A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart by Bart Jacobs, Inge Derese, Sarah Derde, Sarah Vander Perre, Lies Pauwels, Greet Van den Berghe, Jan Gunst, Lies Langouche

“…Conclusions Our results suggest myocardial lipid and glycogen accumulation and suppressed mitochondrial oxidation, with a functionally intact Krebs cycle, in the prolonged phase of sepsis, together with ongoing myocardial inflammation. Whether these alterations have functional consequences and predispose to long-term sequelae of SICM needs further research.…”
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Assessment of salicylic acid and potassium nitrate to mitigate frost stress in autumn-sown potato crop cv. Sutlej by Muhammad Wasim Haider, Syed Mohsin Abbas, Tanveer Hussain, Muhammad Tahir Akram, Umar Farooq, Mona S. Alwahibi, Mohamed S. Elshikh, Zaid Shakeel, Muhammad Nafees, Muhammad Rizwan, Rashid Iqbal

“…The abrupt climate change has affected the weather patterns all over the world, resulting in the reduction of the mean air temperature in autumn by almost 1.6 °C in Pakistan, which in turn, has adversely affected the crop performance and tuber yield. …”
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Efficacy and safety of Xiaoyao San in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis by Qianqian Wang, Jian Zhou, Guanwen Gong

“…However, the quality of evidence was rated “low” due to risk of bias and potential publication bias among the studies.ConclusionXYS, whether alone or with SBT, is effective and safe for improving ER, fatigue, anxiety, and depression in CFS patients. …”
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Longitudinal impact of preregistration interprofessional education on the attitudes and skills of health professionals during their early careers: a non-randomised trial with 4-yea... by Ben Darlow, Jennifer Roberts, Patrick McHugh, Melanie Brown, Eileen McKinlay, Peter Gallagher, Lesley Gray, Gordon Purdie, Christine Wilson, Sue Pullon, Louise Beckingsale, Kaye Cheetham, Ruth Crawford, Sue Floyd, Janice Handley, Jackie Herkt, Lisa Kuperus, Alison Meldrum, Margot Skinner, Rose Schwass, Julie Weaver, James Windle, Lyndie Foster-Page

“…Objective To assess whether a preregistration interprofessional education (IPE) programme changed attitudes towards teamwork and team skills during health professionals’ final year of training and first 3 years of professional practice.Design Prospective, longitudinal, non-randomised trial.Setting Final year health professional training at three academic institutions in New Zealand.Participants Students from eight disciplines eligible to attend the IPE programme were recruited (617/730) prior to their final year of training. 130 participants attended the IPE programme; 115 intervention and 372 control participants were included in outcome analysis.Intervention The 5-week Tairāwhiti IPE (TIPE) immersion programme during which students experience clinical placements in interdisciplinary teams, complete collaborative tasks and live together in shared accommodation.Main outcome measures Data were collected via five surveys at 12-month intervals, containing Attitudes Towards Healthcare Teams Scale (ATHCTS), Team Skills Scale (TSS) and free-text items. …”
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Elderly Patients with Nondistant Metastatic Pancreatic Head Adenocarcinoma Cannot Benefit from More Radical Surgery by Li Chen, Lanning Jia, Zhigang Tian, Yang Yang, Ke Zhao

“…Pancreatic head cancer occurs mainly in people over the age of 60, and its morbidity and mortality increase with age. We investigated whether these elderly patients with nondistant metastases would benefit more from expanded pancreaticoduodenectomy (EPD) compared with standard pancreaticoduodenectomy (SPD). …”
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The First 24 h Hemodynamic Management in NICU after Revascularization Surgery in Moyamoya Disease by Jie Song, Yu Lei, Long Chen, Chao Gao, Wei Ni, Xing Wu, Gang Wu, Ying Mao, Jin Hu, Yuxiang Gu

“…Objective. To evaluate whether hemodynamic factors are risk factors for prognosis in moyamoya disease (MMD). …”
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Effects of a periodic intermittent theta burst stimulation in Alzheimer’s disease by Yue Wu, Lu Wang, Kai Wang, Shanshan Zhou, Pan Wu, Yibing Yan, Ling Wei, Bensheng Qiu, Yanghua Tian, Zhi Geng, Xingqi Wu, Panpan Hu, Guixian Xiao, Gongjun Ji, Hesheng Liu

“…However, the long-term effects of iTBS on cognitive decline and brain structure in patients with AD are unknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised, assessor-blinded, controlled trial, iTBS was administered to the left dorsolateral prefrontal cortex (DLPFC) of 42 patients with AD for 14 days every 13 weeks. …”
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Long COVID and its risk factors in migrants: a nationwide register study from Sweden by Agneta Cederström, George Frederick Mkoma, Thomas Benfield, Charles Agyemang, Marie Nørredam, Mikael Rostila

“…We discovered that disease severity, i.e., whether the person was hospitalized (IRR: 18.6 CI: 17.3–20.0) or treated in an intensive care unit (IRR: 120.5 CI: 111.7–129.8), primarily contributed to the higher risk of long COVID found in migrants while the contribution of vaccinations and social conditions were moderate. …”
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Is There a Noninvasive Source of MSCs Isolated with GMP Methods with Better Osteogenic Potential? by Carla C. G. Pinheiro, Alessander Leyendecker Junior, Daniela Y. S. Tanikawa, José Ricardo Muniz Ferreira, Reza Jarrahy, Daniela F. Bueno

“…Ten cellular strains obtained from each different source (umbilical cord, orbicularis oris muscle, or deciduous dental pulp) were induced to osteogenic differentiation in vitro, and the bone matrix deposition of each primary culture was quantified. To evaluate whether greater osteogenic potential of the established mesenchymal stem cell strains was associated with an increase in the expression profile of neural crest genes, real-time qPCR was performed on the following genes: SRY-box 9, SRY-box 10, nerve growth factor receptor, transcription factor AP-2 alpha, and paired box 3. …”
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Mt or not Mt: Temporal variation in detection probability in spatial capture-recapture and occupancy models by Sollmann, Rahel

