Genetic characteristics involving the PD-1/PD-L1/L2 and CD73/A2aR axes and the immunosuppressive microenvironment in DLBCL by Tingting Zhang, Zhenzhen Zhang, Xiubao Ren, Jin He, Zhengzi Qian, Bin Meng, Lei Jiao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Wenchen Gong, Huilai Zhang, Xianhuo Wang

“…According to the grades of dysfunctional CD8+ T cells we defined, grade 1 dysfunctional CD8+ T cells, with either PD-1+ or A2aR+, were significantly associated with poorer survival than grade 0 dysfunctional CD8+ T cells, with both PD-1− and A2aR−; and patients with grade 2 dysfunctional CD8+ T cells showed the worst clinical outcomes.Conclusions This study describes the additional genetic basis of PD-L1 overexpression and characterizes certain genetic alterations of CD73/A2aR in DLBCL. …”
Get full text

Recent Advances of Surfactant-Polymer (SP) Flooding Enhanced Oil Recovery Field Tests in China by Chen Sun, Hu Guo, Yiqiang Li, Kaoping Song

“…Both technical and economic parameters are used to evaluate these tests. 2 of these ten tests are very successful; the others were either technically or economically unsuccessful. Although laboratory tests showed that SP flooding can attain IORF of more than 15%, the average predicted IORF for these 10 field tests was 12% OOIP. …”
Get full text

Hairy transcriptional repression targets and cofactor recruitment in Drosophila. by Daniella Bianchi-Frias, Amir Orian, Jeffrey J Delrow, Julio Vazquez, Alicia E Rosales-Nieves, Susan M Parkhurst

“…Each of the proteins was tethered to Escherichia coli DNA adenine methyltransferase, permitting methylation proximal to in vivo binding sites in both Drosophila Kc cells and early embryos. …”
Get full text

GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth by Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Michael G Rosenblum, Brian Aguirre, Cheng-Hsiang Lu, Anubhav Chandla, Nidhi Kejriwal, Lucia Liu, Ann M Chan, SuYin Kok, Sergio Duarte, David Casero, Madhuri Wadehra

“…Epithelial membrane protein-2 (EMP2) is highly expressed in invasive breast cancer (BC), including triple-negative BC (TNBC), and represents an attractive therapeutic target.Methods We designed a novel fusion protein (GrB-Fc-KS49) composed of an active GrB fused to an anti-EMP2 single-chain antibody tethered through the immunoglobulin G heavy chain (Fc) domain. …”
Get full text

L’aqueduc du Gier : étude des ponts-siphons du Garon à Brignais et Chaponost (Rhône) et de Beaunant à Sainte-Foy-lès-Lyon (Métropole de Lyon) by Kilian Blanc, Laurie Danielou

“…They were both built in an unusual way: initially constructed with openings between the piers for either economic or aesthetic reasons, the bridges were subsequently filled in because of the risk of the piles collapsing. …”
Get full text

Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

“…TH-CRE rats (N = 47; 24 females and 23 males) received either AAV carrying pseudophosphorylated human tau (htauE14) or a control virus at 3 months of age. …”
Get full text

Excerpts from The Freedom Fight: A Novel of Resistance and Freedom. by Pamela J. Olubunmi Smith

“…Ironically, despite the novel’s tension, the ending is paradoxical. While the freedom seekers succeed in establishing a grassroots movement, first by their own example of charity and basic education, however, their hard-fought campaign is compromised by a less than convincing negotiation for freedom, which they gain by bargaining their forced enslavement for a voluntary servitude. …”
Get full text

CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor by Tingting Li, Xuan Cai, Xiangning Wang, Xueyan Zhang, Hui Zhang, Biwei Xu, Shiwei Li, Jianyan Hu, Qiang Wu

“…Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentiviral particles targeting C/EBP β (LV.shC/EBP β) or control particles (LV.shScrambled). …”
Get full text

The Potential of Digital Storytelling as an Ethnographic Research Technique in Social Sciences by Oğuz Hatice Şule

“…I experienced a number of difficulties in conducting a field research with a sensitive (disadvantaged) group of people such as the asylum seekers. the other is the digital storytelling workshop entitled When I was in the field: Digital Stories from Young Academic Women . …”
Get full text

Factors Influencing Informed Consent Preferences in Digital Health Research: Survey Study of Prospective Participants by Brian J McInnis, Ramona Pindus, Daniah Kareem, Daniela G Vital, Eric B Hekler, Camille Nebeker

