The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

Subjects: Get full text

Moving from an “anti-aging” paradigm toward the concept of “disease-free aging”: the role of senolytics in modern medicine by Ivan Aprahamian, Andréia Pain, Virgílio Garcia Moreira

“…Senolytic therapy requires strong evidence in human trials, and dasatinib and quercetin have shown good results in phase II trials with idiopathic pulmonary fibrosis and diabetic renal disease. …”
Get full text

Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives by Ricardo P. Garay

Subjects: Get full text

A comparative petrophysical evaluation of the Abu Roash, Bahariya, and Kharita reservoirs using well-logging data, East El-Fayoum, Egypt by Mohamed Osman Ebraheem, Hamza Ahmed Ibrahim, Ahmed Hosny Senosy

Get full text

Endothelial calcium firing mediates the extravasation of metastatic tumor cells by Marina Peralta, Amandine Dupas, Annabel Larnicol, Olivier Lefebvre, Ruchi Goswami, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Salvatore Girardo, Naël Osmani, Jacky G. Goetz

Get full text

Mülkiyet Yapısı Bağlamında Türk Bankacılık Sektörünün Tarihçesi - The Historical Background Of Turkish Banking Sector In The Context Of Ownership Structure by Süleyman Şen, Ömür Süer

Get full text

Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

Get full text

Rola marki w procesie podejmowania decyzji zakupu produktów mleczarskich na przykładzie rynku jogurtów by Mariusz Grębowiec

Get full text

The deleterious effects of CDK4/6 inhibition on renal recovery post-acute kidney injury by Shanshan Zhou, Rouzhang Peng, Yanting Shen, Liuwei Huang, Suying Han, Jun Wang, Jie Guo

“…We found that Palb could reverse the senolytic and antifibrotic effects induced by D + Q, which indicates that the profibrotic effect of Palb could be ascribed to its pro-senescent effects. …”
Get full text

MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB by Yihan Ma, Chongfu Zhao, Jingjing Feng, Junjie Gou, Enci Kang, Feng Guan, Qiong Wu, Xiang Li

“…These insights emphasize the necessity of targeting glycosylation modifications of GPNMB in the design of novel senolytic therapies aimed at mitigating cellular ageing and its associated pathologies.…”
Get full text

Fear avoidance beliefs and quality of life quality after lumbar disc surgery by Dogan Gucluhan Guclu, Omer Senormanci, Oya Gonullu, Musa Cirak, Guliz Senomanci, Furuzan Kokturk

Get full text

Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury by Kurt T. K. Giuliani, Purba Nag, Benjamin C. Adams, Xiangju Wang, Seokchan Hong, Anca Grivei, Rebecca L. Johnston, Nicola Waddell, Kenneth K. C. Ho, Yilin Tian, Muhammad Ali Khan, Chang Seong Kim, Monica S. Y. Ng, Glenda Gobe, Jacobus P. J. Ungerer, Josephine M. Forbes, Helen G. Healy, Andrew J. Kassianos

“…Treatment of Hypoxia+IL-1β-treated PTECs with either a type I IL-1 receptor (IL-1RI) neutralizing antibody or a senolytic drug combination, quercetin+dasatinib, attenuated senescent cell burden. …”
Get full text