HES1 revitalizes the functionality of aged adipose-derived stem cells by inhibiting the transcription of STAT1 by Chengcheng Li, Sen Ren, Chengqi Yan, Cheng Wang, Tao Jiang, Yu Kang, Jing Chen, Hewei Xiong, Jiahe Guo, Guoyong Jiang, Shuoyuan Liu, Pengjuan Nie, Zhenbing Chen

“…It has been reported that transcription factors (TFs) play a crucial role in the aging and functionality of stem cells. Nevertheless, there is limited understanding regarding the involvement of TFs in the aging mechanism of ADSCs. …”
Get full text

Microbial Community, Fatty Acid Composition, and Health Potential of Horse Oil Fermented with Barley Nuruk by Jeong-Ha Lee, Sung-Eun Bae, Ho-Min Kang, Yu-Jin Ha, Chang-Gu Hyun

“…Next-generation sequencing (NGS) analysis showed a notable reduction in pathogenic bacteria, such as <i>Salmonella enterica</i>, and a dominance of <i>Lactobacillus acidophilus</i> (95.2%) by day 10. …”
Get full text

Polyol-based ultrasound-assisted extraction: Unlocking the anti-tyrosinase and anti-melanogenesis potential of Vitex trifolia Linn. Leaves by Nuntawat Khat-Udomkiri, Panthipa Petsringoen

Get full text

Revisiting Tension Band Principle Using Fiber Tape in Patella Fractures in Terms of Functional Outcomes, Complications, and Resurgery by Sandeep Deore, Bhushan Patil, Nrupam Mehta, Sachin Kale, Ravi Modi, Rafiuddin Shaikh

“…Introduction: Post-operative complications related to hardware, particularly symptoms caused by it, such as implant impingement, wire breakage, and skin infection are frequently reported following surgical management of patellar fractures with stainless steel wires. …”
Get full text

Effect of rituximab on the manifestations of activity and pulmonary function in patients with systemic sclerosis: one-year follow-up evaluation by L. P. Ananyeva, O. A. Koneva, O. V. Desinova, L. A. Garzanova, S. I. Glukhova, M. N. Starovoitova, O. B. Ovsyannikova, A. V. Volkov, A. P. Aleksankin, E. L. Nasonov

“…Data from a number of studies show that rituximab (RTM) can improve lung function and reduce the severity of skin fibrosis in patients with SS.Objective: to evaluate the efficiency of RTM in a cohort of patients with SS-associated ILD after one-year follow-up. …”
Get full text

Exploration of cosmetic bioactive compounds from cocoa bean shell using polyol-based microwave-assisted extraction: Cytotoxicity, anti-tyrosinase, and anti-melanogenesis properties by Sasakorn Pattanakitjaroenchai, Puthita Pitsawong, Nuntawat Khat-Udomkiri

“…LC-QQQ analysis identified quercetin, catechin, and trigonelline as key contributors to tyrosinase inhibition and melanin content reduction, with PG extracts demonstrating superior functional activity despite similar quercetin levels in both solvents. …”
Get full text

Myofiber structure, sarcoplasmic reticulum Ca2+ handling, and contractile function after muscle‐damaging exercise in humans by V. Handegard, P. K. Lunde, M. Frisk, O. Seynnes, N. Ørtenblad, W. E. Louch, G. Paulsen, T. Raastad

Get full text

Evaluation of the efficacy and safety of injectable glycosaminoglycan-peptide complex (GPC) in patients with osteoarthritis: a multicenter observational study GLADIOLUS (GPC in the... by L. I. Alekseeva, A. E. Karateev, E. Yu. Pogozheva, V. N. Amirdzanova, E. S. Filatova, V. A. Nesterenko

Get full text

IFN-γ Reduces Epidermal Barrier Function by Affecting Fatty Acid Composition of Ceramide in a Mouse Atopic Dermatitis Model by Hiroyuki Kanoh, Asako Ishitsuka, Etsuko Fujine, Shuhei Matsuhaba, Mitsuhiro Nakamura, Hiroyasu Ito, Naoki Inagaki, Yoshiko Banno, Mariko Seishima

“…An impaired stratum corneum barrier function is a hallmark of AD, and it is associated with a reduction in ceramides with long-chain fatty acids (FAs) in the stratum corneum. …”
Get full text

Novel Gels for Post-Piercing Care: Evaluating the Efficacy of Pranoprofen Formulations in Reducing Inflammation by Negar Ahmadi, Maria Rincón, Mireia Mallandrich, Joaquim Suñer-Carbó, Lilian Sosa, Mireya Zelaya, Sergio Martinez-Ruiz, Cecilia Cordero, Ana C. Calpena

