Recent HIV infections and associated risk factors among newly diagnosed individuals in South Korea (2016–2023) by Jin-Sook Wang, Eun Ji Kim, Gayeong Kim, Seolhui Kim, Heui Man Kim, Yea Jin Lee, Ho Gyeong Hong, Min-seong Kim, Na Rae Jo, Tae-Young Heo, Koun Kim, Sungnam Kim, Jeonghee Yu, Myung-Guk Han

“…Abstract Determining the annual proportion of individuals newly diagnosed with human immunodeficiency virus (HIV) infection acquired within the preceding 130 days is essential to inform targeted prevention strategies. We assessed populations at increased risk of HIV infection and identified those with delayed diagnosis by analyzing the proportion of recent infections among newly diagnosed individuals. …”
Get full text

Nitrogen cycling and functional gene diversity of drinking reservoir area in agricultural districts: Implications for nitrogen transformation processes by Mengze Li, Wenwen Wang, Shengwu Yuan, Kun Wang, Shuhang Wang, Wei Li, Xia Jiang, Wenqiang Zhang, Baoqing Shan

“…Nonetheless, the complexity and variability of nitrogen cycling in these reservoirs highlight the need for further targeted research to enhance understanding and improve management practices.…”
Get full text

The efficacy of generic imatinib in patients with chronic myeloid leukemia: A single centre experience by Urošević Ivana, Perčić Ivanka, Dragičević-Jojkić Marina, Dokić Marina, El Farra Amir, Savić Aleksandar, Milošević Ivana, Vlaisavljević Nada, Sekulić Borivoj, Balint Bela

“…The treatment of chronic myeloid leukemia (CML) has changed dramatically with the advent of targeted therapies. This study aimed to assess the efficacy of generic imatinib in CML patients treated in our center. …”
Get full text

Non-communicable diseases in the WHO African region: analysis of risk factors, mortality, and responses based on WHO data by Abbie Barry, Benido Impouma, Caitlin M. Wolfe, Adriana Campos, Nicola Carey Richards, Akpaka Kalu, Cheick Bady Diallo, Prebo Barango, Bridget Farham

“…Accelerated action is essential to meet global and regional NCD reduction targets. Strengthening national NCD targets, improving surveillance, ensuring access to essential medicines, and scaling up risk factor reduction strategies are critical to reversing current trends and achieving the 2030 SDG NCD targets.…”
Get full text

Food-Away-From-Home Options in Local Military Nutrition Environments by Katie M. Kirkpatrick, MS, Deborah J. Robinson, MPH, Sarah J. Hinman, MSPH, Jessica L. Kegel, MA, Rachel A. Chamberlin, PhD, Rory G. McCarthy, PhD, Jonathan M. Scott, PhD

“…The most commonly targeted facility for intervention was the dining facility. …”
Get full text

Regional analysis and stage-specific incidence of breast cancer in Kazakhstan: A comprehensive study by Nurbek Igissin, Assem Toguzbayeva, Zhansaya Telmanova, Gulnur Igissinova, Dulat Turebayev, Dariyana Kulmirzayeva, Nariman Syzdykov, Rustem Moldagali, Daulet Baibosynov, Zarina Bilyalova

“…However, regional disparities in late-stage cancer incidence suggest a need for targeted interventions and improved regional healthcare.…”
Get full text

Enhanced Band‐Crystal Engineering Drives Superior Power Generation in GeTe by Xiaobo Tan, Qian Deng, Jianglong Zhu, Ruiheng Li, Xuri Rao, Fan Feng, Shuang Lyu, Pengfei Nan, Yue Chen, Binghui Ge, Ran Ang

“…Abstract Optimizing both electrical and thermal performance in thermoelectric (TE) materials is challenging due to the inherent coupling between carrier and phonon transport. To address this, targeted modulation of band structure and crystal lattice is achieved in the optimized Ge0.885Zr0.02Pb0.08Te0.985(Cu2Te)0.015 sample. …”
Get full text

