Comprehensive evaluation of the nutritional value and contaminants of alfalfa (Medicago sativa L.) in China by Xiaoyan Zhu, Xiaoyan Zhu, Xiaoyan Zhu, Wenxue Chen, Mengyao Li, Boshuai Liu, Boshuai Liu, Boshuai Liu, Shumin Zhao, Menglin Hu, Jiajing Li, Defeng Li, Defeng Li, Defeng Li, Yinghua Shi, Yinghua Shi, Yinghua Shi, Hao Sun, Hao Sun, Hao Sun, Chengzhang Wang, Chengzhang Wang, Chengzhang Wang

“…IntroductionAlfalfa is used as a feed source for animals and plays an important role in animal nutrition. Nutritional value analysis and contamination evaluation are essential for sustainable utilisation to ensure the quality and safety of alfalfa.AimWe aimed to evaluate the nutritional value and safety of alfalfa in five major regions in China—the Northeast Plain (NP), Inner Mongolia Plateau (IMP), Northwest Desert Oasis (NO), Loess Plateau (LP), and Huanghuaihai Plain (HP).MethodsNinety-five samples representing 44 large-scale pratacultural companies were collected and analysed.ResultsThe average nutritional values of alfalfa hay were 16.43% crude protein (CP), 44.01% neutral detergent fibre (NDF), 33.22% acid detergent fibre (ADF), 10.78% crude ash (Ash), and 91.90% dry matter (DM), which were better in the NO and IMP areas; in particular, the α-linolenic acid value of alfalfa was the highest in the IMP area (p < 0.05). …”
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Digitalisasi Model Sistem Akuntansi Terintegrasi Bagi Usaha Bersama Simpan Pinjam di Kota Kupang by Yustina Alfira Nay, Selfiana Goetha, Maria Goreti Malut

“…Joint Savings and Loans Business (UBSP) has an important role as an investor, especially for housewives who do not have a fixed income. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…However, the mechanism underlying the effects of SSA in prostate cancer treatment remains elusive.MethodsIn this study, a network pharmacology approach was applied to identify relevant targets from drug- and disease-related databases, and intersections were analyzed using Venny2.1 to construct a Protein-Protein interaction (PPI) interaction network. …”
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The geographical variation in grassland forage quality on the eastern Qinghai-Tibet Plateau is driven mainly by climate by Shulan Wu, Xiaotao Lü, Qinghua Liu, Erke Wuda, Liu Li, Chunzhang Zhao, Juanjuan Huang, Shuang Li, Youbang Hu, Wenzhi Du, Hewen Li, Chaoqun Chen, Lin Luo, Ali Raza, Chunying Yin

“…Conclusions This study highlights the role of climate in driving the variation of forage quality in the alpine grasslands. …”
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Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy by Erin L. Fee, Haruo Usuda, Sean W. D. Carter, Hideyuki Ikeda, Tsukasa Takahashi, Yuki Takahashi, Yusaku Kumagai, Michael W. Clarke, Demelza J. Ireland, John P. Newnham, Masatoshi Saito, Sebastian E. Illanes, Binny Priya Sesurajan, Liang Shen, Mahesh A. Choolani, Gokce Oguz, Adaikalavan Ramasamy, Sara Ritchie, Andrew Ritchie, Alan H. Jobe, Matthew W. Kemp

“…These data suggest a potential heritable role in determining ANS responsiveness.…”
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Balanced displacement methods and effect evaluation of heterogeneous combination flooding in different reservoirs by Dejun WU, Jian HOU, Lijie LIU, Kang ZHOU, Zhibin AN

“…Heterogeneous combination flooding further played a role in conformance control and oil displacement at different layers, enhancing the sweep effect and improving oil displacement efficiency, effectively extracting the remaining oil controlled by the interbeds. …”
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The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium by Coral Pardo-Esté, Coral Pardo-Esté, Francisca Urbina, Nicolas Aviles, Nicolas Pacheco, Alan Briones, Carolina Cabezas, Vicente Rojas, Valentina Pavez, Yoelvis Sulbaran-Bracho, Yoelvis Sulbaran-Bracho, Alejandro A. Hidalgo, Juan Castro-Severyn, Juan Castro-Severyn, Claudia P. Saavedra

“…We also infected murine neutrophils to evaluate the expression levels of relevant genes related to the resistance and infection process while facing ROS-related stress. …”
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Machine learning analysis of pathological images to predict 1-year progression-free survival of immunotherapy in patients with small-cell lung cancer by Hirotaka Matsumoto, Hiroaki Akamatsu, Nobuyuki Yamamoto, Yuki Sato, Daichi Fujimoto, Yoshihiko Taniguchi, Motohiro Tamiya, Yasuhiro Koh, Junya Fukuoka, Hisashi Tanaka, Naoki Furuya, Ryota Shibaki, Tsukasa Nozawa, Akira Sano, Yuka Kitamura, Takashi Kijima, Toshihide Yokoyama, Satoru Miura, Akito Hata, Jun Sugisaka

“…The machine learning analysis of the TIME had better accuracy than the human count evaluations (AUC of human count, CD8-positive lymphocyte: 0.681, FoxP3-positive lymphocytes: 0.626, PD-L1 score: 0.567).Conclusions The spatial analysis of the TIME using machine learning predicted the immunotherapy efficacy in patients with SCLC, thus supporting its role as an immunotherapy biomarker.…”
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DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells by Ignacio Melero, Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel

“…DNGR-1 has been involved in both cross-presentation of dead cell-associated antigens and processes of disease tolerance, but its role in antitumor immunity has not been clarified yet.Methods B16 and MC38 tumor cell lines were inoculated subcutaneously into wild-type (WT) and DNGR-1-deficient mice. …”
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Perancangan Perangkat Audit Internal untuk Sistem Keamanan Informasi pada Organisasi XYZ by Arif Rahman Hakim, Rizky Aditya Pratama Wijaya

