Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…The median onset time for AEs related to upadacitinib was 41.00 days (interquartile range [IQR] 10–141.5 days), with the majority occurring within 3 months of treatment initiation (n = 269, 66.09%), particularly in the first month (n = 171, 42.01%).ConclusionOur findings affirm clinical observations and reveal potential new AE signals for upadacitinib, underscoring the need for prospective clinical studies to verify these results and clarify their clinical relevance. This study contributes valuable evidence for ongoing safety evaluations of upadacitinib.…”
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Association between exposure to ambient air pollutants and metabolic syndrome in the vicinity of the Taklamakan Desert by Zhe Wang, Weidong Ji, Yushan Wang, Lin Li, Kai Wang, Hongze Liu, Yining Yang, Yi Zhou

“…To investigate the association between air pollutants and the prevalence of MetS and its components, Spatial Generalized Linear Mixed Models were applied, with adjustments made for relevant covariates. Additional stratified and sensitivity analyses were conducted to further investigate these relationships. …”
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Incremental Lifetime Cancer Risk of PAHs in PM2.5 via Local Emissions and Long-Range Transport during Winter by Shahzada Amani Room, Chia En Lin, Shih Yu Pan, Ta Chih Hsiao, Charles C.-K. Chou, Kai Hsien Chi

“…The incremental lifetime cancer risk (ILCR) of Cr6+ was higher in metal (2.60 × 10‒5) but did not exceed its tolerable limits.…”
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Relative Importance of Mode of Administration in Treatment Preferences among Plaque Psoriasis Patients in the United States by Steven R. Feldman, Anders Holmen Moeller, Sandra T. Erntoft Idemyr, Juan Marcos González

“…We evaluated patient preferences for attributes of psoriasis treatments, including efficacy, tolerability, and mode and frequency of administration. …”
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Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation by Eliot G. Peyster, MD, MSc, Cai Yuan, PhD, Sara Arabyarmohammadi, PhD, Priti Lal, MD, Michael D. Feldman, MD, PhD, Pingfu Fu, PhD, Kenneth B. Margulies, MD, MS, Anant Madabhushi, PhD, FAIMBE, FIEEE, FNAI

“…Computational pathology analysis of allograft stroma yields translationally relevant biomarkers, identifying accelerated remodeling before adverse outcomes occur. …”
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Design and Fabrication of a Car Sports Rims. by Nsimbe Laban

“…A permanent mould is however recommended for this study so as to give a better surface finish and better dimensional tolerance. Low pressure casting is recommended that is by filling the mould cavity from the bottom so as to prevent the risk of air bubbles entering into the mould cavity hence minimizing casting defects. …”
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Neural tube defects in a war-torn Tigray regional state of Ethiopia: a retrospective study of 54,626 deliveries by Birhane Alem Berihu, Afework Mulugeta, Tony Magana, Masresha Tessema, Tafere Gebreegziabher, Yibrah Berhe, Abadi Leul Welderufael, Hayelom Kebede Mekonen

“…Data were collected from hospital records, focusing on cases of neural tube defects (NTDs) and relevant maternal and neonatal characteristics. This retrospective analysis aimed to identify the prevalence of NTDs, as well as factors contributing to their occurrence. …”
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Effectiveness and safety of percutaneous endoscopic debridement and drainage for spinal infections: a systematic review and meta-analysis by Guozhong Zhou, Xiaorong Liu, Zhi Liang, Xuesong Chen, Chao Song

“…Cohort studies on SI treated with PEDD, reporting relevant effectiveness or safety outcomes. We assessed study quality using a modified Newcastle–Ottawa Scale and conducted a random-effects meta-analysis to calculate pooled results. …”
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ECONOMIC ASPECT OF CRIMINAL LAW COUNTERACTION TO JUSTIFICATION OF ARMED AGGRESSION AGAINST UKRAINE: RISKS FOR THE STATE BUDGET IN THE LIGHT OF THE PRACTICE OF THE EUROPEAN COURT OF... by Andrii Lapkin, Daryna Yevtieieva, Daria Kukovynets

“…In this regard, the objective of the present study is to predict the potential financial compensation that may be granted by the European Court of Human Rights (hereinafter – ECHR) in such cases, and the ensuing financial implications for the state budget of Ukraine, which will assume the financial responsibility for the relevant expenditures. In order to achieve this objective, the compliance of Art. 4362 of the CCU by the provisions of Articles 3, 5, 8 and 10 of the Convention and the practice of the ECHR was checked. …”
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Unfolding insights about resilience and its coping strategies by medical academics and healthcare professionals at their workplaces: a thematic qualitative analysis by Salman Yousuf Guraya, Jacqueline Maria Dias, Mohamed Ahmed Eladl, Ayah Mohammad Rajai Rustom, Fatima Audi Saleem Alalawi, Majid Hassan Saleh Alhammadi, Yusra Ahmed Mohammed Ahmed, Amna Ali Omran Taryam Al Shamsi, Sarah Juman Bilalaga, Alfred Nicholson, Hani Malik, Shaista Salman Guraya

