The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…These findings suggest that DX126-262 could serve as a safer and more effective option for HER2-targeted cancer therapy, warranting further clinical studies to confirm its therapeutic potential.…”
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Use of Minimal Residual Disease Status to Reduce Uncertainty in Estimating Long-term Survival Outcomes for Newly Diagnosed Multiple Myeloma Patients by Naomi van Hest, Peter Morten, Keith Stubbs, Nicola Trevor

“…**Discussion:** Alternative methods to estimate long-term survival outcomes, such as a response-based PSM, can reduce uncertainty in modeling predictions around cost-effectiveness estimates for health technology assessment bodies and payers, thereby supporting faster market access for novel therapies with immature survival data. …”
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Impact of early arterial-phase multidetector CT in blunt spleen injury: a clinical outcomes-oriented study by Yu-Hao Wang, Yu-Tung Wu, Huan-Wu Chen, Yu-San Tee, Chih-Yuan Fu, Chien-Hung Liao, Chi-Tung Cheng, Chi-Hsun Hsieh

“…NOM-Obs failure refers to cases initially managed with observation only, but later requiring either TAE or splenectomy. Transarterial embolization (TAE) failure refers to cases initially treated with TAE, but subsequently requiring splenectomy. …”
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Association Between Vaso-Occlusive Crises and Opioid Prescriptions Among Patients with Sickle Cell Disease: A Retrospective Claims-Based Study by Hyeun Ah Kang, Jamie C. Barner, Kristin M. Richards, Menaka Bhor, Jincy Paulose, Abdullah Kutlar

“…SCD guidelines recommend opioids for the treatment of VOC-related pain. Payers and providers should be aware of opioid use in this population, consider appropriate VOC prevention measures, and provide SCD patients with access to appropriate pain management.…”
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Functional Outcome (Short Term) of Modular Cementless Bipolar HemiArthroplasty (Hydroxyapatite-Coated Stem) for Fracture Neck of Femur in the Elderly by Navin K. Shukla, Lata Keshkar, Jayanta Mukherjee, Ratnesh Kumar, Shivendra Singh, Alok C. Agrawal

“…Materials and Methods: Forty-three consecutive elderly patients with NOF fracture underwent BHA through the lateral Hardinge approach. They were followed up after surgery for 1 year. …”
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Genetic parameters and parental and early-life effects of boar semen traits by Pedro Sá, Rodrigo M. Godinho, Marta Gòdia, Claudia A. Sevillano, Barbara Harlizius, Ole Madsen, Henk Bovenhuis

“…Early-life conditions can have an effect on later semen quantity and quality traits. Mitochondrial DNA and Y chromosome inheritances showed no effect on semen traits. …”
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Management of extremity and pelvic fractures in earthquake: our observations and recommendations by Bugra Kundakci, Akif Mirioglu, Bugra Eraslan, Hakki Can Olke, Mustafa Tekin, Melih Bagir, Yusuf Kemal Arslan

“…Most pelvic fractures are simple lateral compression fractures and it is important to follow the patients for crush syndrome in the first days instead of focusing on definitive fracture treatment. …”
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Implementing curriculum at Sekolah Rimba Indonesia by Imaanuddin Muhtar, Haliza Hanif, Winny Azwita Putri, Lisa Amelia

“…This article was written with the aim of providing a better understanding of the curriculum provided at Sekolah Rimba so that other schools can later implement this interesting and creative curriculum. …”
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Anxiety, Depression, and Stress Reaction/Adjustment Disorders and Their Associations with Healthcare Resource Utilization and Costs Among Newly Diagnosed Patients With Breast Cance... by Dingwei Dai, Henriette Coetzer, Sean R. Zion, Michael J. Malecki

“…**Discussion:** Of patients with anxiety, depression, or stress reaction/adjustment disorder, those with incident psychiatric disorders had higher healthcare costs, suggesting that new-onset psychological distress may contribute to higher costs incurred by the payer. Timely treatment of psychiatric disorders in this population may improve clinical outcomes and reduce HCRU and costs. …”
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Investigating the Feasibility of Behavioral Nudges to Reduce the Phenomenon of Escape from Responsibility in Public Sector by Seyed Kamal Vaezi, Mahboubeh Hosseini

“…By empowering managers and by being aware of cognitive biases, promoting collective accountability, and using nudges to change behavior, organizations can create a safer working environment in which managers are motivated and take an active part in fulfilling their responsibilities and duties. …”
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Acetic Acid Chromoendoscopy in the Preliminary Diagnosis of Histological Type of Colon Polyp during Colonoscopy by N. V. Ageykina, E. D. Fedorov, P. G. Malkov, T. V. Nikolaychuk, N. A. Oleynikova

