Metabolic engineering of Saccharomyces cerevisiae for co-production of ethanol and 3-methyl-1-butanol from sugarcane molasses by Sasha Yogiswara, Jonas Rombout, Giovanni Micharikopoulos, Sam De Craemer, Beatriz Herrera-Malaver, Lotte van Landschoot, Sofie Mannaerts, Marcelo do Amaral, Karin Voordeckers, Stijn Spaepen, Jan Steensels, Quinten Deparis, Bart Ghesquière, Kevin J. Verstrepen

“…Finally, we tested in silico-predicted gene deletion targets to reduce the byproduct acetate. Our final engineered strain achieved a 4.4-fold increase in 3MB yield compared to the wild type (1.5 mg/g sugars), average productivity of 5 mg/Lh, and a 3MB proportion increase from 42 to 71% within the fusel alcohol mix, while ethanol production remained comparable to the Ethanol Red® industrial reference. …”
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Feasibility and acceptability of self-directed, remote dim-light melatonin onset collection in pediatric patients diagnosed with chronic pain by Nicole Tacugue, Jessica J. Love, Jessica J. Love, Jessica J. Love, Jakob M. Cherry, Jakob M. Cherry, Jacqueline Lane, Jacqueline Lane, Jacqueline Lane, Jacqueline Lane, Joe Kossowsky, Joe Kossowsky

“…With supplementary research validating this optimized approach to measure endogenous circadian phase, more specific aspects of sleep can be targeted in pain intervention strategies to further optimize clinical outcomes in a greater population of pediatric patients.…”
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Sociodemographic Correlates of High Cardiovascular Health Across Childhood and Adolescence: A Prospective Study Among 2 Cohorts in the ECHO Consortium by Wei Perng, Noya Galai, Qi Zhao, Augusto Litonjua, Sarah Geiger, Katherine A. Sauder, T. Michael O'Shea, Marie‐France Hivert, Emily Oken, Dana Dabelea, Izzuddin M. Aris

“…Disparities in high CVH over time with respect to sociodemographic characteristics were explained by behavioral factors, pointing toward prevention targets.…”
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History of injection drug use in the month preceding incarceration in Iranian prisons by Mitra Darbandi, Willi McFarland, Soheil Mehmandoost, Fatemeh Tavakoli, Maliheh Sadat Bazrafshan, Naser Nasiri, Ali Akbar Haghdoost, Meraj Sharifi, Roya Safari Faramani, Hamid Sharifi

“…Among incarcerated people with a lifetime history of IDU, the average age at which they started IDU was 24.5 ± 5.9 years, and the mean injection duration was 36.8 months (95% CI 33.5, 40.1). …”
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Global, regional, and national burden of sudden infant death syndrome, 1990–2021: a comprehensive analysis of GBD 2021 data with insights into the impact during the COVID-19 pandem... by Yuhan Sun, Haoran Peng, Qiao Chen, Lijie Qin, Ying Ren, Ying Ren, Yanwei Cheng

“…Enhanced healthcare interventions and targeted public health initiatives are crucial, particularly in regions with Low SDI and Minimal health system resources.…”
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“Aria di Ricerca in Valle del Serchio”: a cross-sectional citizen science study to evaluate CKD prevalence and associations with environmental risk factors in the Serchio Valley (L... by Chiara Doccioli, Francesco Sera, Giorgia Stoppa, Bruna De Marchi, Bruna De Marchi, Dolores Catelan, Antonella Ficorilli, Antonella Ficorilli, Giulia Malavasi, Annibale Biggeri

“…These findings underscore the impact of environmental exposures on kidney health, emphasizing the need for targeted interventions and public health measures to mitigate CKD prevalence in pollution-exposed communities.…”
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Amateurs exhibit greater psychomotor efficiency than novices: evidence from EEG during a visuomotor task by Guo Lu, John Elvis Hagan, John Elvis Hagan, Ming-Yang Cheng, Dong-Tai Chen, Chieh-Ju Lu, Fang-Yi Lin, Li-Ju Chen, Dan Li, Kuo-Pin Wang, Kuo-Pin Wang, Kuo-Pin Wang

