THrombosis AETiology of Aviation-Related Travel: The THETA θ study by B F Jacobson, S Louw, E Schapkaitz, F Laher

“…Objective. To investigate the role of high altitude as a risk factor for ART. …”
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A bidirectional Mendelian randomization study integrating genome-wide association studies, expression quantitative trait locus, and methylation quantitative trait locus data reveal... by Zhou An, Meichun Zeng, Xianhua Wang

“…Conclusions: Our study provides evidence of a bidirectional causal association between smoking and Barrett’s esophagus from a genetic perspective, which sheds new light on the potential role of RBM43 as a mediator in facilitating the impact of smoking and Barrett’s esophagus.…”
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Association between prognostic nutritional index and all-cause mortality and cardiovascular disease mortality in American adults with non-alcoholic fatty liver disease by Yuqing Lei, Shaohong Tao, Yubo Yang, Fang Xie, Weining Xie

“…Subgroup analyses were conducted to examine the potential influence of relevant clinical variables on the relationship between PNI and mortality. …”
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Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: A systematic review of pre-clinical and human studies by Jacinta Cheng, Tia Solomon, Mahnuma Estee, Flavia M. Cicuttini, Yuan Z. Lim

“…With the growing burden of obesity, high-quality trials are needed to determine the role of GLP-1A in osteoarthritis.…”
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A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications by Arthi Srinivasan, Arun Gupta, Vigneswaran Narayanamurthy

“…The study explores the transformative role of artificial intelligence (AI) in optimizing collagen extraction processes, enhancing efficiency, yield, and quality while reducing energy consumption and waste generation. …”
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A Cross Sectional Study on Thrombocytopenia with Mean Platelet Volume and Platelet Distribution Width in Patient with Febrile Illness by Vidhya.G, J.Margaret Theresa, J.S. Sukanya, Santha Sandasivan, Gerard Rakesh. J

“…PDW, in particular, plays a critical role among these parameters. When assessed alongside other parameters, PDW can provide important information about the mechanisms behind platelet destruction. …”
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Distribution and clinicopathological characteristics of G-CSF expression in tumor cells and stromal cells in upper tract urothelial carcinoma by Go Kobayashi, Yohei Sekino, Hikaru Nakahara, Kohei Kobatake, Keisuke Goto, Tetsutaro Hayashi, Kazuhiro Sentani, Nobuyuki Hinata

“…Conclusion G-CSF expression in TCs and SCs may play a crucial role in UTUC tumor progression. Notably, stromal G-CSF expression showed significant prognostic value, even when compared to major clinicopathological factors, suggesting that the evaluation of G-CSF expression may contribute to clinical decision-making in patients with UTUC.…”
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NT5E (CD73) as a prognostic biomarker and therapeutic target associated with immune infiltration in lung adenocarcinoma by Leyan Chen, Tuoya Qi, Bishu Zhang, Xuelong Wang, Mingfeng Zheng

“…Gene Set Enrichment Analysis (GSEA) indicated that NT5E plays a crucial role in regulating immune responses, as evidenced by differential gene expression associated with NT5E levels. …”
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Preconceptional brain structure and future conception: a prospective brain MRI study among 321 women by Merel W. de Vries, Eline M. P. Poels, Gennady V. Roshchupkin, Ryan L. Muetzel, Milan Zarchev, Astrid M. Kamperman, Henning Tiemeier, Meike W. Vernooij, Steven A. Kushner

“…Further research is needed to understand the potential role of brain structure and function in conception, in relationship with general health and socioeconomic factors.…”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…Abstract Histone lactylation plays a crucial role in cancer progression, but its impact on breast cancer (BC) tumorigenesis is still unclear. …”
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Comprehensive analysis of proteomic and biochemical responses of Daphnia magna to short-term exposure to polystyrene microplastic particles by Young Sang Kwon, Chang-Beom Park, Seung-Min Lee, Jin-Woo Park, Yeong-Jin Kim, Jong-Hwan Kim, Jong-Su Seo

