A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA by Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu

“…However, the structure and biochemical data of ribozymes have been disagreed on, making the understanding of its catalysis mechanism a longstanding issue. Particularly, the role of conformational dynamics in ribozyme catalysis remains elusive. …”
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Weaving oral health provider perspectives to guide future dental therapy advocacy and implementation efforts by Amanda J. Llaneza, Amanda J. Llaneza, Kara A. Stone, Julie Seward

“…Descriptive statistics were utilized to report the position type of attendees, years of experience in the role, incorporation of clinical courses for DT scope of practice, and clinic management and administration for their patients. …”
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Soil organic carbon contents and their major influencing factors in mangrove tidal flats: a comparison between estuarine and non-estuarine areas by Ting Wu, Jia Guo, Gang Li, Yu Jin, Wei Zhao, Guangxuan Lin, Fang-Li Luo, Yaojun Zhu, Yifei Jia, Li Wen

“…Abstract Background Unvegetated tidal flats of mangrove ecosystems in estuarine and non-estuarine areas play a crucial role in the coastal blue carbon sinks and biogeochemical cycle. …”
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New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease by Ting Fang, Qiaoyan Liu, Xinxin Huangfu, Hongkai Zhu, Hongwen Sun, Liming Chen

“…Diabetic kidney disease is a significant complication of diabetes mellitus, and exposure to certain chemicals may play a role in its development. Triphenyl phosphate (TPHP) is commonly used in plastics and flame retardants. …”
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Metabolic redundancy and specialisation of novel sulfide-oxidizing Sulfurimonas and Sulfurovum along the brine-seawater interface of the Kebrit Deep by Rayyan Alamoudi, Alan Barozzi, Grégoire Michoud, Marc W. Van Goethem, Charlene Odobel, Yue Chen, Ramona Marasco, Daniele Daffonchio

“…This knowledge gap not only hampers our understanding of their adaptation and functional role in DHABs but also their ecological interactions with other microorganisms in these unique ecosystems. …”
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A guide to selecting high-performing antibodies for Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) for use in Western Blot, immunoprecipi... by Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende

“…Abundantly expressed in the brain and involved in a broad range of cellular processes, PPP2R5D plays an essential role in modulating key neuronal pathways and signalling. …”
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The dipeptide carnosine alleviates acute pancreatitis in an experimental model by Heresh Rezaei, Saeed Heidari, Mohammad Mehdi Ommati, Babak Taheri, Forouzan Khodaei, Mohammad Ali Dehghani, Ayeh Rowhanirad, Azadeh Veisi-Goshtasb, Zahra Honarpishefard, Negar Azarpira, Hossein Niknahad, Reza Heidari

“…These findings suggest that carnosine is a protective agent in pancreatitis, with its antioxidative and anti-inflammatory properties playing a pivotal role in its mechanisms of action. Further research is needed to confirm these protective effects in clinical studies and assess carnosine safety in AP.…”
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Changes in Aqueous Humor Cytokine Profile Following Intravitreal Brolucizumab Injection by Ruamviboonsuk V, Kongwattananon W, Chuaypen N

“…The results suggested that type IV cell-mediated hypersensitivity could play a role in IOI following intravitreal brolucizumab injection.Keywords: anti-VEGF, intravitreal injection, inflammation, hypersensitivity, intravitreal injection…”
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Utility of Visceral Adiposity Index and Lipid Accumulation Products to Define Metabolically-Unhealthy Polycystic Ovary Syndrome in Asian Indian Women - A Cross Sectional Study by R. A. Shreenidhi, Reeta Mahey, Monika Rajput, Rohitha Cheluvaraju, Ashish D. Upadhyay, Jai Bhagwan Sharma, Garima Kachhawa, Neerja Bhatla

“…Statistical Analysis Used: Univariate and multivariate logistic regression analysis was used to study the independent role of VAI and LAP to predict MetS. Adjusted and unadjusted odds ratios were calculated. …”
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Analisis Kinerja Algoritma CART dan Naive Bayes Berbasis Particle Swarm Optimization (PSO) untuk Klasifikasi Kelayakan Kredit Koperasi by Eko Arif Riyanto, Tri Juninisvianty, Doddy Ferdian Nasution, Risnandar Risnandar

“…Oleh karena itu perlu adanya perhitungan yang sistematis dalam pemberian kredit kepada para peminjam. …”
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From the Banks of the Orkhon to the Banks of the Neva: the History of Mining and Transit of Mongolian Gold to the Russian Empire at the beginning of the 20th century. by Aldar A. Shirapov, Anna M. Plekhanova

“…The purpose of the research is to study the mechanism of delivery of Mongolian gold to the Russian territory; identify and evaluate the role of the Russo-Chinese Bank and the Kyakhtinsky District Treasury in this process. …”
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Clinical characteristics, metastasis patterns, and treatment outcomes of HER2-low breast cancer by Maria Elena Lacruz, Saskia Thies, Andrea Schmidt-Pokrzywniak, Ian Wittenberg, Tobias Engler, Fabian Reinwald, Monika Klinkhammer-Schalke, Sylke Ruth Zeissig, Bianca Franke, Kerstin Weitmann, Atanas Ignatov