“…During the warm-up session, each participant determined their individual putting distance, targeting a 40–60% success rate. Once established, participants were asked to perform 10 putts per block across 6 blocks in the experimental session.ResultsThe results of the study indicated that amateur golfers demonstrated: (1) higher Fz Theta power, (2) higher Fz, Pz, T7, T8 Alpha 2 power, (3) higher Mu 2 power, and (4) higher SMR power compared with novices during motor preparation. …”
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Impact of yeast-derived nucleotides supplementation in drinking water on production performance and gut health indicators in broiler chickens by Vera Perricone, Marcello Comi, Nida Irshad, Cristina Lecchi, Yasmine Dadi, Lucia Aidos, Paola Cremonesi, Bianca Castiglioni, Filippo Biscarini, Giovanni Savoini, Alessandro Agazzi

“…This mode of administration offers a practical, flexible alternative to feed-based supplementation, allowing targeted use during critical growth periods or under stress conditions. …”
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Reducing tuberculosis transmission by genotype-based contact tracing coupled with public health containment measures: a case study during the COVID-19 pandemic in Taiwan by Yuan-Shan Chien, Chao-Chih Lai, Chen-Yang Hsu, Yu-Chu Hsieh, Shin-Yi Lin, Hsiao Chi Wang, Hung-pin Chen, Tony Hsiu-His Chen, Dih-Ling Luh, Yen-Po Yeh

“…This finding demonstrates that a molecular epidemiological approach with public health containment measures will enable a moderate-burden tuberculosis country to reach the End TB targets by 2035.…”
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ImmuProgML: machine learning-based dissection of cancer-immune dynamics during tumor progression to improve immunotherapy by Hanxiao Zhou, Lan Mei, Qianyi Lu, Yakun Zhang, Yue Sun, Caiyu Zhang, Han Jiang, Jiajun Zhou, Xia Li, Yunpeng Zhang, Shangwei Ning

“…By introducing the DNEX score, an integrative metric combining differential expression and network analysis, ImmuProgML evaluated gene immunomodulation activity during tumor progression and identified immunotherapy targets. High DNEX score correlated with immune-related pathways, including T cell activation and PD1 signaling, in melanoma and NSCLC. …”
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The Application of Machine Learning Algorithms to Predict HIV Testing Using Evidence from the 2002–2017 South African Adult Population-Based Surveys: An HIV Testing Predictive Mode... by Musa Jaiteh, Edith Phalane, Yegnanew A. Shiferaw, Haruna Jallow, Refilwe Nancy Phaswana-Mafuya

“…However, there are insufficient predictive models to inform targeted HIV testing interventions in South Africa. …”
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Investigation of Microbial Community Characteristics in Pepper Rhizosphere at Seedling Stage Under Varied Soil Conditions by Yuyu ZHANG, Zhixiong CHEN, Fang CHEN, Jinqiang YAN, Junyu WU, Qingyuan XI, Shumei GE

“…【Objective】The study was carried out to explore the distribution patterns of rhizospheric microbial communities in different resistant pepper varieties, aiming to provide a basis for the targeted optimization of rhizospheric microbial community structure of pepper.…”
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Neurotechnology-Based, Intensive, Supplementary Upper-Extremity Training for Inpatients With Subacute Stroke: Feasibility Study by Reut Binyamin-Netser, Shirley Handelzalts, Noy Goldhamer, Inbar Avni, Adi Tayer Yeshurun, Yogev Koren, Ofri Bibas Levy, Shilo Kramer, Simona Bar Haim, Lior Shmuelof

