The current status and problems of public health emergency response team building in disease prevention and control institutions in Shanghai city by Zhiwei GUAN, Tianxiang HUANG, Shixiang ZHANG, Xiaoyan HUANG, Yingyin FENG

“…They should further strengthen the recruitment of high-level personnel, enhance the reserve of public health emergency personnel, optimize the composition of emergency response teams, conduct targeted emergency training and drills, and improve the overall quality of emergency response teams to ensure high-quality and sustainable development of public health emergency work.…”
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CO35 | Bleeding phenotype characterization in patients with congenital bleeding disorders: a multigenic approach using next generation sequencing to identify coagulation-modulatin...

“…Genetic analysis was performed using a custom Next-Generation Sequencing (NGS) panel (xGen™ Hyb Panel, Integrated DNA Technologies) targeting 33 coagulation-related genes: A2M, CPB2, F2, F3, F5, F7, F8, F9, F10, F11, F12, F13A1, F13B, FGA, FGB, FGG, KLKB1, KNG1, PLAT, PLG, PROC, PROCR, PROS1, PROZ, SERPINA5, SERPINA10, SERPINC1, SERPIND1, SERPINE1, SERPINF2, TFPI, THBD, VWF. …”
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The use of flowmetry during coronary bypass surgery in patients with diffuse coronary bed lesion by G. G. Borshchev, R. V. Sidorov, D. S. Ulbashev

“…According to our study, to predict the normal patency of shunts in the early postoperative period, it is advisable to use targets MGF above 28 ml/min for internal thoracic artery and 65 ml/min for venous shunts, PI less than 5.0 for all types of conduits, DF above 60 % for autoarterial shunt, and more than 68 % for autovenous graft.…”
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Machine learning algorithms to predict stroke in China based on causal inference of time series analysis by Qizhi Zheng, Ayang Zhao, Xinzhu Wang, Yanhong Bai, Zikun Wang, Xiuying Wang, Xianzhang Zeng, Guanghui Dong

“…Abstract Importance Identifying and managing high-risk populations for stroke in a targeted manner is a key area of preventive healthcare. …”
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Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…Conclusions This study highlights the heterogeneous effects of meteorological factors on HFRS incidence across different epidemic regions. Targeted preventive measures should be taken during cold and dry spring days in Rattus-dominant regions, and during warm and moderately humid winter days in Apodemus-dominant regions. …”
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High-BMI-related low back pain in China: a GBD-based observational study on sex–age trends and projections (1990–2021) by Juxiang Xu, Jianhua Li, Heqing Huang, Tiangao Lin, Zhiping Liao, Weibo Zhang, Jianing Wu, Fangchao Wu

“…By comparing national and global trajectories, we inform targeted strategies addressing this dual epidemic. …”
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Next-Generation Sequencing–Based Molecular Profiling of Conjunctival Squamous Cell Carcinoma and Its Potential Application for Therapy by Hakan Demirci, MD, Josh N. Vo, PhD, Yi-Mi Wu, PhD, Victor Elner, MD, Arul M. Chinnaiyan, MD, PhD, Dan Robinson, PhD, F. Yesim Demirci, MD

“…Objective: Targeted next-generation sequencing–based genomic and transcriptomic analyses of conjunctival squamous cell carcinoma (cSCC) samples using a panel of >1700 cancer-related genes. …”
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Characterization and expression analysis of transcription factors in Spartina alterniflora unveil their critical roles in salt stress resistance by Yuanyuan Jiang, Yuanyuan Jiang, Yuanyuan Jiang, Shoukun Chen, Shoukun Chen, Shoukun Chen, Shuqiang Gao, Shuqiang Gao, Shuqiang Gao, Jiahui Geng, Jiahui Geng, Qin Shu, Qin Shu, Shang Gao, Shang Gao, Huihui Li, Huihui Li

“…Gene structure analysis revealed an average of 5.05 exons per TF, with significant variation in exon number, coding sequence length, and GC content across families, reflecting their structural and functional diversity. …”
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Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls by M. Frances Vest, M. Frances Vest, Alexandru Mihai Dumitrescu, Alexandru Mihai Dumitrescu, Matthew W. Johnson, Elliot Thompson, Elliot Thompson, Alfred Thomas, James C. Patterson, James C. Patterson, James C. Patterson, Kevin S. Murnane, Kevin S. Murnane, Kevin S. Murnane

“…Targeting these constructs in treatment may improve outcomes for individuals recovering from MUD.…”
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Aberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV by Ke Xu, Xinyu Zhang, Kesava Asam, Bryan C. Quach, Grier P. Page, Deborah Konkle‐Parker, Claudia Martinez, Cecile D. Lahiri, Elizabeth F. Topper, Mardge H. Cohen, Seble G. Kassaye, Jack DeHovitz, Mark H. Kuniholm, Nancie M. Archin, Amir Valizadeh, Phyllis C. Tien, Vincent C. Marconi, Dana B. Hancock, Eric O. Johnson, Bradley E. Aouizerat

“…Findings suggest potential molecular targets for eradication strategies.…”
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Electromagnetic shocking treatment induced grain bridging improved the impact toughness of 6082 aluminum alloys by Qian Sun, Qi Xiang, Guojing Ren, Lin Hua, Yi Yang

