Mechanism of hsa_circ_0069443 promoting early pregnancy loss through ALKBH5/FN1 axis in trophoblast cells by Bai-xue Li, Mei-yao Wu, Zhi-hui Wang, Dong-mei Zhou, Jian-qi Li, Bing-feng Lu, Xiao-ling Lin, Yang Zhao, Xiu-jie Sheng

“…Based on sequencing and functional experiments, we found that hsa_circ_0069443 can regulate the function of trophoblast cells, and its presence is found in the exosomes secreted by trophoblast cells. It is known that exosomes mediate the interaction between the uterus and embryo, which is crucial for successful pregnancy. …”
Get full text

Biliary Adenofibroma with Carcinoma In Situ: A Rare Case Report by N. Thao T. Nguyen, Theresa R. Harring, Laurie Holley, John A. Goss, Christine A. O’Mahony

“…This exophytic, multicystic, 6.5 × 5.0 cm mass was composed of complex tubulocystic structures lined by nonmucin-secreting, biliary epithelium embedded in fibrous stroma, consistent with biliary adenofibroma. …”
Get full text

How Bacteria-Induced Apoptosis of Intestinal Epithelial Cells Contributes to Mucosal Inflammation by Martin Hausmann

“…Tumor necrosis factor (TNF) secreted after exposure to invasive bacteria induces both apoptosis and cell shedding. …”
Get full text

Pituitary adenoma: important genetic factors and clinical diagnostic issues by G. Juknytė, E. Karinauskė, R. Liutkevičienė

“…PA invasiveness and tumor-caused metabolic disorders can also be fatal, as almost every human organ and tissue is directly or indirectly affected by hormones secreted by the anterior or posterior pituitary gland. …”
Get full text

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications by Eva Sticova, Milan Jirsa, Joanna Pawłowska

“…Cholestasis is characterised by impaired bile secretion and accumulation of bile salts in the organism. …”
Get full text

3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation by Jianing Yan, Zhichao Ye, Yiwei Lu, Yuyang Yuan, Xiaofeng Wang, Tingting Yan, Jun Yin, Yifan Wang

Get full text

Managing Conflicts with Wildlife: Living with Frogs by Steven A. Johnson, Holly K. Ober, William M. Giuliano

“…Research on the substances frogs secrete through their skins has even led to the creation of new painkillers and antibiotics. …”
Get full text

Managing Conflicts with Wildlife: Living with Frogs by Steven A. Johnson, Holly K. Ober, William M. Giuliano

“…Research on the substances frogs secrete through their skins has even led to the creation of new painkillers and antibiotics. …”
Get full text

Positron emission tomography for phenotyping inflammation of cardiovascular diseases by Xiaoyun Luo, Chentao Jin, Hetian Chen, Xiaohui Zhang, Yan Zhong, Peili Cen, Hong Zhang, Mei Tian

“…The rapid development of positron emission tomography (PET) imaging not only enhances our understanding of biological processes in vivo but also contributes significantly to clinical management as a non-invasive biomarker. This review summarizes the PET imaging of key immune cell responses in CVDs, including immune cell metabolism, ligand/receptor interactions, and enzyme secretion, and discusses emerging opportunities and challenges in PET imaging-based inflammatory phenotyping and future perspectives.…”
Get full text

Managing Scale Insects on Ornamental Plants by Eileen A. Buss, Adam Dale

“…They damage plants and secrete a waxy covering that makes them difficult to control using most chemical control measures. …”
Get full text

Managing Scale Insects on Ornamental Plants by Eileen A. Buss, Adam Dale

“…They damage plants and secrete a waxy covering that makes them difficult to control using most chemical control measures. …”
Get full text

Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage by Johanna Richter, Amanda J. Cork, Yvette Ong, Nadia Keller, Andrew J. Hayes, Mark A. Schembri, Amy V. Jennison, Mark R. Davies, Kate Schroder, Mark J. Walker, Stephan Brouwer

