Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration. by Passley Hargrove-Grimes, Anupam K Mondal, Jessica Gumerson, Jacob Nellissery, Angel M Aponte, Linn Gieser, Haohua Qian, Robert N Fariss, Juan S Bonifacino, Tiansen Li, Anand Swaroop

“…RabGEF1 protein in retinal photoreceptors interacts with Rabaptin-5, and RabGEF1 absence leads to reduction of early endosomes consistent with studies in other mammalian cells and tissues. …”
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Quantitative assessment of retinal thickness and vessel density using optical coherence tomography angiography in patients with Alzheimer's disease and glaucoma. by Przemyslaw Zabel, Jakub J Kaluzny, Katarzyna Zabel, Martyna Kaluzna, Aleksander Lamkowski, Damian Jaworski, Jaroslaw Makowski, Martyna Gebska-Toloczko, Robert Kucharski

“…<h4>Purpose</h4>Assessment and a direct comparison of retinal vessel density with the thickness of inner retinal layer (IRL) and outer retinal layer (ORL) in the same regions of the macula in subjects with Alzheimer's disease (AD) and primary open-angle glaucoma (POAG).…”
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Varicella Zoster Virus-induced Acute Retinal Necrosis Following Acute Meningoencephalitis in a Patient with Presumed COVID-19 by Kiana Hassanpour, Faezeh Khorasanizadeh, Mahmood Nabavi, Narsis Daftarian, Alireza Ramezani

“… Purpose: To report the coincidence of acute retinal necrosis (ARN) syndrome following acute meningoencephalitis and presumed coronavirus disease 2019 (COVID-19) in an immunocompetent patient. …”
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Microphthalmia and Disrupted Retinal Development Due to a LacZ Knock-in/Knock-Out Allele at the Vsx2 Locus by Napoli FR, Li X, Hurtado AA, Levine EM

“…Germline transmission was assessed with genomic DNA PCR and Western blot analysis was used to describe VSX2 expression from the mutant allele (LacZ). …”
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Expanding Genetic and Clinical Spectra of Inherited Retinal Dystrophies: Identification of Three Novel <i>PRPH2</i> Variants by Raffaella Cascella, Jacopo Sebastiani, Claudia Strafella, Giulia Calvino, Sarah Andreucci, Michele D’ambrosio, Stefania Zampatti, Jung Hee Levialdi Ghiron, Benedetto Falsini, Andrea Cusumano, Emiliano Giardina

“…<b>Background/Objectives</b>: Pathogenic variants in the <i>PRPH2</i> gene are implicated in a wide spectrum of Inherited Retinal Dystrophies (IRDs), which show significant phenotypic heterogeneity. …”
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Combination of αCD4 antibody and retinal antigen injection induces long-term disease control in autoimmune uveitis by Dijie Qiao, Lu Zhang, Yajie Zhong, Dongmei Liu, Zilin Chen, Wai Po Chong, Wai Po Chong, Wai Po Chong, Jun Chen

“…Transcriptomic analysis revealed significant downregulation of inflammation-related genes following treatment.ConclusionThese findings support the long-term immunomodulatory effect of combining αCD4 antibody and retinal antigen injection, offering a potential strategy for managing chronic progressive autoimmune uveitis.…”
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In-vitro effect of aflibercept and dexamethasone on the expression level of genes associated with epithelial-mesenchymal transition in retinal pigment epithelial cells by M. Hossein Nowroozzadeh, Hajar Farvardin, Seyed Ali Nabavizadeh, Fatemeh Sanie-Jahromi

“…Purpose: Proliferative vitreoretinopathy (PVR) is the primary cause of surgical failure in retinal detachment repair, and the epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells plays a crucial role in the pathophysiology of PVR. …”
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Protective Role and Enhanced Intracellular Uptake of Curcumin in Retinal Cells Using Self-Emulsifying Drug Delivery Systems (SNEDDS) by Elide Zingale, Sebastiano Masuzzo, Tatu Lajunen, Mika Reinisalo, Jarkko Rautio, Valeria Consoli, Agata Grazia D’Amico, Luca Vanella, Rosario Pignatello

“…Cell uptake studies confirmed an enhanced accumulation of CUR within the retinal cells following exposure to CUR-SNEDDS compared to neat CUR. …”
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Investigation of early-stage cardiovascular-kidney-metabolic syndrome on retinal structure and function evaluated by optical coherence tomography angiography by Yunyi Liang, Congbi Liang, Jianping Yang, Wanhua Li, Runyi Liang, Kun Li, Jingfeng Zhang, Peiqiong Lao, Junhua Zhu, Lin An, Zhaohao Liang, Chubin Ou

“…BackgroundThe retina serves as a non-invasive window to visualize systemic health, with optical coherence tomography angiography (OCTA) enabling simultaneous assessment of retinal structural thickness and vascular density. …”
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m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells by Qian Zhou, Xianyang Liu, Huiping Lu, Na Li, Jiayu Meng, Jiaxing Huang, Zhi Zhang, Jiangyi Liu, Wei Fan, Wanqian Li, Xingran Li, Xiaoyan Liu, Hangjia Zuo, Peizeng Yang, Shengping Hou

