Novalis Tx radiosurgical platform experience in National Medical Research Centre for Oncology of the Ministry of Health of Russian by O. I. Kit, V. I. Voshedskii, P. G. Sakun, M. A. Gusareva, S. G. Vlasov, K. N. Museiko, M. A. Komandirov, Yu. A. Kultysheva

“…In radiosurgical surgery, radiation therapy was performed with a single high-precision approach of the therapeutic dose to the target for the purpose to reach biological effect in the irradiated volume with minimal impact on the surrounding tissues. …”
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ApoE [−/−] CA1-overexpressing knock-in mice aggravated atherosclerosis by increasing M1 macrophages by Jinbao Zong, Changyuan Wang, Hongji Zhou, Yu Song, Kehua Fang, Xiaotian Chang

“…Background: Carbonic anhydrase I (CA1) has been reported to be a diagnostic and therapeutic target for atherosclerosis (AS). This study aimed to verify the essential role of CA1 in AS progression in CA1-overexpressing mice. …”
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Semimetal–dielectric–metal metasurface for infrared camouflage with high-performance energy dissipation in non-atmospheric transparency window by Zhou Dongjie, Zhang Jinguo, Tan Chong, Li Liyan, Qiu Qianli, Zhang Zongkun, Sun Yan, Zhou Lei, Dai Ning, Chu Junhao, Hao Jiaming

“…For infrared camouflage, it necessitates precise control over surface emissivity and temperature to ensure that the target blends effectively with the surrounding infrared background. …”
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Physical activity promotion in the early childcare setting: a content analysis of the federal-state-wide educational framework plans in Germany by Stefanie Do, Maike Till, Sven Messing, Peter Gelius, Mirko Brandes, Jonas D. Finger, Sylke Oberwöhrmann, Sarah Forberger, Antje Hebestreit

“…Most of the educational framework plans targeted children up to 6 years and considered different subgroups. …”
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MICRORNA IN MONITORING OF THE EVOLUTION OF GLIAL CEREBRAL TUMORS by R. Yu. Seliverstov, M. I. Zaraiskiy, R. V. Tyurin, A. G. Naryshkin, V. G. Valerko, V. V. Semiglazov, Ch. Takahachi

“…MicroRNA is a large class of endogenous small RNA molecules that inhibit mRNA translation of target genes involved in the evolution of GCT. It was shown that miRNA-21 has antiapoptotic and invasive functions by means of silencing of the PTEN tumor suppressor. …”
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Indicators of vaccination status in patients with chronic kidney disease: the importance of recommendations from healthcare providers by Gizem Kumru, İrem Akdemir, Cengiz Kaan Demir, Kenan Ates, Sehsuvar Erturk, Gokhan Nergizoglu, Kenan Keven, Sim Kutlay, Sule Sengul

“…Abstract Background Influenza and pneumococcal vaccinations are strongly encouraged for individuals with chronic kidney disease (CKD); however, vaccination rates remain below the target. Establishing factors influencing vaccination status may guide approaches to enhance vaccine uptake among this vulnerable patient population. …”
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Novel Laser System-Assisted CT-Guided Percutaneous Transthoracic Lung Biopsy in Patients with COPD Combined with Pulmonary Nodules by Li C, Hu X, Li C, Jiang G, Jiang YL

“…With the use of LGS, 73% (22/30) of the procedures hit the target on the first needle insertion, compared to only 6.7% (2/30) in the conventional group. …”
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Enhancing education quality with hybrid clustering and evolutionary neural networks in a multi phase framework by Saleem Malik, Chandrakanta Mahanty, Jnanaranjan Mohanty, Krunal Vaghela, T. Narmadha, R. Sivaranjani, Javed Khan Bhutto, Saiful Islam, Anwar Khan, Amanuel Zewdie

