External Validation of Deep Learning Models for Classifying Etiology of Retinal Hemorrhage Using Diverse Fundus Photography Datasets by Pooya Khosravi, Nolan A. Huck, Kourosh Shahraki, Elina Ghafari, Reza Azimi, So Young Kim, Eric Crouch, Xiaohui Xie, Donny W. Suh

“…Retinal hemorrhage (RH) is a significant clinical finding with various etiologies, necessitating accurate classification for effective management. …”
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Mutation screening of retinal dystrophy patients by targeted capture from tagged pooled DNAs and next generation sequencing. by Christopher M Watson, Mohammed El-Asrag, David A Parry, Joanne E Morgan, Clare V Logan, Ian M Carr, Eamonn Sheridan, Ruth Charlton, Colin A Johnson, Graham Taylor, Carmel Toomes, Martin McKibbin, Chris F Inglehearn, Manir Ali

“…<h4>Results</h4>Molecular analysis of 20 DNAs from retinal dystrophy patients identified likely pathogenic mutations in 12 cases, many of them known and/or confirmed by segregation. …”
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Gain of 20q11.21 in human pluripotent stem cells enhances differentiation to retinal pigment epithelium by Loriana Vitillo, Fabiha Anjum, Zoe Hewitt, Owen Laing, Nidaa A. Ababneh, Duncan Baker, Ivana Barbaric, Peter J. Coffey

“…The final cell therapy product consists of retinal pigment epithelium (RPE) cells differentiated from hPSCs. …”
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Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalk by Qing Xia, Kun-Che Chang, Yanan Sun, Michael Nahmou, Takahiko Noro, Yun Cheng, Xiangmei Kong, Xiaofen Mo, Jeffrey L. Goldberg, Suqian Wu

“…Here we developed a cell-to-cell interaction model to identify a retinal ganglion cell (RGC)-protective factor derived from induced pluripotent stem cells (iPSCs). …”
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Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth into Retinal Photoreceptor-Like Cells and Their Sustainability In Vivo by Xiaoxia Li, Jing Xie, Yue Zhai, Tengjiaozi Fang, Nanquan Rao, Shuang Hu, Liping Yang, Yuming Zhao, Yixiang Wang, Lihong Ge

“…In addition, calcium influx was significantly greater in the retinal-induced than in noninduced SHEDs. In vivo tracking confirmed at least 2 weeks of good survival by bioluminescent imaging and 3 months of sustainability of SHEDs by histological analysis. …”
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Can off-the-shelf visual large language models detect and diagnose ocular diseases from retinal photographs? by Tien Yin Wong, Yih Chung Tham, Ching-Yu Cheng, Wendy Wong, Ya Xing Wang, Hongwei Ji, Zhi Da Soh, Xiaofei Wang, Jocelyn Hui Lin Goh, David Ziyou Chen, Krithi Pushpanathan, Sahana Srinivasan, Weizhi Ma

“…This study aimed to evaluate the capabilities of commonly available VLLMs, such as OpenAI’s GPT-4V and Google’s Gemini, in detecting and diagnosing ocular diseases from retinal images.Methods and analysis From the Singapore Epidemiology of Eye Diseases (SEED) study, we selected 44 representative retinal photographs, including 10 healthy and 34 representing six eye diseases (age-related macular degeneration, diabetic retinopathy, glaucoma, visually significant cataract, myopic macular degeneration and retinal vein occlusion). …”
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Islet1 and Brn3 Expression Pattern Study in Human Retina and hiPSC-Derived Retinal Organoid by Ziming Luo, Chaochao Xu, Kaijing Li, Bikun Xian, Yuchun Liu, Kang Li, Ying Liu, Huifeng Rong, Mingjun Tang, Dongpeng Hu, Sijing Yang, Meifang Ye, Xiufeng Zhong, Jian Ge

“…Immunofluorescence analysis showed that Islet1 was expressed in retinal ganglion cells in the fetal retina, human adult retina, and retinal organoids. …”
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Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa by Hyun Beom Song, Laura Campello, Anupam Mondal, Holly Y Chen, Milton A English, Michael Glen, Phillip Vanlandingham, Rafal Farjo, Anand Swaroop

“…The female rats demonstrate better preservation of both rod and cone photoreceptors following reserpine treatment. Retinal transcriptome analysis reveals sex-specific responses to reserpine, with significant upregulation of phototransduction genes and proteostasis-related pathways, and notably, genes associated with stress response. …”
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Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure by Yuchen Li, Yuyao Qu, Hanze Zhang, Yue Bian, Langxuan Yuan, Jingbo Hu, Shengrui Xu, Xiayu Xu, PhD, Jianqin Lei, MD

“…Results: A total of 54 eyes from 44 participants were included after screening. Univariate analysis revealed a significant negative impact of MAP on averaged caliber of retinal artery (B = −0.003, P = 0.004) and averaged caliber of retinal vein (ACvein) (B = −0.002, P = 0.045), whereas age, sex, BMI, AL, and IOP showed no significant impact on these metrics. …”
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A Novel NPHP5 Gene Mutation in Three Siblings With Nephronophthisis Without Retinitis Pigmentosa: A Case Report by Randah Abdullah Dahlan, Roaa Hani Fairoozy