“…The upregulation of endocytosis-related proteins, including caveolin-1 (CAV1) and phosphatidylinositol-4-phosphate 5-kinase (PIP5K), highlights their role in actively internalizing and compartmentalizing MP, potentially as a protective mechanism against oxidative damage. …”
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Mechanical resistance comparison between interlocking micro-nail and tension band for fractures subject to muscular flexion forces by Alois Foltran Müller, Silvio Henrique de Freitas, Renata Gebara Sampaio Dória, Julia Belotto Guaraná, Fábio de Souza Mendonça, Atanásio Serafim Vidane, Lázaro Manoel de Camargo, Rachel Santos Bueno Carvalho, Antônio Carlos Shimano, Carlos Eduardo Ambrósio, Bruno Watanabe Minto

“…ABSTRACT: The ulna, humerus, femur, tibia, and calcaneus fractures repair, which are under constant tension due to exerted forces by the muscle groups adhered thereto, play a key role in the clinical-surgical routine, both in veterinary and human medicine. …”
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MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway by Zigui Chen, Chao Liu, Wei Zheng, Zhilong Li, Yuanhui Tang, Jun Peng, Changfeng Miao, Dandan Zheng, Ying Xia

“…In summary, we suggest that MYH9 is a potential molecular marker for predicting tumour progression and prognosis and highlight its role in a new molecular mechanism of tumour metastasis.…”
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Exploration of the anti-inflammatory potential of Polygonum bistorta L.: protection against LPS-induced acute lung injury in rats via NF-ĸβ pathway inhibition by Sajida Parveen, Kashif ur Rehman Khan, Shahid Muhammad Iqbal, Hanan Y. Aati, Areej M. Al-taweel, Liaqat Hussain, Musaddique Hussain, Musaddique Hussain

“…In conclusion, P. bistorta roots mitigate inflammation and oxidative stress by improving redox signaling and NF-ĸβ (p65) pathways and can thus play a role in strategies for overcoming therapeutic challenges.…”
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The antibiotic procurement saga: a long-neglected stewardship target to combat antimicrobial resistance in Pakistan by Shairyar Afzal, Mishal Bajwa, Nabeel Ahmed, Jawaria Jabeen, Mian Shahzeb Haroon, Rana Muhammad Zahid Mushtaq, Zikria Saleem

“…This study seeks to understand hospital pharmacists’ perspectives on the antibiotic procurement process, its efficiency in ensuring consistent access to antibiotics, and the role of clinical pharmacists in rational procurement. …”
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Effect of tree size attributes on fruit production and animal-mediated seed dispersal web in Melia azedarach L. (Chinaberry) in north-west Himalaya, India by Sukumaran Arun, Sasidharan Sarath, Khanduri Vinod Prasad, Suraj, Rawat Shweta, Chand Vaisakhy Prem

“…Furthermore, we observed the seed dispersers to determine their role in fruit removal and dispersal. The average fruit production among sample trees varied from 1.8 × 103 to 1.18 × 105. …”
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Amine modified sodium alginate: Synthesis, characterization and in vivo evaluation in rainbow trout (Oncorhynchus mykiss) by Samira Salarvand, Seyed Amir Hossein Jalali, Nasrollah Mahboobi Soofiani, Alireza Allafchian

“…This improvement can be attributed to the modified alginate's nature and the amine groups' role in its structure. Therefore, amine-modified alginate can be suggested as an immunostimulant.…”
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Efficacy and safety of antifibrotic drugs for interstitial lung diseases other than IPF: A systematic review, meta-analysis and trial sequential analysis. by Mei Yang, Yuying Tan, Ting Yang, Dan Xu, Mei Chen, Lei Chen

“…<h4>Background</h4>The therapeutic role of antifibrotic therapy has been well-established in idiopathic pulmonary fibrosis (IPF). …”
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Analysis of Vaginal Microbiome in Women with or Without Episodes of Spontaneous Abortion in Eastern Nigeria by Felix Emele Emele, Prisca Onyeulor, Francisca Nwaokorie, Damian Asogwa

“…This study aimed at comparing the vaginal microbiome of women who have had episodes of spontaneous abortion with those who have not experienced any incident - in order to find out any possible role of vaginal microbiota in spontaneous abortion. …”
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Reconstruction of climatic events from the 16th century in Transylvania: interdisciplinary analysis based on historical sources by Ovidiu Răzvan Gaceu, Tudor Caciora, Ștefan Baias, Cezar Morar, Mihai Dudaș, Marius Stupariu, Maria Maxim

“…Finally, the manuscript emphasizes the significant role of the climate in shaping the historical and socio-economic landscape of Transylvania in the 16th century, offering perspectives on the complex interactions between the climate and the human component.…”
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