Infrared Compositional Measurements in Comet C/2017 K2 (Pan-STARRS) at Heliocentric Distances Beyond 2.3 au by Chemeda Ejeta, Erika Gibb, Michael A. DiSanti, Hideyo Kawakita, Boncho P. Bonev, Neil Dello Russo, Nathan X. Roth, Younas Khan, Adam J. McKay, Michael R. Combi, Lori Feaga, Mohammad Saki, Ronald J. Vervack Jr, Yinsi Shou

“…We also report (or stringently constrain) abundance ratios (mixing ratios) of the targeted species with respect to CO, C _2 H _6 , and (when detected) H _2 O. …”
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Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT by Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Helen Page, Christopher Dowrick, Michael Moore, Mark Gabbay, Geraldine Leydon, Guiqing Lily Yao, Shihua Zhu, Paul Little, Gareth Griffiths, Glyn Lewis, Carl May, Joanna Moncrieff, Chris F Johnson, Una Macleod, Simon Gilbody, Rachel Dewar-Haggart, Samantha Williams, Wendy O’Brien, Riya Tiwari, Catherine Woods, Tasneem Patel, Naila Khan, Emma Maund, Nadja van Ginneken, Amy Din, Claire Reidy, Rebecca Lucier, Bryan Palmer, Taeko Becque, Yumna Masood, Natalie Thompson, Ellen van Leeuwen, Marta Glowacka, Adam WA Geraghty

“…Sample size The original sample size calculation gave a target of 402 patients for 90% power with one-sided significance of 2.5% to determine non-inferiority of the intervention, within 2 points on the Patient Health Questionnaire-9 items. …”
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Mechanistic insights into the cardiovascular effects of acute heat exposure: A multi-omics analysis based on a randomized crossover trial by Xinlei Zhu, Xihao Du, Yixiang Zhu, Lu Zhou, Cong Liu, Yue Niu, Qingli Zhang, Yixuan Jiang, Haidong Kan, Renjie Chen

“…Genome-wide DNA methylation, untargeted serum proteomics, metabolomics, and 15 targeted serum biomarkers were analyzed. Linear mixed-effects models were used to analyze the data. …”
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The effects of dietary energy level on the growth performance of yaks (Bos grunniens) were studied based on omics technique by Yahui Jiang, Jiali Zhang, Kaiwen Wang, Hengbo Feng, Yuting You, Peng Dai, Zhisheng Wang, Rui Hu, Quanhui Peng, Huawei Zou, Jianxin Xiao, Lizhi Wang, Bai Xue

“…Additional, 16S rDNA sequencing analyzed the rumen and fecal microbiota, and serum non-targeted metabolomics profiling was performed.ResultsResults showed that ME and HE diets significantly increased average daily gain and nutrient digestibility while reducing feed conversion ratios (P < 0.05). …”
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Global, regional, and national trends in the incidence of pneumoconiosis among populations aged 20 and above from 1990 to 2021 by Qiyun Cheng, Qiyun Cheng, Shiyue He, Shiyue He, Shiyue He, Shiyue He, Yongbin Hu, Yongbin Hu, Pinhua Pan, Pinhua Pan, Pinhua Pan, Pinhua Pan, Xinyue Hu, Xinyue Hu, Xinyue Hu, Xinyue Hu, Shuya Liao, Shunjun Wang, Hui Li

“…Our findings could inform governments and policymakers in developing targeted prevention strategies to mitigate this burden. …”
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Insights from metagenomics on microbial biosynthesis of vitamins B and K2 in chicken gut microbiota by Hai-Long Yu, Hai-Long Yu, Xin-Wen Hou, Ji-Xin Zhao, Guo-Hua Liu, Jin-Xin Meng, Jin-Xin Meng, Yong-Jie Wei, Yanan Cai, Jian Liu, Kai-Meng Shang, Hong-Bo Ni, Rui Liu, He Ma, Fu-Long Nan, Xiao-Xuan Zhang, Bei-Ni Chen, Xing Yang

“…These results suggest a collaborative microbial effort in vitamin biosynthesis, with potential implications for optimizing poultry health and nutrition through targeted microbial interventions.…”
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An interpretable machine learning model for predicting myocardial injury in patients with high cervical spinal cord injury by Jiaqi Li, Jiaqi Li, Bingyu Zhang, Bingyu Zhang, Ye Liao, Ye Liao, Liqin Wei, Qinfeng Huang, Qinfeng Huang, Lijun Lin, Lijun Lin, Jiaxin Chen, Jiaxin Chen, Hui Chen, Hui Chen

