Targeting TRPM3 as a potential therapeutic approach for autosomal dominant polycystic kidney disease by Hüseyin Gül, Jamie A. Davies

“…Abstract Cystic diseases, especially autosomal dominant polycystic kidney disease (ADPKD; incidence approx. 1/1000), are a leading cause of renal failure, caused by appearance and growth of renal cysts that can lead to renal failure in middle age. …”
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Massive celestial amplitudes and celestial amplitudes beyond four points by Reiko Liu, Wen-Jie Ma

“…Finally, we show that a new series of operators appears when turning on the mass of the first incoming particle. …”
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Chronic Inflammatory Demyelinating Polyneuropathy with Atypical Symptoms: A Rare Case of Tongue Fasciculation and Facial Muscle Weakness by Shafiq ur Rehman, Saba Zaidi, Mahzareen

“…Over 3 months, the patient experienced progressive limb weakness ascending from lower limbs to upper limbs with marked tongue fasciculations and facial muscle weakness without dysarthria or dysphagia. …”
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A Novel Computational Framework for Visual Snow Syndrome by Damiano Perri, Osvaldo Gervasi

“…Visual Snow Syndrome (VSS) is a neurological condition that impairs the perceived image by causing the appearance of numerous constantly flickering dots, similar to those seen on a television screen that does not receive the antenna signal properly. …”
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ETHNIC POLITICS AND SUSTAINABLE DEMOCRACY IN NIGERIA by UKWU FELIX EMEKA

“…Despite numerous reform efforts, the outcome appears to deteriorate with each successive general election. …”
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Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6. by Alison K Gillingham, Sean Munro

“…Yel1 appears structurally related to the EFA6 family of GEFs, having an N-terminal Sec7 domain and C-terminal PH and coiled-coil domains. …”
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THE POLITICS OF OIL EXPLORATION AND THE CHALLENGES OF SUSTAINABLE DEVELOPMENT IN NIGERIA: THE ISSUE OF BAYELSA STATE by FRANK FUNKEYE SAPELE, AYOOLA BABATUNDE FADOLA

“… This paper focuses on politics of oil exploration with regards to the challenges of sustainable development in Nigeria, the Bayelsa State Experience. …”
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STUDY OF Bacillus licheniformis BACTERIA AS A BIO-CONTROL AGENT IN REDUCING AFLATOXIN B1 TOXICITY IN DRIED GRAPE SAMPLES by H. Z. Hussein, E. K. Abdul-Karim, M. I. Alghannoum

“…The isolation results the fungus A. flavus was the most frequent and appeared in the samples, reaching 54.5 and 44.4%, respectively. …”
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Chronological Levels of As, Pd, V, and Sr in 356-year-old Pinus nigra Annual Rings in Northern Türkiye by İsmail Koç

“…Contrary to expectations, the results did not show a correlation between increasing air pollution in recent decades and the concentrations of these metals in annual rings. Thus, P. nigra wood appears unsuitable as a biomonitor for tracking long-term heavy metal pollution in air. …”
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Acalypha wilkesiana by Edward F. Gilman

“…The dense, much-branched growth habit creates a full shape, but plants occasionally need shaping to maintain a neat appearance. The upright growth of copperleaf can reach 10 to 15 feet in height, making it well-suited to use as an accent in mixed shrubbery borders. …”
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Evaluation of some properties of elastomeric dental impression materials after disinfection by Jawad Mohammed Mikaeel, Mustafa Kamil Namuq

“…Results: The results of this study showed a significant difference of the dimensions between immediate and 48 hours after disinfection P<0.05 with the maximum change (1.5%) appeared with vinyl polysiloxane material when immersed in sodium hypochlorite for 10 minutes and stored for 48 hours, but this change was acceptable by the ADA. …”
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COVID-19 Outbreak: Routes of Transmission, Precautions, and Economic Impact on Dentistry-A Review Article by Mohammed Tahir Abdalqadir