Characterization and source analysis of trace metal pollution in coastal shallow marine sediments, Wanning area, Hainan Island, China by Suimiao Wang, Suimiao Wang, Xianqin Wang, Xianqin Wang, Zhaofan Wang, Zhaofan Wang, Guangfei Guo, Guangfei Guo, Liang Chen, Liang Chen, Zanhui Huang, Zanhui Huang, Dinghui Fu, Dinghui Fu, Pingru Li, Pingru Li, Xiuyu Yun, Xiuyu Yun

“…These findings highlight the need for targeted pollution control measures to ensure sustainable coastal development and marine environmental protection.…”
Get full text

Alternative therapeutic approaches for combating multi-drug-resistant bacteria: Reverse vaccinology against Enterobacter cloacae by Gabriela Guerrera Soares, Marcelo Silva Folhas Damas, Pedro Mendes Laprega, Rebecca Elizabeth Shilling, Eduarda Oliva Ribeiro Rangel, Louise Teixeira Cerdeira, Murillo Rodrigo Petrucelli Homem, André Pitondo-Silva, Andrea Soares da Costa-Fuentes, Maria-Cristina da Silva Pranchevicius

“…VEC1 showed the most consistent performance, with the highest average binding affinity (−24.07 kcal/mol), docking score (−322.21), and the most favorable dissociation constant at 37 °C. …”
Get full text

Secular Trends in the Incidence, Prevalence, and Disability-Adjusted Life Years of Caries in Permanent Teeth in Six Asian Countries: 1990 to 2021 by Min Deng, Xihua Yuan, Xiaoying Zhu, Jiaqiang Wei, Minsi Li, Ziyi Yang, Na Yu, Xiaofeng Qin

“…Clinical Relevance: These findings underscore the need to develop targeted oral health solutions in Asia.…”
Get full text

Prevalence of eating disorders in South Asian countries: a systematic analysis of Global Burden of Disease (1990–2021) by Prakasini Satapathy, Vijay Kumar, Mahalaqua Nazli Khatib, Lalji Baldaniya, Suhas Ballal, V. Kavitha, Laxmidhar Maharana, Renu Arya, Ganesh Bushi, Muhammed Shabil, Rukshar Syed, Manika Gupta, Sunil Kumar, Sabah Ansar, Sanjit Sah, Diptismita Jena, Edward Mawejje

“…Conclusions The rising burden of EDs in South Asia underscores an urgent need for culturally sensitive prevention strategies and public health policies. Targeted interventions addressing sociocultural drivers are essential to mitigate the growing impact of EDs in this region. …”
Get full text

Trends in coronary artery disease mortality among hyperlipidemic patients: Geographic, gender, and racial insights from CDC WONDER data (1999–2020) by Muhammad Abdullah Naveed, Sivaram Neppala, Himaja Dutt Chigurupati, Bazil Azeem, Ahila Ali, Faizan Ahmed, Sabin Zafar, Muhammad Omer Rehan, Rabia Iqbal, Manahil Mubeen, Hassaan Abid, Anum Mubasher, Timir Paul

“…The overall increase in AAMRs from 1999 to 2020 underscores the need for targeted public health interventions to address these growing inequities.…”
Get full text

Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library by Stacey E. Chin, Pablo Gallego, Anna Aagaard, Sara Carmen, Nathalie Barrett, Marcin Wolny, Sophie Cloarec, Judy Paterson, Rohan Sivapalan, James Hunt, Thomas V. Murray, Tracy Delaney, Tove Sjögren, Frances Neal

“…Initial phage display selections revealed a preference of hits for a longer than average complementarity-determining region 3 (CDR3) in the heavy chain variable domain (VH). …”
Get full text

