Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential by Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu, Yu-ming Xu, Yu-ming Xu

“…Based on the available studies, we propose that targeting PGC-1α could serve as a promising novel therapeutic strategy for one or more neurological diseases.…”
Get full text

Studying The Mental Health Status Of Nurses In The Era Of Covid-19 (A Rapid Review Study In Iran) by Mahshid Zare, Zahra Kavosi, Sedighe Sadat Tabatabaei Far

“…Several factors, such as demographic variables and the specific departments where nurses served, were identified as influencing their mental health. …”
Get full text

Ankrd1 as a potential biomarker for the transition from acute kidney injury to chronic kidney disease by Hailin Li, Lemei Hu, Changqing Zheng, Ying Kong, Ming Liang, Quhuan Li

“…The expression levels of hub genes were validated using the bulk RNA-seq data (GSE98622) and further confirmed through RT-qPCR and immunohistochemical analysis in ischemia-reperfusion injury (uIRI) mice. …”
Get full text

Optimizing a modified cetyltrimethylammonium bromide protocol for fungal DNA extraction: Insights from multilocus gene amplification by Dar Gulam Jeelani, Nazir Ruqeya, Wani Shakil A., Farooq Saleem, Aziz Tariq, Albekairi Thamer H.

“…Based on anticipated gDNA yield and quality, extraction time, cost effectiveness, successful amplification, and waste management, our findings serve as a guide for selecting techniques of gDNA extraction from fungal species. …”
Get full text

Systematic analysis of the pharmacogenomics landscape towards clinical implementation of precision therapeutics in Greece by George P. Patrinos, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Maria Skokou, Zoe Kordou, Eirini Sparaki, Margarita Skaraki, Christina Mitropoulou

“…This study would not only provide the foundations for expediting the adoption of PGx in clinical reality in Greece but can also serve as a paradigm for replicating future studies in other European countries, to expand on previously available pilot studies.…”
Get full text

From Bench to Brain: A Metadata-driven Approach to Research Data Management in a Collaborative Neuroscientific Research Center by Marlene Pacharra, Tobias Otto, Nina Olivia Caroline Winter

“…The practice paper outlines the approach of the interdisciplinary Collaborative Research Center (CRC) 1280 ‘Extinction Learning’ with 81 researchers from biology, psychology, medicine, and computational neuroscience across four different institutions. This framework can serve as a transferable model for other collaborative research initiatives lacking predefined metadata schemas or repositories. …”
Get full text

TCAD analysis of the high-temperature reverse-bias stress on AlGaN/GaN HEMTs by Franco Ercolano, Luigi Balestra, Sebastian Krause, Stefano Leone, Isabel Streicher, Patrik Waltereit, Michael Dammann, Susanna Reggiani

“…This calibration step ensured an accurate representation of the device electrical performance, serving as a solid foundation for further TCAD stress analysis. …”
Get full text

Left Atrial Appendage Occlusion: Expanding Indications and New Developments by Grant W. Reed, MD, MSc, Shady Nakhla, MD, Rhonda Miyasaka, MD, Serge Harb, MD, Mohamed Kanj, MD, Ousamma Wazni, MD, Samir R. Kapadia, MD, Amar Krishnaswamy, MD

“…As the evidence supporting LAAO continues to evolve, this review will serve as a primer on the recent and upcoming advances in device technology and management strategies positioned to further push LAAO forward into the future.…”
Get full text

The Adoption of Technology Acceptance Model in E-commerce with Artificial Intelligence as a Mediator by Aram Massoudi, Muslim N. Zaidan, Azwar Qasim Agha

“…However, there has been little research conducted on how consumers adapt to and utilize artificial intelligence powered online stores. This study seeks to examine the connection between the elements of the Technology Acceptance Model and E-commerce, with artificial intelligence serving as a mediator in this relationship. …”
Get full text

The importance of transportation networks and urban services in assessing the functional balance of human settlements: The case of the Makkah region in Saudi Arabia by Amani Derbali, Salma Dwidar, Amal Abdelsattar, Donia Abdelgawad, Abdallah Farhi

