Circadian Regulator-Mediated Molecular Subtypes Depict the Features of Tumor Microenvironment and Indicate Prognosis in Head and Neck Squamous Cell Carcinoma by Ling Aye, Zhanying Wang, Fanghua Chen, Yujun Xiong, Jiaying Zhou, Feizhen Wu, Li Hu, Dehui Wang

“…Specifically, PER3 indicated a better prognosis and inhibited HNSCC cell proliferation. Moreover, HNSCC tissues displayed three circadian regulator patterns with distinct clinical outcomes, transcriptomic characteristics, and microenvironment features. …”
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Epithelial cells with high TOP2A expression promote cervical cancer progression by regulating the transcription factor FOXM1 by Wei Sun, Wei Sun, Lu Chen, Xiaoling Feng

“…This subpopulation exhibited disrupted mitosis and cell cycle regulation, along with features of high proliferation, high energy metabolism, and matrix plasticity. …”
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Suppressive effects of deep balanced anesthesia on cellular immunity and protein expression: a randomized-controlled pilot study by Xuan Duc Nguyen, Audrey Horn, Dania Fischer, Grietje Beck, Cora C. Spannenberger, Brice Gaudilliere, Jean-Louis Horn, Hermann-Josef Thierse, Thomas Frietsch

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Matrix Architecture and Mechanics Regulate Myofibril Organization, Costamere Assembly, and Contractility in Engineered Myocardial Microtissues by Samuel J. DePalma, Javiera Jilberto, Austin E. Stis, Darcy D. Huang, Jason Lo, Christopher D. Davidson, Aamilah Chowdhury, Robert N. Kent III, Maggie E. Jewett, Hiba Kobeissi, Christopher S. Chen, Emma Lejeune, Adam S. Helms, David A. Nordsletten, Brendon M. Baker

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Depth-dependent contributions of various vascular zones to cerebral autoregulation and functional hyperemia: An in-silico analysis. by Hadi Esfandi, Mahshad Javidan, Rozalyn M Anderson, Ramin Pashaie

“…To determine relative contributions of distinct vascular zones across different cortical depths in CBF regulation, we developed a simplified yet detailed and computationally efficient model of the mouse cerebrovasculature. …”
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Pyroptosis regulation by Salmonella effectors by Yuan Meng, Yuan Meng, Qianjin Zhang, Qianjin Zhang, Mengen Xu, Mengen Xu, Ke Ding, Ke Ding, Ke Ding, Zuhua Yu, Zuhua Yu, Jing Li, Jing Li

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Epigenetic regulation of cancer stemness by Claudia Galassi, Gwenola Manic, Manel Esteller, Lorenzo Galluzzi, Ilio Vitale

“…Here, we provide an in-depth discussion of the impact of epigenetic alterations on cancer stemness, i.e., the ability of a small population of poorly differentiated malignant cells to (1) self-renew while generating a more differentiated progeny, and (2) exhibit superior tumor initiating/repopulating potential along with exceptional plasticity and improved resistance to environmental and therapy-elicited stress. …”
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Housing Market Segmentation as a Driver of Urban Micro-Segregation? An In-Depth Analysis of Two Viennese Districts by Robert Musil, Jiannis Kaucic

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In-depth and high-throughput spatial proteomics for whole-tissue slice profiling by deep learning-facilitated sparse sampling strategy by Ritian Qin, Jiacheng Ma, Fuchu He, Weijie Qin

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TRIM21: a multifaceted regulator in cancer by Aizhuo Li, Jiannan Wang, Yi Qu

“…Moreover, TRIM21 has been found to play a multi-faceted role in cellular autophagy, metabolic reprogramming, immune escape, tumor proliferation, metastasis and resistance to cell death by regulating the stability and function of key proteins. …”
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Expression of CXCR-4 and CD 133 and it’s Correlation with Prognostic Pathologic Factors in Resectable Oral Squamous Cell Carcinoma: A Research Protocol by Nirlipta Swain, Arvind Shridhar Bhake

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Integrative metabolomics as emerging tool to study autophagy regulation by Sarah Stryeck, Ruth Birner-Gruenberger, Tobias Madl

“…Recent technological developments in metabolomics research have enabled in-depth characterization of complex metabolite mixtures in a wide range of biological, biomedical, environmental, agricultural, and nutritional research fields. …”
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Multiple roles of ALDH1 in health and disease by Wenqi Zhao, Wenqi Zhao, Yu Xia, Yu Xia, Zhiqi Gao, Zhiqi Gao, Jian Chen, Jian Chen, Erlong Zhang, Erlong Zhang

“…Aldehyde dehydrogenase 1 (ALDH1) is an important aldehyde-metabolizing enzyme that plays a key role in various biological processes, such as regulating cellular growth, modulating retinoic acid (RA) signaling pathways, and contributing to stem cell function. …”
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Optogenetic regulation of endogenous gene transcription in mammals by E. S. Omelina, A. V. Pindyurin

“…Despite the rapid development of approaches aimed to precisely control transcription of exogenous genes in time and space, design of systems providing similar tight regulation of endogenous gene expression is much more challenging. …”
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Regulation of protein arginine methyltransferase in osteoporosis: a narrative review by Ruiming Wen, Ruiqi Huang, Mianmian Yang, Jing Yang, Xuejie Yi

“…In-depth studies have found that these enzymes also play key roles in bone matrix protein metabolism, skeletal cell proliferation and differentiation, and signal pathway regulation to regulate bone formation, bone resorption balance, or both and jointly maintain bone health and stability. …”
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Planktonic foraminifera regulate calcification according to ocean density by Stergios D. Zarkogiannis, James W. B. Rae, Benjamin R. Shipley, P. Graham Mortyn

“…We observe that their shell weights increased with habitat depth, enabling the living cells to adjust their overall density to match that of the surrounding liquid. …”
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Annexins: central regulators of plant growth and stress signaling by Xie Chen, Zhu Mingyue, Shi Ruirui, Yang Liu, An Xiaoya, Wang Chao

“…Although research on plant annexins has aroused great interest, their depth and breadth still need further expansion compared with those of animal annexins. …”
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Recent insights on the impact of SWELL1 on metabolic syndromes by Mianhong Qin, Xuejie Yi, Ziqiang Duan, Bo Chang, Tao Li

“…SWELL1 is a key component of the volume-regulated anion channel (VRAC) and participates in cell volume regulation as an ion channel plasma membrane protein. …”
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The Generation and Regulation of Tissue-Resident Tregs and Their Role in Autoimmune Diseases by Shuang Wang, Xueyang Zou, Yi Zhang, Xiaoya Wang, Wei Yang, Yi Li

“…Regulatory T cells (Tregs), as an important subset of T cells, play an important role in maintaining body homeostasis by regulating immune responses and preventing autoimmune diseases. …”
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Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury by Zeping Liu, Chunyu Xiang, Xu Zhao, Toshimi Aizawa, Renrui Niu, Jianhui Zhao, Fengshuo Guo, Yueying Li, Wenqi Luo, Wanguo Liu, Rui Gu

“…Dynamic spatiotemporal neuroinflammation is vital to neurological recovery, which is collectively constituted by the dynamic changes in a series of inflammatory cells, including microglia, neutrophils, and astrocytes, among others. …”
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