“…Two video game–based platforms were used: one platform (tech 1) targeted proximal movements involving the shoulder and elbow, while the second platform (tech 2) emphasized distal movements of the wrist and fingers. …”
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Confronting needlestick and sharp injuries in healthcare: a decade of struggle and progress in a university teaching hospital by Shuk-Ching Wong, Lithia Lai-Ha Yuen, Germaine Kit-Ming Lam, Monica Oi-Tung Kwok, Crystal Yuen-Ki Siu, Bella Hong-Yan Li, Jonathan Hon-Kwan Chen, Simon Yung-Chun So, Kelvin Hei-Yeung Chiu, Vincent Chi-Chung Cheng

“…This study analyzes the incidence and characteristics of NSIs at Queen Mary Hospital and assesses the effectiveness of targeted training programs for interns. Methods A retrospective analysis was conducted on NSI reports from 2014 to 2023, focusing on episodes involving medical, nursing, allied health, and other staff. …”
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Global burden of nasopharyngeal carcinoma attributable to alcohol use: a 1990–2021 analysis with projections to 2040 by Zhenyi Lu, Zhenyi Lu, Zhenyi Lu, Shujun Yang, Mengqi Dai, Guixiang Wu, Fabao Wang, Kai Zhang, Kai Zhang, Kai Zhang

“…Trends were quantified by average annual percentage change (AAPC) and projections were generated using Bayesian age–period–cohort models.ResultsFrom 1990 to 2021, global ASMR declined from 0.31 to 0.19 per 100,000 population (AAPC −1.66; 95% CI −1.79 to −1.52) and ASDR fell with an AAPC of −1.72 (95% CI −1.87 to −1.57). …”
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Trends and disparities in inflammatory bowel disease and cardiovascular disease-related mortality in the United States from 1999 to 2023: A CDC WONDER analysis by Syed Anjum Gardezi, Nakul Sachdeva, Insiya Mohammed Rampurawala, Akalanka Ranasinghe, Muhammad Umair Shehzad, Kieran Gill, Raheel Qureshi, Ashish Gupta, Ali Hasan, Muzammil Farhan, Azeem Hassan, Eeshal Zulfiqar, Mushood Ahmed, Raheel Ahmed

“…Temporal trends were assessed using Joinpoint regression analysis to estimate the annual percent change (APC) and average annual percent change (AAPC) in mortality rates. …”
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Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021 by Jelena Milešević, Milica Zeković, Ivana Šarac, Marija Knez, Marija Takić, Jasmina Debeljak, Mirjana Gurinović

“…The Serbian food consumption database serves as an evidence platform for decision-making processes in public health nutrition policies and strategies, diet monitoring, exposure risk assessments, and interventions targeting identified nutritional challenges in particular population groups. …”
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The heterogeneous association between education and the adoption of safe food handling practices in Ethiopia by Kai Su, Barbara Kowalcyk, Devin LaPolt, Lina Gazu, Silvia Alonso, Binyam Moges Azmeraye, Desalegne Degefaw, Galana Mamo, Dessie Abebaw Angaw, Amete Mihret Teshale, Robert Scharff

“…This has important implications for developing targeted policies focused on individuals most susceptible to foodborne diseases. …”
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Guanine derivatives as promising candidates for the development of purine-based antimalarial drugs by Worlanyo Tashie, Harry P. de Koning, Nancy O. Duah-Quashie, Nancy O. Duah-Quashie, Neils B. Quashie, Neils B. Quashie, Neils B. Quashie

“…To understand their cellular targeting, molecular docking of the same analogues was performed using the structure of P. falciparum Equilibrative Nucleoside Transporter 1 (PfENT1). …”
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The global burden of smoking-related prostate cancer from 1990 to 2021 and projections to 2031 by Qian Cai<sup>‡<sup>, Bohao Liu<sup>‡<sup>, Chen Zou<sup>‡<sup>, Huabin Su, Xiao Zhao, Fang Jia, Xiaoyang Li, Weian Zhu, Yun Luo

“…Conclusions Despite improved global equity in smoking-related PCa burden, targeted interventions for elderly populations, enhanced tobacco control policies, and region-specific prevention strategies remain essential to further reduce this preventable disease burden worldwide.…”
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