Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer’s Disease Animal Model... by HyeJu Jeong, Ok Joon Kim, Seung-Hun Oh, Sanghoon Lee, Han A. Reum Lee, Kee Ook Lee, Boo-Yong Lee, Nam Keun Kim

“…Neprilysin (NEP) is the main cleavage enzyme of β-amyloid (Aβ), which plays a major role in the pathology and etiology of AD. We evaluated whether transplantation of MSCs with NEP gene modification enhances the therapeutic effects in an AD animal model and then investigated these pathomechanisms. …”
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Role of IPF genetic risk loci in post-COVID-19 lung abnormalities: a cohort study by James Johnston, Christopher Carlsten, Christopher J Ryerson, Alyson W Wong, Cameron J Hague, Julia Yang, Janice Leung, Daniel-Costin Marinescu, Aditi Shah, Darra Murphy

“…Similar parenchymal changes are observed in idiopathic pulmonary fibrosis (IPF). We investigated whether common genetic risk factors in IPF are associated with developing lung parenchymal abnormalities following severe COVID-19 disease.Methods Consecutive adults hospitalised for laboratory-confirmed COVID-19 infection were prospectively recruited from March to May 2020. …”
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Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway by Chen Feng, Wei Mao, Chenyang Yuan, Pin Dong, Yuying Liu

“…Abstract The mucosal epithelium of the head and neck region (including the oral cavity, nasal cavity, pharynx, nasopharynx, and larynx) is the primary site exposed to tobacco smoke, and its presence of nicotinic acetylcholine receptors (nAChRs) has been observed in the mucosal epithelial cells of this area. It remains unclear whether HNSC cells can migrate and invade through nAChR signaling. …”
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اعادة الهندسة الاداریة کمدخل لتمیز مؤسسات المعرفة by د. أمنیة خیر توفیق

“…Different types of knowledgeinstitutions need to re-engineer management , whether they suffer or not fromproblems of re-engineering in knowledge institutions : Service of reengineering ,reengineering process , reengineering ofmanagement systems , reengineering requires management improvementand development especially in the areas of organizational work , process outputs, system , and resources .A set of reengineering approaches that can be reliably applied toknowledge institutions is available from the results of the application of thereengineering approach to knowledge institutions : the transformation ofbusiness units from functional departments to operations teams , transformingjobs from simple tasks to complex work , the focus shifts on performancestandards , rewards and activities to results , Examples of obstacles that arepreventing the re-engineering approach to knowledge. institutions : the existenceof a culture of resistance to change, the lack of clarity of the knowledge        institution's vision , its organizational culture in the process of re-engineering, theuse of non-cadres to lead the process of administrative re-engineering, assigningadministrative re-engineering to retiring individuals , non-discrimination betweenadministrative re-engineering and other change programs, An example of therequirements for : The adequate awareness of the wishes of the beneficiaries ,an analysis of the institution's position and the design of the objectives of change, the belief of the senior management in the importance of change andencouragement of employees and understanding of the process of reengineeringadministrative management .Recommendations of the study : The need to adopt conscious leaders indifferent types of knowledge institutions , providing the necessary budget forapplying administrative reengineering in knowledge institutions , establishing aspecialized unit for reengineering of knowledge institutions , setting a plan for aspecific period of time of different types , especially the leaders in which newskills and knowledge on the reengineering management , monitoring theexperiences and management practices distinct in the field of reengineeringmanagement services facilities to document and benefit from them , increasingdependence needed to support administrative processes of reengineeringmethod of information technology .…”
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Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with... by Jianrong Zhang, Yu Huang, Hengrui Liang, Wenhua Liang, Jianxing He, Yiyin Zhang, Jiaxi He, Jieyu Wu, Long Jiang, Shiyan Tang, Qihua He, Lindsey Tristine Hamblin, Zhiheng Xu, Yaoqi Chen, Difei Chen, Xinyu Wang, Kexin Deng, Shuhan Jiang, Jiaqing Zhou, Jiaxuan Xu, Xuanzuo Chen

“…The aim of this study is to investigate whether systematic bias existed in RCTs by comparing the treatment effects of efficacy endpoints between central and local assessments.Design Literature review, pooling analysis and correlation analysis.Data sources PubMed, from 1 January 2010 to 30 June 2017.Eligibility criteria for selecting studies Eligible articles are phase III RCTs comparing anticancer agents for advanced solid tumours. …”
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The Genetic Expression Difference of A2058 Cells Treated by Plasma Direct Exposure and Plasma-Treated Medium and the Appropriate Treatment Strategy by Chao-Yu Chen, Chung-Hsien Chou, Yun-Chien Cheng

“…We also aimed to understand whether plasma-generated RONS were involved in this process using genetic evidence. …”
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Characterization of the Vibrio anguillarum VaRyhB regulon and role in pathogenesis by Yingjie Li, Xinran Yu, Peng Li, Xin Li, Lushan Wang

“…When iron is depleted, Fur also functions as an activator, playing an important role in pathogenesis. It is unclear whether this upregulation model is mediated by a small RNA, RyhB. …”
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Remnant cholesterol and its variability independent of low density lipoprotein cholesterol predict metabolic dysfunction associated steatotic liver disease by Yuting Sun, Xinlei Miao, Manling Hu, Xiaoling Xie, Shuang Liu, Ziping Song, Jiayi Deng, Fei Xu, Meng Li, Yangxuan He, Song Leng

“…Abstract This study aimed to determine whether remnant cholesterol (RC) and its variability can predict the onset of metabolic dysfunction-associated steatotic liver disease (MASLD) independently of low-density lipoprotein cholesterol (LDL-C) levels. …”
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The effect of repetitive transcranial magnetic stimulation on sleep quality in patients with more than mild depressive mood: a systematic review and meta-analysis by Yu’ang Liu, Silang Huang, Xinxin Zhang, Huangying Liao, Weiguo Liu, Zhi Zhang, Xianhui Qu, Ziwen Wang