“…Electromagnetic shocking treatment (EST) induced grain bridging is targetedly utilized to further improve the impact toughness of aged 6082 aluminum alloys. …”
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Human‐wildlife conflict at high altitude: A case from Gaurishankar conservation area, Nepal by Abhinaya Pathak, Saneer Lamichhane, Maheshwar Dhakal, Ajay Karki, Bed Kumar Dhakal, Madhu Chetri, Jeffrey Mintz, Prakash Pun, Pramila Neupane, Tulasi Prasad Dahal, Trishna Rayamajhi, Prashamsa Paudel, Ashim Thapa, Pramod Raj Regmi, Shankar Thami, Ganesh Thapa, Suraj Khanal, Supriya Lama, Jenisha Karki, Sujan Khanal, Arockia E J Ferdin

“…The study analyzes a decade of HWC reports and identifies goats as the livestock most targeted by leopards. The Dolakha district of GCA received the highest number of reports, highlighting the need for mitigation measures in the area. …”
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Rice-SVBDete: a detection algorithm for small vascular bundles in rice stem’s cross-sections by Xiaoying Zhu, Weiyu Zhou, Jianguo Li, Jianguo Li, Mingchong Yang, Mingchong Yang, Haiyu Zhou, Haiyu Zhou, Jiada Huang, Jiada Huang, Jiahua Shi, Jun Shen, Guangyao Pang, Lingqiang Wang, Lingqiang Wang, Lingqiang Wang

“…Our approach enhances the YOLOv8 architecture by incorporating three key innovations: Dynamic Snake-shaped Convolution (DSConv) in the Backbone network to adaptively capture intricate structural details of small targets. A Multi-scale Feature Fusion (MFF) mechanism, combining features from the Backbone, Feature Pyramid Network (FPN), and Path Aggregation Network (PAN), to better handle objects at multiple scales. …”
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Global, regional and national burden of rheumatoid arthritis from 1990 to 2021, with projections of incidence to 2050: a systematic and comprehensive analysis of the Global Burden... by Yingnan Ma, Haiyan Chen, Wenhua Lv, Siyu Wei, Yuping Zou, Ruilin Li, Jiacheng Wang, Wei She, Linna Yuan, Junxian Tao, Xuying Guo, Shuo Bi, Hongsheng Tian, Ye Ma, Hongmei Sun, Chen Sun, Jing Xu, Yu Dong, Jingxuan Kang, Hongchao Lv, Mingming Zhang, Yongshuai Jiang

“…Abstract Background To provide insights into rheumatoid arthritis (RA) epidemiological trends, including prevalence, incidence, disability-adjusted life years (DALYs), corresponding average annual percentage change (AAPC), gender disparities, regional variations, age-specific rates, socio-economic correlations, risk factors, and future projections. …”
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Uncovering <i>Fusarium</i> Species Associated with Fusarium Wilt in Chickpeas (<i>Cicer arietinum</i> L.) and the Identification of Significant Marker–Trait Associations for Resist... by Sojida M. Murodova, Tohir A. Bozorov, Ilkham S. Aytenov, Bekhruz O. Ochilov, Dilafruz E. Qulmamatova, Ilkhom B. Salakhutdinov, Marufbek Z. Isokulov, Gavkhar O. Khalillaeva, Laylo A. Azimova, Sodir K. Meliev

“…Notably, these TA42, TA125 (A) and TA125 (B), TA37, and TAASH MTAs, commonly found in both models, emerge as potential candidates for the targeted enhancement of FW resistance in chickpeas. …”
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Epidemiology characteristics of the drinking patterns and alcohol consumption among adults in Hainan Province, China by Tingting Ou, Juan Jiang, Dingwei Sun, Ying Liu, Changfu Xiong, Xiaohuan Wang, Xue Zhou, Hongying Wu, Lijie Zhang, Chao Wang, Chao Wang, Bin He

“…The findings provide a scientific basis for developing targeted public health strategies, highlighting the need for effective interventions to mitigate alcohol-related health issues among high-risk populations.…”
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Pathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative by Hind A. Beydoun, May A. Beydoun, Rebecca L. Kinney, Simin Liu, Rona Yu, Matthew Allison, Robert B. Wallace, Qian Xiao, Longjian Liu, Philippe Gradidge, Su Yon Jung, Hilary A. Tindle, Shawna Follis, Robert Brunner, Jack Tsai

“…Conclusions Nonveteran postmenopausal women exhibit more complex pathways between SES and major CVD events than their veteran counterparts, informing the design, conduct, and evaluation of preventive strategies targeting CVD by veteran status.…”
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Modeling the impact of social determinants on breast cancer screening: a data-driven approach by Guofang Ma, Miranda G. Scully, Jiahui Luo, Jiazuo H. Feng, Jiazuo H. Feng, Christine M. Gunn, Christine M. Gunn, Roberta M. diFlorio-Alexander, Anna N. A. Tosteson, Anna N. A. Tosteson, Anna N. A. Tosteson, Sally A. Kraft, Sally A. Kraft, Wesley J. Marrero, Wesley J. Marrero

“…This framework offers valuable guidance for healthcare providers to better understand and improve patients’ screening behaviors through targeted, evidence-based interventions.…”
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The current status, trends, and challenges of Alzheimer’s disease and other dementias in Asia (1990–2036) by Ziyang He, Ziyang He, Haoqin Zhang, Haoqin Zhang, Guishan Hu, Yinan Qiao, Can Yin, Jianqiao Li, Hong Lin, Anguo Wu, Dalian Qin, Betty Yuen-Kwan Law, Guangqiang Hu, Lu Yu

“…It is imperative to implement targeted prevention and intervention strategies, enhance chronic disease management, and control risk factors.…”
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Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features by Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray, Kathy Y. Wei

“…Unlike mAbs that bind to single targets, multispecific biologics (msAbs) have garnered particular interest owing to the advantage of engaging distinct targets. …”
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