Building bridges to operationalize One Health — A longitudinal two years’ AMR study in England using clinical and wastewater-based surveillance approaches by Like Xu, Nicola Ceolotto, Kishore Jagadeesan, Richard Standerwick, Megan Robertson, Ruth Barden, Helen Lambert, Barbara Kasprzyk-Hordern

“…Of the 17 antibiotics targeted, amoxicillin and clarithromycin were clearly affected by COVID-19 restrictions during the years 2020 to 2021 with an average of 31.5% (P < 0.01) and 13.5% (P < 0.05) lower usage, respectively, followed by an increase in 2021 to 2022. …”
Get full text

Dissecting the genetic architecture of polygenic nutritional traits in maize through meta-QTL analysis by Bhupender Kumar, Shrikant Yankanchi, Rakhi Singh, Pushpendra, Debjyoti Sarkar, Pardeep Kumar, Krishan Kumar, Mukesh Choudhary, Bahadur Singh Jat, H.S. Jat

“…A comprehensive literature search revealed 29 mapping studies encompassing 308 QTLs for the targeted traits. A total of 34 stable MQTLs were identified, with an average CI of 4.59 cM. …”
Get full text

Characteristics and in-hospital outcomes of patients undergoing balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: a time-trend analysis from the Japa... by Shun Kohsaka, Hideki Ishii, Tetsuya Amano, Toshiro Shinke, Mitsuyoshi Takahara, Issei Komuro, Jiro Ando, Yuji Ikari, Shun Minatsuki, Arihiro Kiyosue, Satoshi Kodera, Masaru Hatano

“…The average age of the patients was 66±13 years, and 72.1% were women. …”
Get full text

Evaluation of Taraxacum officinale phytoconstituents as potential JNK1 inhibitors: Perspectives from ADMET, molecular docking, molecular dynamics, and density functional theory by Sphelele C. Sosibo, Hendrik G. Kruger, Wonder P. Nxumalo, Zimbili Zondi

“…This study provides insights into possible anti-type-2 diabetes properties of Taraxacum officinale targeting JNK1.…”
Get full text

Domain‐Specific Customization for Language Models in Otolaryngology: The ENT GPT Assistant by Brenton T. Bicknell, Nicholas J. Rivers, Adam Skelton, Delaney Sheehan, Charis Hodges, Stevan C. Fairburn, Benjamin J. Greene, Bharat Panuganti

“…The E‐GPT‐A was developed using targeted instructions and customized to otolaryngology. …”
Get full text

Albumin-Based Nanoparticles with Factorial Design as a Promising Approach for Remodeled Repaglinide: Evidence from In Silico, In Vitro, and In Vivo Evaluations by Mennatullah M. Faisal, Eman Gomaa, Mohamed S. Attia, Rana M. Abdelnaby, Adel Ehab Ibrahim, Ahmed Al-Harrasi, Sami El Deeb, Al Zahraa G. Al Ashmawy

“…A molecular docking simulation showed a strong affinity to several protein targets, and the results were very promising, where Repaglinide gave a score of −7.70 Kcal/mol compared to Mevastatin (−6.71 Kcal/mol) and Atorvastatin (−8.36 Kcal/mol). …”
Get full text

Exposure to hepatitis B virus, post-exposure prophylaxis knowledge, and related factors among healthcare workers in a tertiary care military facility in Ghana: A cross-sectional an... by Berlinda Lasidji Narh, Vivian Efua Senoo-Dogbey, Monica Charlotte Akpagloh

“…Knowledge of hepatitis B prevention and post-exposure prophylaxis management varied, with an average score of 73.6 % (± 11.9). While 68.3 % of participants demonstrated high knowledge, 30.3 % had moderate knowledge, and 1.4 % had low knowledge. …”
Get full text

Dynamic Monitoring and Driving Factors Analysis of Eco-Environmental Quality in the Hindu Kush–Himalaya Region by Fangmin Zhang, Xiaofei Wang, Jinge Yu, Huijie Yu, Zhen Yu

“…These findings elucidate the spatiotemporal dynamics of HKH’s eco-environmental quality and underscore the combined effects of climatic and geomorphic factors, offering a scientific basis for targeted conservation and sustainable development strategies.…”
Get full text

Insurance Payor Status and Outcomes in Pediatric Sports-Related Injuries: A Rapid Review by Katherine M. Kutzer, Lulla V. Kiwinda, Daniel Yang, John Kyle Mitchell, Emily J. Luo, Emily J. Harman, Stephanie Hendren, Kendall E. Bradley, Brian C. Lau

“…Future research should explore targeted solutions to ensure equitable care for this vulnerable population.…”
Get full text

The impact of cockroach control intervention on infectious diarrhea in Songjiang District, Shanghai, China - an interrupted time series analysis by Jie Feng, Chi Zhang, Bowen Pang, Meng Li, Xihong Lv, Ye Yao

“…If local baseline data can be consulted before intervention to select targeted intervention time and prevention methods, it is easier to achieve ideal results.…”
Get full text

Effect of Cholecalciferol Supplementation on Disease Activity and Quality of Life of Systemic Lupus Erythematosus Patients: A Randomized Clinical Trial Study by Fiblia Fiblia, Iris Rengganis, Dyah Purnamasari, Alvina Widhani, Teguh H Karjadi, Hamzah Shatri, Rudi Putranto

