Pathomorphological Changes of the Retina in Chronic Intraocular Pressure Increase by T. A. Zhigalskaya, O. I. Krivosheina, V. P. Khazhieva

“…Thus, for example, the issue of the primacy of damage to the fundus structures in the development of glaucomatous optic neuropathy remains debatable.This review presents a modern view of the main pathomorphological changes in the retina in chronically elevated intraocular pressure (IOP). The analysis of structural changes in various layers of retinal tissue, primarily retinal ganglion cells in glaucoma, is carried out. …”
Get full text

Morphofunctional Studies in the Early Diagnosis of Primary Open-Angle Glaucoma by E. E. Kazaryan, I. A. Ronzina, V. M. Sheludchenko, T. V. Smirnova, D. M. Safonova, M. V. Khasyanova

“…The indices of the electrosensitivity of the inner layers of the retina, the conductivity of the axial fasciculus of the optic nerve, and CFSC also corresponded to normal values. Analysis of CCEA results showed a significant decrease of NRF volume of and the thickness of the retinal layer of nerve fibers compared to the control group, while in the group of patients with suspected glaucoma in 71 % of cases, the decrease of indicators correlated with the abnormalities in the static perimetry that was carried out earlier. …”
Get full text

Quantitative comparison of mean macular thickness in COVID-19 patients versus healthy individuals using optical coherence tomography by Nagilton Bou Ghosn, Marcos Balbino, Ana Carolina Pasquini Raiza, Camila Sayuri Vicentini Otani, Victoria Moreira Fernandes, Vitor Kazuo Lotto Takahashi, Beatriz Silveira Seixas, Laura Vanalli Guimarães, Luiz Paulo Dias Mario, Regina Cele Silveira Seixas

“…These results highlight the importance of age-stratified analysis and support further investigation into the long-term ocular effects of COVID-19.…”
Get full text

Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy by T. A. Pavlenko, S. Yu. Petrov, E. N. Iomdina

“…The modern pathogenesis of the neurodegenerative process in glaucoma identifies several key risk factors for its development: ischemia/hypoxia, mitochondrial dysfunction, oxidative stress and neuroinflammation. An analysis of recent studies shows that in glaucomatous optic neuropathy, as in other neurodegenerative diseases, the immune system is involved in the pathological process, and immunoregulation is carried out mainly by retinal glial cells, microglia, astrocytes, Müller cells and the complement system. …”
Get full text

OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma by T. N. Yurieva, S. I. Zhukova

“…Changes in the choroid thickness and capillary density of the retinal peripapillary layer may be considered as the most informative biomarkers in the diagnosis of glaucoma and the evaluation of antihypertensive therapy effectiveness.…”
Get full text

Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia by Wenxin Ma, Lian Zhao, Biying Xu, Robert N Fariss, T Michael Redmond, Jizhong Zou, Wai T Wong, Wei Li

“…We then performed xenotransplantation of these hiPSC-derived microglia into the subretinal space of adult mice whose endogenous retinal microglia have been pharmacologically depleted. …”
Get full text

Differential Visual Outcomes in Neovascular AMD Based on Ellipsoid Zone Integrity and Fluid Presence: Insights from a Phase III Trial by Justis P. Ehlers, Sari Yordi, Hasan Cetin, Reem Amine, Karen Matar, Asmita Indurkar, Katherine E. Talcott, Peter K. Kaiser, Arshad M. Khanani, Joanne Hu, Sunil K. Srivastava

“…<b>Background/Objectives</b>: To investigate the effect of ellipsoid zone (EZ) integrity and retinal fluid on best-corrected visual acuity (BCVA) in neovascular, age-related macular degeneration. …”
Get full text

Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina by Tatyana Appelbaum, David A. Smith, Kei Takahashi, Jennifer C. Kwok, Hannah Sorenson, William A. Beltran

“…RNA in situ hybridization (RNA-ISH) confirmed efficient internalization of PEGylated mRNA lipoplexes by cultured RAW264.7 and ARPE19 cells, though corresponding protein expression varied between cell lines. Analysis at 24 hours post-intravitreal injection of PEG-DMG- and HA-PEG-DPPE-stabilized enhanced green fluorescent protein (eGFP) mRNA lipoplexes revealed limited mRNA accumulation in inner retinal layers. …”
Get full text

Evaluation of TGF-Beta 2 and VEGFα Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retin... by Joanna Stafiej, Karolina Kaźmierczak, Katarzyna Linkowska, Paweł Żuchowski, Tomasz Grzybowski, Grażyna Malukiewicz

