Chronic pain is a risk factor for all-cause and cancer-specific mortality in cancer survivors: a population-based cohort study by Yeying Zhang, Yuna Guo

“…Abstract Background Evidence is lacking on whether chronic pain is related to the risk of cancer mortality. …”
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Regulation of LPS-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells via TLR4-Mediated NF-κB and MAPK Signaling Pathways by Lactoferrin by Kai Zhang, Ruizhen Zhang, Yuanyuan Zhang, Min Zhang, Hong Su, Feifei Zhao, Daqing Wang, Guifang Cao, Yong Zhang

“…An inflammatory injury model was established by stimulating BMECs with LPS to investigate whether LF at different concentrations (10, 50, 100, and 200 μg·mL⁻¹) could inhibit the inflammatory response before and after the onset of inflammation. …”
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L-shaped association of body mass index with prognosis in individuals with sepsis: a multicenter cohort study by Kunping Cui, Xiangnan Teng, Wei liu, Xiaoxiao Zhao, Shanling Xu, Lang Bai

“…We performed the log-rank test to detect whether there is a difference in prognosis among different groups in two different cohorts. …”
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Variability and correlations of economically valuable traits in cowpea from the VIR collection in the environments of Astrakhan provincer by M. V. Gurkina

“…The widest ranges of variability were demonstrated in the quantitative yield characters of cowpea accessions: number of pods per plant (CV = 33‑49%), number of flower stalks (CV = 38‑51%), and seed weight per plant (CV = 38‑44%), which means that cowpea yield is quite susceptible to weather conditions. During the three years of studying, the lowest levels of variability in economically valuable traits were characteristic of the accessions of the early-ripening group: k‑668 and k‑873 (China); mid- ripening group: k‑971 (India); and late-ripening group: k‑141 (China). …”
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MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension by Yi Tang, Xiaowei Huo, Junyu Liu, Yijin Tang, Min Zhang, Wenlin Xie, Zhaofen Zheng, Jin He, Jiayan Lian

“…Dual-luciferase reporter assay verified whether miR-325-3p and HE4 were targeted. Results. …”
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Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

“…In settings where glycaemic control is typically poor and food insecurity is common, long-acting insulin analogues may offer tangible clinical benefits for people with T1D. To determine whether insulin glargine, a long-acting insulin analogue, reduces the risk of serious hypoglycaemia and/or improves glycaemic time-in-range (TIR) versus human insulin regimens in this population, we are conducting the Human vs Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings randomised controlled trial.Methods and analysis This is a 1:1 randomised, parallel-group clinical trial comparing biosimilar insulin glargine with human insulin (Neutral Protamine Hagedorn (NPH) or premixed 70/30 insulin) in 400 youth with type 1 diabetes (T1D) recruiting in Dhaka, Bangladesh (n=250) and Mwanza, Tanzania (n=150). …”
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Variability of daily feed intake as an indicator of resilience in Pietrain pigs by C. Casto-Rebollo, P. Nuñez, S. Gol, J. Reixach, N. Ibáñez-Escriche

“…A Bayesian linear model was used to determine whether the differences in progeny mortality rate between the levels of resilience were relevant. …”
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The association of travel distance and other patient characteristics with breast cancer stage at diagnosis and treatment completion at a rural Rwandan cancer facility by Kayleigh Bhangdia, Abirami Natarajan, Niclas Rudolfson, Stéphane Verguet, Marcia C. Castro, Jean-Marie Vianney Dusengimana, Cyprien Shyirambere, Lauren E. Schleimer, Lawrence N. Shulman, Aline Umwizerwa, Catherine Kigonya, John Butonzi, Emily MacDuffie, Temidayo Fadelu, Daniel S. O’Neil, Cam Nguyen, Tharcisse Mpunga, Nancy L. Keating, Lydia E. Pace

“…Abstract Background Butaro Cancer Center of Excellence (BCCOE) was founded to serve Rwanda’s rural low-income population, providing subsidized cancer diagnosis and treatment with transport stipends for the lowest-income patients. We examined whether travel distance to BCCOE was associated with advanced-stage diagnoses and treatment completion. …”
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History of Pain Research and Management in Canada by Harold Merskey

“…Scattered accounts of the treatment of pain by aboriginal Canadians are found in the journals of the early explorers and missionaries. French and English settlers brought with them the remedies of their home countries. …”
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The Assessment of Different Dietary Selenium Resources on Reproductive Performance, Spawning Indicators, and Larval Production of Red Tilapia (Oreochromis mossambicus × O. niloticu... by Mohammed A. E. Naiel, El-Sayed H. Eissa, Yasmin M. Abd El-Aziz, Saadea Saadony, Heba E. Abd Elnabi, Salah El-Sayed Sakr

“…This trial aimed to investigate whether dietary selenium form influenced the reproductive performance of red tilapia broodfish. …”
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Gene mutation in diabetic patients with lung adenocarcinoma: a real-world retrospective cohort study by Lei Yang, Yang Hong, TingTing Zeng, HongMei Yue, DePeng Jiang

