Advancing Diabetic Retinopathy Screening: A Systematic Review of Artificial Intelligence and Optical Coherence Tomography Angiography Innovations by Alireza Hayati, Mohammad Reza Abdol Homayuni, Reza Sadeghi, Hassan Asadigandomani, Mohammad Dashtkoohi, Sajad Eslami, Mohammad Soleimani

“…Optical Coherence Tomography Angiography (OCTA) now enables non-invasive, layer-specific visualization of the retinal vasculature, facilitating more precise identification of early microvascular changes. …”
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Diabetic Retinopathy Assessment through Multitask Learning Approach on Heterogeneous Fundus Image Datasets by Hongkang Wu, MS, Kai Jin, MD, PhD, Yiyang Jing, MD, Wenyue Shen, MD, Yih Chung Tham, PhD, Xiangji Pan, PhD, Victor Koh, MD, PhD, Andrzej Grzybowski, MD, PhD, Juan Ye, MD, PhD

“…Subjects: The study included 1500 retinal images from 957 participants aged 18 to 83 years. …”
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Screening Blood and Vitreous for Biomarkers Associated with Proliferative Diabetic Retinopathy by Stephen Richard, Rawan Kharouba, Jawad Abu-dbai, Oksana Gagarin, Assaf Kratz, Basel Obied, Alon Zahavi, Nitza Goldenberg-Cohen

“…All participants had undergone pan-retinal photocoagulation and two had received anti-VEGF injections before vitrectomy. …”
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NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway by Alexander J. Gill, Matthew D. Smith, Danny Galleguillos, Thomas Garton, Jackson W. Mace, Sachin P. Gadani, Swati Kumar, Aayush Pokharel, Krista Solem, Saahith Potluri, Omar Hussein, Giuliana Sardi Rogines, Arihant Singh, Annatje Clark, Peter A. Calabresi, Marjan Gharagozloo

“…In this model, we found more severe microgliosis and astrogliosis in the optic nerve of Nlrx1 −/− Rag −/− mice compared to Rag −/− mice, suggesting a regulatory role of NLRX1 in innate immune cells. Transcriptome analysis in primary astrocytes activated with LPS and IFNγ demonstrated that NLRX1 suppresses NF-κB activation and regulates mitochondrial oxidative phosphorylation in inflammatory reactive astrocytes. …”
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Generating evidence to support the role of AI in diabetic eye screening: considerations from the UK National Screening Committee by Trystan Macdonald, MBChB, Zhivko Zhelev, PhD, Xiaoxuan Liu, PhD, ProfPhD Christopher Hyde, PhD, Jiri Fajtl, PhD, Catherine Egan, PhD, ProfMD Adnan Tufail, PhD, Alicja R Rudnicka, PhD, ProfPhD Bethany Shinkins, PhD, Rosalind Given-Wilson, FRCR, J Kevin Dunbar, MBChB, ProfPhD Steve Halligan, MBChB, ProfMD Peter Scanlon, MBChB, ProfPhD Anne Mackie, MBChB, ProfPhD Sian Taylor-Philips, MBChB, ProfPhD Alastair K Denniston, MBChB

“…There is long-standing interest in the possibility of automating parts of this process through artificial intelligence, commonly known as automated retinal imaging analysis software (ARIAS). A number of such products are now on the market. …”
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Enhanced clindamycin delivery using chitosan-coated niosomes to prevent Toxoplasma gondii strain VEG in pregnant mice: an experimental study by Mitra Sadeghi, Seyed Abdollah Hosseini, Shahabeddin Sarvi, Pedram Ebrahimnejad, Hossein Asgaryan Omran, Zohre Zare, Shirzad Gholami, Alireza Khalilian, Seyedeh Melika Ahmadi, Fatemeh Hajizadeh, Mostafa Tork, Ahmad Daryani, Sargis A. Aghayan

“…Finally, statistical analysis was conducted using GraphPad Prism 8.0 and SPSS 26, comparing test and control groups with T test and Mann–Whitney test. …”
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Clinical features of the pulmonary tuberculosis course combined with different diabetes mellitus types in the Zaporizhzhia region by O. M. Raznatovska, Yu. M. Bobrovnycha-Dvizova