“…Accounting for imperfect and variable detection is important for obtaining unbiased estimates of state variables. Here, I investigate whether closed spatial capture-recapture (SCR) and single season occupancy models are robust to ignoring temporal variation in detection probability. …”
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UK medical students’ mental health and their intention to drop out: a longitudinal study by Asta Medisauskaite, Antonia Rich, Milou Silkens, Neha Lagisetty

“…It may be useful for medical schools to help applicants/medical students understand whether medical school is the right decision for them and provide them with resources should they wish to leave.…”
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Co-benefits of nature-based solutions: A health impact assessment of the Barcelona Green Corridor (Eixos Verds) plan by Tamara Iungman, Sergi Ventura Caballé, Ricard Segura-Barrero, Marta Cirach, Natalie Mueller, Carolyn Daher, Gara Villalba, Evelise Pereira Barboza, Mark Nieuwenhuijsen

“…We computed the percentage increase in GS (land use) and tree cover and converted them into Normalized Difference Vegetation Index (NDVI) to conduct the HIA, employing a Generalized Additive Model (GAM). We used the Weather Research and Forecasting model (WRF) coupled with the urban parameterizations “Building Effect Parameterization” (BEP) and “Building Energy Model” (BEM) for temperature modelling. …”
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Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants by Aktham Mestareehi, Xiangmin Zhang, Berhane Seyoum, Zaher Msallaty, Abdullah Mallisho, Kyle Jon Burghardt, Anjaneyulu Kowluru, Zhengping Yi

“…Protein phosphatase 2A (PP2A), a major serine/threonine protein phosphatase, plays a pivotal role in cellular processes, such as signal transduction, cell proliferation, and apoptosis, and acts through dephosphorylating key signaling molecules such as AKT and AMPK. However, whether PP2A plays a role in metformin-induced insulin sensitivity improvement in human skeletal muscle cells remains to be elucidated. …”
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Metode Deteksi Intrusi Menggunakan Algoritme Extreme Learning Machine dengan Correlation-based Feature Selection by Sulandri Sulandri, Achmad Basuki, Fitra Abdurrachman Bachtiar

“…This research analyzes the network traffic to find out whether the packet contains intrusion or is a normal packet. …”
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CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer’s disease mice by Yuanyu Shen, Xiaolei Zhang, Siqi Liu, Lijing Xin, Wentao Xuan, Caiyu Zhuang, Yue Chen, Beibei Chen, Xinhui Zheng, Renhua Wu, Yan Lin

“…Riluzole is a Glu modulator originally approved for amyotrophic lateral sclerosis that has shown potential neuroprotective effects in various neurodegenerative disorders. However, whether riluzole can improve Glu and GABA homeostasis in AD brain and its related mechanism of action remain unknown. …”
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Exploring the barriers to cervical screening and perspectives on new self-sampling methods amongst under-served groups by Stephanie Gillibrand, Helen Gibson, Kelly Howells, Sean Urwin, Jennifer C. Davies, Emma J. Crosbie, Caroline Sanders

“…However, there is limited evidence on whether self-sampling methods address known barriers to cervical screening and subsequently increase uptake amongst under-screened groups. …”
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Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa by Katrien F.M. Bracké, Laura Monteiro Rente Dias, Marisha N. Meijer, Cathelijne P.M. Steegers, Laurinde F. den Heijer, Tess van der Harst, Marjolein H.G. Dremmen, Meike W. Vernooij, Gwen C. Dieleman, Tonya White

“…Linear regression analyses were conducted to assess differences in RS-FC between AN and TD participants, as well as to assess whether RS-FC was associated with clinical symptoms at baseline and at one-year of follow-up. …”
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Short bouts and long-term exercise reduce sedentary-induced bone loss and microstructural changes by modulating bone formation and resorption in healthy young male rats by L.Y. Wang, L.M. Liang, X.X. Zhang, H. Chi, F. L. Peng

“…Our findings suggest that SED leads to alterations in the bone mass and microstructure, which are associated with the changes in the OPG protein and bone remodeling. Exercise, whether in short daily bouts or continuous long-term sessions, can ameliorate the harmful effects of SED. …”
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Supporting primary care clinicians in caring for patients with alcohol use disorder: study protocol for Records for Alcohol Care Enhancement (RACE), a factorial four-arm randomized... by Kara M. Magane, Richard Saitz, Sarah Fielman, Marc R. LaRochelle, Christopher W. Shanahan, Christine A. Pace, Michael LaValley, Kaley Penington, Skylar Karzhevsky, Emily Hurstak

“…This four-arm factorial design randomized trial will assess whether population health management (PHM) and clinical care management (CCM) support for primary care providers (PCPs) are associated with improved AUD treatment engagement among their patients, beyond electronic health record (EHR) prompting and decision support alone. …”
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Hindguts of Kyphosus sydneyanus harbor phylogenetically and genomically distinct Alistipes capable of degrading algal polysaccharides and diazotrophy by Cesar T. Facimoto, Kendall D. Clements, W. Lindsey White, Kim M. Handley

“…Results highlight host-specific adaptations among Alistipes in the fish hindgut that likely contribute to K. sydneyanus digesting their seaweed diet, and diverse and redundant carbohydrate-degrading capabilities across these Alistipes species.IMPORTANCEDespite numerous reports of the Alistipes genus in humans and ruminants, its diversity and function remain understudied, and there is no clear consensus on whether it positively or negatively impacts host health. …”
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