Get full text

Bifidobacterium animalis subsp. Lactis BX-BC08 modulates gut microbiota and secretes alpha-Ketoglutaric acid to alleviate MC903-induced atopic dermatitis by Jiamin Zhao, Ling Kui, Jinqun Huang, Jie Deng, Lingjun Liu, Chenwei Zhu, Yanqiang Shi, Chengyi Li, Yue Xiao, Jinshi Yu, Qing Li, Bin Yang, Bingfeng Leng, Hung Chan

Get full text

Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis by Raimondo Sollazzo, Domenica Donatella Li Puma, Giuseppe Aceto, Fabiola Paciello, Claudia Colussi, Maria Gabriella Vita, Guido Maria Giuffrè, Francesco Pastore, Alessia Casamassa, Jessica Rosati, Agnese Novelli, Sabrina Maietta, Francesco Danilo Tiziano, Camillo Marra, Cristian Ripoli, Claudio Grassi

“…Notably, sAD-hNs demonstrated a marked reduction in LIMK1 phosphorylation, which could be the underlying cause for the changes in cytoskeletal dynamics that we found, leading to the morphological and functional modifications observed in sAD-hNs. …”
Get full text

Comparison of Cytotoxicity and Antioxidant, Antibacterial, and Anti-Inflammatory Activity of Aqueous and Ethanolic Extracts from <i>Malus domestica</i>, <i>Prunus armeniaca</i>, an... by Martyna Zagórska-Dziok, Aleksandra Ziemlewska, Magdalena Wójciak, Ireneusz Sowa, Ewa Wąsik-Szczepanek, Zofia Nizioł-Łukaszewska

“…Cytotoxicity assays (Alamar Blue, Neutral Red) demonstrated increased skin cell viability by up to 35% at ≤50 or 125 µg/mL, while higher doses reduced viability by up to 70%, depending on the extract. …”
Get full text

Tumor cell-released autophagosomes (TRAPs) induce PD-L1-decorated NETs that suppress T-cell function to promote breast cancer pulmonary metastasis by Jing Chen, Ning Pan, Li-Xin Wang, Xiaohe Zhou, Chengdong Wu, Xuru Wang, Xiaotong Sun, Bohao Chen, Shiya Zheng, Yiting Wei, Yuyang Wu, Fengjiao Zhu, Jinpeng Chen, Huabiao Chen

Get full text

Evaluating the Cosmetic Efficacy of Topical <i>Micrococcus luteus</i> Q24 Probiotic Balm: A Pilot Study in Healthy Adults by Abigail L. Voss, Stephanie A. Mattison, Sonali S. Sali, John D. F. Hale, Rohit Jain

“…The skin microbiome is a focus for innovative skincare. …”
Get full text

Bioactivity of Marine-Derived Peptides and Proteins: A Review by Fereidoon Shahidi, Abu Saeid

“…This review emphasizes the enormous scope of marine-derived peptides and proteins in the pharmaceutical, nutraceutical, cosmeceutical, and functional food industries, emphasizing their role in health promotion and risk reduction of chronic diseases.…”
Get full text

Knee Arthodesis, as a salvage procedure for Non-union of floating knee after ilizarov fixation-A case report by Harsh Kumar, Raj Suhas Kamble, Suhas Laxman Kamble

“…A floating knee on the right side was unsuitable for open reduction and internal fixation due to poor skin health. …”
Get full text

Outcomes of complex decongestive therapy in managing upper limb lymphedema in female breast cancer patients at a palliative care unit of a tertiary care hospital in Bangladesh. by Rifat Jahan, A K M Motiur Rahman Bhuiyan, Afroja Alam, Mostofa Kamal Chowdhury, Romena Hassan, Nisha Mortuja Aktar

“…<h4>Background</h4>Lymphedema is a chronic condition that significantly affects both physical function and quality of life of breast cancer patients. …”
Get full text

Geroderma Osteodysplastica With Concomitant Transposition of Great Vessels: A Case Report and Literature Review by Charbel Saad, Christine Aoun, Charbel Iskandar, Tony Hayek, Maroun Matar, Andre Megarbane

“…A loss of function mutation in GORAB results in the disease. …”
Get full text

Small fiber pathology in fibromyalgia syndrome by Claudia Sommer, Nurcan Üçeyler

“…Microneurography in particular has shown increased spontaneous activity, mechanosensitivity, and enhanced activity-induced slowing in C fibers of patients with fibromyalgia. Generalized reduction of skin innervation, ie, proximally and distally, was associated with higher symptom severity and more pronounced central nervous system changes as seen in magnetic resonance tomography. …”
Get full text