average adherence rate was 76%. …”
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Investigating the hemodynamic response to iTBS of the left DLPFC: A concurrent iTBS/fNIRS study by Adam W.L. Xia, Minxia Jin, Bella B.B. Zhang, Rebecca L.D. Kan, Tim T.Z. Lin, Penny P. Qin, Xiao Wang, Wanda M.W. Chau, Nancy M.X.Y. Shi, Priya Kannan, Erin Y. Lu, Tifei Yuan, Jack Jiaqi Zhang, Georg S. Kranz

“…Background: Intermittent theta burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (DLPFC) is an established treatment regimen for major depressive disorder, but its instantaneous effects on neural excitability during and immediately after the stimulation remain unclear. …”
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Comprehensive analysis of antimicrobial resistance dynamics among broiler and duck intensive production systems by Zsombor Szoke, Peter Fauszt, Maja Mikolas, Peter David, Emese Szilagyi-Tolnai, Georgina Pesti-Asboth, Judit Rita Homoki, Ildiko Kovacs-Forgacs, Ferenc Gal, Laszlo Stundl, Levente Czegledi, Aniko Stagel, Sandor Biro, Judit Remenyik, Melinda Paholcsek

“…Despite its limitations, this research provides key insights into AMR trends in two major poultry types, guiding targeted interventions and sustainable management strategies.…”
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Global, regional, and national burdens of pertussis among adults: a systematic analysis of age-specific trends using Global Burden of Diseases 2021 data by Kangguo Li, Jiadong Wu, Ruixin Zhang, Yulun Xie, Zecheng Zhou, Qi Yin, Qi Chen, Jia Rui, Xuhua Guan, Zeyu Zhao, Tianmu Chen

“…These findings emphasise the need for targeted vaccination strategies and sustained surveillance to address regional disparities and prevent the resurgence of the disease. …”
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Compassion fatigue and satisfaction among frontline staff in long term care facilities: psychometric properties of the Serbian version of the professional quality of life scale by Milutin Vracevic, Milutin Vracevic, Vedrana Pavlovic, Natasa Todorovic, Natasa Todorovic, Natasa M. Milic, Natasa M. Milic, Bojana Matejic, Predrag Brkic, Nikola V. Milic, Marko Savic, Srdjan Masic, Andrija Pavlovic, Vladislav Stanisic, Ana Tasic, Dragan Spaic, Sandra Matovic, Danijela Tiosavljevic, Danijela Tiosavljevic, Dejana Stanisavljevic

“…The findings should guide decision-makers in developing targeted interventions and policies that promote the psychological resilience and well-being of LTC workers, thereby enhancing both individual and organizational outcomes in the healthcare sector.…”
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Efficacy of an intranasally administered live attenuated PRRSV-2 vaccine against challenge with a highly virulent PRRSV-1 strain by E. Mateu, M. Cortey, M. S. Serena, I. Domingo-Carreño, M. Alberch, L. Aguirre, I. Diaz, M. Martín, J. M. Sanchez-Carvajal, I. M. Rodriguez-Gomez, J. H. Lara-Puente, C. Artigas-Cabre, D. Sarfati-Mizrahi, B. Lozano-Dubernard

“…Macroscopic lung lesions at 10 days post-challenge (DPC) were reduced in vaccinated groups (13–14% of pneumonic lung on average in vaccinated groups vs. 35% in NV/Ch), yet microscopic lesions persisted, correlating with lung viral loads at 28 DPC (R2 = 0.54, p < 0.001). …”
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Experiences of care home staff in the delivery of heart failure care: a grounded theory by Gary Mitchell, James McMahon, Lana Cook, Oonagh McCloy, Paul Tierney, David R Thompson, Laura Creighton, Stephanie Craig, Elizabeth Henderson, Loreena Hill, Jan Cameron, Doris Yu, Debra K. Moser, Karen Spilsbury, Nittaya Srisuk, Jos M G A Schols, Mariëlle van der Velden-Daamen, Christine Brown Wilson

“…Abstract Background Heart failure is a complex syndrome affecting 64 million people globally, with an average patient age of 76 years. Management challenges include medication titration difficulties and patient self-management issues. …”
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Whole genome and transcriptome analyses identify genetic markers associated with growth traits in Qinchuan black pig by Yaxin Wang, Guangquan Lv, Zhe Liu, Ye Cheng, Rongrong Ding, Gongshe Yang, Taiyong Yu

“…In conclusion, this study elucidated the molecular genetic mechanisms of growth traits and identified new molecular breeding targets, offering a robust scientific basis for advancing breeding strategies and genetic investigations within this breed.…”
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Influence of micro-topography on the spatial heterogeneity of above-ground biomass: Lessons from the Qinglan Port Mangrove Nature Reserve, China by Meihuijuan Jiang, Penghua Qiu, Dezhi Wang, Minghui Wu, Ruiquan Lai, Xinqing Zou, Tingting Si, Hui Li, Qidong Shi, Yi Lin, Genzong Xie, Yanli Yang, Siang Wan