Global incidence, risk factors, and temporal trends of nasal cancer: A population‐based analysis by Junjie Huang, Wing Sze Pang, Fung Yu Mak, Sze Chai Chan, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero‐Prisno III, Wanghong Xu, Zhi‐Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong, NCD Global Health Research Group, Association of Pacific Rim Universities (APRU)

“…Trend analysis was conducted using the joinpoint regression analysis program, and the average annual percentage change (AAPC) was calculated. …”
Get full text

Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses by Markus Zettl, Melanie Wurm, Otmar Schaaf, Sven Mostböck, Iñigo Tirapu, Ilse Apfler, Ivo C. Lorenz, Lee Frego, Cynthia Kenny, Michael Thibodeau, Elisa Oquendo Cifuentes, Markus Reschke, Jürgen Moll, Norbert Kraut, Anne Vogt, Jonathon D. Sedgwick, Irene C. Waizenegger

“…Upregulation of inhibitory receptors, such as lymphocyte activation gene-3 (LAG-3), may limit the antitumor activity of therapeutic antibodies targeting the programmed cell death protein-1 (PD-1) pathway. …”
Get full text

Treatable traits in idiopathic pulmonary fibrosis: focus on respiratory tract infections—a systematic review and a meta-analysisResearch in context by Zsombor Matics, Anna Bardóczi, Csongor Galkó, Bence Szabó, Noémi Gede, Zsolt Molnár, Gábor Duray, Caner Turan, Péter Hegyi, Gábor Horváth, Veronika Müller

“…Future clinical trials should focus on targeting treatable traits like RTIs. Funding: None.…”
Get full text

Mortality trends related to cardiogenic shock in heart failure patients aged 25 and older across the United States: A study utilizing the CDC WONDER database from 1999 to 2023 by Abdullah Naveed Muhammad, Sivaram Neppala, Himaja Dutt Chigurupati, Muhammad Omer Rehan, Hamza Naveed, Rabia Iqbal, Bazil Azeem, Ahila Ali, Mushood Ahmed, Prakash Upreti, Mobeen Zaka Haider, Yasar Sattar, Jamal S. Rana, Gregg C. Fonarow

“…Special focus should be on high-risk groups like men, Black individuals, and rural residents, as targeted interventions could mitigate disparities and enhance outcomes.…”
Get full text

Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020 by Muhammad Abdullah Naveed, Sivaram Neppala, Himaja Dutt Chigurupati, Ahila Ali, Muhammad Omer Rehan, Ayman Fath, Bazil Azeem, Rabia Iqbal, Manahil Mubeen, Hamza Naveed, Muhammad Naveed Uz Zafar, Mushood Ahmed, Jamal S. Rana, Brijesh Patel

“…These findings emphasize the need for targeted interventions and improved access to care.…”
Get full text

Estimated impact of long‐acting injectable PrEP in South Africa: a model comparison analysis by Sarah E. Stansfield, Mia Moore, Lise Jamieson, Gesine Meyer‐Rath, Leigh F. Johnson, David Kaftan, Anna Bershteyn, Jennifer Smith, Valentina Cambiano, Loveleen Bansi‐Matharu, Andrew Phillips, Jesse Heitner, Ruanne V. Barnabas, Brett Hanscom, Deborah J. Donnell, Marie‐Claude Boily, Dobromir Dimitrov

“…PrEP expansion scenarios differed in targeted overall coverage, speed of expansion, coverage of high‐exposure groups, and relative coverage of women and men. …”
Get full text

Exploring the effect of different tea varieties on the quality of Sichuan Congou black tea based on metabolomic analysis and sensory science by Liran Yang, Xueping Luo, Qi Wang, Mingli Liu, Jingna Yan, Congming Wang, Yuanhua Xian, Kangli Peng, Kunyi Liu, Bin Jiang

“…The quality of WNZ and FDDB was relatively average. Using non-targeted metabolomics, 4,476 metabolite ion features were detected, and 75 significantly differential metabolites were identified (p < 0.05 and VIP > 1.0). …”
Get full text