“…The neural network model showed the best overall performance and, with SHAP interpretation, provided transparent and individualized risk insights, supporting early diagnosis and targeted management in clinical practice.…”
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BioCompNet: A Deep Learning Workflow Enabling Automated Body Composition Analysis toward Precision Management of Cardiometabolic Disorders by Jianyong Wei, Hongli Chen, Lijun Yao, Xuhong Hou, Rong Zhang, Liang Shi, Jianqing Sun, Cheng Hu, Xiaoer Wei, Weiping Jia

“…On internal and external validation datasets, BioCompNet achieved average Dice similarity coefficients of 0.944 and 0.938 for abdominal compartments and 0.961 and 0.936 for thigh compartments, respectively. …”
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Genetic progress in stem lodging resistance of the dominant wheat cultivars adapted to Yellow-Huai River Valleys Winter Wheat Zone in China since 1964 by Hong-jun ZHANG, Teng LI, Hong-wei LIU, Chun-yan MAI, Guang-jun YU, Hui-li LI, Li-qiang YU, Ling-zhi MENG, Da-wei JIAN, Li YANG, Hong-jie LI, Yang ZHOU

“…Clustering analysis based on the first two principle components further indicated the targets of wheat lodging-resistant breeding have changed from reducing plant height to strengthening stem strength over the breeding periods. …”
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Co-inoculation maintains yields and lowers N2O emission by affecting rhizosphere bacterial diversity in common bean grown on a C-rich clayey Ferralsol by Pablo Schulman, Marcia Thais de Melo Carvalho, Raquel Neves de Mello, Beata Emoke Madari, Pedro Luiz Oliveira de Almeida Machado, Enderson Petronio de Brito Ferreira, Tatiana Maris Ferraresi, Tereza Cristina de Oliveira Borba, Rodrigo Mendes, Edson Hirose, Wilker Alves de Araujo, Matheus Mentone de Britto Siqueira, Ryan Rodrigues da Silva, Pedro Augusto de Oliveira Morais

“…N2O–N fluxes were measured using manual static chambers targeting days following co-inoculation and N fertilization applications, while the 16S rRNA microbiome composition was assessed by metabarcoding samples collected during flowering. …”
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Exploring the COVID-19 pandemic’s influence on eating disorders: insights from an Italian residential center by Francesco Monaco, Francesco Monaco, Annarita Vignapiano, Annarita Vignapiano, Paolo Meneguzzo, Stefania Palermo, Annaluce Caputo, Ilona Forte, Antonella Boccia, Anna Longobardi, Marilena Di Pierro, Ernesta Panarello, Benedetta Di Gruttola, Annarita Mainardi, Rossella Bonifacio, Emanuela Ferrara, Alessandra Marenna, Martina Piacente, Stefania Landi, Mauro Cozzolino, Luca Steardo Jr, Giulio Corrivetti, Giulio Corrivetti

“…This underscores the urgent need for targeted, integrated treatment approaches for EDs in the context of global crises, including the development of strategies to address the increased severity of comorbid conditions and higher frequency of hospital readmissions observed in this study. …”
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The rising burden of diabetes and state-wise variations in India: insights from the Global Burden of Disease Study 1990–2021 and projections to 2031 by Shubham Chauhan, Mahalaqua Nazli Khatib, Suhas Ballal, Pooja Bansal, Kiran Bhopte, Abhay M. Gaidhane, Balvir S. Tomar, Ayash Ashraf, M. Ravi Kumar, Ashish Singh Chauhan, Muhammed Shabil, Diptismita Jena, Ganesh Bushi, Prakasini Satapathy, Lara Jain, Vaibhav Jaiswal, Manvi Pant

“…With variations in disease burden across states, a detailed understanding of trends in incidence, prevalence, and Disability Adjusted Life Years (DALYs) is essential for targeted interventions.MethodsThis study utilized Global Burden of Disease (GBD) data from 1990 to 2021 to examine trends in diabetes across Indian states. …”
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Coeliac plexus radiosurgery for pain management in patients with advanced cancer : study protocol for a phase II clinical trial by Laura A Dawson, Camilla Zimmermann, Aisling Barry, Galia Jacobson, Ronen Fluss, Amira Dany-BenShushan, Talia Golan, Tikva Meron, Marcin Miszczyk, Michael Buckstein, Dayssy Diaz Pardo, Artur Aguiar, Liat Hammer, Adam P Dicker, Maoz Ben-Ailan, Ofir Morag, David Hausner, Zvi Symon, Yaacov R. Lawrence

“…This clinical trial investigates a novel approach in which high-dose radiation (radiosurgery) is targeted to the retroperitoneal coeliac plexus nerve bundle. …”
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Screen time exposure and academic performance, anxiety, and behavioral problems among school children by Mohammad Sidiq, Balamurugan Janakiraman, Faizan Kashoo, Rayan Jastania, Abdullah Ibrahim Alhusayni, Abdullah Alzahrani, Aksh Chahal, Alagappan Thiyagarajan, Imran Khan, Chandan Kumar, Rajkumar Krishnan Vasanthi, Fahad Alanazi, Mehrunnisha Ahmad, Chhavi Arora Sehgal, Shabnam Khan, Mshari Alghadier

