Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…Remarkably, in a clinically relevant mouse model resistant to systemic ICB, intratumoral VVGM-αCTLA-4 synergized with αPD-1 to reject cold tumors.Conclusion Our findings demonstrate in vivo proof of concept for spatial restriction of Treg depletion-optimized immune checkpoint blocking, vectorized αCTLA-4 as a highly effective and safe strategy to target CTLA-4. …”
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Analisa Strategi Teknologi Informasi Pemasaran UKM Kuliner di Media Sosial Menggunakan Metode SWOT by Fahmi Ajismanto, Andika Widyanto

“…Create hashtags or keywords that are relevant to the products offered, build a brand image (Personal Branding), and create interesting advertising content (S1, T1, T3). …”
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Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…HAQ alone achieves about 40% of the performance improvements seen with SPACE images as input, allowing for fast and accurate, fully automated detection of small (< 1 cm) BMs. Relevance statement Training with higher-quality annotations, created using the SPACE sequence, improves the detection and delineation sensitivity of DL methods for the detection of brain metastases (BMs)on MPRAGE images. …”
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Alte in Vilnius herausgegebene Kalender (16.-17. Jh). Zusamrnenfassung by Stasė Matulaitytė

“…Vollständige Exemplare sind auch in Bibliotheken Polens noch nicht gefunden worden. Informationen darüber finden sich nur in bibliographischen Quellen. …”
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Pemodelan Kausal Faktor-Faktor Beban Keluarga dalam Merawat Pasien Kanker Menggunakan Algoritma S3C-Latent by Rizki Surtiyan Surya, Christantie Effendy, Ridho Rahmadi

“…Dalam merawat pasien dengan penyakit kronis, bukan hanya pasien tetapi kesejahteraan dan kualitas hidup family caregiver juga penting. Oleh karena itu sangat penting untuk mengetahui bagaimana beban family caregiver dan faktor-faktor yang mempengaruhi beban keluarga dalam merawat pasien.  …”
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Penerapan Metode K-Means Clustering dan Simple Moving Average untuk Memprediksi Jenis Penyakit di Provinsi Jawa Timur by Shynta Ayu Dwi Darmawan, Karmilasari

“…The research objectives are to cluster cases into relevant and identifiable groups, predict trends in disease cases based on historical data in each region from year to year, build a website-based system as a medium for implementing predictions and clustering. …”
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GIS-based modeling and analytical approaches for groundwater quality suitability for different purposes in the Egyptian Nile Valley, a case study in Wadi Qena by Hanaa A. Megahed, Abd El-Hay A. Farrag, Amira A. Mohamed, Mahmoud H. Darwish, Mohamed A. E. AbdelRahman, Heba El-Bagoury, Paola D’Antonio, Antonio Scopa, Mansour A. A. Saad

“…Comparative analysis against standard quality guidelines indicated that most groundwater samples exceeded safe levels for major constituents, TDS, TH, pH, and EC, making them unsuitable for drinking but potentially suitable for irrigation of high salt-tolerant crops. The results of hydrochemical analysis maps and analytical diagrams of groundwater samples revealed that the water was characterized by natural to alkali and the total dissolved solids (TDS) increasing from the Nubian to Quaternary and high ranges of sodium absorption (SAR). …”
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Network Automation pada Beberapa Perangkat Router Menggunakan Pemrograman Python by Setiya Nugroho, Bambang Pujiarto

“…Aplikasi telah diuji coba untuk mengkonfigurasi tiga buah roter Cisco dan tugas buah router Mikrotik secara bersamaan. …”
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Microbial community succession characteristics in an anaerobic baffled reactor during phenol gradient acclimation by Yuan LI, Chunmei YU, Daqiang CANG

“…However, phenol in polluted effluents can destabilize AD performance. To increase phenol tolerance to AD microbial communities, stepwise acclimatization is commonly employed. …”
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Construct validation of a complete postpartum health and well-being patient reported outcome measure: prospective cohort studyAJOG Global Reports at a Glance by Laura J. O'Byrne, BMBS, MSc, PhD, Gillian M. Maher, PhD, Jill M. Mitchell, MB, BCh, BAO, Ali S Khashan, PhD, Richard M. Greene, MB, BCh, BAO, John P. Browne, PhD, Fergus P. McCarthy, MB, BCh, BAO, PhD

