CatSkill: Artificial Intelligence-Based Metrics for the Assessment of Surgical Skill Level from Intraoperative Cataract Surgery Video Recordings by Binh Duong Giap, PhD, Dena Ballouz, MD, Karthik Srinivasan, MD, MS, Jefferson Lustre, BS, Keely Likosky, BS, Ossama Mahmoud, MD, Shahzad I. Mian, MD, Bradford L. Tannen, MD, JD, Nambi Nallasamy, MD

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Idebenone vs. rAAV2-ND4 gene therapy in the treatment of Leber’s hereditary optic neuropathy: An indirect comparison meta-analysis by Amr K Hassan, Hashem Abu Serhan

“…Secondary outcome measures were improvement of retinal nerve fiber layer thickness, ganglion cell layer volume, and visual field mean deviation. …”
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Efficacy of anti-VEGF and laser photocoagulation in the treatment of visual impairment due to diabetic macular edema: a systematic review and network meta-analysis. by Stephane Régnier, William Malcolm, Felicity Allen, Jonathan Wright, Vladimir Bezlyak

“…The outcome was chosen following acceptance by NICE of a Markov model with 10-letter health states in the assessment of ranibizumab for DME.<h4>Meta-analysis</h4>Bayesian network meta-analyses with fixed and random effects adjusted for differences in baseline BCVA or central retinal thickness.…”
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Integrated proteomics analysis and network pharmacology to elucidate the mechanism of Zhilong Huoxue Tongyu Capsule alleviate hypertensive retinopathy in Ang II infusion mice model by Jiao Wu, Wen Xie, Yucen Xie, Maryam Mazhar, Junguo Duan, Junguo Duan

“…Finally, Western blot, ELISA, IF, and other techniques were utilized to detect the expression of proteins related to inflammation, oxidative stress, and NLRP3 inflammasome activation.ResultsZLHXTY significantly alleviated retinal dysfunction, increased retinal blood flow, and mitigated pathological changes such as retinal tissues edema in HR mice. …”
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An analysis of the driving forces and resistance in the implementation of the "Integrated Control and Prevention of Three Highs and Six Diseases" strategy for chronic disease manag... by Haipeng WANG, Wenyu FAN, Xi CHEN, Xueying DU, Yu ZHANG, Liangxia CHEN, Gaohui ZHANG, Junjian SONG

“…The "Integrated Control and Prevention of Three Highs (high blood pressure/glucose/lipids) and Six Diseases (coronary heart disease, stroke, renal lesions, retinal lesions, peripheral neuropathy, and peripheral vascular lesions)" strategy is an important measure to establish and improve the integrated management service system for medical treatment and prevention of chronic diseases in Shandong province. …”
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Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis by Aljuhani HS, Hubayni RA, Qedair J, Bukhari ZM, Alzahrani A, Bawazir RO, Badghaish OS, Alqahtani F

“…The outcomes were changes in best-corrected visual acuity (BCVA), retinal thickness, choroidal neovascularization (CNV) leakage area from baseline based on fluorescein angiography, and adverse events.Results: Five studies involving 2,039 patients were included. …”
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Anti-VEGF drugs compared with laser photocoagulation for the treatment of proliferative diabetic retinopathy: a systematic review and individual participant data meta-analysis by Mark Simmonds, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Matthew Walton, Rob Hodgson, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, João Pereira Figueira, Sobha Sivaprasad, John G Lawrenson, Tunde Peto, David Steel

“…Background Proliferative diabetic retinopathy is a major cause of sight loss in people with diabetes, with a high risk of vitreous haemorrhage, tractional retinal detachment and other complications. Panretinal photocoagulation is the primary established treatment for proliferative diabetic retinopathy. …”
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Visual outcomes and treatment adherence of patients with macular pathology using a mobile hyperacuity home-monitoring app: a matched-pair analysis by Livia Faes, Lucas M Bachmann, Martin K Schmid, Dawn A Sim, Michael A Thiel, Meriam Islam, Nico Gross, Andrew Schimel

“…These effects were similar across retinal pathologies.Conclusions This data suggest that patients capable of performing mobile hyperacuity home monitoring benefit in terms of visual acuity and discontinue treatment less often than patients not using home monitoring.…”
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Combined intravitreal anti-VEGF and photodynamic therapy versus photodynamic monotherapy for polypoidal choroidal vasculopathy: a systematic review and meta-analysis of comparative... by Wei Wang, Miao He, Xiulan Zhang

“…Patients in the combined therapy group also might benefit from reduced retinal haemorrhage (OR: 0.32; 95% CI: 0.14, 0.74; P = 0.008). …”
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Proteomic Analysis of Retinas in a Rat Model of High-Fat Diet-Induced Type 2 Diabetes: Implications of Interventional Targets for Nonproliferative Diabetic Retinopathy by Pang X, Bai S, Feng Z, Zhang Y, Hu B, Zhang Y

