Longitudinal Comparison of Geographic Atrophy Enlargement Using Manual, Semiautomated, and Deep Learning Approaches by Jacob Bogost, Rachel E. Linderman, PhD, Robert Slater, PhD, Thomas F. Saunders, OD, Caleb Pacheco, Jeong Pak, PhD, Rick Voland, PhD, Barbara Blodi, MD, Amitha Domalpally, MD, PhD

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Multi-Comparison of Different Ocular Imaging Modality-based Deep Learning Models for Visually Significant Cataract Detection by Jocelyn Hui Lin Goh, BEng, Xiaofeng Lei, MSc, Miao-Li Chee, MPH, Yiming Qian, PhD, Marco Yu, PhD, Tyler Hyungtaek Rim, MD, PhD, Simon Nusinovici, PhD, David Ziyou Chen, MBBS, FRCOphth, Kai Hui Koh, BSc, Samantha Min Er Yew, BSc, Yibing Chen, BEng, Victor Teck Chang Koh, MBBS, MMed, Charumathi Sabanayagam, MD, PhD, Tien Yin Wong, MD, PhD, Xinxing Xu, PhD, Rick Siow Mong Goh, PhD, Yong Liu, PhD, Ching-Yu Cheng, MD, PhD, Yih-Chung Tham, PhD

“…Researchers have utilized various imaging modalities, including slit beam, diffuse anterior segment, and retinal imaging, to develop deep learning (DL) algorithms for automated cataract analysis. …”
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Unveiling a TGFBI Variant in the Retinal Capillary Hemangioblastoma, Type II Granular Corneal Dystrophy, and Von Hippel–Lindau Families: Unlocking Potential for Early Intervention... by Fatemeh Azimi, Golnaz Khakpour, Ahad Sedaghat, Fatemeh Mostafaiee, Hengameh Kasraei, Masood Naseripour

“…Purpose: To identify the potential genetic factors responsible for retinal capillary hemangioblastoma (RCH) and Type II granular corneal dystrophy (GCDII), with autosomal dominant inheritance. …”
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Factors associated with optic disc parameters and circumpapillary retinal nerve fiber layer thickness in 8-year-old children: The Yamanashi Adjunct Study of the Japan Environment a... by Ryo Harada, Mingxue Bao, Natsuki Okabe, Yuka Kasai, Airi Takahashi, Chio Kuleshov, Yumi Shigemoto, Tadao Ooka, Hiroshi Yokomichi, Kunio Miyake, Reiji Kojima, Ryoji Shinohara, Hideki Yui, Sanae Otawa, Megumi Kushima, Zentaro Yamagata, Kenji Kashiwagi, Yamanashi Adjunct Study of the Japan Environment and Children’s Study Group

“…The purpose of this study was to investigate the relationships between the circumpapillary retinal nerve fiber layer thickness (cpRNFL) and optic disc parameters and associated factors in 8-year-old Japanese children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study (JECS). …”
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A Distinct Phenotype of Mevalonic Acidemia with Absence of Pathogenic Mutations of Mevalonate Kinase Gene by Imad Dweikat, Nadera Damsa, Enas Naser

“…Both patients excreted moderate amounts of mevalonic acid. Molecular analysis of MVK gene showed no abnormalities and plasma 7-dehydrocholesterol and serum immunoglobulin D were normal. …”
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Real-Life Efficacy of Bevacizumab Treatment for Macular Edema Secondary to Central Retinal Vein Occlusion according to Pro Re Nata or Treat-and-Extend Regimen in Eyes with or witho... by Moustafa Hamam, Neil Lagali, Elie Abdulnour, Helen Setterud, Björn Johansson, Pierfrancesco Mirabelli

“…We carried out a retrospective analysis of 58 eyes (56 patients) with new-onset CRVO treated only with intravitreal bevacizumab according to TER or PRN. …”
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LEDGF(1-326) decreases P23H and wild type rhodopsin aggregates and P23H rhodopsin mediated cell damage in human retinal pigment epithelial cells. by Rinku Baid, Robert I Scheinman, Toshimichi Shinohara, Dhirendra P Singh, Uday B Kompella

“…<h4>Background</h4>P23H rhodopsin, a mutant rhodopsin, is known to aggregate and cause retinal degeneration. However, its effects on retinal pigment epithelial (RPE) cells are unknown. …”
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The causal effect of glaucoma and diabetic retinopathy: a Mendelian randomization study by Shuyun Chen, Ming Lin, Yu Hong

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Exploiting Microperimetry as a Functional End Point in Healthy Aging and Different Stages of Age-Related Macular Degeneration by Johannes Schrittwieser, MD, Klaudia Birner, MD, Leonard M. Coulibaly, MD, Ursula Schmidt-Erfurth, MD, Gregor S. Reiter, MD, PhD

