Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States by Finn RS, Iyer R, Kalman RS, Parikh ND, Cabrera R, Babajanyan S, Kaseb AO

“…Richard S Finn,1 Renuka Iyer,2 Richard S Kalman,3 Neehar D Parikh,4 Roniel Cabrera,5 Svetlana Babajanyan,6 Ahmed O Kaseb7 1Department of Medicine, University of California, Los Angeles, CA, USA; 2Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA; 3Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA; 4Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA; 5Department of Medicine, University of Florida Health, Gainesville, FL, USA; 6US Medical Affairs, Oncology, Bayer Healthcare, Whippany, NJ, USA; 7Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Richard S Finn, Department of Medicine, University of California, Los Angeles, CA, USA, Tel +1-310-586-2091, Email rfinn@mednet.ucla.eduIntroduction: While several systemic therapies are available for unresectable hepatocellular carcinoma (uHCC), there is a lack of granular real-world evidence to support the efficacy and safety of these therapies. …”
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Las metatipologías espaciales y sus lógicas proyectuales poéticas particulares by Jorge Pokropek

“…Estas acciones proyectuales poetizantes han generado respuestas arquetípicas para ciertos programas arquitectónicos simbólico-operativos de empleo frecuente, originando, así, la noción de tipología como aquel territorio que reúne a dichas configuraciones para revisarlas y renovarlas críticamente, generando, a veces, nuevas tipologías, entendidas, asimismo, como ideas arquitectónicas o formales que incrementan el saber disciplinar. La enseñanza y práctica del proyecto arquitectónico puede y debe mejorar si se instrumenta el aprendizaje explícito de una teoría del proyecto poético que implique el reconocimiento, deslinde y capacidades estético-operativas de cada una de estas metatipologías, así como el sabio empleo de sus lógicas proyectuales poéticas particulares. …”
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Baltic place in barbarian world's typology (towards the evoliution of M. Schiukin "seven worlds" theory) by Manvydas Vitkūnas

“…Aus dem Osten und bedeutend heftiger beeinflussten die Balten die von dem Byzantinischen Einfluss eingewirkten Slawen, die zur gleichen Zeit besonders starken Einfluss der skandinavischen Wikinger spürten. …”
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2-Heptanone Produces Sensorial-Emotional Changes, Depending on Length of Exposure / La 2-heptanona produce cambios sensorio-emocionales, dependiendo del tiempo de exposición by Ana Gloria Gutiérrez-García, Carlos M. Contreras, María Remedios Mendoza-López

“…In part one of this study, a sample of 24 women provided urine specimens taken around their supposed ovulation days, and a second sample 12 days later. As exclusion criteria, women with anxiety (based on the State-Trait Anxiety Inventory, Spielberger), mood disorders (based on the Clinical Diagnosis of Depression Questionnaire), and premenstrual dysphoric disorder (based on the Daily Symptoms Report) were not included in the study. …”
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Key experimental technologies and their development directions for the exploration and production of deep coalbed methane by Xia YAN, Fengyin XU, Xianyue XIONG, Feng WANG, Chunhu LI, Jiyuan ZHANG, Borui XU, Qianhui CHENG, Xiong HU, Xueguang ZHU, Wei LIANG, Pu YUAN, Yanqing FENG, Zhenji WEI

