Large-scale discovery of promoter motifs in Drosophila melanogaster. by Thomas A Down, Casey M Bergman, Jing Su, Tim J P Hubbard

“…A key step in understanding gene regulation is to identify the repertoire of transcription factor binding motifs (TFBMs) that form the building blocks of promoters and other regulatory elements. …”
Get full text

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. by Karen S Kelly-Spratt, Kay E Gurley, Yutaka Yasui, Christopher J Kemp

“…Skin tumors were induced in wild-type, p19(Arf)-deficient, and p53-deficient mice using the DMBA/TPA two-step protocol. Activating mutations in Hras were detected in all papillomas and carcinomas examined, regardless of genotype. …”
Get full text

Colorectal cancer vaccines: in silico identification of tumor-specific antigens associated with frequent HLA-I alleles in the costa rican Central Valley population by Diego Morazán-Fernández, José Arturo Molina-Mora

“…We used public data of human exome (DNA regions that produce functional products, including proteins). A variant calling analysis was implemented to detect tumorspecific SNVs, in comparison to healthy tissue. …”
Get full text

Membrane Permeability Monitoring to Antipsychotic Olanzapine Using Platinum Black-Modified Electrodes by Murugaiya Sridar Ilango, Dayananda Desagani, Srikanth Jagadeesan, Alexander Snezhko, Gad Vatine, Hadar Ben-Yoav

“…The blood–brain barrier (BBB) is key to the regular functioning of the central nervous system. The dysfunction of the BBB has been described in various neurological disorders, including schizophrenia. …”
Get full text

Methodology for Verification of Geometrically Complex Components Through Reverse Engineering by Peter Gabštur, Marek Kočiško, Jakub Kaščak, Martin Pollák

“…Verification of geometrically complex components is a crucial step in ensuring the quality and functionality of industrial products. …”
Get full text

Automatic Filtering of Sugarcane Yield Data by Eudocio Rafael Otavio da Silva, José Paulo Molin, Marcelo Chan Fu Wei, Ricardo Canal Filho

“…This study proposes an automatic filtering technique for sugarcane harvesting data to automate the process. A three-step automated filtering algorithm based on a sliding window was developed and further evaluated with four configurations of the maximum variation factor <i>f</i> and six SW sizes. …”
Get full text

Prevalence and coexistence of locomotive syndrome with reduced mobility and metabolic syndrome: a cross-sectional study of 35,059 Japanese adults by Chihiro Goto, Kohei Maruya, Yasuhiro Morita, Tomoyuki Arai, Satoshi Yamaguchi, Keiko Yamada, Masaru Moriyama, Hideaki Ishibashi, Ryo Nakagawa

“…MetS was diagnosed using the modified National Cholesterol Education Program Adult Treatment Panel III criteria, and LS was assessed using the LS risk test, which includes the stand-up test, two-step test, and the 25-question Geriatric Locomotive Function Scale. …”
Get full text

CPTU-Based Offshore Wind Monopile Rigid Bearing Mechanism Analysis by Jie Zhou, Renjie Gu, Panpan Shen, Chengjun Liu, Zeyao Li, Kefan Zhu, Zhenming Shi

“…A self-compiling parameter function is applied to soil modeling and an innovative mobile boundary function is created to simulate CPTU penetration. …”
Get full text

New Possibilities for Evaluating Markers of Alzheimer's Disease in Blood Serum by S. V. Vorobev, A. Yu. Plekhanov, I. K. Ternovykh, A. S. Usikov, A. А. Lebedev, A. N. Smirnov, N. M. Shmidt, M. S. Dunaevskiy, S. P. Lebedev

“…Results. Graphene functionalized with sulfo groups from pyranine exhibits sufficient ability to immobilize antibodies. …”
Get full text

The effect of body-conforming passive wearable device with knee flexion taping on dynamic knee stability by Sung-Jin Park, Seongok Chae, Hyung-Soon Park

“…In this research, 20 healthy women performed single leg drop (SLD) and step-up (SU) tests with and without muscle fatigue. …”
Get full text