“…The guide was validated by content experts and was piloted on a small group of MHAs of the University of Sharjah (UoS) and HCPs from different hospitals of the United Arab Emirates to test its relevance, internal consistency, and inter-observer validity. …”
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Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation by Tristan Whitmarsh, Wei Cope, Julia Carmona-Bozo, Roido Manavaki, Stephen-John Sammut, Ramona Woitek, Elena Provenzano, Emma L. Brown, Sarah E. Bohndiek, Ferdia A. Gallagher, Carlos Caldas, Fiona J. Gilbert, Florian Markowetz

“…Furthermore, the correlation with tumour grade highlights the clinical relevance of our approach. These findings suggest that our method could have substantial implications for improving prognostic assessments and personalizing therapeutic strategies in breast cancer treatment.…”
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Examining the Effects of Construction Project Delays on Costs from the Perspective of Stakeholders Using a System Dynamics Approach: Insights from a Commercial Complex Project in Q... by Amirhosein Saffarinia, Hamidreza Yazdani

“…Due to the limitations of the case study, the number of project delay effects was reduced. Relevant variables were defined and incorporated into the System Dynamics model for simulation. …”
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The Consequences of Digital Storytelling-Based Customer Engagement in Social Media for the Tourism Industry by Meysam Ahmadnia, Taher Roshandel Arbatani, Abbas Nargesian, Seyed Mahdi Sharifi, Khabat Derafshi

“…Management personnel can mitigate and eliminate adverse influences by recognizing and addressing the aftermath of negative customer interactions. By making relevant adjustments to strategies and adopting suitable methodologies, they can avoid potential harm and negative impacts on marketing efforts and brand integrity. …”
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Enhancing Semi-Supervised Learning With Concept Drift Detection and Self-Training: A Study on Classifier Diversity and Performance by Jose L. M. Perez, Roberto S. M. Barros, Silas G. T. C. Santos

“…Algorithms exposed to a larger and more relevant amount of training data tend to perform better. …”
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Survey of medication history of patients with stroke after discharge from an acute hospital ward: a case series study by Yuko Fukuda, Risa Ito, Misaki Kakihana, Tsutomu Takahashi, Tetsuji Kanemoto, Toshiyuki Sahara, Masahiko Tsujikawa, Mitsuko Onda

“…We extracted and assessed prescription continuity and carefully examined clinically relevant discrepancies after comparing the discharge prescription with that at the first outpatient visit. …”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…This meta-analysis aims to assess whether the integration of HAIC with lenvatinib and PD-1 inhibitors (referred to as the HAIC-L-P group) leads to better treatment effectiveness and security compared to lenvatinib and PD-1 inhibitors alone (L-P group) in uHCC.MethodsAn exhaustive search of the literature was conducted, including PubMed, the Cochrane Library, Embase, ClinicalTrials.gov, and Web of Science, from the start of each database until September 2024, to ensure a thorough and up-to-date compilation of relevant studies. Extract data on outcome measures such as overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs). …”
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The AFFIRM Framework for gender-affirming care: qualitative findings from the Transgender and Gender Diverse Health Equity Study by Meg Quint, Schuyler Bailar, Alexis Miranda, Shalender Bhasin, Devin O’Brien-Coon, Sari L. Reisner

“…Analyses were conducted using immersion crystallization and reflexive thematic analysis; interview transcripts were double coded by two coders. …”
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Ethics and end-of-life in pediatric and neonatal ICUs: a systematic review of recommendations by Diana Špoljar, Sunčana Janković, Dina Vrkić, Geraldine McNamara, Marko Ćurković, Milivoj Novak, Boris Filipović-Grčić, Stefan Grosek, Chris Gastmans, Bert Gordijn, Ana Borovečki

“…Methods Systematic search was limited to the period from 1990 to 2023 and encompassed 6 bibliographic databases (Medline, PubMed, CINAHL, APA PsycINFO, Web of Science Core Collection, and Scopus), grey literature sources and relevant reference lists. The international, national, or institutional papers providing expert guidelines and recommendations comprehensively addressing either withholding/withdrawing of life sustaining treatment, palliative care, and/or intentional life terminating actions in NICUs and PICUs were included in analysis. …”
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Healthcare trajectories of aging individuals during their last year of life: application of process mining methods to administrative health databases by Delphine Bosson-Rieutort, Alexandra Langford-Avelar, Juliette Duc, Benjamin Dalmas

“…Conclusion Despite some limitations related to data and visual limitations, process mining seems to be a method that is both relevant and simple to implement. It provides a visual representation of the processes recorded in various health system databases and allows for the visualization of the different trajectories of healthcare utilization.…”
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Pengembangan Aplikasi Berlatih Membaca Cepat Berbahasa Inggris Berbasis Progressive Web App dengan Metode Prototyping by Muhammad Fajar Alfath, Lutfi Fanani, Agi Putra Kharisma

“…A survey conducted among 30 students explored their engagement in speed reading and its relevance to English. Surprisingly, 76.7% of participants were unaware of their reading speed, while 56.7% acknowledged frequent reading of English texts. …”
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