Efficacy and Safety in Retinal Vein Occlusion Treated with at Least Three Consecutive Intravitreal Dexamethasone Implants by Julia Proença Pina, Khalil Turki, Julien Labreuche, Alain Duhamel, Thi Ha Chau Tran

“…A total of 18 eyes were included for analysis. Mean interval of retreatment with DI was 5.1 months between the first and second DI and 5.4 months following the second DI. …”
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Protective Effect of Hesperetin and Naringenin against Apoptosis in Ischemia/Reperfusion-Induced Retinal Injury in Rats by Selcuk Kara, Baran Gencer, Turan Karaca, Hasan Ali Tufan, Sedat Arikan, Ismail Ersan, Ihsan Karaboga, Volkan Hanci

“…Animals were given either hesperetin, naringenin, or the solvent intraperitoneally immediately following reperfusion. Thickness of retinal layers and retinal cell apoptosis were detected by histological analysis, tunel assay, and immunohistochemistry assay. …”
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Retinal and Choroidal Thickness in relation to C-Reactive Protein on Swept-Source Optical Coherence Tomography by Dawei Fang, Qingjian Li, Ke Yan, Sennan Xu, Jing Jiang, Xin Che, Yu Zhang, Yiwen Qian, Zhiliang Wang

“…According to Pearson’s correlation analysis, the CRP was significantly negatively correlated with the choroidal thickness in all sectors and the retinal thickness only in the inner temporal and outer nasal sectors of the ETDRS grid. …”
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Proinflammatory Cytokines Trigger the Onset of Retinal Abnormalities and Metabolic Dysregulation in a Hyperglycemic Mouse Model by Gaganashree Shivashankar, Julie C. Lim, Monica L. Acosta

“…Recent evidence has shown that retinal inflammation is a key player in diabetic retinopathy (DR) pathogenesis. …”
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Ocular pharmacokinetics of intravitreal conbercept in a rabbit model following retinal scatter laser photocoagulation by Lanlan Chen, Lanlan Chen, Hua Liu, Hua Liu, Qingrong Zhang, Qingrong Zhang, Houbin Huang

“…ObjectiveThe present study aims to evaluate the ocular pharmacokinetics of intravitreal conbercept after retinal scatter laser photocoagulation.MethodsThirty male Chinchilla rabbits (60 eyes) were used in this study. …”
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Diagnostic whole exome sequencing in presumably autosomal recessive inherited retinal dystrophies in an Iranian population by Pam A.T. Heutinck, Adriana I. Iglesias, Dariush D. Farhud, Marianne van Tienhoven, Atiyeh Khoshraftar, Marjan Zarif-Yeganeh, Sima Kheradmand Kia, Mohsen Ghanbari, Magda A. Smoor, Caroline C.W. Klaver, Lies H. Hoefsloot, Alberta A.H.J. Thiadens, Virginie J.M. Verhoeven

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Enhancing retinal disease diagnosis through AI: Evaluating performance, ethical considerations, and clinical implementation by Maryam Fatima, Praveen Pachauri, Wasim Akram, Mohd Parvez, Shadab Ahmad, Zeinebou Yahya

“…Findings: The search identified 145 studies, of which 61 met the inclusion criteria and were eligible for analysis. The narrative summary of findings indicated that AI algorithms generally demonstrated high accuracy, sensitivity, and specificity in detecting retinal diseases. …”
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OCT5k: A dataset of multi-disease and multi-graded annotations for retinal layers by Mustafa Arikan, James Willoughby, Sevim Ongun, Ferenc Sallo, Andrea Montesel, Hend Ahmed, Ahmed Hagag, Marius Book, Henrik Faatz, Maria Vittoria Cicinelli, Amani A. Fawzi, Dominika Podkowinski, Marketa Cilkova, Diana Morais De Almeida, Moussa Zouache, Ganesham Ramsamy, Watjana Lilaonitkul, Adam M. Dubis

“…This step was iterated three times, improving layer annotations’ quality iteratively, ensuring a reliable dataset for automated retinal image analysis.…”
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Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease by Kerstin Schweyer, Tobias Mantel, Benjamin Knier, Lilian Aly, Jan S. Kirschke, Tobias Meindl, Bernhard Haslinger

“…Results: Significant positive correlations were found between cognitive impairment measured by MoCA and specific retinal layers (IPL, GCL, and RNFL). Of these, strong associations were observed between the IPL and GCL and cortical thickness in brain the temporal lobe and limbic cortex, with more detailed further analysis showing significant correlations particularly within the middle and posterior cingulate cortex in the limbic cortex and the middle and superior temporal gyrus in the temporal lobe. …”
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The Impact of Macronutrients on Retinal Microvasculature among Singapore Pregnant Women during the Mid-Late Gestation. by Ling-Jun Li, Peng Guan Ong, Marjorelee T Colega, Chad Yixian Han, Ling Wei Chen, Ryan Man Eyn Kidd, Ecosse Lamoureux, Peter Gluckman, Kenneth Kwek, Yap Seng Chong, Seang Mei Saw, Keith M Godfrey, Tien Yin Wong, Mary Chong Foong-Fong, GUSTO study group

“…<h4>Results</h4>In adjusted model, each 20 points decrease in HEI-AP score was associated with a significant increase of 1.70 μm (p<0.05) in retinal venular calibre. Each 0.1 log increase in percentage of total fat intake was associated with a significant increment of 1.84 μm (p<0.05) in retinal venular caliber. …”
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Comparison of 25- and 27-Gauge Pars Plana Vitrectomy in Repairing Primary Rhegmatogenous Retinal Detachment by Keiko Otsuka, Hisanori Imai, Ayaka Fujii, Akiko Miki, Mizuki Tagami, Atsushi Azumi, Makoto Nakamura