Industrial-grade collaborative robots for motor rehabilitation after stroke and spinal cord injury: a systematic narrative review by Aisha Raji, Urvashy Gopaul, Jessica Babineau, Milos R. Popovic, Cesar Marquez-Chin

“…This initial focus serves as a preliminary step toward assessing their applicability for individuals with stroke and SCI. …”
Get full text

Synthesis of novel sulphonamide derivatives from tunable quinolines with computational studies by Nagesh Dhanaji Chavan, S. Sarveswari, V. Vijayakumar

“…Abstract The synthesis of new quinoline-sulphonamide derivatives was accomplished through a meticulous five-step molecular assembly utilizing Suzuki, acid–amine cross-coupling reactions and N-alkylation. …”
Get full text

Correlating NAD(P)H lifetime shifts to tamoxifen resistance in breast cancer cells: A metabolic screening study with time-resolved flow cytometry by Samantha Valentino, Karla Ortega-Sandoval, Kevin D. Houston, Jessica P. Houston

“…Differences in fluorescence lifetime were detected and this was associated with sensitivity to the commonly prescribed therapeutic tamoxifen. …”
Get full text

Super-Resolution Three-Dimensional Topography Measurement Using Microsphere-Aided Broadband Light Interferometry by Keran Deng, Yangyi Liu, Fan Yang, Jian Huang, Lianghua Wen

Get full text

Kink Wave Phenomena in the Nonlinear Partial Differential Equation Representing the Transmission Line Model of Microtubules for Nanoionic Currents by Safyan Mukhtar, Weaam Alhejaili, Mohammad Alqudah, Ali M. Mahnashi, Rasool Shah, Samir A. El-Tantawy

“…The equation introduced here in this form is suitable for critical nanoscience concerns like cell signaling and might continue to explain some of the basic cognitive functions in neurons. We employ advanced procedures to replicate the previously detected solitary waves. …”
Get full text

A Cell-Based Assay to Measure the Activity of the Complement Convertases by Małgorzata Stasiłojć, Grzegorz Stasiłojć, Alicja Kuźniewska, Santiago Rodriguez de Córdoba, Marcin Okrój

“…Results: The assay detects recombinant gain-of-function (GoF) components of both convertase types within human serum or plasma. …”
Get full text

SEX DIFFERENCES OF VLF100 AND VLF50 SPECTRUM OF HEART RATE VARIABILITY IN HEALTHY INDIVIDUALS OF YOUNG AGE AND OLDER SUBJECTS WITH VASCULAR PATHOLOGY IN TERMS OF SEVEN-TEST, HYPERV... by Арнольд Наумович Флейшман, Татьяна Валентиновна Кораблина, Игорь Германович Халиулин, Станислав Альфредович Петровский, Артем Андреевич Неретин

“…Physiological methods included a five-step registration of heart rate with functional tests of low intensity (seven-test, deep breathing and active orthostasis). …”
Get full text

Dietary Patterns and Socioeconomic Status in the Very Old: The Newcastle 85+ Study. by Antoneta Granic, Karen Davies, Ashley Adamson, Thomas Kirkwood, Tom R Hill, Mario Siervo, John C Mathers, Carol Jagger

“…<h4>Conclusions</h4>In this cohort of very old adults, we detected a favourable DP ('Low Meat'), which was associated with better health and functioning and higher SES.…”
Get full text

Erqember Mitigates Neurotoxic Effects of Aluminum Chloride in Mice: Phytochemical Insights With Neurobehavioral and In Silico Approaches by Habiba Khan, Sana Javaid, Waseem Ashraf, Farhan Siddique, Mehvish Bibi, Tanveer Ahmad, Muhammad Shoaib Ali Gill, Asad Abrar, Faleh Alqahtani, Imran Imran

“…Further, the study also included in silico studies to understand the interaction of detected phytocompounds with acetylcholinesterase protein. …”
Get full text

Background of standardization and regulation of training and use of pharmaceutical regular resource potential in XI–XVI centuries by M. S. Ponomarenko, O. S. Soloviov, T. M. Krasnianska, Yu. M. Grygoruk

“…The main stages of development of the property (material) and human resources to provide medical treatment and patients have been detected. The basic steps of transformation and delimitation of professional functions pharmacist-physician have been set. …”