Lawsonia intracellularis T3SS effector LI0758, an Rce1 ortholog, activates MAPK and NF-κB signaling in mammalian cells by Yuanxiu Zhong, Yiyun Duan, Fenju Lai, Jinhua Zhang, Yimin Dai

“…While displaying unique activity in the yeast a-factor reporter system, LI0758 restores Ras2 localization in Rce1Δ mutant strains, implying functional similarity. Our findings underscore LI0758’s pivotal role in activating MAPK pathways and suggest its potential to modulate the localization and function of host CAAX proteins. …”
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Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models by Lisa Blackmer-Raynolds, Lyndsey D. Lipson, Isabel Fraccaroli, Ian N. Krout, Jianjun Chang, Timothy Robert Sampson

“…Therefore, we performed an in-depth longitudinal study over 16 months, assessing cognition in these two strains, as well as assessments of motor function. …”
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Association between sleep deprivation and fertility - a literature review by Adriana Dukacz, Anna Konarska, Anna Machowiak, Barbara Ufnalska, Justyna Lisiecka, Mateusz Janik, Michał Nowak, Joanna Rychlewska-Duda, Wojciech Firlej, Artur Fabijański

“…For women on the other hand sleep depravation produces a huge hormonal dysregulation. Temporarily the impact of sleep depravation is being inconsistent about estradiol, prolactin and melatonin. …”
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Nucleoside analogues in treatment of liver cirrhosis as an outcome of chronic hepatitis B by I. G. Bakulin

“…Its antiviral effect limited basically by development of drug resistance of a virus as a result of mutant strains development. Terms of lamivudine treatment for patients with liver cirrhosis should be no less than 22 months, and clearance HBV DNA is achieved in 93,9 % of patients. …”
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Differential Sensitivity of Nitrogen-Fixing, <i>Azolla Microphylla</i> to Organochlorine and Organophosphate Insecticide by W Raja, P Rathaur, R Ashiq

“…Present study was aimed to study the comparative effect of two such pesticides, a well-known species of Azolla, Azolla Microphylla were selected for their stress responses to an Organochlorine insecticide - Endosulfan, and Organophosphate insecticide-Monocrotophos with reference to their growth, Free radicals, Antioxidant enzymes and metabolites. Azolla microphylla strains were adversely affected by the insecticide doses and inhibition was dose dependent. …”
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An extreme North Atlantic Oscillation event drove the pelagic Sargassum tipping point by Julien Jouanno, Sarah Berthet, Frank Muller-Karger, Olivier Aumont, Julio Sheinbaum

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Estimating the Prevalence of Opioid use Disorder in the Cincinnati Region using Probabilistic Multiplier Methods and Model Averaging by Peter J. Mallow, Nila Sathe, Michael Topmiller, Jennifer Chubinski, Dillon Carr, Roni Christopher

“…**Background:** Opioid use disorder (OUD) and its consequences have strained the resources of health, social, and criminal justice services in the Cincinnati region. …”
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Development of animal models to study aggressive thyroid cancers by Shovan Dutta, Jeffrey A Knauf

“…The earliest mouse models of thyroid cancer relied on hormone, radiation or chemical carcinogenesis to induce tumors. …”
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Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women by Leonie Fleige, Silvia Capellino

“…Moreover, B cells from men showed higher dopamine receptor (DR) expression, which was shown to be further increased by sex hormones only in men. In monocytes from women, an acute inflammatory stimulus via CpG combined with dopaminergic stimulation caused a switch to a proinflammatory phenotype, which was less pronounced in men. …”
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Numerical Investigation on the Effects of Embedding PVC Pipes in Reinforced Concrete Beams. by Ampaire, Comboni

“…After the analysis was turned in, the results were compared to those of a solid beam, including stresses, strains, the load-deflection ductility index, and crack patterns. …”
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Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis by Wenpin Qin, Zhangyu Ma, Guo Bai, Wen Qin, Ling Li, Dongxiao Hao, Yuzhu Wang, Jianfei Yan, Xiaoxiao Han, Wen Niu, Lina Niu, Kai Jiao

“…The dynamic Schiff base bonds and boronic ester bonds allow for injectability, self-healing, and pH/reactive oxygen species dual responsiveness. …”
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The Relationship Between Sleep Quality and Blood Pressure in Students by Muhammad Irwan, Irfan Irfan, Evawaty Evawaty, Rahmin Rahmin, Risnah Risnah, Salmah Arafah