“…This study reveals the relationship between micro-topography and mangrove AGB, providing crucial scientific support for the targeted protection and restoration of mangrove wetlands.…”
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Incidence, mortality, and risk factors of bladder, kidney, prostate and testicular cancers in China and comparisons with the United States, the United Kingdom, Japan, and the Repub... by Gaohaer Kadeerhan, Zhongji Jiang, Hong Guo, Xinzhi Ma, Jin Zhang, Wenmin Guo, Jiedong Jia, Yibo Gao, Dongwen Wang

“…Conclusions The distinct age-specific patterns, elevated rates within specific age groups, and marked upward temporal trends of genitourinary cancers in China underscore the critical need for targeted, age-stratified public health interventions.…”
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Changing trends in oral mucosal diseases in China (2016–2024): a cross-sectional study of 316,166 patients with focus on COVID-19 impact and use of chinese patent medicines by Peiru Zhou, Xu Zhang, Yifan Chen, Jiakun Fang, Yanhong Meng, Furong Yang, Pan Wei, Hong Hua

“…Statistical comparisons were made using t-tests and chi-square tests, with significance set at P < 0.05. Results The average patient age was 49.42 ± 17.92 years, and women were significantly overrepresented (male/female ratio: 0.59). …”
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Secular trend and projection of overweight and obesity among Chinese children and adolescents aged 7–18 years from 1985 to 2019: Rural areas are becoming the focus of investment by Jiajia Dang, Yunfei Liu, Shan Cai, Panliang Zhong, Di Shi, Ziyue Chen, Yihang Zhang, Yanhui Dong, Jun Ma, Yi Song, Jing Ni, Xuehong Zhang

“…Urgent action is needed to address health inequities and increase investments, particularly policies targeting rural children and adolescents.…”
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Changing epidemiology of leptospirosis in China from 1955 to 2022 by Zengliang Wang, Ke Li, Yuanhua Liu, Michael P. Ward, Yue Chen, Shuting Li, Jidan Zhang, Yu Zhao, Na Wang, Haiyan Qiu, Yueran Lian, Cuicai Zhang, Zhijie Zhang, Biao Kan

“…The main identified risk factors of leptospirosis occurrence were annual average precipitation (3.68, 95% CI: 2.50 to 5.12), GDP per capita (-3.70, 95% CI: − 5.97 to − 1.41), and the total power of agricultural machinery (− 2.51, 95% CI: − 3.85 to − 1.17). …”
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Global, regional and national disease burden of food-borne trematodiases: projections to 2030 based on the Global Burden of Disease Study 2021 by Lu Liu, Li-Dan Lu, Guo-Jing Yang, Men-Bao Qian, Kun Yang, Feng Tan, Xiao-Nong Zhou

“…From 1990 to 2021, Lao PDR, Thailand, and the Philippines showed the most substantial declines in FBTs, while Kazakhstan had the largest average annual percentage change in DALYs (− 6.60, 95% UI: − 7.10, − 6.10). …”
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Socioeconomic health and impact of sickle cell disease and vaso-occlusive crises in India: results from B-VOCAL study by Dipty Jain, Ravindra Kumar, Nandakumar Menon, Disha Shetty, Tulika Seth, Shashank Udupi, Suman Jain, Seema Bhatwadekar, Rabindra Jena, Bharat Parmar, Anil Goel, Ashvin Vasava, Anupam Dutta, Priyanka Samal, Riya Ballikar, Deepa Bhat, Tuphan Kanti Dolai, Jina Bhattacharyya, Manish Mistry, Shomik Ray

“…Overall, catastrophic healthcare expenditure (CHE) for total annual average SCD care with VOC management was experienced by 624 patients (62.40%). …”
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Impact of Blood Metabolic Profile and Ingestive Behaviours Registered with Noseband Sensor on Methane Emission During Transition Period in Dairy Cows by Justina Krištolaitytė, Karina Džermeikaitė, Arūnas Rutkauskas, Greta Šertvytytė, Gabija Lembovičiūtė, Samanta Arlauskaitė, Akvilė Girdauskaitė, Violeta Juškienė, Remigijus Juška, Walter Baumgartner, Ramūnas Antanaitis

“…Cows were retrospectively classified into low, medium, and high rumination groups according to their average daily rumination duration to investigate the effects of behavioural influences. …”
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Current and prospective development trends of farmland resource conservation in coastal cities: a case study of Jiangsu, China by Yuting Li, Shu Zhuang, Yujie Li, Yixin Xu, Nana Wang, Yongxiang Feng

“…Additionally, statistical analysis identified GDP, population density, annual precipitation, and annual average temperature as the main driving factors influencing land-use change. …”
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Plasma Sphingomyelins as Biomarkers for Diabetic Retinal Neurodegeneration: The Maastricht Study by Siddhita A. Jadhav, MSc, Birke J. Benedikter, PhD, Sara B.A. Mokhtar, MSc, Frank C.T. van der Heide, MD, PhD, Govindasamy Kumaramanickavel, MD, Marleen M.J. van Greevenbroek, PhD, Carroll A.B. Webers, MD, PhD, Tos T.J.M. Berendschot, PhD

“…Understanding these relationships may help identify early biomarkers and therapeutic targets for preventing or slowing the progression of diabetic retinopathy. …”
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