Mechanism of warmed malate ringer’s solution in fluid resuscitation in improving the lethal triad of severe trauma by WU Yinyu, SHE Han, SHE Han, DU Yunxia, DU Yunxia

“… ‍Objective‍　‍To explore the role and mechanism of warm malate ringer’s solution (MR) in resuscitation of the lethal triad caused by severe trauma. …”
Get full text

Classification of risk for transmission of vaccine-preventable diseases in Brazilian municipalities: comparative analysis before and after the national movement for vaccination and... by Ana Catarina de Melo Araújo, Thales Philipe Rodrigues da Silva, Janaina Fonseca Almeida Souza, Krishna Mara Rodrigues Freire, Fernanda Penido Matozinhos, Eder Gatti Fernandes

“…Conclusion The study concludes that VC surveillance, in conjunction with the Microplanning for High-Quality Vaccination Activities methodology developed by the Ministry of Health in 2023, played a crucial role in resuming immunization efforts that had been hindered by science denialism and the COVID-19 pandemic.…”
Get full text

Coarse-scale vertical distribution of pelagic amphipods in two contrasting seasons of the southern Gulf of Mexico by Marco Violante-Huerta, Laura Sanvicente-Añorve, Miguel Alatorre-Mendieta, Edlin Guerra-Castro

“…As well, we think that the zooplankton biomass (as a measure of food availability) will play a significant role in regulating the amphipod distribution and abundance. …”
Get full text

Effects of Different Vegetation Restoration Measures on the Disintegration Characteristics of Eroded Degraded Land of Pinus massoniana in Red Soil Region by XI Jie, WU Zehua, LIN Qiang, WU Jieling, ZHANG Liu, ZHOU Shiqi, ZHOU Qin, SUN Lili, ZHA Xuan

“…The tree-shrub-grass furrow model (E3) was more suitable for the treatment of severely degraded P. massoniana land. (2) Soil organic carbon content, total phosphorus content, available phosphorus content, total potassium content, available potassium content, water content and aggregate characteristics were the main influencing factors of soil disintegration. (3) Among various factors affecting soil disintegration, soil geometric mean diameter (GMD) was the main direct influencing factor and played a dominant controlling role. [Conclusion] The size of soil disintegration characteristics under different vegetation restoration measures follows the order of CK > E1 > E2 > E3. …”
Get full text

Guidance and Counselling and Learners’ Discipline in Kasese District: A Case of Selected Government-Aided Secondary Schools in Bukonzo County. by Kule, Samson

“…The study showed that the majority of respondents had positive perceptions towards the role played by guidance and counselling in managing the learners’ discipline. …”
Get full text

The Contribution of the Hotel Industry on Youth Empowerment in Mbarara City: A Case Study of Hotel Triangle Mbarara City. by Owomuhangi, Emmanuel

“…However, when it came to Education playing a crucial role in securing higher-ranking positions 76% of the respondents in agreed just 19% disagreed, and 5% were unsure. …”
Get full text

Guidance and Counselling and Learners’ Discipline in Kasese District: A Case of Selected Government-Aided Secondary Schools in Bukonzo County. by Kule, Samson

“…The study showed that the majority of respondents had positive perceptions towards the role played by guidance and counselling in managing the learners’ discipline. …”
Get full text

Individual Attitude and Youth Unemployment in Nyakagyeme Sub-County Rukungiri District. by Ainamani, Viola

“…The Population of this study comprised unemployed youth, parents, and opinion leaders from Nyakagyeme sub-county who were added up to get 120 because they were the basis of the study and this provided the relevant answers to the study questions. For this to be achieved, the researcher used 92 respondents using Sloven’s formula. …”
Get full text

Increased Intra-Abdominal Pressure as One of the Links in the Pathogenesis of Secondary Diffuse Purulent Peritonitis by D. V. Cherdantsev, O. V. Ovchinnikova, Yu. G. Trofimovich, I. G. Noskov, O. V. Pervova, A. A. Kovalenko

“…To measure this indicator, a Foley catheter inserted into the bladder is used in medical practice. …”
Get full text

Vagal nerve stimulation dynamically alters anxiety-like behavior in rats by A.G. Butler, J.K. Bassi, A.A. Connelly, M.R. Melo, A.M. Allen, S.J. McDougall

“…The VNS current required to elicit the A-fiber-mediated Hering-Breuer Reflex (HBR) was determined for each animal. Based on this threshold, animals received either sham stimulation or VNS at 1.5 (mid-intensity VNS) or 3 (higher-intensity VNS) times the threshold for HBR activation. …”
Get full text