“…Participants (N=79) were surveyed and asked to choose between 2 variations of the text snippets, either indicating a preference for the institutional review board–approved original or a version that was modified to improve readability. …”
Get full text

Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Mar... by Aydan Mutis Alan, Zehra Sezer, Ahmet Oz, Cebrail Karaca, Mevlüt Tamer Dinçer, Ahmet Murt, Fatma Beyza Sag, Selma Alagoz, Serdar Sahin, Mustafa Sait Gonen, Elif Güzel, Sinan Trabulus, Nurhan Seyahi

“…Z-scores were utilized to evaluate low bone mineral density, with low Z-scores identified in either lumbar spine or femoral neck measures being seen as indicative of low bone mineral density. …”
Get full text

Music’s Vibratory Enchantments and Epistemic Injustices. Reflecting on Thirty Years of Feminist Thought in Music Theory by Judy Lochhead

“…These new perspectives have, in part, resulted in an increased diversity in the demographics of musicology, but there have not been changes of sufficient significance in either content or methodology in North American music theory and the demographics of music theory remain dominated by white, male practitioners. …”
Get full text

EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…Based on these findings, we demonstrated that dual inhibition of NAT10 and EGFR using Remodelin and the EGFR-specific monoclonal antibody cetuximab resulted in improved therapeutic efficacy compared to either drug alone. Moreover, we observed that 5-Fluorouracil promoted the interaction between NAT10 and UBR5, which increased the ubiquitin-mediated degradation of NAT10, leading to ERRFI1 downregulation and EGFR reactivation. …”
Get full text

SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase by Xiaobin Wang, Shulin Li, Zichen Li, Zhuona Lin, Zhifeng Wang

“…The Cell Counting Kit-8 assay was used to determine the cell viability by treating cells with a medium containing either the vehicle solution (control), the cell membrane hybrid liposomes (ML), 3025@ML, or compound 3 K. …”
Get full text

Functional Evaluation of Open Carpal Tunnel Release in Carpal Tunnel Syndrome Patients by Swagat Mahapatra, Devta Singh, Prakhar Mishra, Jaydeep Patel, Madhusudan Mishra, Animesh Gupta

“…Materials and Methods: This prospective cohort study was performed in the department of orthopedics at our institute for 8 months (January 2021 to August 2022) on carpal tunnel syndrome patients of either sex age ranging 20–60 years who attended orthopedic outpatient department and orthopedic wards, and who confirmed consent and found fitted according to inclusion criteria were recruited for this study. …”
Get full text

Unraveling the transcriptomic effects of leucine supplementation on muscle growth and performance in basketball athletes. by Sinan Wang, Weishuai Guo, Rui Dong

“…Participants were then given a functional drink containing either leucine (50 mg/kg body weight) or a placebo for 28 days. …”
Get full text

A comparison of new and existing rootstocks to reduce canker of apple trees caused by Neonectria ditissima (Nectriaceae, Hypocreales) by Lucas A. Shuttleworth, Sonia Newman, Ioannis Korkos

“…There were up to 31.25% dead trees in Kent (EMR-004), and 30% in Gloucestershire (M9 337 with GD interstock, M26), but there were no significant differences in number of dead trees due to rootstock type in either Kent or Gloucestershire. The Kendall’s rank correlation analysis indicated there was almost no dependence of trunk circumference on canker. …”
Get full text

Effects of population aging on quality of life and disease burden: a population-based study by Jun-Yan Xi, Bo-Heng Liang, Wang-Jian Zhang, Bo Yan, Hang Dong, Yuan-Yuan Chen, Xiao Lin, Jing Gu, Yuan-Tao Hao

“…In Scenarios 1 and 2, the disease burden rates in 2030 were assumed to  either remain at 2020 levels or follow historical trends. …”
Get full text

Consumer Products Nerve Injuries Among Patients Products Presenting to United States Emergency Departments Between 2012 and 2021: A Nationwide Cohort by Ganga A, Mukhdomi T, Kim EJ, Ly E, Patel Y, Dankievitch KN, Kendall MC

“…Injuries often occur either due to activity (ie sports related injury) or due to consumer products such as stairs or bedframes. …”
Get full text

Application of the flipped classroom model based on Bloom’s Taxonomy of Educational Objectives in endodontics education for undergraduate dental students by Yaru Wei, Zhengjun Peng

“…Two groups of undergraduate students majoring in stomatology received instruction in a portion of the endodontics curriculum using either the lecture method or flipped classroom model of teaching. …”
Get full text