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    Assisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism. by Steven J Soll, Sam J Wilson, Sebla B Kutluay, Theodora Hatziioannou, Paul D Bieniasz

    Published 2013-01-01
    “…First, HIV-1 was passaged in engineered human cells expressing rhTRIM5α. Second, a library of randomly mutagenized capsid protein (CA) sequences was screened for mutations that reduced rhTRIM5α sensitivity. …”
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