“…ProspectsThis study posits seven development directions for deep CBM production and in-situ coal conversion experiments: (1) Clear, direct observation techniques for micropores (< 2 nm) in deep coal seams with ultra-low porosity and permeability, full-scale pore size splicing technology for multiscale pore structure characterized by abundant micropores, a few mesopores, and many macropores, and assessment techniques for pore-fracture connectivity. (2) Isothermal adsorption test technologies for raw coals considering the effects of deep coal seam wettability, fracturing fluid invasion, and high total dissolved solids (TDS) under high-temperature, high-pressure in-situ conditions; (3) Sealed coring devices and in-situ pressure-retaining coring technologies featuring high pressure retaining success rates, heat preservation rates, and traceable gas volume. (4) Nanoscience-based assessment technologies for gas and water occurrence in micropores in deep coal seams under high-temperature and high-pressure multi-field coupling, and experimental technologies for desorption, diffusion, and seepage across nano-micro-millimeter scales. (5) Techniques for developing and testing multifunctional mechanical experiment equipment applicable to in-situ conditions of deep coal seams featuring high stress, low modulus of elasticity, and high Poisson's ratio. (6) Experimental techniques for the purpose of enhancing CBM recovery of deep coal seams, including reservoir stimulation (microwaves, laser, and electric heating), stimulation for permeability enhancement (electromagnetic pulses, pulsed ultrasonic waves, and controlled shockwaves), displacement via CO2 injection, and mechanical pulsation with supercritical CO2. (7) Experimental techniques for in-situ coal conversion and utilization, including pyrolysis, underground coal gasification (UCG), geothermal utilization, and CO2 geological storage. …”
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Pengembangan Aplikasi E-Learning Edu IT : Pembuatan Aplikasi Ujian Essay Online serta Upload Download Materi Kuliah by Maria Bellaniar Ismiati, Latius Hermawan

“…In addition to this application will also be added a menu to upload and download lecture materials so it will later become a complete e-learning. The result is that the interactions between students and lecturers are not conventionally and can reduce paperless.  …”
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Perancangan User Experience Portal Media Interaksi Komunitas Kampus dengan Pendekatan Social Media Platform by Asyora Dewi Prabandani, Herman Tolle, Retno Indah Rokhmawati

“…As a result, students face difficulties in carrying out activities whether as students or when they graduate later. The interaction media portal is a place for online social interactions. …”
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Efficacy of 5 µg and 10 µg Dexmedetomidine as Adjuvants to 3 mL 0.5% Hyperbaric Bupivacaine in Pelvic and Lower Limb Orthopaedic Surgeries: A Randomised Clinical Study by Jigisha Bharatbhai Mehta, Shreya Jatin Patel, Nilesh Vrajmohan Shah, Dinesh K Chauhan, Sara Mary Thomas

“…For lower limb orthopaedic surgeries, to provide sufficient anaesthesia and prolong postoperative analgesia in a less cumbersome way, author can add potent adjuvants like dexmedetomidine (an alpha-2 adrenergic receptor agonist) in effective and safer doses intrathecally. Aim: To compare the effects of intrathecal 5 μg dexmedetomidine versus 10 μg dexmedetomidine as adjuvants to 3 mL of 0.5% hyperbaric bupivacaine in pelvic and lower limb orthopaedic surgeries. …”
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Codicology in Lithuania in 1918-1990: Between Book History and Palaeography by Rima Cicėnienė

“…His insights about the poor quality of manuscript books in the GDL were later developed to some extent but remained mainly unchanged until the 1990s, and apparently influenced the subsequent development of research. …”
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Analisis Perbandingan Model Bert Dan Xlnet Untuk Klasifikasi Tweet Bully Pada Twitter by Teuku Radillah, Okta Veza, Sarjon Defit

“…These findings can help platforms like Twitter identify and prevent bullying content, thereby creating a safer online environment for users, and can be used as a basis for the development of more sophisticated and efficient bullying detection systems in the future. …”
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Effects of Teenage Pregnancy on Girl Child Education in Buhunga Sub-County Uganda. by Twikirize, Edwig

“…Education is a global concern that closes the gap between social classes for safer communities. Promoting girl child education is possible once the schools embrace leadership styles for the same. …”
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Sistem Informasi Geografis Penyebaran Usaha Mikro Kecil Menengah (UMKM) di Kabupaten Majalengka by Muhammad Darul Husni Santoso, Ikbal Jamaludin, Evi Dewi Sri Mulyani

“…At present, Majalengka Regency does not yet have a system capable of providing information that is displayed spatially about the distribution of MSME locations, where later this system aims to provide information that can be used as appropriate consideration in determining policies relating to the growth of Micro, Small and Medium Enterprises ( MSMEs) in Majalengka Regency, such as procurement of business training, provision of venture capital and so on. …”
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Notation publications in the context of musical life in Lithuania in the XVI-XVII centuries by Jūratė Trilupaitienė