“…The outcomes of the study were processed by modern analysis methods on a personal computer using the statistical package of the Statistica® for Windows 6.0 (StatSoft Inc., No. …”
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Microinvasive pars plana vitrectomy versus panretinal photocoagulation in the treatment of severe non-proliferative diabetic retinopathy (the VIP study): study protocol for a rando... by Xiaohu Ding, Tao Li, Lin Lu, Ling Jin, Yuan Ma, Yizhi Liu, Ying Lin, Yuqing Wu, Bingqian Liu, Shida Chen, Wenbin Zheng, Kunbei Lai, Sainan Xiao, Jizhu Li

“…In this trial, we aim to compare the effectiveness of microinvasive PPV with that of PRP for sNPDR progression control.Methods and analysis This single centre, parallel group, randomised controlled trial aims to evaluate the clinical efficacy of microinvasive PPV in preventing the progression of sNPDR compared with PRP. …”
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Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration by Inês Costa, Ana Carvalho, Helton Andrade, Bruno Pereira, Pedro Camacho

“…Slight reductions in retinal thickness were more accentuated in the inner ring in the atrophic AMD (-13%; P<0.01). …”
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In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies by Emily Alefeld, André Haase, Dario Van Meenen, Bettina Budeus, Oliver Dräger, Natalia Miroschnikov, Saskia Ting, Deniz Kanber, Eva Biewald, Nikolaos Bechrakis, Nicole Dünker, Maike Anna Busch

“…Abstract Retinoblastoma (RB) is an intraocular tumor arising from retinal cone progenitor cells affecting young children. …”
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Methylene Blue Reduces Electroretinogram Distortion and Ganglion Cell Death in a Rat Model of Glaucoma by Ronan Nakamura, Nicolás S. Ciranna, Juan C. Fernández, Rafael Peláez, Álvaro Pérez-Sala, Miriam Bobadilla, Juan J. López-Costa, César F. Loidl, Alfredo Martínez, Manuel Rey-Funes

“…Glaucoma is the second leading cause of blindness worldwide and is, in most cases, a consequence of elevated intraocular pressure (IOP), ultimately resulting in the death of retinal ganglion cells (RGCs). Current treatments are mostly focused on normalizing IOP, but we propose the additional use of neuroprotective agents, including methylene blue (MB), to block the loss of RGCs. …”
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Levels of Zinc, Iron, and Copper in the Aqueous Humor of Patients with Primary Glaucoma by Yangjiani Li, Zhe Liu, Zhidong Li, Yingting Zhu, Shuxin Liang, Hongtao Liu, Jingfei Xue, Jicheng Lin, Ye Deng, Caibin Deng, Simei Zeng, Yehong Zhuo, Yiqing Li

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Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): study protocol... by Timothy L. Jackson, Catey Bunce, Riti Desai, Jost Hillenkamp, Chan Ning Lee, Noemi Lois, Tunde Peto, Barnaby C. Reeves, David H. Steel, Rhiannon T. Edwards, Jan C. van Meurs, Hatem Wafa, Yanzhong Wang

“…Eligible participants have large, fovea-involving SMH of no more than 15 days duration due to treatment-naïve or previously treated neovascular AMD, including idiopathic polypoidal choroidal vasculopathy and retinal angiomatous proliferation. A total of 210 participants are randomised in a 1:1 ratio to pars plana vitrectomy, off-label subretinal TPA up to 25 μg in 0.25 ml, intravitreal 20% sulfahexafluoride gas and intravitreal aflibercept, or intravitreal aflibercept monotherapy. …”
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Convergent and divergent transcriptional reprogramming of motor and sensory neurons underlying response to peripheral nerve injury by Jian Yang, Shuqiang Zhang, Xiaodi Li, Zhifeng Chen, Jie Xu, Jing Chen, Ya Tan, Guicai Li, Bin Yu, Xiaosong Gu, Lian Xu