“…The lowest retinal sensitivity was observed in patients with GA. …”
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Possible Role of Endothelial-Derived Cellular and Exosomal-miRNAs in Lipid-Mediated Diabetic Retinopathy: Microarray Studies by Khaled Elmasry, Samar Habib, Inas Helwa, Mariam Lotfy Khaled, Ahmed S. Ibrahim, Amany Tawfik, Mohamed Al-Shabrawey

“…Comparing the impact of 15-HETE versus DG or diabetic mouse retina elaborated commonly changing miRNAs. Pathway and target analysis for miRNAs changed in 15-HETE-treated HRECs revealed multiple targets and pathways that may be involved in 15-HETE-induced retinal endothelial dysfunction. …”
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Evaluating anti-VEGF responses in diabetic macular edema: A systematic review with AI-powered treatment insights by S Tamilselvi, M Suchetha, Dhanashree Ratra, Janani Surya, S Preethi, Rajiv Raman

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Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelero... by Stephanie J. Zawada, Ali Ganjizadeh, Bart M. Demaerschalk, Bradley J. Erickson

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TECHNIQUES OF EVALUATION OF HEMOGLOBIN OXYGEN SATURATION IN CLINICAL OPHTHALMOLOGY by S. Yu. Petrov, A. A. Antonov, I. A. Novikov, T. A. Savelieva

“…Currently, monitoring of oxygen saturation in retinal blood vessels, i.e. retinal oximetry, is well developed. …”
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The Beneficial Role of the Thyroid Hormone Receptor Beta 2 (<i>thrb2</i>) in Facilitating the First Feeding and Subsequent Growth in Medaka as Fish Larval Model by Jiaqi Wu, Ke Lu, Ruipeng Xie, Chenyuan Zhu, Qiyao Luo, Xu-Fang Liang

“…Following the successful knockout of thyroid hormone receptor beta 2 (<i>thrb2</i>) using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology, there was an increase in the expression of UV opsin (short-wave-sensitive 1, <i>sws1</i>), while the expression of other cone opsins was significantly decreased. Further analysis of the retinal structure demonstrated that the <i>thrb2</i> knockout resulted in an increased lens thickness and a decreased thickness of the ganglion cell layer (GCL), outer plexiform layer (OPL), and outer nuclear layer (ONL) in the retina. …”
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Interruption of the visual cycle in a novel animal model induces progressive vision loss resembling Stargardts Disease by Fabiana Sassone, Catherine Estay-Ahumada, Michel J. Roux, Dominique Ciocca, Paola Rossolillo, Marie-Christine Birling, Janet R. Sparrow, Diego Montenegro, David Hicks

“…Transmission electron microscopy showed large numbers of lipid inclusions in treated but not control retinal pigmented epithelium. Finally, ultra-high performance liquid chromatography analysis of whole P. obesus eyes showed the presence of all-trans retinal-dimer, not detected in rod-rich rat eyes. …”
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Correlation of Blood Glucose Control With Cystoid Macular Edema and Central Macular Thickness After Cataract Surgery in Diabetics by Ding R, Wu B, Sun Y, Zhang X, Mi H, Kong Y, Ma Y

“…The aim of this study was to investigate the correlation between postoperative HbA1c levels and postoperative cystoid macular edema (CME) and central macular thickness (CMT) in diabetic cataract patients.Methods: Retrospective analysis was conducted on 80 patients with diabetic cataracts from December 2018 to December 2023. …”
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Age-Related Macular Degeneration and Circadian Preference by Garces E, Slota K, Stewart MW, Guzman MP, Werninck NM, Castillo PR

“…Within the retina, a subset of cells, called melanopsin-containing intrinsically photosensitive retinal ganglion cells, are implicated in circadian rhythms, prompting a search for a potential connection between circadian behavior and AMD. …”
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Efficacy and safety of adalimumab for inflammatory flare prevention in paediatric non-infectious anterior uveitis with peripheral retinal vascular leakage: a study protocol for a s... by Fei Gao, Yuelun Zhang, Donghui Li, Chan Zhao, Meifen Zhang, Hang Song, Yujing Qian, Junyan Xiao

“…This study aims to assess the efficacy and safety of adalimumab for inflammatory flare prevention in non-infectious paediatric anterior uveitis with peripheral retinal vascular leakage, compared with methotrexate.Methods and analysis Children weighed ≥30 kg and aged between 4 and 16 years old with active non-infectious anterior uveitis with peripheral retinal vascular leakage on ultra-wildfield fluorescein fundus angiography will be included. …”
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Preference of Near-optical Low-vision Devices among Patients with Low Vision Attending Low-vision Clinic of a Tertiary Eye Hospital in Nepal by Bigyan Bhusal, Hari Bahadur Thapa, Dikshya Khadka

“…The major causes of low vision were retinitis pigmentosa (16.7%) followed by nystagmus (15.2%). …”
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Genetic context modulates aging and degeneration in the murine retina by Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

“…Genetic background strongly modulated these aging signatures. Analysis of cell type-specific marker genes predicted age-related loss of photoreceptors and retinal ganglion cells (RGCs) in WSB and NZO, respectively. …”
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