“…These findings suggest the need for a more clinically relevant postpartum PROM.…”
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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…Objectives To assess the beneficial and harmful effects of duloxetine versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder.Design Systematic review with meta-analysis and trial sequential analysis of randomised trials.Data sources Cochrane Central Register of Controlled Trials, MEDLINE, Embase, PsycINFO and other relevant databases up until January 2023. We requested clinical study reports from 36 competent authorities.Eligibility criteria for selecting studies All randomised clinical trials comparing duloxetine versus placebo, ‘active placebo’ or no intervention, irrespective of publication type, publication status, publication year and language for treatment of major depressive disorder in adults.Data extraction and synthesis Five authors in pairs extracted data using a standardised data extraction sheet. …”
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Identification and Spatial Mapping of Locality of Streetscapes in Shanghai Hengfu Historic and Cultural Preservation Area by Yuhan SHAO, Sinan YIN, Dongbo MA, Yuting YIN

“…The research proposes that streetscape locality should include the physical, social, historical and aesthetic aspects, with relevant indicators being identified for the four aspects respectively. …”
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Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, I. . A.s. Trukhmanov, Ye. K. Baranskaya, O. B. Dronova, O. V. Zayratyants, R. G. Sayfutdinov, A. A. Sheptulin, T. L. Lapina, S. S. Pirogov, Yu. A. Kucheryavy, O. A. Storonova, D. N. Andreyev

“…Prokinetic drugs promote recovery of a normal physiological state of the esophagus, controlling the pathogenic mechanisms of GERD, reducing the number of transient lower esophageal sphincter relaxations and improving esophageal clearance due to stimulation of the lower gastrointestinal motor function. …”
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A key technology for synergistic backfilling of coal-based solid waste and high-salinity wastewater by Shuning DONG, Shujiang YU, Xingling DONG, Buqin ZHANG, Xiaoming GUO, Xiaodong WANG, Kai WANG, Shibin ZHU, Boqiang WU, Lei LIU

“…Therefore, the technology for synergistic treatment of coal-based solid waste and mine high-salinity water can meet the relevant standards in the assessment of mechanical properties and environmental stability. …”
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Editorial by Jörg Tremmel, Marisa dos Reis, Joseph Burke, Raphaelle Schwarzberg (†)

“…In this piece, Sébastien Jodoin, a legal research fellow with the Centre for International Sustainable Development Law, identifies relevant aspects of the Rome Statute that can be used to protect future generations through the harm committed to present individuals as members of groups. …”
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Differential management and associations of dyslipidaemia and hypertension by glycaemic status in urban South Africans by N Peer, L Kotzé-Hörstmann, J Hill, A-P Kengne

“…Participants at high risk for diabetes but without KD underwent oral glucose tolerance tests; those who were subsequently classified as NDD or normoglycaemic were included in this study. …”
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Serum Ferritin Levels in Pregnancy and Their Association with Gestational Diabetes Mellitus: A Prospective Longitudinal Study by Qin Z, Du Y, Wang Z, Qin X, Wu H, Yu X, Zhao C, Mo L, Huang B

“…We measured SF levels in the1st, 2nd, and 3rd trimesters, as well as plasma malondialdehyde (MDA) and C-reactive protein (CRP) in the 1st trimester, blood glucose levels in the oral glucose tolerance test (OGTT), and glycosylated hemoglobin (HbA1c) in the 2nd trimester. …”
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Anatomy, histology, and morphology of fish gills in relation to feeding habits: a comparative review of marine and freshwater species by Mohamed A. M. Alsafy, Hanan H. Abd-Elhafeez, Ahmed M. Rashwan, Atef Erasha, Safwat Ali, Samir A. A. El-Gendy

“…The lymph space contains many types of immunological cells, including lymphocytes, granular leukocytes, and rodlet cells. The gill arch comprises sensory structures known as neuromasts and hyaline cartilaginous support. …”
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Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…Rafaela Hillerbrand (RWTH Aachen, Germany) addresses the question of how epistemic uncertainties are of relevance for practical decision making. It is shown that the precautionary principle fails to adequately deal with uncertainties as they arise in climate modeling. …”
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Life Cycle Assessment (LCA) of Carbon Emission of Garden Pavement by Peiyong WANG, Ruixing LU

“…Firstly, the carbon emission accounting model is constructed based on the life cycle of garden pavement projects: the carbon emission factor method is adopted to calculate carbon emissions in such stages as material production, construction and transportation, maintenance and material recycling of garden pavement projects, during which the specific calculation parameters are mainly derived from the engineering practical experience, national standards and relevant research data. Secondly, after calculating the total amount of carbon emissions released during the life cycle of each type of garden pavement, the data are normalized by “carbon emission per square meter per year”, and the research results are obtained. …”
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