“…While metastatic behaviour, treatment and long-term response in HER2-low were comparable to HER2-zero, the hormone receptor status seems to play a critical role in these outcomes.…”
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Analisis Ketersediaan Data Indikator Smart City Kabupaten Tegal by Maria Dolorosa Kusuma Perdani, Inasari Widyastuti, Daru Nupikso

“…The purpose of this study is to assess the availability of smart city indicator data and its relevance to related policies in Tegal Regency. This research uses quantitative methods with purposive sampling technique in taking the sample. …”
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Multiple low-dose radiation ameliorates type-2 diabetes mellitus via gut microbiota modulation to activate TLR4/MyD88/NF-κB pathway by Lijing Qin, Rongrong Liu, Zhen Jia, Weiqiang Xu, Li Wang, Hongyuan Tian, Xinru Lian, Wen Li, Yali Qi, Huan He, Zhicheng Wang

“…Conclusion These results suggest that LDR may exert a beneficial role in T2DM by modulating gut microbiota and metabolites, especially in TLR4/MyD88/NF-κB pathway.…”
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CH4-C3H8 mixed gas hydrates formation in marine mud and foraminifera-rich sand from the South China Sea: an experimental approach by Peixiao Mao, Peixiao Mao, Peixiao Mao, Judith M. Schicks, Mengdi Pan, Mengdi Pan, Nengyou Wu, Nengyou Wu

“…CH4-C3H8 mixed gas hydrates are widely distributed in deep-sea weakly-consolidated muddy sediments of the South China Sea, enriched with biological clastics like foraminifera-rich sand. However, the role of complex mineral composition of mud and foraminifera-rich sand on the formation of these natural gas hydrates remains unclear. …”
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Tata Kelola Teknologi Informasi Pada Sektor Publik: Penyelarasan Teknologi Informasi Dengan Visi Kepemimpinan (Studi Kasus: Kota Salatiga dan Kabupaten Bengkayang) by Andeka Rocky Tanaamah, Agustinus Fritz Wijaya, Sarah Ayu Maylinda

“…This study found factors that play a role such as the commitment of the regional head, the ability to describe the vision and mission, the availability of regulations and rules, support for implementing IT, the ability to consolidate and manage, institutional structuring, support, and budget allocation, availability of infrastructure, resources human resources, and the ability to develop implementation strategies. …”
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The relationship between vision status and its influencing factors among primary and secondary school students: The masking effect of physical activity level and the moderating eff... by Jiyan Xu, Yanjun Li, Siyuan Ma, Shimeng Dai, Weiwei Xu, Mengjiao Sang, Kaijie Feng

“…The physical activity level played a significant masking effect between lifestyle behaviors and vision status (a*b = 0.002, c’=-0.044), and academic stress played a moderating role in the process of lifestyle behaviors affecting physical activity level and vision status. …”
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Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study by Mohsen Shaygan Tabar, Maryam Nilghaz, Azita Hekmatdoost, Fereshteh Pashayee-Khamene, Zeinab Mokhtari, Sara Karimi, Saleheh Ahmadzadeh, Mehdi Saberifiroozi, Behzad Hatami, Zahra Yari

“…Abstract The role of diet in reducing the burden of liver disease and mortality attributed to cirrhosis is very imperative. …”
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Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States by Hao Deng, Mengmeng Sun, Zhentong Zhao, Kun Fan, Zizhang Zhao, Yifan Chi, Wei Sheng

“…These findings have significant clinical relevance and may inform clinicians regarding the management of SAAC. …”
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ASSESSMENT OF THE REGION'S INVESTMENT ENVIRONMENT AND POLICY INSTRUMENTS FOR THE IMPLEMENTATION OF ITS INVESTMENT POTENTIAL IN WARTIME by Ruslan Boiko, Roman Martsenyuk, Arsen Protsykevych

“…At the same time, the following shortcomings and weaknesses remain in the region's investment development: the presence of systemic deficiencies in the region's investment climate; small volumes of investment (per unit of resources) and limited rates of their increase; low investment activity in the real sector of the economy with high added value; low investment in intangible assets in industries that form human and innovative potential; critically low volumes of foreign investment, especially direct investment; limited public, intermunicipal and cross-border investment; underdeveloped system of risk financing of investment in innovation; underdeveloped stock market and small role of bank lending. It is substantiated that effective instruments of regional investment policy in the context of critical instability are: military risk insurance and diversification; use of concession agreements; private and public investments in the defence industry and critical infrastructure industries/sectors (energy, transport and logistics, medicine and pharmaceuticals, natural resources); support for innovative and technological startups in the areas of security, the real economy and infrastructure; stimulation of investments in human resources; support for investments in business projects of demobilised persons, war veterans and other combatants; encouragement of investments in the development of export potential to maintain the country's financial security.…”
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