Experimental study on the impact of perpendicular and parallel bedding planes on the physical and geomechanical characteristics of carbonate rocks by Ahmed K. Abd El-Aal, Ahmed E. Radwan, Jabir Hussain, Mahrous A. M. Ali

“…Drilling wells into the subsurface should be performed at a lower attack angle to enable easier drilling and more stable holes. The empirical relationships with moderate/high correlation coefficients established here allow significant rock parameters to be computed using regularly measured parameters, allowing rocks to be evaluated considerably more rapidly and effectively.…”
Get full text

Att lära om naturen från naturen och i naturen by Sara Planting-Bergloo, Emma Rova, Charlotte Lennartsdotter, Per Rohlin, Maria Andrée

“…Learning about nature from nature in nature: Knowledge interests in lower secondary school Biology field work This study focuses on the role of scientific inquiry in outdoor lower secondary Biology education. …”
Get full text

Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model by Shunan Wang, Ming Shen, Bo Pang, Bo Zhou, Yuan Yuan, Mei Lu, Xiangling Deng, Min Yang, Shufang Liu, Qiong Wang, Mei Xue, Qisheng Xia, Zhixin Zhang

“…Purpose This study aims to elucidate the role of DNAJC12 in intellectual disability and explore the mechanisms by which DNAJC12 deficiency leads to hyperphenylalaninemia through developing a DNAJC12 gene knockout mouse model. …”
Get full text

Modeling Factors Influencing Project Financing Risk by Gholamreza Sharafi, Kiamars Fathi Hafashjani, Faegh Ahmadi

“…Its significance has grown notably in recent decades within the financial market, reflecting its pivotal role in facilitating economic development. Notably, in developing countries, the establishment of robust economic infrastructure is a pressing priority, serving as a cornerstone for overall growth and advancement across multiple economic sectors. …”
Get full text

Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…Additionally, CCRE decreased UVB-induced IL-6 expression and IKK phosphorylation, which play a crucial role in inflammaging. Notably, CCRE treatment also improved cell viability upon UVB exposure and mitigated UVB-induced cell apoptosis, further underscoring its potential to preserve cellular integrity and function in relation to environmental stressors. …”
Get full text

Analysis of the Spatial Pattern of Military River Defense on the Ming Great Wall: A Case Study of the Shanxi Section of the Yellow River by Tianlian WANG, Zhe LI

“…ObjectiveRiver defence plays a vital role in the development of the Ming Great Wall’s military defence system. …”
Get full text

Peripheral mitochondrial transplantation alleviates diabetes-associated cognitive dysfunction by suppressing cuproptosis by Juan Hu, Qiao Li, Shiqiu Jiang, Yingying Deng, Lan Yang, Mengyu Du, Shuxuan He, Fuxing Xu, Chaoying Yan, Wei Gao, Yansong Li, Yaomin Zhu

“…Given that imbalances in copper homeostasis and cuproptosis are associated with various neurodegenerative disorders and diabetic myocardial damage, we hypothesize a role for cuproptosis in the pathogenesis of DACD. …”
Get full text

Structure-activity relationship and in silico docking analysis of dicarboximide fungicides on 17β-hydroxysteroid dehydrogenase 1 of human, rat, and pig by Huiqian Chen, Sailing Chen, Yunbing Tang, Yingfen Ying, Shaowei Wang, Yang Zhu, Yiyan Wang, Ren-shan Ge, Ping Duan

“…The dithiothreitol treatment demonstrated that the formation of irreversible bonds between dicarboximide fungicides and the cysteine residues played a key role in the inhibition of 17β-HSD1 activity. In conclusion, dicarboximide fungicides inhibit 17β-HSD1 depending on lipophilicity, species, and cysteine residue interactions.…”
Get full text

CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma by Victoria Jennings, Kevin Harrington, Hardev Pandha, Alan Melcher, Adel Samson, Fiona Errington-Mais, Victoria Roulstone, Eva Crespo-Rodriguez, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Martin McLaughlin, Malin Pedersen, Richard Vile, Joan Kyula, Jehanne Hassan, Lizzie Appleton, Charleen ML Chan Wah Hak, Gabby Baker, Edward Armstrong, Matthew Chiu, Masahiro Ono

“…The only T cell subset which correlated with a reduction in tumor growth was within Tocky signal positive conventional CD4+, supporting their therapeutic role. Targeting CD25 high, antigen-engaged Treg with a depleting anti-CD25 ICI, achieved complete cures in 100% of mice with triple therapy. …”
Get full text