“…Unlike previously described mutations in the IQCB1/NPHP5 gene, the patient and his affected siblings do not have retinitis pigmentosa. We report this novel gene variant in a Saudi family, describe its associated clinical features, and present the results of the family segregation analysis.…”
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A comparative study of retinal vein occlusion and serum 25 hydroxy Vitamin D at a tertiary care centre by Aishwarya Bhattacharya, Swati Majumdar, Manali Sinha Ray, Debasmita Nandi, Sambuddha Ghosh, Debolina Banerjee

“…BACKGROUND: Prevalence of retinal vascular occlusion is second to diabetic retinopathy and age-related macular degeneration. …”
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The Main Patterns of Disorders of the Visual System in Patients with Retinal Detachment in Pediatric and Adult Practice in Terms of the Level of Antioxidant Protection by A. A. Sergienko, A. V. Malyshev, A. S. Apostolova

“…The study included patients with a verified diagnosis of “Traction retinal detachment” (RD) in pediatric (50 patients, mean age 13.8 ± 1.1 years, age range from 11 to 18 years) and adults (50 patients, mean age 54, 6 ± 2.2 years, age range 19 to 72 years). …”
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Quantitative assessment of depolarization by the retinal pigment epithelium in healthy and glaucoma subjects measured over a large field of view. by Alice R Motschi, Florian Schwarzhans, Sylvia Desissaire, Stefan Steiner, Hrvoje Bogunović, Philipp K Roberts, Clemens Vass, Christoph K Hitzenberger, Michael Pircher

“…We present measurements of depolarization introduced by the retinal pigment epithelium (RPE) over a 45° field of view using polarization sensitive optical coherence tomography. …”
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Dysregulated lipid metabolism in a retinal pigment epithelial cell model and serum of patients with age-related macular degeneration by Ana Álvarez-Barrios, Lydia Álvarez, Pilar Sáenz de Santa María, Montserrat García, Jorge R. Álvarez-Buylla, Rosario Pereiro, Héctor González-Iglesias

“…Abstract Background Age-related macular degeneration (AMD) is a leading cause of blindness, characterized by retinal pigment epithelium (RPE) dysfunction, extracellular deposit formation, and disrupted lipid metabolism. …”
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Functional and molecular characterization of rod-like cells from retinal stem cells derived from the adult ciliary epithelium. by Gian Carlo Demontis, Claudia Aruta, Antonella Comitato, Anna De Marzo, Valeria Marigo

“…We also identified voltage-gated channels necessary for rod maturation and viability. This level of analysis for the first time provides evidence that adult retinal stem cells can generate highly homogeneous rod-fated cells.…”
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Optical coherence tomography findings as a predictor of clinical course in patients with branch retinal vein occlusion treated with ranibizumab. by Akira Shiono, Jiro Kogo, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Naoto Tokuda, Yasushi Kitaoka, Hitoshi Takagi

“…OCT parameters influencing BCVA and number of IVRs were evaluated using multivariate analysis. Correlations between nonperfusion areas (NPAs) and thinning areas and changes in retinal thickness of BRVO-affected areas were assessed.…”
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Nanoprobe synchrotron X-ray fluorescence microscopy reveals selenium-rich spherical structure in mouse retinal pigment epithelium by Marta Ugarte, Kalotina Geraki, Elizabeth Bentley, Roger Cox

“…This study presents the first nanoprobe X-ray fluorescence microscopy image analysis of adult mouse light adapted outer retinal complex from the whole tissue to subcellular structures. …”
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SHMT2 overexpression improves glaucoma by enhancing mitophagy in retinal ganglion cells through promoting the phospho of PINK1 by Liying Cui, Baojun Wang

“…Abstract Background Glaucoma is a major eye disease that causes blindness. The loss of retinal ganglion cells (RGCs) due to mitophagy impairment is a key driver of glaucoma. …”
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Retinal vascular fractal dimension, childhood IQ, and cognitive ability in old age: the Lothian Birth Cohort Study 1936. by Adele M Taylor, Thomas J MacGillivray, Ross D Henderson, Lasma Ilzina, Baljean Dhillon, John M Starr, Ian J Deary

“…IQ scores were available from childhood. Retinal vascular Df was calculated with monofractal and multifractal analysis, performed on custom-written software. …”
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Exploring the impact of oxidative stress, excitotoxicity, and apoptosis of retinal ganglion cells in streptozotocin-induced rats: A comprehensive investigation by Maharani, Arief Sjamsulaksan Kartasasmita, Fifin Luthfia Rahmi, Arief Wildan, Hermawan Istiadi, Annisa Dentin Nugroho, Banundari Rachmawati

“…This process contributes to retinal ganglion cell (RGC) apoptosis through the expression of N-methyl-D-aspartate (NMDA) receptors and nitric oxide (NO). …”
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