“…This algorithm’s strong feature selection and clustering help target educational interventions by revealing student learning behaviors. …”
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Reducing irrigation of livestock feed is essential to saving Great Salt Lake by Brian D. Richter, Kat F. Fowler, Gambhir Lamsal, Christopher L. Lant, William J. Ripple, Richard R. Rushforth

“…Agriculture accounts for 71% of anthropogenic depletions, with 80% of agricultural water going to cattle-feed crops (alfalfa and grass hay) to support ∼980,000 head of cattle for dairy and beef production. We propose a target goal of reducing total anthropogenic consumption by 35% to stabilize and begin refilling the lake, and explore potential policy solutions for attaining this conservation goal. …”
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Possibilities of Combination of Beta-blockers and Ivabradine in Patients with Stable Angina Pectoris by V. V. Kashtalap, O. L. Barbarash, D. Yu. Sedykh, K. E. Krivoshapova, D. P. Tsygankova, O. V. Tsygankova

“…To evaluate the therapeutic efficacy of a combination of ivabradine and beta-blockers (BAB) in patients with stable angina, initially taking only BAB and not reaching the target heart rate (HR) due to the risk of hypotension.Material and methods. …”
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Relationship between depression and oral microbiome diversity: analysis of NHANES data (2009–2012) by Xichenhui Qiu, Ting Xu, Yiqing Huang, Changning Wei, Lina Wang, Bei Wu

“…Hence, oral dysbiosis may serve as a therapeutic target or biomarker of depression. However, the underlying mechanisms require further investigation.…”
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Enhanced prediction of heat transfer in jet impingement cooling using an artificial intelligence: A case study by Mehmet Berkant Özel, Ufuk Durmaz, Muhammed Ali Nur Öz, Ahmet Ümit Tepe, Cemil Öz, Ünal Uysal, Orhan Yalçinkaya, Ali Cemal Beni̇m, Norah Alomayrah, M.S. Al-Buriahi

“…Jet impingement cooling was examined with four different Reynolds numbers (16250, 21700, 27100, 36250) and six dimensionless gaps between the jet and the target surface (G/D = 1, 2, 3, 4, 5, and 6). Mean and local Nusselt number (Nu) distributions were investigated in particular. …”
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Graph2Mat: universal graph to matrix conversion for electron density prediction by Pol Febrer, Peter Bjørn Jørgensen, Miguel Pruneda, Alberto García, Pablo Ordejón, Arghya Bhowmik

“…In this work, we show the power of targeting the density matrix (DM), a linear-scaling sparse SE(3) equivariant matrix that encodes the exact density. …”
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Analysis of the disease burden of malignancies in the female reproductive system in China from 1990 to 2019: an age-period-cohort study and joinpoint analysis by Jinlin Du, Xinyu Zhao, Huanwen Tang, Kena Lin, Xiaoman Li, Zhiwen Zeng, Jiayi Li, Zule Ning, Qinxian Liu

“…Middle-aged and elderly women are the key target group for prevention and control.…”
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MRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus by Nadezhda I. Ryumshina, Alla Y. Falkovskaya, Anna M. Gusakova, Victor F. Mordovin, Vladimir Y. Usov

“…BACKGROUND: Damage of arterial walls in diabetes mellitus associated with arterial hypertension is major factor delivering lesion of target organs. Currently, enough data is not available about imaging and quantitative evaluations of arterial wall. …”
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Design and evaluation of the “Feel Good” feasibility study – a multi-component fruit and vegetable intervention in children measuring cognitive and mental health outcomes by Nicola A. Gillies, Jeanette P. Rapson, Amy L. Lovell, Karen E. Waldie, Clare R. Wall

“…Results Seventy children were recruited (79% of target recruitment rate), with an average retention rate of 89%. …”
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High-density SNP-based linkage map construction and QTL analysis for growth-related traits in Luciobarbus brachycephalus using whole-genome resequencing data by Xuanpeng Wang, Dandan Gao, Gaowei Zhang, Yongchun Ge, Xinhai Wang