“…To evaluate the expression profiles of the VEGFα and TGFβ in the ERMs and ILMs in retinal disorders. Methods. In this nonrandomized prospective study, 75 patients (34 females and 41 males) referred to pars plana vitrectomy (PPV) due to different retinal diseases were enrolled to the study. …”
Get full text

Predictive factors for adherence to intravitreal anti-vascular endothelial growth factor therapy in Palestinian patients with diabetic retinopathy, retinal vein occlusion, and age-... by Hamza Abualhasan, Ithar M Beshtawi, Mohammad Noor, Othman Mustafa, Salem Hantoli

“…Abstract Background The burden of retinal vascular and degenerative diseases on patients and healthcare systems can be significant if patients do not complete scheduled intravitreal injections. …”
Get full text

Ocular markers of microangiopathy and their possible association with cardiovascular risk in patients with systemic inflammatory rheumatic diseases: a systematic review by Bengta Sturm, Anna-Lena Zang, Julia Stingl, Rebecca Hasseli-Fräbel, Antonis Fanouriakis, Andreas Schwarting, Andreas Schwarting, Christian Geber, Julia Weinmann-Menke, Mohammed Alhaddad, Konstantinos Triantafyllias, Konstantinos Triantafyllias

Subjects: “…retinal vessel analysis (RVA)…”
Get full text

Caspase-1 knockout disrupts pyroptosis and protects photoreceptor cells from photochemical damage by Xiaoping Yu, Jiayuan Peng, Qian Zhong, Ailin Wu, Xiaoming Deng, Yanfeng Zhu

“…Aim: Retinal photochemical damage (RPD) plays a significant role in the development of various ocular diseases, with Caspase-1 being a key contributor. …”
Get full text

Myopic Strain: a normalized metric concept for assessing axial myopia by Qi Ren, Zhe Chu

“…In an analysis of 242 eyes, ΔAL and Myopic Strain were derived from Morgan’s optometric model. …”
Get full text

The Relevance of Optical Coherence Tomography Angiography in Screening and Monitoring Hypertensive Patients with Carotid Artery Stenosis by Irina Cristina Barca, Vasile Potop, Stefan Sorin Arama

“…<b>Methods</b>: We conducted a study on hypertensive patients with ICAS using six OCTA parameters in the analysis of the retinal vasculature and carotid Doppler US velocities of three carotid arteries and the vertebral artery (VA). …”
Get full text

Spectral-domain optical coherence tomography imaging findings in patients receiving teprotumumab for thyroid eye disease by Timothy Truong, Rona Z. Silkiss, Johnell Renz Amoroso, Huanye Li, Quan V. Hoang, Kasra Eliasieh, Jesse J. Jung

Subjects: Get full text

Secreted phosphoprotein 1 on ophthalmic diseases by LIU Yuan, SANG Aimin

Get full text

Involvement of tdTomato-Tagged RPE cells in a mouse PVR model with enzymatically compromised retina by Yao Chen, Xiao Liu, Ashwini Kini, John Y. Liu, Xiaoqin Lu, Ling Gao, Henry J. Kaplan, Douglas C. Dean, Yongqing Liu

“…Abstract Ocular trauma and surgery are considered the most common cause for proliferative vitreoretinopathy (PVR). Many retinal cell types are thought to be the cellular source for PVR although most risk factors for PVR are associated with intravitreal dispersion of the retinal pigment epithelium (RPE) cells. …”
Get full text

Application of Artificial Intelligence Models to Predict the Onset or Recurrence of Neovascular Age-Related Macular Degeneration by Francesco Saverio Sorrentino, Marco Zeppieri, Carola Culiersi, Antonio Florido, Katia De Nadai, Ginevra Giovanna Adamo, Marco Pellegrini, Francesco Nasini, Chiara Vivarelli, Marco Mura, Francesco Parmeggiani

“…The complex retinal tissue is well-suited for scanning and easily accessible by modern AI-assisted multi-imaging techniques. …”
Get full text

POLYMORPHISMS OF EXTRACELLULAR CONNECTIVE TISSUE REMODELING PROTEINASES AND <i>MMP2, MMP3, MMP9</i> GENES, AND NEOANGIGENESIS <i>VEGF</i> GENE IN RETINAL MICROANGIOPATHY IN THE PAT... by A. V. Shevchenko, V. F. Prokofiev, V. I. Konenkov, V. V. Klimontov, N. V. Tyan, D. V. Chernykh, A. N. Trunov, V. V. Chernykh

Get full text

OCT RNFL and Macular GCC by Nisha Chaudhary, Neha Sachdeva, Umesh Sharma

“…Subjective errors in disc evaluation and visual field analysis is one of the major factor which reduces reliability of diagnosing and monitoring glaucoma progression. …”
Get full text