Mutation Spectrum of the ABCA4 Gene in a Greek Cohort with Stargardt Disease: Identification of Novel Mutations and Evidence of Three Prevalent Mutated Alleles by Kamakari Smaragda, Kokkinou Vassiliki, Koutsodontis George, Stamatiou Polixeni, Giatzakis Christoforos, Anastasakis Anastasios, Aslanides Ioannis Minas, Koukoula Stavrenia, Panagiotoglou Theoni, Datseris Ioannis, Tsilimbaris K. Miltiadis

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Characterization of Shifts of the Cellular Component the Immune Status of Patients with Long-Term Course of Chronic Post-Traumatic Uveitis by N. V. Balatskaya, I. A. Filatova, I. G. Kulikova, V. O. Denisyuk, I. M. Mohammad

“…Individual analysis revealed multidirectional shifts from the norm of cellular immune status of patients with PU in both groups. …”
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Relationship between renal function and prognosis of Chinese proliferative diabetic retinopathy patients undergoing the first vitrectomy: protocol for a prospective cohort study by Chunyan Lei, Meixia Zhang, Keren Zhang, Tiancong Chang, Qibo Ran

“…Generalise additive mixed models will be used to explore the association between the renal profile and surgical outcomes including BCVA, and retinal and choroidal microvasculature/microstructure. …”
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Predictive Model for the Type of Active Retinopathy of Prematurity Based on Data from Angiological Studies by I. G. Trifanenkova, A. V. Tereshchenko

“…The discriminant analysis was used to estimate the contribution of the studied quantitative indicators to the intergroup differences in the type of active ROP. …”
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Experience in Application of the Combinations Dorzolamide / Timolol and Brinzolamide / Timolol for the Prevention of Intraocular Hypertension in Patients with Silicone Oil Tamponad... by A. N. Kazennov, A. D. Chuprov, I. A. Kazennova, A. S. Firsov

“…Fyodorov Eye Microsurgery Federal State Institution during 2022. A retrospective analysis of case histories of 60 patients with retinal detachment and severe proliferative syndrome was carried out. …”
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Differential Change in Retina Structure and Function in Children and Adolescents with Drusens of the Optic Nerve Disk by A. G. Shchuko, D. Yu. Samsonov, S. I. Zhukova, T. N. Iureva, I. M. Mikhalevich, A. V. Grigorieva, Yu. S. Samsonova

“…The compression effect of drusen is accompanied with changes in the volume of the optic nerve disc, a violation of retinal hemodynamics, damage to the neuroglia and ganglion cells, which allows treating this pathology as a progressive neuroopticopathy, and the revealed dependence of changes on the localization of druses requires supplementing the existing classification.…”
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Association Between Low Serum Vitamin A Level and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Hospital-Based Study by Zhang MJ, Cheng F

“…Multivariate logistic regression analysis showed that VAD was a predictor for DR in T2DM patients (OR = 0.81, P = 0.004, 95% CI 0.26– 0.97). …”
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Four-Year Outcome of Aflibercept Treatment-Naïve Patients for Neovascular Age-Related Macular Degeneration: Evidence from a Clinical Setting by Yanel Gayadine-Harricham, Virginie Rufin, Sandrine Law-Koune, Thi Ha Chau Tran

“…This is a prospective, monocenter, observational case series analysis. Data from treatment-naïve patients with nAMD with at least 4 years of follow-up were included in the analysis. …”
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The Effect of CM082, an Oral Tyrosine Kinase Inhibitor, on Experimental Choroidal Neovascularization in Rats by Chengda Ren, Hui Shi, Juanjuan Jiang, Qingyu Liu, Yaru Du, Mengmei He, Wenting Cai, Qingquan Wei, Jing Yu

“…The effects of CM082 on the CNV lesions were assessed using fundus fluorescein angiography (FFA), CNV histology, and retinal pigment epithelium- (RPE-) choroid-sclera eyecup analysis. …”
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Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. by James Bellingham, Shyam S Chaurasia, Zara Melyan, Cuimei Liu, Morven A Cameron, Emma E Tarttelin, P Michael Iuvone, Mark W Hankins, Gianluca Tosini, Robert J Lucas

“…In mammals, the melanopsin gene (Opn4) encodes a sensory photopigment that underpins newly discovered inner retinal photoreceptors. Since its first discovery in Xenopus laevis and subsequent description in humans and mice, melanopsin genes have been described in all vertebrate classes. …”
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Anti-VEGF Treatment of Diabetic Macular Edema: Two-Year Visual Outcomes in Routine Clinical Practice by Mojca Urbančič, Pia Klobučar, Matej Zupan, Katja Urbančič, Alenka Lavrič

“…Our analysis provides some information about the effectiveness of anti-VEGF treatment in routine clinical practice in Slovenia. …”
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Metabolomic biomarkers in vitreous humor: unveiling the molecular landscape of diabetic retinopathy progression by John Kim Hiller, Elise Mørk Sandås, Helge Rootwelt, Anja Østeby Vassli, Xhevat Lumi, Morten Carstens Moe, Tor Paaske Utheim, Katja Benedikte Prestø Elgstøen, Goran Petrovski