“…The music was composed in Vilnius by Wenceslaus Schamotulinus and Ciprianus Basilicus, who were in Radvila's employ. Later Protestant hymnals with notation were published in 1563-4 in Nesvyžius, and in 1580, 1581, 1594, 1598, and 1600 in Vilnius, and in 1614 and 1620 in Lubcza. …”
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Komparasi Machine Learning Berbasis Pso Untuk Prediksi Tingkat Keberhasilan Belajar Berbasis E-Learning by Elin Panca Saputra, Siti Nurajizah, Mawadatul Maulidah, Nadiyah Hidayati, Taufik Rahman

“…Maka dari itu dapat disimpulkan penerapan menggunakan algoritma Naïve Bayes(NB) berbasis PSO mendapatkan hasil kenerja dengan bobot sebesar 94.40% dan angka AUC sebesar 94.50%, berikutnya Algoritma Support Vectore Machine(SVM) Berbasis PSO dengan hasil kinerja akurasi sebesar 88.20 dan nilai AUC seberar 91.10%, dan Artificial Neural Network(NN) berbasis Particle Swarm Optimizatio(PSO) menghasilkan skor hasil kinerja akurasi dengan bobot 99.20% dan nilai akurasi sebesar 98.50%, maka Artificial Neural Network(NN)  berbasis PSO memiliki keunggulan lebih besar dari pada algoritma naïve bayer berbasis PSO dan Support Vector Machine(SVM) dengan PSO. …”
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Zolpidem: Efficacy and Side Effects for Insomnia by Amber N. Edinoff, Natalie Wu, Yahya T. Ghaffar, Rosemary Prejean, Rachel Gremillion, Mark Cogburn, Azem A. Chami, Adam M. Kaye, Alan D. Kaye

“…When prescribed to elderly patients, the dose should be adjusted to account for their slower drug metabolism. Still, zolpidem is considered a reasonable choice of therapy because it has a lower incidence of residual daytime sleepiness and risk of falls when compared to other drugs. …”
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Editorial by Thomas Duve

“…Eine ausführliche Rezension gilt einer Quellensammlung zur portugiesischen Rechtsgeschichte, eine andere der Webseite Slavery, Law & Power in the British Empire and Early America (SLP). …”
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Implementasi Metode Naive Bayes untuk Mendeteksi Stres Siswa Berdasarkan Tweet pada Sistem Monitoring Stres by Diva Fardiana Risa, Fajar Pradana, Fitra Abdurrachman Bachtiar

“…Therefore, this research will build a feature to detect stress levels via tweet on a twitter account using the Naïve Bayes method which will be able to classify students' stress levels based on student tweets into three classes, namely light stress, moderate stress and severe stress classes. This feature will later be implemented in a website-based student stress monitoring system as a consideration for students and counseling teachers in the student counseling process. …”
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Identification and Spatial Mapping of Locality of Streetscapes in Shanghai Hengfu Historic and Cultural Preservation Area by Yuhan SHAO, Sinan YIN, Dongbo MA, Yuting YIN

“…Streetscape with appropriate human scale is safer than others, which may be due to the fact that both the two human scale and safety characteristics can positively influence the comfort of perception. …”
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Changes of Narrative: Osvald Sirén’s Photographic Modeling of Modern Research on Chinese Garden by Jiuwen GU, Yuanfeng SHI, Shan JIA

“…ObjectivePhotography, as an innovative method of recording Chinese gardens in the late nineteenth and early twentieth centuries, has a significant impact on the research on gardens both then and in later generations. In spite of this, garden research and photographic research do not overlap much as they are two parallel disciplines. …”
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La chirurgie cardiaque mini-invasive vidéo-assistée : une étude comparative à la voie conventionnelle [Less-invasive video-assisted cardiac surgery : a comparative study with the c... by Sami Bouchenafa, Ahmed Zaki Boukli-Hacene, Boukri Hamouda, Mohamed Atbi

“…Conclusion - The minimally invasive video-assisted is a simpler, safer and more effective procedure with excellent results and low morbidity. …”
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