“…In terms of treatment duration, compared with the 2-week and 4-week groups, the group with more than 4 weeks of treatment had better treatment outcomes (I2 = 0%, MD = −2.81, 95%CI = −3.22 to −2.40, p < 0.00001). In terms of whether combination therapy was used or not, compared with the combination therapy group (I2 = 29%, MD = −1.39, 95%CI = −2.30 to −0.48, p = 0.003), the non-combination therapy group had a better treatment effect (I2 = 0%, MD = −2.93, 95%CI = −3.36 to −2.50, p < 0.00001).ConclusionrTMS significantly improves sleep quality in patients with more than mild depression. …”
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An Investigation of the Knowledge and Perceptions of Arthritis amongst the Student Population in Ireland. by Laura Dunleavy, Máire McCallion

“…Aim: To investigate students’ knowledge and perception of arthritis and to determine whether education and more awareness about arthritis is needed amongst students. …”
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Clonal hematopoiesis of indeterminate potential is a risk factor of gastric cancer: A Prospective Cohort in UK Biobank study by Zhihui Xi, Huolun Feng, Kunling Chen, Xin Guo, Dandan Zhu, Jiabin Zheng, Yong Li

“…Objective: To examine whether clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor of gastric cancer. …”
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Chemopreventative potential of Salsola tuberculatiformis Botch and Compound A in the differential regulation of IL-1Ra:IL-1α in UVB exposed skin keratinocytes by T. Magcwebeba, L. McEvoy, S. Hayward, T. Tait, J.L Quanson, L. Kelbe, WCA Gelderblom, M. Lilly, A.C Swart, P. Swart

“…Additionally, Compound A has shown potent anti-inflammatory and anti-cancer effects in skin, raising the question of whether the S. tuberculatiformis extract might exhibit similar properties. …”
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Inverse association between dietary flavonoid intake and nocturia in middle-aged and older adults from NHANES 2007–2010 by Yu Cai, Ying-Chao Liang, Xin-Yu Hu, Ling Li, De-Liang Liu, Shu-Fang Chu, Hui-Lin Li

“…Restricted cubic spline (RCS) was utilized to explore whether there is a non-linear association between total flavonoid intake and nocturia. …”
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Color Confinement, Hadron Dynamics, and Hadron Spectroscopy from Light-Front Holography and Superconformal Algebra by Stanley J. Brodsky

“…Finally, I address the interesting question of whether the momentum sum rule is valid for nuclear structure functions.…”
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Do Human Papilloma Virus and Cytological Testing Results Before Colposcopy Alter the Pathological Grading of Colposcopy Acetic Acid Visual Examination?: A Retrospective Study by Gao S, Qian B, Wang T, Wang J

“…Songkun Gao,1 Boyang Qian,2 Tong Wang,1 Jiandong Wang1 1Gynecologic Oncology Department,Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, People’s Republic of China; 2Nantong University, Nantong, Jiangsu, 226019, People’s Republic of ChinaCorrespondence: Tong Wang; Jiandong Wang, Gynecologic Oncology Department,Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, People’s Republic of China, Email fcyywt@ccmu.edu.cn; wangjiandongxy@ccmu.edu.cnObjective: To understand whether human papillomavirus (HPV) and cytological testing (TCT [ie, “thinprep” cytological testing]) results can provide more information beyond visual information for vaginal colposcopy examinations to upgrade or downgrade the visual diagnosis of vaginal colposcopy.Patients and Methods: Data from 519 patients, who underwent vaginal colposcopy at the Beijing Obstetrics and Gynecology Hospital (Beijing, China) between January and June 2020, were included. …”
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An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure by Seth Kwadjo Angmorterh, Andrew England, Sonia Aboagye, Eric Kwasi Ofori, Peter Hogg

“…The current study assessed the impact on IP values for the head from using a thin silicone gel surface overlay during radiographic procedures and identified whether this reduced the risk of PUs. Materials and Methods. …”
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Measuring the Average Peak Timing of Kinematic Variables in Youth and Adolescent Baseball Pitchers by Mark Boland, Daniel Zambanini, Ivan Mulligan, Sean Donegan

“… # Purpose To determine whether youth and adolescent baseball pitchers will experience peaks in certain kinematic variables at different times throughout the pitching cycle compared to professional/collegiate pitchers…”
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Effects of milk extracellular vesicles from Holstein Friesian and Brown Swiss heat-stressed dairy cows on bovine mammary epithelial cells by S. Castellani, L. Basiricò, A. Maggiolino, C. Lecchi, P. De Palo, U. Bernabucci

“…This study investigated whether the small extracellular vesicles (sEV) isolated from milk of heat-stressed Holstein Friesian (H) and Brown Swiss (B) cows affect the cellular response of a bovine mammary epithelial cell line (BME-UV1). …”
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Evaluation of the Content Validity of the COVID-19 Symptoms Daily Diary by Dine J, Guan Y, Milien M, Ervin C, Byrne DD, Brown ML, De Anda C, Norquist JM

“…This study aimed to evaluate CSDD content validity, to determine whether it is fit for the purpose of supporting efficacy endpoints in clinical trials of treatments for COVID-19. …”
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Time Course of Acute Hip Adduction Range of Motion Changes Following Foam Rolling by Anthony D’Amico, Kevin Silva, Joseph Gallo

“… # Conclusion An acute bout of 3 sets of 20 seconds of FR may be effective for transiently increasing ROM. Whether these short-term increases have implications for chronic flexibility changes is unclear…”
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