“…Abstract Background Diabetic retinopathy (DR) is a progressive retinal disease that leads to vision loss if not detected early. …”
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Artificial intelligence algorithms for the diagnosis of signs of diabetic retinopathy, diabetic macular edema, age-related macular degeneration, vitreomacular interface abnormaliti... by E.A. Katalevskaya, A.Yu. Sizov, M.I. Tyurikov, Yu.V. Vladimirova

“…The volume of training databases was 3600 fundus images and 10 000 OCT scans, the volume of validation databases was 400 fundus images and 1000 OCT scans. For fundus images analysis algorithms accuracy, sensitivity, specificity, AUROC were calculated for the following structures: microaneurysms, intraretinal hemorrhages, hard exudates, soft exudates, retinal and optic disc neovascularization, preretinal hemorrhages, epiretinal fibrosis, laser coagulates. …”
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Intraocular Medulloepitheliomae (Clinical Case Series) by S. V. Saakyan, A. I. Tsygankov, A. M. Maybogin, A. G. Amiryan, M. R. Khlgatyan, M. G. Zhiltsova, I. P. Khoroshilova‑Maslova, G. P. Zakharova

“…Purpose. Retrospective analysis of clinical, instrumental, cytological and pathological features of intraocular medulloepithelioma based on our own experience in the period from 2005 to 2018. …”
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Ferroptosis-related hub genes and immune cell dynamics as diagnostic biomarkers in age-related macular degeneration by Jinquan Chen, Zhao Long, Dandan Shi, Qian Zhang, H. Peng

“…Through Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, we identified differentially expressed genes (DEGs) that were significantly enriched in functions associated with ferroptosis. …”
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A pH-Responsive Poly Beta-Amino Ester Nanoparticulate Thermo-Responsive PEG-PCL-PEG Hydrogel Dispersed System for the Delivery of Interferon Alpha to the Ocular Surface by Yosra Abdalla, Lisa Claire du Toit, Philemon Ubanako, Yahya Essop Choonara

“…This was followed by characterisation via Fourier transform infrared spectroscopy (FT-IR), ¹H-nuclear magnetic resonance (¹H-NMR) analysis, differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) analysis, thermogravimetric analysis (TGA), and thermal-transition analysis of the PECE hydrogels. …”
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Visualization of FDA Adverse Drug Reaction Reports: Development and Usability Study of the VisDrugs Web Server by Renjun Yang, Nuoya Yin, Yang Zhang, Francesco Faiola

“…About 2,700,000 reports from health care professionals, where only a single drug was implicated, were aggregated and processed using R for statistical analysis and visualization. The results are presented on a web-based platform for web-based analysis. …”
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Quantitative assessment of colour fundus photography in hyperopia children based on artificial intelligence by Yuan Zhang, Yingting Zhu, Zhirong Wang, Yue Xiao, Yehong Zhuo, Zhidong Li, Guitong Ye, Jianqi Chen, Ruiyu Luo, Rui Xie, Jinan Zhan

“…Objectives This study aimed to quantitatively evaluate optic nerve head and retinal vascular parameters in children with hyperopia in relation to age and spherical equivalent refraction (SER) using artificial intelligence (AI)-based analysis of colour fundus photographs (CFP).Methods and analysis This cross-sectional study included 324 children with hyperopia aged 3–12 years. …”
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Multimodal imaging biomarkers for progression from intermediate to advanced age-related macular degeneration (AMD): a 10-year prospective longitudinal cohort study from the Univers... by Alan Palestine, Anne M Lynch, Naresh Mandava, Ramya Gnanaraj, Andres Lisker-Cervantes, Jennifer Patnaik, Vivian Rajeswaren, Nihaal Mehta, William Gange, Marc Mathias, Niranjan Manoharan, Talisa E de Carlo Forest

“…Objective To evaluate multimodal imaging (MMI) biomarkers for predicting progression from intermediate to advanced age-related macular degeneration (AMD).Methods and analysis This prospective longitudinal cohort study included patients with intermediate AMD (iAMD) enrolled in the University of Colorado AMD registry between July 2014 and August 2023, with follow-up through February 2024. …”
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Positive allosteric regulation of PAC1-R up-regulates<?A3B2 ACK?>PAC1-R and its specific ligand PACAP by Fan Guangchun, Tao Zhengxin, Chen Shang, Zhang Huahua, Yu Rongjie

“…>’s disease are synchronously inhibited by 2-bromopalmitate, which are positively correlated with the nuclear translocation of PAC1-R induced by PACAP(28-38) or TAT. Bioinformatics analysis and motif enrichment analysis following ChIP-sequencing show that the transcription factors including SP1, Zic2, GATA1, REST and YY1 may be recruited by nuclear PAC1-R and involved in regulating the promoter activities of PAC1-R and PACAP. …”
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