“…In other hand, this audit tool plays an important role in determining vulnerability of the systems. …”
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Designing a Model for Implementing Digital Banking Policy Based on Using Big Data in Iranian Banking Industry by Rahmatollah Gholipour Souteh, Hamed Esmaeili Rad

“…The research emphasizes the pivotal role of big data technology, which has received limited attention but has a significant impact on achieving the goals and ensuring the optimal implementation of digital banking. …”
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Analyzing power errors in the optical pumping system of atomic spin comagnetometers by Jiale QUAN, Ye LIU, Longyan MA, Wenfeng FAN, Wei QUAN

“…The spin exchange relaxation-free (SERF) atomic comagnetometer is a highly sensitive device designed to measure rotation rates with extreme precision. …”
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Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…Wheat has a pivotal role in food chains and human diet, and the understanding of its productive and qualitative performance under elevated CO2 (e[CO2]) is therefore a primary research target. …”
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Optimasi Algoritma Naive Bayes dengan Diskritisasi K-Means pada Diagnosis Penyakit Jantung by Nafa Fajriati, Budi Prasetiyo

“…This shows that K-means discretization plays a role in optimizing the performance of the Naïve Bayes algorithm to produce better accuracy. …”
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IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells by Laetitia Camard, Tharshana Stephen, Hanane Yahia-Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, Milena Hasan, Huimeng Wang, Sidonia B.G. Eckle, Anne M. Fourie, Carrie Greving, Barbara Joyce-Shaikh, Raphaelle Parker, Daniel J. Cua, Elisabetta Bianchi, Lars Rogge

“…Summary: IL-23 signaling plays a key role in the pathogenesis of chronic inflammatory and infectious diseases, yet the cellular targets and signaling pathways affected by this cytokine remain poorly understood. …”
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Jaringan Syaraf Tiruan Perambatan Balik untuk Klasifikasi Covid-19 Berbasis Tekstur Menggunakan Orde Pertama Berdasarkan Citra Chest X-Ray by Muchtar Ali Setyo Yudono, Eki Ahmad Zaki Hamidi, Jumadi Jumadi, Abdul Haris Kuspranoto, Aryo De Wibowo Muhammad Sidik

“…Chest radiological imaging such as chest X-ray has a vital role in the early diagnosis of this disease. Due to the low RT-PCR sensitivity of 60%-70%, symptoms can be detected by examining the patient's radiological images even if a negative result is obtained. …”
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Collagen turnover biomarkers to predict outcome of patients with biliary cancer by Leonard Kaps, Muhammed A. Genc, Markus Moehler, Stephan Grabbe, Jörn M. Schattenberg, Detlef Schuppan, Rasmus Sund Pedersen, Morten A. Karsdal, Philipp Mildenberger, Annett Maderer, Nicholas Willumsen

“…Abstract Background The collagen-rich tumor stroma plays a crucial role in biliary tract cancer (BTC). Collagen biomarkers of type I collagen (reC1M), type III collagen (PRO-C3), type IV collagen (C4G), type VIII collagen (PRO-C8), type XI collagen (PRO-C11), type XVII collagen (PRO-C17) and type VIII collagen (TUM) may be used as potential non-invasive biomarkers. …”
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Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease by Liu X, Zhang Y, Wang Y, Xu Y, Xia W, Liu R, Xu S

“…Xing Liu,1,* Yuanyuan Zhang,1,* Yan Wang,2,3,* Yanfeng Xu,2,4,5 Wenhao Xia,2,5– 7 Ruiming Liu,4,5 Shiyue Xu2,5,6 1Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 3Health Management Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 4Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 5National - Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 6NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 7Department of Cardiovascular Medicine, Guangxi Hospital Division of The First Affiliated Hospital of Sun Yat-sen University, Nanning, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shiyue Xu, Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China, Email xushy25@mail.sysu.edu.cn Ruiming Liu, Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China, Email liuruim@mail2.sysu.edu.cnPurpose: Inflammatory activation of immune cells plays a pivotal role in the development of coronary artery diseases (CAD). …”
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Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones by Zhuoqi Zhu, Juanhua Li, Yang Peng, Ning Qin, Jiemei Li, Ying Wei, Biwen Wang, Yunfei Liao, Huaicai Zeng, Lu Cheng, Han Li

“…Mediation analysis evaluated the role of thyroid hormones in the link between metals exposure and cognitive function. …”
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Diagnosis and Treatment of Patients with Autoimmune Hepatitis (Experts’ Agreement) by Yu. G. Sandler, E. V. Vinnitskaya, K. L. Raikhelson, K. V. Ivashkin, S. N. Batskikh, E. N. Aleksandrova, D. T. Abdurakhmanov, D. I. Abdulganieva, I. G. Bakulin, A. O. Bueverov, S. L. Vorobyev, O. A. Gerasimova, A. I. Dolgushina, M. S. Zhuravleva, L. Yu. Ilchenko, V. E. Karev, N. V. Korochanskaya, I. L. Kliaritskaia, N. S. Karnaukhov, S. V. Lapin, M. A. Livzan, M. V. Maevskaya, N. V. Marchenko, T. P. Nekrasova, I. G. Nikitin, A. A. Novikov, R. G. Saifutdinov, E. V. Skazyvaeva, V. E. Syutkin, M. K. Prashnova, T. Yu. Khaymenova, S. G. Khomerik

“…This publication presents the main discussion points of the agreement regarding methods and algorithms for detecting autoantibodies, the role of liver biopsy, revised morphological criteria for AIH, optimized immunosuppressive therapy regimens, updated criteria for assessing the response to therapy.Conclusions. …”
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