“…These insights shall be used for development of targeted tailored interventions and strategies to reduce childhood obesity related to screen time. …”
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The interaction between genetic predicted gut microbiome abundance and particulate matter on the risk of incident asthma in adults by Hehua Zhang, Yong Feng, Honghao Yang, Yuqian Li, Zheng Ma, Liuxin Li, Liangkai Chen, Yuhong Zhao, Lishen Shan, Yang Xia

“…A higher level of GMA has the potential to alleviate the detrimental effect of PM2.5 exposure on the risk of asthma in adults. Strategies targeting GMA, such as modifying diet and using probiotics supplement may be helpful for preventing asthma derived from PM2.5 exposure.…”
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Sleep hygiene and sleep quality among yoga and naturopathy medical students in India: a multisite cross-sectional study by Karishma Silwal, Prakash Babu Kodali, Hemanshu Sharma, Nair Dhiren Ajit, Abhay M. Shankaregowda, Renjish Mohanan, M. Jerin Subha, K. Vibhas, S. Sivaraman, Kinjal Bhalavat, V. R. Dhilip, Jyoti Nair, Vanitha Shetty, A. N. Vineetha, Dhanya U. M. Kumar, Rakesh Gupta, Ayswarya Rohini Pandian, Vakeel Khan, Pradeep M. K. Nair

“…Contributing factors include poor sleep hygiene, anxiety, stress, unhealthy eating habits, and Internet addiction. Targeted interventions are needed to improve sleep hygiene and overall wellbeing.…”
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Dietary pattern and nutritional assessment in a cohort of mothers identified by neonatal screening for cobalamin deficiency in offspring: an Italian single center experience by Martina Tosi, Martina Tosi, Veronica Maria Tagi, Veronica Maria Tagi, Alice Colombo, Alessandra Cecchini, Marianna Zobele, Chiara Montanari, Chiara Montanari, Simona Ferraro, Alessandra Bosetti, Eleonora Bonaventura, Eleonora Bonaventura, Fabio Bruschi, Fabio Bruschi, Diego De Zan, Giulia Fiore, Giulia Fiore, Cristina Cereda, Cristina Cereda, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti, Elvira Verduci, Elvira Verduci

“…Most of the cohort (47%) was from Asia, with an average age of 32.5 years. Plasma vitamin B12 levels averaged 240 pg/ml. …”
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Tregs levels and phenotype modifications during Amyotrophic Lateral Sclerosis course by Elisabetta Zucchi, Elisabetta Zucchi, Federico Banchelli, Cecilia Simonini, Sara De Biasi, Ilaria Martinelli, Giulia Gianferrari, Giulia Gianferrari, Domenico Lo Tartaro, Andrea Cossarizza, Andrea Cossarizza, Roberto D’Amico, Roberto D’Amico, Jessica Mandrioli, Jessica Mandrioli

“…However the observed changes in Treg phenotypes, such as the decrease in PD1+Tregs, indicate that phenotypic variations may warrant further investigation for their potential role in ALS progression and therapeutic targeting.…”
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Factors influencing nutrition literacy in patients of colorectal cancer: a cross-sectional study by Jing Zhang, Jing Zhang, Dan Li, Dan Li, Dan Li, Jiai Yan, Jiai Yan, Ju Yang, Ju Yang, Jing Sun, Jing Sun, Jing Sun, Yiran Liu, Yiran Liu, Yanping Xia, Yanping Xia, Yanping Xia, Hong Cao, Hong Cao, Hong Cao, Jiao Hua, Feng Zhang, Feng Zhang, Feng Zhang, Yingyu Wang, Yingyu Wang

“…From a clinical perspective, this evidence-based framework enables the development of stratified nutritional intervention protocols, specifically targeting vulnerable subgroups (e.g., elderly patients, rural dwellers, and those with extended illness duration). …”
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Associations of lung function impairment and biological aging with mortality and cardiovascular disease incidence: findings from UK biobank participants by Jiali Chen, Cheng Wang, Pengyu Duan, Yonghong Bi, Yao Meng, Weiyu Feng, Zhehao Jin, Hangbing Li, Huihui Wang, Xiaoyan Li, Kun Zuo, Xiangcheng Zhao, Longfei Li, Yuling Xing, Lan Luo, Yang Yu, Miao Yu, Muyan Cui, Bing Zhang

“…Mediation and interaction analyses further examined the associations between lung function impairment, biological aging, and adverse health outcomes.ResultsOver an average follow-up of 13.8–14.4 years, 28,059 deaths and 34,863 incident CVD cases were recorded. …”
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