“…Rat retinas were collected for morphology analysis, TMT proteomics analysis, and Western blotting. …”
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Anatomical and functional outcome of surgical correction of optic disc pit maculopathy using autologous scleral patch graft: a long-term retrospective analysis by Naresh Babu Kannan, Avik Dey Sarkar, MuthuKrishnan Vallinayagam, Swikruti Jena, Shraddha Shah, Kim Ramasamy

“…Methods This is a retrospective analysis of 54 patients with ODP maculopathy who were followed up for 12 months post-operatively. …”
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Morphological features of immune inflammation in patients with persistent post-traumatic uveitis by G. P. Zakharova, I. A. Filatova, V. O. Denisyuk

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Visual recovery in a patient with optic neuropathy secondary to copper deficiency by Arman Mosenia, Soman Khan, Moe H. Aung

“…On initial optical coherence tomography (OCT) analysis, retinal nerve fiber layer (RNFL) measurements were normal OU; however, GCL loss was noted in both eyes, left eye (OS) being worse than right eye (OD). …”
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Chloroquine and hydroxychloroquine-related ocular adverse events in SLE treatment: a real-world disproportionality analysis based on FDA adverse event reporting system (FAERS) by Xiang Li, Xiang Li, Xiang Li, Xiang Li, Xiang Li, Xiang Li, Xiang Li, Xiang Li, Si-Qi Zhang, Ke-Rui Wang, Ke-Rui Wang, Shi-Nan Wu, Shi-Nan Wu, Meng-Yuan Wang, Meng-Yuan Wang, Cui-Ting Chen, Cui-Ting Chen, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong

“…The most frequently reported ocular conditions were cataract, macular degeneration, and glaucoma. Disproportionality analysis demonstrated strong associations between HCQ/CQ use and retinal degeneration (ROR = 28.5, 95%CI: 19.94–40.74), cystoid macular oedema (ROR = 12.46, 95%CI: 8.01–19.37), and optic atrophy (ROR = 6.55, 95%CI: 3.51–12.19). …”
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Comparative efficacy of photodynamic therapy (PDT), ranibizumab, aflibercept monotherapy, and combination therapies for polypoidal choroidal vasculopathy: a network meta-analysis o... by Miguel A. Quiroz-Reyes, Erick A. Quiroz-Gonzalez, Miguel A. Quiroz-Gonzalez, Virgilio Lima-Gomez

“…Abstract Purpose Polypoidal choroidal vasculopathy (PCV) is recognized as a distinct clinical condition characterized by persistent serous leakage, bleeding, and the presence of polypoidal lesions beneath the retinal pigment epithelium (RPE). This systematic review and meta-analysis aimed to evaluate the effectiveness of combination treatments that include antivascular endothelial growth factor (anti-VEGF) agents, such as ranibizumab and aflibercept, along with photodynamic therapy (PDT), in comparison to monotherapy options for managing PCV. …”
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Distributed, layered and reliable computing nets to represent neuronal receptive fields by Arminda Moreno-Díaz, Gabriel de Blasio, Moreno-Díaz Jr.

“…In most cases, the nature of the responsessuggests the existence of a kind of distributed computation prior to the integration by the final cell which is evidently supported by the anatomy.We describe a new kind of discrete and continuous filters to model the kind of computations taking place in the receptive fields of retinal cells. To show their performancein the analysis of different non-trivial neuron-like structures, we use a computer tool specifically programmed by the authors to that effect. …”
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Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration by Siegfried Priglinger, Jakob Siedlecki, Benedikt Schworm, Franziska Eckardt, Michael Hafner, Ben Asani, Caspar Liesenhoff, Alexander Kufner, Johannes Benedikt Schiefelbein

“…Future studies with a larger patient cohort and prospective study setting should explore long-term outcomes and integration of artificial intelligence-driven analysis.…”
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Med-DGTN: Dynamic Graph Transformer with Adaptive Wavelet Fusion for multi-label medical image classification by Guanyu Zhang, Yan Li, Tingting Wang, Guokun Shi, Li Jin, Zongyun Gu, Zongyun Gu

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Dihydromyricetin attenuates age-related macular degeneration: pharmacological effects and exploration of putative targets by Hongyu Zhou, Jianhui Pang, Baiyang Wu, Yanan Zhuang, Shenjun Li, Jing Jiang, Jing Jiang

“…Subsequent oral gavage with DHM (50 or 100 mg/kg) was administered. Integrated network analysis, molecular docking, and RT- qPCR validation were employed.ResultsRT-qPCR analysis revealed that DHM reversed SI-induced aberrant expression of AMD-associated biomarkers (ICAM-1, APOE, HTRA1, ABCA4). …”
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Formation of the pediatric electroretinogram database parameters for the development of doctor’s decisionmaking algorithm by A. E. Zhdanov, A. Yu. Dolganov, V. N. Kazaykin, V. I. Borisov, V. O. Ponomarev, L. G. Dorosinsky, A. V. Lizunov, E. Luchian, X. Bao

“…It should be noted that the literature on retinal diseases demonstrates clinical cases in which patients may have several retinal diseases at the same time. …”
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