“…Use of acetic acid leads to fast acetowhitening reaction of lesions and surrounding mucosa. 2 groups were distinguished (table): 1) Loss of acetowhitening (LAW) of polyps occurs earlier than LAW of surrounding mucosa — «acetowhitening negative». 2) LAW of polyps occurs later than LAW of surrounding mucosa — «acetowhitening positive». …”
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The Cost-effectiveness of Celecoxib versus Non-steroidal Anti-inflammatory Drugs plus Proton-pump Inhibitors for Treating Osteoarthritis in Algeria by Nadir Hammoumraoui, Sid Ahmed Kherraf, Joaquin Mould-Quevedo, Tarek A. Ismail

“…The analysis was conducted from a healthcare payer’s perspective. The average daily treatment costs and frequencies of resource use for adverse events were based on data collected in August 2011 from a private clinic located in Cheraga, Algiers, Algeria. …”
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Impact of Oxycodone HCl Extended-release Formulary Restrictions on Extended-release Opioid Market Share, Healthcare Resource Utilization and Costs in Commercial and Medicare Plans by Rolin L. Wade, Chi-Chang Chen, Ajita P. De, Jaren C. Howard

“…**Objective:** This study evaluated, from payer perspective, the impact of formulary restrictions (PA, NF, or step therapy [ST]) for branded oxycodone HCl extended release (OER) on market share, and healthcare resource utilization/costs in ER opioids patients for multiple types of health plans in the United States. …”
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Prospective study of the association between chronotype and cardiometabolic risk among Chinese young adults by Tingting Li, Yang Xie, Shuman Tao, Liwei Zou, Yajuan Yang, Fangbiao Tao, Xiaoyan Wu

“…Prospective longitudinal association analysis also showed that lower MEQ-5 scores were associated with 2 years later higher fasting glucose (β=-0.018, 95%CI: -0.034~-0.003), higher fasting insulin (β=-0.384, 95%CI: -0.766~-0.003), higher HOMA-IR (β=-0.089, 95%CI: -0.176~-0.002), and higher CM-risk score (β=-0.109, 95%CI: -0.214~-0.003) after adjustment for covariates. …”
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Evaluation of Treatment Patterns and Maintenance Dose Titration Among Patients With Crohn’s Disease Initiating Biologics With 3 Years of Follow-Up by Ruizhi Zhao, Zhijie Ding, Parul Gupta, Laurence Gozalo, Robert Bruette, Victor M. Johnson, Keshia Maughn, Yihang Liu, Sumesh Kachroo

“…**Methods:** This retrospective observational study was conducted using the STATinMED RWD Insights all-payer medical and pharmacy data. Adult patients with at least 1 CD medical claim and at least 1 medical/pharmacy claim for a biologic (adalimumab \[ADA\], certolizumab pegol (CZP), infliximab \[IFX\] and its biosimilar products \[IFX-BS\], ustekinumab \[UST\], and vedolizumab \[VDZ\]) between September 2016 and October 2018 were identified. …”
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Radiological assessment of cup anteversion with a novel 3D-printed highly-porous titanium dual mobility cup by Nicole Puteo, Edoardo Matteo Valentino, Vittorio Davidoni, Domenico Tigani

“…Conversely, RA measurements of conventional DMC are more consistent but less accurate if performed on cross-table lateral radiographs by Woo-Morrey method than AP radiographs.…”
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Penerapan Euclidean Probability dalam Mendiagnosis Atopik Dermatis by Puji Sari Ramadhan

“…The use of this method in making a diagnosis later can contribute to the development and novelty of the use of techniques in scientific expert systems in generating diagnosis conclusions. …”
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Interacciones docente-estudiantes y maltrato infantil: análisis microgenético desde la perspectiva sociocultural/ Teacher-Student Interactions and Child Abuse: Microgenetic Analysi... by María Natalia Rodríguez, Julian David Torres, Mónica Roncancio

“…Los resultados indican que las significaciones del maltrato infantil, que emergen en la práctica educativa de la educadora, están permeadas por un sistema cultural más amplio, a saber, la religión católica, y que a través de lo religioso se comunica con sus estudiantes para alinear sus objetivos a los de ellos. …”
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A pilot cluster randomized controlled trial assessing uptake of PrEP and contraception in hair salons in South Africa by Ingrid V. Bassett, Joyce Yan, Sabina Govere, Sthabile Shezi, Lungile M. Ngcobo, Shruti Sagar, Jana Jarolimova, Dani Zionts, Anele Khumalo, Zinhle Zwane, Christina Psaros, Nduduzo Dube, Robert A. Parker

“…Women could receive contraception and/or oral PrEP at the initial visit or opt in at a later visit. We defined uptake as the proportion of eligible women who accepted salon-based PrEP and/or salon-based contraception at any visit. …”
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Water Risk and Mining Firms’ Stock Return by Maryam Davallou, Shirin Mehrali

“…ResultsThe significance of the water risk effect on stock returns of mining companies indicates the pricing and the confirmation power of this risk factor to explain the changes in stock returns over time, in a way that one unit increase in water risk will cause a decrease of about 3% in the excess return of the firm’s stock three quarters later. Also, the results showed that the amount of rainfall and drought in the region affects the firm's stock returns only up to three seasons, and its long-term effect is zero with a slight tolerance. …”
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