“…Methods: We analyzed two large-scale RNA-seq datasets of in situ captured sensory neurons (SNs) and motoneurons (MNs) upon PNI, retinal ganglion cells and spinal cord upon CNS injury. …”
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6PPD and 6PPDQ embryonic exposure induced distinct developmental neurotoxicity in zebrafish by Liang Yang, Xiangqi Lu, Dongliang Pan, Yusong Zhang, Yi Zheng, He Mei, Bo Yang, Da Sun, Qiong Li, Jian Lin, Jiangfei Chen

“…Transgenic strain analyses demonstrated that 6PPD markedly activated Gfap and Olig2 expression in the eye-brain axis region, whereas 6PPDQ specifically enhanced Olig2 expression in brain region. Retinal müller cells (labeled by Gfap) and cone cell patterns were disrupted exclusively by 6PPD, as was the fan-like lens arrangement visualized via Cms1 mitochondrial labeling. …”
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Chorioretinal microvascular changes in slow flow coronary phenomenon: a multi-center study by MohammadHossein MozafaryBazargany, Elias Khalili Pour, Ali Shamsedini, Seyed Ali Banifatemeh, Amir Azimi, Amir Manavishad, Saeed Sadr, Parham Sadeghipour, Ata Firouzi, Armin Elahifar, Mohammadreza Baay, Mohammad Javad Alemzadeh-Ansari, Zahra Mahdizad, Hooshang Faghihi, Hassan Asadigandomani, Niloofar Gholami, Sara Adimi, Ehsan Khalilipur, Reza Mirshahi, Hamid Riazi-Esfehani

“…We found that decreased retinal microvascular density may serve as a potential biomarker for the diagnosis of SCFP. …”
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HEROIC: a 5-year observational cohort study aimed at identifying novel factors that drive diabetic kidney disease: rationale and study protocol by Neil Ashman, Ben Caplin, David Wheeler, Tahseen Ahmad Chowdhury, Kieran Mccafferty, Sinead Knight, Paul Hockings, Stanley L Fan, Johannes Hulthe, Robert Kleta, Vasilios Papastefanou, Hemal Mehta, Alan Salama, Sinela Hadzovic, Lisa Jarl, Robert Unwin, Benjamin Challis, Anna K Sundgren, Muhammad Magdi Yaqoob

“…Measured glomerular filtration rate (GFR), echocardiography, retinal optical coherence tomography angiography and kidney and cardiac MRI will be performed at baseline and twice more during follow-up. …”
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Apolipoprotein E dysfunction in Alzheimer’s disease: a study on miRNA regulation, glial markers, and amyloid pathology by Printha Wijesinghe, Hao Ran Li, Zhengyuan Ai, Matthew Campbell, Si Xuan Chen, Jeanne Xi, Wellington Pham, Wellington Pham, Joanne A. Matsubara, Joanne A. Matsubara

“…This study explores ApoE’s role in AD by analyzing brain and eye samples from Apoe-ko mice, focusing on identifying potential retinal biomarkers associated with ApoE dysfunction.MethodsWe compared female Apoe-ko mice on a regular diet to age-matched C57BL/6J controls at 3 and 9 months. …”
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The impact of diagnosis-related group-based medical insurance payment model on the prognosis and nursing care of patients undergoing composite trabeculectomy: a retrospective cohor... by Yu Wang, Yu-yun Zhang, Jie Yan, Tian-bo Ji, Luo-dan Fan, Hai-di Wang, Tong Sun, Dan He

“…Data on hospital stay, visual acuity, intraocular pressure, visual field, and retinal nerve fiber layer (RNFL) thickness were collected and analyzed. …”
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Disturbances of visual perception in non-demented patients with Parkinson’s disease by R. Timofejavaitė, V. Vilda, A. Liveikienė, R. Kaladytė-Lokominienė

“…Patients underwent ophthalmological examination which provided data on colour discrimination, contrast sensitivity, eye pressure, and retinal ganglion cell layer thickness (RGCL). The relations between minor hallucinations and clinical factors were investigated by comparison of PD and control groups, and PD group. …”
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