“…To delve into the critical aspects of cell-mediated angiogenesis, we analyzed our previously published single-cell data. Our analysis revealed that retinal pigment epithelium (RPE) cells serve a crucial promotional function in angiogenesis. …”
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Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration by Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Sylvia Bolz, Andjela Sekulic, Marius Ueffing, Marius Ueffing, Simon J. Clark, Simon J. Clark, Simon J. Clark, Nadine Reichhart, Sergio Crespo-Garcia, Nicola Wilck, Nicola Wilck, Nicola Wilck, Nicola Wilck, Olaf Strauß

“…IntroductionAge-related macular degeneration (AMD) is a leading cause of blindness with limited treatment options. Dysfunction of the retinal pigment epithelium (RPE) is a unifying salient feature of the pathology and a primary end-point damage leading to complications such as geographic atrophy (GA), which represents the most common end-stage of AMD.MethodsHuman and murine ocular tissues were used for histological examinations. …”
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Nitro-Oleic acid protects from neovascularization, oxidative stress, gliosis and neurodegeneration in oxygen-induced retinopathy by Vaglienti María Victoria, Paz María Constanza, Gutierrez Maria Victoria, Subirada Paula Virginia, Luna Jose, Bonacci Gustavo, Sánchez María Cecilia

“…Loss of retinal function in OIR mouse model measured by electroretinography was ameliorated, mainly at P26 OIR, after NO2-OA treatment. …”
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Oct Angiography: The Basics by Khushboo Chawla

“…OCT angiography is a new imaging technology that provides volumetric analysis of retina, choroid, and optic nerve. It helps to delineate early hemodynamic alteration in the vasculature of retina and choroid. …”
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Causes of failure of pneumatic retinopexy by Roberto E. Flaminiano, MD, Robert T. Sy, MD, Milagros H. Arroyo, MD, Pearl Tamesis-Villalon, MD

“…Two-tailed Fisher’s exact test and Chi square test were used in the analysis of statistical significance. Results: The following variables were shown to be significantly correlated with failure: eyes with breaks outside the 11-1 o’clock meridians (p = 0.02), eyes with less than or equal to 3 quadrants of retinal detachment (p = 0.05), and preoperative visual acuity worse than 5/60 (p < 0.100). …”
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Prediction of late results of surgical treatment of traumatic retina detachment in eye injury of multiple origin by N. L. Leparskaya

“…A comprehensive analysis of the clinical picture (using 22 features) and long-term results of surgical treatment of 427 patients with traction traumatic RD (TRD) after open and closed eye injury was carried out. …”
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Adult-onset Coats’ disease: a review by V. E. Tankovskiy, S. I. Ponomareva

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Meta-analysis: long/short-term efficacy of anti-VEGF vs. panretinal photocoagulation in preventing severe complications in proliferative diabetic retinopathy by Tiago N. O. Rassi, Lucas M. Barbosa, Dillan Cunha Amaral, Ricardo N. Louzada, Helvécio N. F. Filho, Guilherme N. Marques, Breno C. Vieira, Sobha Sivaprasad, Mauricio Maia

“…Abstract Background Studies diverge on the relevance of long-term protection of anti-VEGF against severe proliferative diabetic retinopathy (PDR) complications compared to pan-retinal photocoagulation (PRP). We aim to assess this dispute through a meta-analysis. …”
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Assessment of retinal and choroidal structural and microvascular changes in early diabetic retinopathy using swept-source optical coherence tomography angiography. by Jin Jiang, Xiaole Wang, Hongjun Bian

“…<h4>Materials and methodologies</h4>This study is a retrospective analysis that included patients with early DR admitted to the Affiliated Third Hospital of Nantong University from January 2024 to December 2024. …”
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Klotho null mutation leads to retinal degeneration characterized by functional impairment, gliosis, and deposition of amyloid-beta and hyperphosphorylated tau proteins. by Zhi-Jia Chen, Chun-Yen Wu, Fang-Yan Hsiao, Jing-Chun Ma, Gabriel Lai, Han-Hsin Chang, David Pei-Cheng Lin

“…The electroretinogram results showed retinal function impairment with Klotho null mutation, as compared with their littermates. …”
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Comparison of intravitreal anti-VEGF agents and oral carbonic anhydrase inhibitors in the treatment of cystoid macular edema secondary to retinitis pigmentosa by Jia Liang, Xueping Wu, Lu Chen, Lujia Feng, Xiangqing Hei, Yingying Diao, Yuke Ji, Huiyan Zheng, Zhenhua Zou, Dong Fang, Shaochong Zhang

“…PurposeTo compare the efficacy of intravitreal antivascular endothelial growth factor (anti-VEGF) agents with oral carbonic anhydrase inhibitors (CAIs) in treating cystoid macular edema (CME) secondary to retinitis pigmentosa (RP).MethodsThis retrospective study analyzed 98 patients (98 eyes) with RP-CME: 47 (48.0%) received intravitreal anti-VEGF agents (Ranibizumab or Bevacizumab) and 51 (52.0%) were treated with oral CAIs (methazolamide 50 mg/day or acetazolamide 500 mg/day). …”
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