“…PurposeThe incidence of lung cancer is closely associated with diabetes; however, it remains unclear whether diabetes influences the genetic mutations present in lung cancer. …”
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Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review by Lauren M Henry, Morkeh Blay-Tofey, Clara E Haeffner, Cassandra N Raymond, Elizabeth Tandilashvili, Nancy Terry, Miryam Kiderman, Olivia Metcalf, Melissa A Brotman, Silvia Lopez-Guzman

“…Moderation (conditional upon sufficient heterogeneity of outcomes) and mediation (ie, whether changes in proximal outcomes mediate the relation between JITAIs and distal outcomes) will be conducted as appropriate. …”
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Ginsenoside Rg1 alleviates chronic testicular damage caused by cranial irradiation through the SCF/PI3K/Akt/mTOR pathway in mice by Qiuhua Zhou, Yiquan Ou, Xiangsheng Tian, Yujun Ning, Yuwei Mao, Weichao Zhao, Dingxin Long

“…Objective: To investigate whether Ginsenoside Rg1 can mitigate the adverse effects of cranial irradiation on distal reproductive function in mice and to explore the underlying mechanisms. …”
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Cucumeropsis mannii seed oil shields against cyclophosphamide-induced hepatorenal toxicity by modulating redox imbalance and iNOS/IL-β1 signalling in rats by Amaka Cecilia Agbara, Ejike Daniel Eze, Christian Emeka Offor, Adam Moyosore Afodun, Ezebuilo Ugbala Ekpono, Peter Chinedu Agu, Chinyere Aloke, Nkeiru Nwaamaka Ezeani, Emmanuel Orire Ikuomola, Ekom Monday Etukudo, Ilemobayo Victor Fasogbon, Angela Mumbua Musyoka, Patrick Maduabuchi Aja

“…This study aimed to determine whether C. mannii seed oil (CMSO) could shield rats from cyclophosphamide-induced hepatorenal toxicity. …”
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Sex-biased prevalence in infections with heterosexual, direct, and vector-mediated transmission: a theoretical analysis by Andrea Pugliese, Abba B. Gumel, Fabio A. Milner, Jorge X. Velasco-Hernandez

“…The study is focused on understanding whether and how this bias in transmission reflects in sex differences in final attack ratios (i.e. the fraction of individuals of each sex that eventually gets infected). …”
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Do You Speak Dialect? Yes! by Vytautas Kardelis, Gabriela Forgeron

“…In essence, the methodology involved a dual-faceted approach: first, to ascertain whether informants employed dialectal language in informal settings with family members and friends from their country of origin; and second, to examine the practical implementation of this linguistic phenomenon. …”
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Nitrogen bound to manure fiber is increased by applications of simple phenolic acids by Jonathan J. Halvorson, Scott L. Kronberg, Rachael G. Christensen, Ann E. Hagerman, David W. Archer

“…Thus, N mineralization may be impacted by increasing or decreasing the amount of N bound to manure fibers or other recalcitrant soil compounds such as lignin, but it is unclear whether such N would be less available to plants, or for volatilization, or leaching.…”
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Do Nonsuicidal Severely Depressed Individuals with Diabetes Profit from Internet-Based Guided Self-Help? Secondary Analyses of a Pragmatic Randomized Trial by Sandra Schlicker, Kiona K. Weisel, Claudia Buntrock, Matthias Berking, Stephanie Nobis, Dirk Lehr, Harald Baumeister, Frank J. Snoek, Heleen Riper, David D. Ebert

“…The aim of the study was to test whether disease-specific severity indicators moderate the treatment outcome in a 6-week minimally guided web-based self-help intervention on depression and diabetes (GET.ON Mood Enhancer Diabetes (GET.ON M.E.D.)) and to determine its effectiveness in a nonsuicidal severely depressed subgroup. …”
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End-tidal carbon dioxide-guided extracorporeal cardiopulmonary resuscitation improves neurological prognosis in patients: a single-center retrospective cohort study by Xiaozu Liao, Chen Gu, Zhou Cheng, Kepeng Liu, Qing Yin, Binfei Li

“…In this retrospective cohort study, the patients were divided into Conventional CPR (CCPR) and ETCO2-GDCPR groups based on whether ETCO2 was used as a guide for CPR. Results: A total of 71 patients were included, of whom 46 comprised the CCPR group and 25 comprised the GDCPR group. …”
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An Update of the Appropriate Treatment Strategies in Anaplastic Thyroid Cancer: A Population-Based Study of 735 Patients by Nai-si Huang, Xiao Shi, Bo-wen Lei, Wen-jun Wei, Zhong-wu Lu, Peng-cheng Yu, Yu Wang, Qing-hai Ji, Yu-long Wang

“…The aim of the current study is to explore whether aggressive treatment is beneficial, especially the appropriate extent of surgery in ATC. …”
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