“…The habit of poor sleep quality or a short amount of sleep is also associated with an increase in an individual's blood pressure. If someone's sleep duration is short, the sympathetic nervous system activity will increase, making the person vulnerable to stress, ultimately leading to an increase in blood pressure. …”
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Effect of Basal Testosterone and Dehydroepiandrosterone Sulphate Levels on in Vitro Fertilization Outcome in Normoresponders by İnci Kahyaoğlu, Nafiye Yılmaz, Serkan Kahyaoğlu, Ayten Türkkanı, Mahmut Nedim Çiçek, Leyla Mollamahmutoğlu

“…RESULTS: No significant difference was found between pregnant and non-pregnant groups regarding the AFC, hormone and controlled ovarian hyperstimulation (COH) parameters (total dose of gonadotrophins (1995.7±851.1 vs 2296.4±845.3 IU), >14 mm follicles (9.3±3.1 vs 7.3±3.9), retrieved oocytes (12.4±5.1 vs 8.7±6.1) or number of good quality embryos (7.4±3.7 vs 4,4±3.6) (p>0.05). …”
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The NIN transcription factor coordinates CEP and CLE signaling peptides that regulate nodulation antagonistically by Carole Laffont, Ariel Ivanovici, Pierre Gautrat, Mathias Brault, Michael Anthony Djordjevic, Florian Frugier

“…Overall, these results demonstrate that a cytokinin-MtCRE1-MtNIN regulatory module coordinates the expression of two antagonistic, symbiosis-related, peptide hormones from different families to fine-tune nodule number.…”
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Is COVID-19 pandemic associated with sadness? A prepandemic and postpandemic comparison by Samuel Carvalho Dumith, Elizabet Saes-Silva, Fernanda de Oliveira Meller, Antônio Augusto Schäfer, Micaela Rabelo Quadra, Lauro Miranda Demenech

“…The exposure variables were infection by the coronavirus SARS-COV-19, contact with someone infected by COVID-19, presence of any symptoms of COVID-19, remote work after the pandemic, social distancing, infodemic behavior, and fear of COVID-19. …”
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Comprehensive review of preclinical evaluation strategies for COVID-19 vaccine candidates: assessing immunogenicity, toxicology, and safety profiles by Delaram Doroud, Mojtaba Daneshi, Fatemeh Kazemi-Lomedash, Zohre Eftekhari

“…In toxicology studies, several factors must be considered, such as the appropriate animal species and strains, dosing timetable, mode of administration, time of sampling for biochemistry and antibody evaluation, and necropsy. …”
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Dysbiosis and extraintestinal cancers by Ruishan He, Pingqian Qi, Linzhen Shu, Yidan Ding, Peng Zeng, Guosheng Wen, Ying Xiong, Huan Deng

“…The oncogenic cascade always engages in the disruption of hormonal regulation and inflammatory responses, the induction of genomic instability and mutations, and the dysregulation of adult stem cell proliferation. …”
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Antibiotic resistance gene occurrence in poultry farms in northeast Brazil by Henrique Francisco de Almeida, Paulo Ricardo Conceição Marques Trindade, César Roberto Viana Teixeira, Claudson Oliveira Brito, Silvio Santana Dolabella, Sona Jain, Maíra Pompeu Martins, Ana Andréa Barbosa

“… The misuse of antibiotics in food-producing animal farming practices exerts selective pressure on bacterial strains, intensifying the spread of pathogenic and commensal bacteria carrying antibiotic resistance genes (ARGs). …”
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Natural products against resistant bacterial infections: A systematic literature review by Harshit Kaushik, Ruchika Sharma, Anoop Kumar

“…The results have indicated the antibacterial potential of natural products in concentration/dose/dosage manner under in-vitro, in-vivo, and clinical conditions via different mechanisms of action Conclusion: Overall, available evidence has indicated the potential of natural products against various types of resistant bacterial strains under in-vitro, in-vivo, and clinical conditions.…”
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Parathyroid carcinoma and pheochromocytoma in a patient with neurofibromatosis type 1: a rare association by Jardelina Brena Rocha Leite, Nicole Ramalho De Freitas, Rafaella Nelice de Holanda Cardoso, Erik Trovão Diniz, Gabriel Rodrigues de Assis Ferreira, Fernão Henrique Costa e Alvim, Camila Ribeiro Coutinho Madruga, Ana Carolina Thé Garrido, Luciano Albuquerque, Patricia Sampaio Gadelha, Ruy Lyra, Lucio Vilar

“…The case report outlines a 33-year-old woman with neurofibromatosis type 1 (NF1) presenting complex symptomatology including a cervical mass, bone pain and significantly elevated calcium and parathyroid hormone levels, indicative of parathyroid carcinoma accompanied by cystic fibrous osteitis. …”
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