“…A retrospective comparative analysis of 62 consecutive eyes from 62 patients with 6 months of follow-up was performed. …”
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Transplacental Transfer of Oxytocin and Its Impact on Neonatal Cord Blood and In Vitro Retinal Cell Activity by Claudette O. Adegboro, Wenxiang Luo, Meha Kabra, Ryan M. McAdams, Nathaniel W. York, Ruwandi I. Wijenayake, Kiana M. Suchla, De-Ann M. Pillers, Bikash R. Pattnaik

“…Our previous research revealed that the oxytocin receptor (OXTR), essential in forming the blood–retina barrier, is expressed in the retinal pigment epithelium (RPE). We hypothesized that perinatal OXT administration might influence the development of the neural retina and its vasculature, offering therapeutic potential for retinal diseases such as retinopathy of prematurity (ROP). …”
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Changes in retinal microvasculature and serum Gremlin-1 levels in acromegaly: A case-control study by Gokcen Unal Kocabas, Onur Furundaoturan, Cumali Degırmencı, Su Ozgur, Meltem Kocamanoglu, Cigdem Gozde Arslan, Esma Pehlivan Koroglu, Filiz Afrashı, Yasemin Akcay, Ilgin Yildirim Simsir, Banu Sarer Yurekli

“…Objective: There are controversial results about the effects of GH/IGF-1 on retinal vasculature. Gremlin-1 has roles in both pituitary tumorigenesis and angiogenesis. …”
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Ultra-Widefield Retinal Optical Coherence Tomography (OCT) and Angio-OCT Using an Add-On Lens by Bartosz L. Sikorski

“…This study also shows a high agreement of the ETDRS sector’s thickness measurements between UWF and standard retinal scans, which allows UWF to be used for quantitative macular thickness analysis. …”
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Deep learning assisted retinal microvasculature assessment and cerebral small vessel disease in Fabry disease by Yingsi Li, Xuecong Zhou, Junmeng Li, Yawen Zhao, Yujing Yuan, Bo Yang, Jingjing Xu, Qijie Wei, Xiaoming Yan, Wei Zhang, Yuan Wu

“…Results Utilizing artificial intelligence-assisted analysis, compared with controls, FD patients exhibited reduced diameter (p = 0.001 for central retinal artery equivalent, p = 0.049 for central retinal vein equivalent), density (p < 0.001 for vessel area density, p = 0.001 for length density), fractal dimension (p < 0.001), and heightened arteriolar and venular asymmetry ratios (p = 0.002 and p = 0.037, respectively), venular curvature tortuosity (p = 0.037), and simple tortuosity (p = 0.037) in retinal microvascular networks. …”
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Bile Acid Metabolism Changes in Patients with a CRB1-Associated Inherited Retinal Degeneration by Lude Moekotte, MD, PhD, Joke H. de Boer, MD, PhD, Sanne Hiddingh, MSc, Bram Gerritsen, PhD, Jutta Lintelmann, PhD, Alexander Cecil, PhD, L. Ingeborgh van den Born, MD, PhD, Xuan-Thanh-An Nguyen, MD, PhD, Camiel J.F. Boon, MD, PhD, Maria M. van Genderen, MD, PhD, Jonas J.W. Kuiper, PhD

“…Purpose: To compare the plasma metabolic profile of patients with a Crumbs homolog 1-associated inherited retinal degeneration (CRB1-IRD) with that of healthy controls (HCs). …”
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Cytokine profile of intraocular fluids to predict macular edema in surgical treatment of rhegmatogenous retinal detachment by I.V. Khizhnyak, E.V. Boiko, I.E. Panova, A.N. Trunov, E.M. Svistunova, Yu. P. Koval’chuk

“…Material and methods. An analysis of the treatment of 28 patients (28 eyes) with RRD complicated by PVR Sr type 1–4 involving the macular area was carried out. …”
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Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis by Meng Xiong, Meng Xiong, Meng Xiong, Jun Peng, Shunhua Zhou, Shunhua Zhou, Shunhua Zhou, Qing Gao, Qing Gao, Qing Gao, Jing Lu, Jing Lu, Chen Ou, Houpan Song, Houpan Song, Houpan Song, Qinghua Peng, Qinghua Peng, Qinghua Peng

“…This study systematically reviewed the key active metabolites in L. barbarum L., including L. barbarum polysaccharides, carotenoids, and flavonoids, that exert retinal protective effects. A comprehensive analysis of the pharmacological effects and underlying molecular mechanisms of L. barbarum L. and its active metabolites in the prevention and treatment of retinal cell apoptosis, including essential aspects such as antioxidant activity, anti-inflammatory properties, autophagy regulation, and mitochondrial function preservation, is essential to establish a comprehensive and solid theoretical basis for further investigation of the medicinal value of L. barbarum L. in ophthalmology and provide a reference for future research directions.…”
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Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats by Yang Bai, Rui Wang, Can Jin, Can Jin, Lili Wang, Yun Tang, Han Wang, Kan Ding, Kan Ding, Shanjun Cai

“…Retinal neovascularization, a pathological form of angiogenesis, is a leading cause of blindness. …”
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Quantitative analysis of peripapillary RNFL capillary density and thickness in patients with mild nonproliferative diabetic retinopathy by Zelie Cao, Tao Tian, Ru Liu, Jinli Peng, Guoping Kuang

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