“…The GAS M1UK lineage has contributed significantly to the recently reported increases in scarlet fever and invasive infections. However, the basis for its evolutionary success is not yet fully understood. …”
Get full text

High-Yield Generation of Glucose-Responsive Pseudoislets From Murine Insulinoma Cells for Studies and Longitudinal Monitoring of Graft Survival by Grisell C. Gonzalez, Chris M. Li, Ilaria Pasolini, Sophia I. Pete, Connor Verheyen, Sofia M. Vignolo, Teresa De Toni, Aaron A. Stock, Alice A. Tomei

“…To enable non-invasive longitudinal monitoring of graft survival in vivo , we transduced NIT-1 cells with green fluorescent protein-luciferase and confirmed comparable morphology, viability, and GSIS to untransduced cells in vitro . …”
Get full text

Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment by Bassel Alsaed, Linh Lin, Jieun Son, Jiaqi Li, Johannes Smolander, Timothy Lopez, Pinar Ö. Eser, Atsuko Ogino, Chiara Ambrogio, Yoonji Eum, Tran Thai, Haiyun Wang, Eva Sutinen, Hilma Mutanen, Hanna Duàn, Nina Bobik, Kristian Borenius, William W. Feng, Behnam Nabet, Satu Mustjoki, Sanna Laaksonen, Benjamin K. Eschle, Michael J. Poitras, David Barbie, Ilkka Ilonen, Prafulla Gokhale, Pasi A. Jänne, Heidi M. Haikala

“…The EGFR-low cells secrete Transforming growth factor beta (TGFβ) family cytokines, leading to increased recruitment of cancer-associated fibroblasts and immune suppression, thus contributing to the drug-tolerant tumor microenvironment. …”
Get full text

Positive Pneumocystis jirovecii Sputum PCR Results with Negative Bronchoscopic PCR Results in Suspected Pneumocystis Pneumonia by Kelly Pennington, John Wilson, Andrew H. Limper, Patricio Escalante

“…Sputum P. jirovecii-PCR testing may be a viable alternative to invasive testing.…”
Get full text

Urine proteomics defines an immune checkpoint-associated nephritis signature by Cassian Yee, Jamie S Lin, James P Long, Shailbala Singh, Yanlan Dong

“…Thus, there is an urgent need for non-invasive biomarkers that can rapidly and accurately distinguish ICI-AIN from other causes of AKI.The urine and plasma proteome contain actively secreted proteins that provide real-time insights into dynamic physiological processes. …”
Get full text

PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…Angiogenesis and secretion of certain matrix metalloproteinases and extracellular matrix proteins within the tumor microenvironment are also regulated by PPARγ. …”
Get full text

Development and in vitro evaluation of biomimetic injectable hydrogels from decellularized human nerves for central nervous system regeneration by Gopal Agarwal, Kennedy Moes, Christine E. Schmidt

“…Compared to LPS-activated cells on tissue culture plates (TCP), astrocytes within iHPN maintained a quiescent state, as evidenced by reduced GFAP expression and IL-1β secretion. RAW 264.7 and HMC3 cells in iHPN displayed an anti-inflammatory phenotype, as shown by increased CD206 and decreased CD86/CD68 expression, along with higher IL-4 and lower TNF-α/IL-1β secretion. …”
Get full text

Biomarkers of inflammation and colorectal cancer risk by Yuting Li, Yuting Li, Yuting Li, Yuexin Luo, Yue Ran, Furong Lu, You Qin

“…Adiponectin and leptin, secreted by adipocytes, have complex associations with CRC, with gender disparities noted. …”
Get full text

Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis by Svetla Nikolova, Milka Dikova, Dobrin Dikov, Assen Djerov, Gyulnas Dzhebir, Ventseslav Atanasov, Alexey Savov, Ivo Kremensky

“…Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). …”
Get full text