“…In late 2019, a novel coronavirus appeared in Wuhan, Hubei province, China, and then rapidly spread around the world. …”
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Library Website as a Tool for Information Dissemination for Students At Mbarara University Of Science And Technology. by Kyomugisha, Adrine

“…Regarding challenges, students reported limited internet access, which hampers their ability to utilize online resources, search the catalog, or download materials from the website. …”
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Investigating the Factors that Affect Structural Integrity of Buildings Under Construction in Kampala Region. by Tusingwire, Moses

“…However, this in Uganda is being challenged with poor integrity of structures leading to failure and collapse of many structures. This collapse happens 6 (Six) times on average yearly prompting the need to research on what causes this loss of structural integrity. …”
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Early tolerance and late persistence as alternative drug responses in cancer by Simona Punzi, Davide Cittaro, Guido Gatti, Gemma Crupi, Oronza A. Botrugno, Antonino Alex Cartalemi, Alon Gutfreund, Caterina Oneto, Valentina Giansanti, Chiara Battistini, Giovanni Santacatterina, Lucrezia Patruno, Ilaria Villanti, Martina Palumbo, Daniel J. Laverty, Francesca Giannese, Alex Graudenzi, Giulio Caravagna, Marco Antoniotti, Zachary Nagel, Ugo Cavallaro, Luisa Lanfrancone, Timothy A. Yap, Giulio Draetta, Nathalie Balaban, Giovanni Tonon

“…The central regulator of mitophagy PINK1 drives this reduction in DNA repair via the cytoplasmic relocalization of the cell identity master HNF4A, thus hampering HNF4A transcriptional activation of DNA repair genes. …”
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Multi-locus CRISPRi targeting with a single truncated guide RNA by Molly M. Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J. Cruz, Yanjing V. Liu, Nauman Javed, Salvador Casaní-Galdón, Jason D. Buenrostro, Charles B. Epstein, Eugenio Mattei, John G. Doench, Bradley E. Bernstein, Noam Shoresh, Fadi J. Najm

“…We screen over 13,000 possible CTCF binding sites with 24 guides at 10 nucleotides in spacer length. These truncated guides direct CRISPRi-mediated deposition of repressive H3K9me3 marks and disrupt transcription factor binding at most sequence match target sites. …”
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Effect of Low Dose Aspirin in Low Risk Pregnant Ladies with Abnormal Uterine Artery Doppler Results, and the Evaluation of Maternal and Fetal outcomes: A Randomized Clinical Trial by Parzhin Jalal Ali, Chro Najmaddin Fattah

“…Conclusion: Doppler study of the uterine artery at 16 weeks or higher in low risk pregnant women appears to be useful as a screening test and low dose of aspirin therapy at early stage of pregnancy will decrease the incidence of preeclampsia.   …”
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Ecotoxicological evaluation in aquaculture in state park Serra do Mar-SP, Nucleo Itariru by Bruno Galvão de Campos, Denis Moledo de Souza Abessa, Mauro Cornacchioni Lopes, Newton José Rodrigues da Silva

“…However, farming tanks appeared to function as biological filters, due to the occurrence of physical, chemical and biological (microbial degradation) processes, producing non toxic effluents. …”
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Hepatoprotective effects of propolis ethanol extract on D-galactose-induced aging mice: A metabolomics and transcriptomics analysis focusing on insulin resistance pathways by Jinjia Liu, Songhao Tian, Jixiang Wang, Qing Sang, Wenting Su, Jinqiang Wu, Fenglei Zai

“…Mechanistically, PEE appeared to exert hepatoprotective effects by modulating the insulin resistance pathway, particularly through the PI3K-AKT/PP1 signaling axis, thereby enhancing glycogen synthesis in the damaged liver. …”
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Eastern equine encephalitis virus: Pathogenesis, immune response, and clinical manifestations by Bhumika Parashar, Rishabha Malviya, Sathvik Belagodu Sridhar, Tarun Wadhwa, Sirajunisa Talath, Javedh Shareef

“…Although rare, infections in humans and horses are associated with high mortality rates and severe neurological effects. Climate change appears to be increasing the spread of this virus. …”
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