“…The exceptional marker density (average inter-marker distance = 0.10 cM) establishes this as the most precise genetic map reported for this species to date, enabling the accurate candidate gene localization and enhanced marker-assisted selection. …”
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A National Cross-Sectional Survey on Real-World Experiences of Calcitonin Gene-Related Peptide (CGRP) Monoclonal Antibody Use in Adults with Migraine in Finland by Caroline S. Casey, Mari Pölkki, Elisa K. Suvanen, Ilona Iso-Mustajärvi, Timo Purmonen, Essi J. Peltonen, Camilla K. Appel, Niraj J. Patel, Lill-Brith Von Arx

“…Abstract Introduction Calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) were the first preventive migraine treatment group to target the underlying cause of migraine. This survey evaluated real-life experiences of adults with migraine in Finland before and after using their current subcutaneous CGRP mAb treatment. …”
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The pig pose recognition method based on pig body semantic segmentation by Nuonan Huang, Deli Zhu, Liang He, Yi Li

“…Pose recognition in pigs faces several challenges in practical applications, primarily due to high annotation costs, the labor-intensive nature of annotation processes, and the difficulty of achieving accurate target detection in complex environments. To address these challenges, this paper proposes a novel pig pose recognition method based on the semantic segmentation of pig body parts. …”
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Improvement of modeling methods in rats with diabetic nephropathy and the expression level of IL-10 in kidney tissue by CAO Dong-dong, LI Niu, CAO Zi-yu, HOU Yu-long, NI Wen-juan, LENG Xiao-min, LIU Yun, SHI Jing-jing, Guo Ming-hao, MA Dong-hong

“…Objective To improve the modeling method in diabetic nephropathy rats,and to detect the expression of IL-10 in kidney tissue.Methods Forty-eight male SD rats were randomly classified as normal control group(NC group,n=24)and diabetes group(DM group,n=24).In the DM group intraperitoneal injection of STZ at a dose of 40 mg/kg was performed one time to induce a diabetes model.Blood sugar,urine sugar,urinary microalbumin,urinary creatinine levels were detected at 0,4,8,12 weeks after successfully modeling,respectively.At the same time, the kidney pathology of rats at different time points was observed,and IL-10 expression levels was detected with immunohistochemical method.Results Compared with NC group,the modeling success rate of rats in the DM group was 75%,and the modeled rats showed significantly increased drink,food uptake and urine.By 12 weeks the average weight of rats in the DM group was(478.0±79.1)g,significantly lower than that in NC group(650.0 ±26.9)g.Blood glucose in the DM group(25.6±5.3)mmol/L was significantly higher than that in the NC group(5.2±0.2)mmol/L.Until the end of the experiment,it was found that blood sugar was still maintained at(23.0±5.5)mmol/L.In the DM group rats,urine microalbumin creatinine ratios at 8 weeks and 12 weeks were(39.0 ±18.6)mg/g and(77.0±12.3)mg/g,respectively,significantly higher than those in the control group(15.1±5.4)mg/g,(15.8±7.0)mg/g).Optical microscope observation indicated that DM group rat experienced renal interstitium edema and inflammatory cell infiltration at 0 weeks,and mild thickening of the glomerular base membrane and renal tubular epithelial vacuolar degeneration at 12 weeks.The results of immunohistochemistry showed that the expression of IL-10 in NC group was higher than that in DM group.Conclusions When high sugar and high-fat combined with a small dose of STZ are used to establish a DKD model,at 12 weeks the kidney has mild thickening of renal glomerular base membrane,vacuolar degeneration of renal tubular epithelial cells and other pathological changes.However,Blood glucose ≥16.7 mmol/L in the tail vein ≥16.7 mmol/L cannot be used alone to judge success of the modeling of DKD.The decreased expression of IL-10 in renal tissues further demonstrates that IL-10 is involved in the pathogenesis of DKD and may be the target of DKD treatment.…”
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