“…We suggested a participatory redistributive approach aiming to foster engagement of marginalized centers and attend to urban–rural linkages, which can serve the urban goals of the 2030 vision through a well-established urban infrastructure and equitable access to services for the regional population.…”
Get full text

Looking outside the box with a pathology aware AI approach for analyzing OCT retinal images in Stargardt disease by Parisa Khateri, Tiana Koottungal, Damon Wong, Rupert W. Strauss, Lucas Janeschitz-Kriegl, Maximilian Pfau, Leopold Schmetterer, Hendrik P. N. Scholl

“…Optical Coherence Tomography (OCT) provides high-resolution retinal images, serving as a valuable tool for deriving potential outcome measures, such as retinal thickness. …”
Get full text

Research on Correlations of lncRNA ST7-AS1 with Progression and Therapeutic Targets of Esophageal Cancer by Xiao Lin, Sijia Sun, JiWen Zhang, Yan Cai, Quan Cheng

“…Conclusion: Knockdown of ST7-AS1 may alleviate tumor progression by targeting miR-4262, indicating that ST7-AS1 is anticipated to serve as a therapeutic biomarker for patients with esophageal cancer.…”
Get full text

Optimal WSN Deployment to Measure Air Quality in Dynamic Multi-Source Dispersion Scenarios: A Case Study in Arequipa by Alexander Hilario-Tacuri, Alberth Tamo, Marco Pinares-Mamani, Walter Butron, Romel Jimenez

“…The first problem enhances pollution sensing capabilities, the second maximizes the population served, aiming to ensure that air quality information is accessible to as many residents as possible, and the third one prioritizes the needs of vulnerable groups. …”
Get full text

Evaluation of the Effect of Five-Finger Shoes on Calf Muscle Electromyography Activity in Novice Runners by Behrouz Hajilou, Elaheh Azadian, Sara Sadeghi, Rounak Mohammadi Sasan

“…Objective The foot is the most distal part of the moving human body and serves as the sole point of contact with the ground, transmitting significant forces from the ground to the foot. …”
Get full text

Frk positively regulates innate antiviral immunity by phosphorylating TBK1 by Xiaomei Zhang, Ying You, Tingrong Xiong, Tingrong Xiong, Xiaokai Zhang, Haibo Wang, Jinxia Geng, Miao Wang, Yanyan Xu, Shanshan Gao, Shanshan Gao, Xiaoyan Wu, Yue Zheng, Xianhua Wen, Haoyu Yang, Yu Wang, Yu Wang, Xiaohua Wen, Congcong Zhao

“…Type I interferons (IFN-I) are crucial for the initial defense against viral infections. TBK1 serves as a key regulator in the production of IFN-I, with its phosphorylation being essential for the regulation of its activity. …”
Get full text

Forecasting Dissolved Organic Carbon Levels Utilizing Metaheuristic Optimization with Artificial Intelligence Techniques by Peng He, Chengjun Ma

“…These values for the test data set are calculated as 0.999754, 0.1625, and 2×10-4, respectively. …”
Get full text

Second-generation laryngeal mask airway as an alternative to endotracheal tube in prolonged laparoscopic abdominal surgery: a comparative analysis of intraoperative gas exchanges by Sukhee Park, Ja Eun Lee, Gyu Sung Choi, Jong Man Kim, Justin Sangwook Ko, Duck Hwan Choi, Gaab Soo Kim

“…Conclusion: During prolonged laparoscopic abdominal surgery, second-generation LMA facilitates adequate intraoperative gas exchange and may serve as an alternative to ETT.…”
Get full text

Scaling to new heights: methodological insights for uplifting research on grassroots digital innovation by Paolo Gerli, Fabio Neves da Rocha, Luca Mora

“…These innovations played a crucial role in mitigating the impact of lockdown measures, specifically serving the needs of communities often neglected by commercial offerings from large tech companies. …”
Get full text

Steganography in Game Actions by Ching-Chun Chang, Isao Echizen

“…Each agent, acting as an encoder, learns a policy to disguise the very existence of hidden messages within actions seemingly directed toward innocent objectives. Meanwhile, an observer, serving as a decoder, learns to associate behavioural patterns with their respective agents despite their dynamic nature, thereby unveiling the hidden messages. …”
Get full text