“…Background: Increase in the prevalence and survival rates has led to the assessment of disease activity and quality of life of SLE patients as targets in treatment. Cholecalciferol was considered as having a role in reducing disease activity and improving quality of life. …”
Get full text

Informatics-driven unsupervised learning of comorbidity clusters for COVID-19 reinfection risk: A finite mixture modeling approach by Grant B. Morgan, Andreas Stamatis, Chelsea C. Yager, Ali Boolani

“…The findings may support targeted prevention, data-driven resource allocation, and precision medicine strategies by highlighting subgroups at elevated risk. …”
Get full text

Integrated assessment of human health risks from groundwater pollutants in Nubian Aquifer, Sudan: Combining source apportionment and probabilistic analysis by Musaab A.A. Mohammed, Norbert P. Szabó, Elamin D. Suliman, Magboul M.S. Siddig, Mohammed N.M. Hassan, Péter Szűcs

“…These findings underscore the urgent need for targeted interventions, such as advanced water treatment, stricter pollution controls, and public health awareness programs to mitigate groundwater contamination and protect vulnerable populations.…”
Get full text

The GWAS-MAP platform for aggregation of results of genome-wide association studies and the GWAS-MAP|homo database of 70 billion genetic associations of human traits by T. I. Shashkova, D. D. Gorev, E. D. Pakhomov, A. S. Shadrina, S. Zh. Sharapov, Y. A. Tsepilov, L. C. Karssen, Y. S. Aulchenko

“…Information from summary statistics can be used for multiple purposes – from fundamental research in biology and genetics to the search for potential biomarkers and therapeutic targets. While the amount of GWAS summary statistics collected by the scientific community is rapidly increasing, the use of this data is limited by the lack of generally accepted standards. …”
Get full text

MobilitApp: A Deep Learning-Based Tool for Transport Mode Detection to Support Sustainable Urban Mobility by Gerard Caravaca Ibanez, Luis J. de la Cruz Llopis, Adrian Catalin Diaconeasa, Alberto Bazan Guillen, Monica Aguilar Igartua

“…In alignment with these objectives, the European Climate Law mandates a minimum 55% reduction in greenhouse gas emissions by 2030 and climate neutrality by 2050. Achieving these targets requires robust tools to collect and analyze mobility data, enabling the evaluation of citizens&#x2019; travel habits and the planning of sustainable urban infrastructure. …”
Get full text

The impact of the COVID-19 pandemic on HIV testing in Peru: an interrupted time series analysis from 2014 to 2022 by Robinson A. Yrene-Cubas, Jesus Perez-Castilla, Daniel E. Reynaga-Cottle, Maria José Bringas, David R. Soriano-Moreno, Daniel Fernandez-Guzman, Jose A. Gonzales-Zamora

“…Additionally, we applied an Autoregressive Integrated Moving Average (ARIMA) model. Results We included 211,359 participants aged 15 to 49 years. …”
Get full text

Carbon footprint reduction associated with a surgical outreach clinic by David Forner, Chad Purcell, Victoria Taylor, Christopher W. Noel, Larry Pan, Matthew H. Rigby, Martin Corsten, Jonathan R. Trites, Antoine Eskander, Ted McDonald, S. Mark Taylor

“…Abstract Background Healthcare systems generate substantial carbon footprints that may be targeted to decrease greenhouse gas emissions. Outreach clinics may represent tools to assist in this reduction by optimizing patient related travel. …”
Get full text

Patient preferences for stroke prevention treatments in atrial fibrillation in Asia: A discrete choice experiment by Rosa Wang, Hui Lu, Gabriela Fernandez, Nicolas Krucien, Dong Huang, Hiroshi Higashiyama, Juan Du, Xin Ye, Tommi Tervonen, Matthew Quaife

“…Methods: A discrete choice experiment (DCE) survey was developed based on a targeted literature review and discussions with clinical and methodological experts. …”
Get full text

A cross-sectional study of the current status of psychological health and its correlation with academic performance in medical students: taking medical students in a medical univer... by Han Chunhong, Han Chunhong, Ding Jingjing, He Huan, Zheng Peiyao, Zhang Xiaona, Yang Xiaowen, Zheng Aiming

“…This study examines the psychological health of medical students in a Chinese university and its impact on academic performance, aiming to inform targeted interventions.Methods2022 undergraduate and postgraduates from an independent medical university in Eastern China were selected to score using the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7(GAD-7), Insomnia Severity Index (ISI), Perceived Stress Scale (PSS), and Beck Scale for Suicide Ideation(BSSI); and the total grade point averages (GPAs) of 2022 undergraduates in the first and second academic years were determined to analyse the main psychological influencing factors.ResultsThe general survey of 2022 new medical students at admission showed that the various scores of postgraduates were higher than those of undergraduates. …”
Get full text

Are hematopoietic cell transplant recipients with Gram‐negative bacteremia spending more time outpatient while on intravenous antibiotics? Addressing trends over 10 years at a sing... by Margaret L. Lind, Steven Roncaioli, Catherine Liu, Andrew Bryan, Ania Sweet, Frank Tverdek, Mohamed Sorror, Amanda I. Phipps *, Steven A. Pergam *

“…These findings suggest the need for additional interventions targeting outpatient antibiotic treatment among allogeneic HCT recipients with GNRBs.…”
Get full text